2篇
您的检索式：作者名="Priya Handa"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 2 | Endothelial Acyl-CoA Synthetase 1 Is Not Required for Inflammatory and Apoptotic Effects of a Saturated Fatty Acid-Rich Environment显示文摘 | Xin Li Oscar Gonzalez Xia Shen Shelley Barnhart Farah Kramer Jenny E. Kanter Anuradha Vivekanandan-Giri Kyoichiro Tsuchiya Priya Handa Subramaniam Pennathur Francis Kim Rosalind A. Coleman Jean E. Schaffer Karin E. Bornfeldt | 2013 | Arteriosclerosis, Thrombosis, and Vascular Biology2013，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员