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| 1 | Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains显示文摘The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion injury.The current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli(ST36)and Fengchi(GB20) stimulation.Rats were divided into five groups:uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes(3 times or 18 times)of electro-acupuncture stimulation before experimental cerebral ischemia was induced.Bcl-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments(P<0.05).The production was higher with 18 electro-acupuncture treatments in the ST36 groups(P<0.05).In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments(P<0.05).No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint groups.However,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups(P<0.05).The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon Mason CP Leung | 2012 | Neural Regeneration Research2012，7，24： | 3 |
| 2 | Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke显示文摘AIM To examine the safety and efficacy of mesenchymal stem cell(MSC) therapy for intracerebral haemorrhage with neurological dysfunctions for a year.METHODS MSC were ex vivo expanded from 29 mL(17-42 mL) autologous bone marrow. Patients were randomized to have two intravenous injections of autologous MSC or placebos in four weeks apart. Neurological functions and clinical outcomes were monitored before treatment and at 12^(th), 16^(th), 24^(th), 36^(th) and 60^(th) week upon completion of^(th)e treatment. RESULTS A mean of 4.57 × 10~7(range: 1.43 × 10~7-8.40 × 10~7) MSC per infusion was administered accounting to 8.54 × 10~5(2.65 × 10~5-1.45 × 10~6) per kilogram body weight in two occasions. There was neither adverse event at time of administration nor sign of de novo tumour development among patients after monitoring for a year post MSC therapy. Neuro-restoration and clinical improvement in terms of modified Barthel index, functional independence measure and extended Glasgow Outcome Scale were evident among patients having MSC therapy compared to patients receiving placebos. CONCLUSION Intravenous administration of autologous bone marrowderived MSC is safe and has the potential of improving neurological functions in chronic stroke patients with severe disability. | Kam Sze Tsang Chi Ping Stephanie Ng Xian Lun Zhu George Kwok Chu Wong Gang Lu Anil Tejbhan Ahuja Ka Sing Lawrence Wong Ho Keung Ng Wai Sang Poon | 2017 | World Journal of Stem Cells2017，9，8： | 3 |
| 3 | Failure mode and effects analysis using a group-based ev- idential reasoning approach 显示文摘 | Kwai-Sang Chin Ying-Ming Wang Gary Ka Kwai Poon et al | 2009 | Computers Operations Re- search2009，，36： | 1 |
| 4 | Risk evaluation in failure mode and effects analysisusing fuzzy weighted geometric mean显示文摘 | WANG Ying-Ming Kwai-Sang Chin Gray Ka Kwai Poon | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 5 | Geostatistical modelling of the spatial distribution of sewage pollution in coastal sediments显示文摘 | Poon Ka fai Wong R W H Lam M H W | 2000 | Water Research2000，34，1： | 1 |
| 6 | Risk evaluation in failure mode and effects analysis u- sing fuzzy weighted geometric mean 显示文摘 | Wang Ying-Ming Chin Kwai-Sang Kwai Poon Gary Ka | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 7 | Failure mode and effects analysis using a group- based evidential reasoning approach 显示文摘 | Chin Kwai-Sang Wang Ying-Ming Kwai Poon Gary Ka | 2009 | Computers & Operations Research2009，36，6： | 1 |
| 8 | Risk evaluation in failure mode and effects analysis using fuzzy weighted geometric mean显示文摘 | Wang Y M Chin K S Ka Kwai Poon G Yang J B | 2009 | Expert Syst Appl2009，36，： | 1 |
| 9 | Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma 显示文摘 | Poon RT Ka Kit Chung Siu Tim Cheung | 2004 | Clin Cancer Res2004，10，： | 1 |
| 10 | Risk evaluation in failure mode and effects analysis using fuzzy weighted geometric mean显示文摘 | KWAI SANG CHIN YING-MING WANG GARY KA KWAI POON | 2009 | Expert Systems with Applications2009，36，： | 1 |
| 11 | Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma显示文摘 | Danny Ka Ho Wong Fung Yu Huang Ching Lung Lai Ronnie Tung Ping Poon Wai Kay Seto James Fung Ivan Fan Ngai Hung Man Fung Yuen | 2011 | Hepatology2011，，3： | 1 |
| 12 | Failure model and effects analysis by data envelopment analysis 显示文摘 | Chin Kwaisang Wang Yingming Gary Ka Kwai Poon | 2009 | Decision Support Systems2009，48，： | 1 |
| 13 | Risk evaluation in failure mode and effects analysis using fuzzy weighted geometric mean显示文摘 | Wang Ying-Ming Chin Kwai-Sang Poon Gary Ka Kwai | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 14 | Transplantation of mesenchymal stem cells to the brain by topical application in an experimental traumatic brain injury model显示文摘 | Ping Kuen Lam Anthony Wing Ip Lo Kevin Ka Wan Wang Henry Chi Ho Lau Kevin Kai Chung Leung Kathy Tung Ching Li Paul Bo San Lai Wai Sang Poon | 2012 | Journal of Clinical Neuroscience2012，，： | 1 |
| 15 | Failure mode and effects analysis using a group-based evidential reasoning approach显示文摘 | Chin Kwaisang Wang Yingming Gary Ka Kwai Poon | 2009 | Computers & Operations Research2009，36，6： | 1 |
| 16 | Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression显示文摘 | Patrick Kwan Wai Sang Poon Ho-Keung Ng David E. Kang Virginia Wong Ping Wing Ng Colin H.T. Lui Ngai Chuen Sin Ka S. Wong Larry Baum | 2008 | Pharmacogenetics and Genomics2008，，11： | 1 |
| 17 | Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response显示文摘 | Brigette B.Y. Ma Vivian W.Y. Lui Fan Fong Poon S.C. Cesar Wong Ka Fai To Elaine Wong Honglin Chen Kwok Wai Lo Qian Tao Anthony T.C. Chan | 2010 | Investigational New Drugs2010，，3： | 1 |
| 18 | Preclinical safety profile of trastuzumab emtansine(T-DM1):mechanism of action of its cytotoxic component retained with improved tolerability显示文摘 | Poon KA Flagella K Beyer JA Kaur S Saad O Yi J | 2013 | Toxicol Appl Pharmacol2013，273，2： | 1 |
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