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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | A search of the missing carbon sink:a model of terrestrial biospheric response to landuse change and atmospheric CO2显示文摘 | King A W Emanuel W R Wullschleger S D and Post W M | 1995 | Tellus1995，47，： | 1 |
| 3 | Balance between angiopoetin-1 and angiopoetin-2 is in favour of angiopoetin-2 in atherosclerotic plaques with high microvessel density 显示文摘 | Post S Peeters W Busser E | 2008 | J Vasc Res2008，45，3： | 1 |
| 4 | Electron beam CT versus helical CT scans for assessing coronary calcification: Current utility and future directions显示文摘 | NASIR K BUDOFF M J POST W S | 2003 | Am Heart J2003，146，6： | 1 |
| 5 | Studies in Silico-organic Compounds,ⅩⅩⅩⅢ:Organosilicon Compounds Containing Tin显示文摘 | PAPETTI S POST H W | 1957 | J Org Chem1957，22，5： | 1 |
| 6 | Balance between angiopoetin-1 and angiopoetin-2 is in favour of angiopoetin-2 in atherosclerotic plaques with high microvessel density显示文摘 | Post S Peeters W Busser E | 2008 | J Vasc Res2008，45，3： | 1 |
| 7 | The potential response of terrestrial carbon storage to changes in climate and atmospheric CO2 显示文摘 | KING A W POST W M WULLSCHLEGER S D | 1997 | Clim Change1997，35，2： | 1 |
| 8 | Isolation of Arcanobacterium(Actinomyces) pyogenes from cases of feline otitis externa and canine cystitis 显示文摘 | Billington S J Post K W Jost B H | 2002 | J Vet Diagn Invest2002，14，2： | 1 |
| 9 | Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction:a systematic review and bivariable meta-analysis显示文摘 | Cnossen J S Morris R K ter Riet G Mol B W van der Post J A Coomarasamy A | 2008 | CMAJ2008，178，： | 1 |
| 10 | Feasibility of a classification system for physical therapy,occupational therapy,and sports therapy interventions for mobility and self-care in spinal cord injury rehabilitation显示文摘 | van Langeveld S A Post M W van Asbeck F W | 2008 | Arch Phys Med Rehabil2008，89，8： | 1 |
| 11 | Heritability of left ventricular mass The Framingham heart study mass The Framingham heart study显示文摘 | Post W S Larson M G Myers R H | 1997 | Hypertension1997，30，5： | 1 |
| 12 | Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk:summary and discus- sion of the American society of echocardiography consen- sus statement 显示文摘 | Stein J H Korcarz C E Post W S | 2009 | Prey Cardiol2009，12，1： | 1 |
| 13 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 14 | Isolation of Arcanobacterium (Actinomyces) pyogenes from cases of feline otitis externa and canine cystitis 显示文摘 | Billington S J Post K W Jost B H | 2002 | J Vet Diagn Invest2002，14，2： | 1 |
| 15 | Measuring nursing needs of stroke patients in clinical rehabilitation: A comparison of validity and sensitivity to change be- tween the Northwiek Park Dependency Score and the Barthel Index 显示文摘 | Post M W Visser-Meily J M Gispen L S | 2002 | Clin Rehabil2002，16，2： | 1 |
| 16 | Modeling the variable amplitude fatigue of composite materials: a review and evaluation of the state of the art for spectrum loading显示文摘 | Post N L Case S W Lasko J J | 2008 | International Journal of Fatigue2008，，30： | 1 |
| 17 | Soil organic matter models and global estimates of soil organic carbon 显示文摘 | Post W King A Wullschleger S | 1996 | In: Evaluation of Soil Organic Matter Models: Springer1996，38，6： | 1 |
| 18 | Temperature-independent diel variation in soil respiration observed from atemperate deciduous forest 显示文摘 | Liu Q Edwards N Post W Gu L Ledford J Lenhart S | 2006 | Global Change Biol2006，12，11： | 1 |
| 19 | Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils显示文摘 | Ponath P D Qin S Post T W | 1996 | J Exp Med1996，183，6： | 1 |
| 20 | The effect of a single fraction compared to multipie fractions on painful bone metastases; a global analysis of the dutch bone metastasis study显示文摘 | Houwelingen H V Post W J | 1999 | Radiother Oncol1999，52，： | 1 |
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