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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Growth and characterization of InGaN blue LED structure on Si (111)by MOCVD显示文摘 | Mo C L Fang W Q Pu Y | 2005 | JCrystGrowth2005，285，： | 1 |
| 3 | Hydrophilicmodification of poly (ether sulfone) ultrafiltration membranesurface by self-assembly of T1O2 nanoparticles 显示文摘 | Luo M L Zhao J Q Tang W Pu C S | 2005 | Applied Surface Science2005，249，： | 1 |
| 4 | Climate sensitivity of the Xiao Dongkemadi glacier in the Tanggula Pass 显示文摘 | WANG N L YAO T D Pu J C | 1996 | Cryosphere1996，18，2： | 1 |
| 5 | Theory of fractional covariance matrix and its applications in PCA and 2DPCA显示文摘 | Gao C B Zhou J L Pu Q | | 0，，： | 1 |
| 6 | Effects of stocking density on growth and non-speci-c immune responses in juvenile soft-shelled turtle, Pelodiscus sinensis显示文摘 | Chen X R Niu C J Pu L J | 2007 | Aquacult Res2007，38，： | 1 |
| 7 | Efficient and robust routing on scale-free networks显示文摘 | PU C L ZHOU S Y WANG K | 2012 | Physical A: Statistical Me- chanics and Its Applications2012，391，3： | 1 |
| 8 | Surface structure and biomedical properties of chemically polished and electropolished NiTi shape memory alloys显示文摘 | CHU C L WANG R M HU T YIN L H PU Y P LIN P H WU S L CHUNG C W YEUNG K W K CHU P K | 2008 | Materials Scienceand Engineering C2008，28，8： | 1 |
| 9 | Estimation of subpixel land surface temperature using an endmember index based technique:a case examination on ASTER and MODIS temperature products over a heterogeneous area显示文摘 | Yang G J Pu R L Zhao C J Huang W J and Wang J H | | 0，，05： | 1 |
| 10 | Biaryl-based macrocyclic and polymeric chiral(salophen)Ni(Ⅱ)complexes:synthesis and spectroscopic study显示文摘 | Zhang H C Huang W S Pu L | 2001 | J Org Chem2001，66，： | 1 |
| 11 | RGD-modified endostatin frag-ments showed anti-tumor effect via anti-angiogenesis 显示文摘 | Pu C Y Xu H M Hu J L | 2012 | Anticancer drugs2012，，： | 1 |
| 12 | 查看详情显示文摘 | Hu QS Vitharana D Zheng X F Wu C Kwan C M S and Pu L | | 0，，： | 1 |
| 13 | Carbon supported and unsupported Pt-Ru anodes for liquid feed direct methanol fuel cells显示文摘 | Liu L Pu C Viswanathan R | 1998 | Electrochim Acta1998，43，24： | 1 |
| 14 | Neuroprotective effects of phenylethanoid glycosides from cistanches salsa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced dopaminergic toxicity in C57 mice显示文摘 | Geng X C Song L W Pu X P | 2004 | Biol Pharm Bull2004，27，6： | 1 |
| 15 | Methanol oxidation on singlephase Pt-Ru-Os ternary alloys 显示文摘 | KEY K L LIU R PU C | 1997 | J Electrochem Soc1997，144，： | 1 |
| 16 | Fiber Tracking fiom DTI Using I,Linear State Space Models: Detectability of the Pyramideal Traet显示文摘 | Go'ssl C Fahrmeir L Pu' tz B | 2002 | Neurolmage2002，16，： | 1 |
| 17 | Fuzzy torque control strategy for parallel hybrid electric vehicles显示文摘 | PU J H YIN C L ZHANG J W | 2005 | International Journal of Automotive Technology2005，6，5： | 1 |
| 18 | The role of duloxetine in stress urinary inconti- nence: a systematic review and meta- analysis显示文摘 | Li J Yang L Pu C | 2013 | International Urology and Nephrology2013，45，3： | 1 |
| 19 | Combustion synthesis and photoluminescence of SrAl2O4:Eu,Dy phosphor nanoparticles显示文摘 | Peng T Y Yang H P Pu X L Hu B Jiang Z C Yan C H | | 0，，3： | 1 |
| 20 | Synthesis and properties of novel photochromic poly( methyl methacrylate-co-diarylethene) s 显示文摘 | Shen L Ma C Pu S Z | 2009 | New J Chem2009，33，4： | 1 |
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