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67篇 您的检索式:作者名="Pu Tan"
    题名 作者 年代 出处 被引量
1Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer显示文摘Shuanqyan Tan Qiheng Gou Wenchen Pu Chenglin Guo Yun Yang Ke Wu Yaxin Liu Lunxu Liu Yu-Quan Wei Yong Peng 2018Cell Research2018,28,6:24
2Geochemical Characteristics and Genesis of the Luxi-Xianrenzhang Diabase Dikes in Xiazhuang Uranium Orefield, Northern Guangdong Province显示文摘The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment in large ion lithophile elements, slight enrichment in light rare earth elements, depletion in Zr and Hf, and basically no depletion in Nb and Ta and no Eu anomaly. They are similar to intraplate basalt in terms of trace element characteristics. They have high εNd(t) values (3.6–4.9), initial 87Sr/86Sr ratios (0.70530–0.70641) and δ18O values and Dupal anomaly of Pb isotope compositions. Their Sr-Nd, Pb-Sr, Pb-Nd and Pb-Pb isotopes plot between DMM and EMII, with Pb similar to EMII, Nd relatively close to DMM and Sr in between. This profile suggests that the diabase dikes studied were derived from partial melting of a mantle source that had been subjected to metasomatism by fluids originated from a subduction zone under a tectonic environment of crustal extension and lithosphere thinning in the late Yanshanian.LING Hongfei SHEN Weizhou DENG Ping JIANG Shaoyong JIANG Yaohui YE Haimin PU Wei TAN Zhengzhong 2005Acta Geologica Sinica(English Edition)2005,79,4:13
3Integrating multisource RS data and GIS techniques to assist the evaluation of resource-environment carrying capacity in karst mountainous area显示文摘The karst mountainous area is an ecologically fragile region with prominent humanland contradictions.The resource-environment carrying capacity(RECC)of this region needs to be further clarified.The development of remote sensing(RS)and geographic information system(GIS)provides data sources and processing platform for RECC monitoring.This study analyzed and established the evaluation index system of RECC by considering particularity in the karst mountainous area of Southwest China;processed multisource RS data(Sentinel-2,Aster-DEM and Landsat-8)to extract the spatial distributions of nine key indexes by GIS techniques(information classification,overlay analysis and raster calculation);proposed the methods of index integration and fuzzy comprehensive evaluation of the RECC by GIS;and took a typical area,Guangnan County in Yunnan Province of China,as an experimental area to explore the effectiveness of the indexes and methods.The results showed that:(1)The important indexes affecting the RECC of karst mountainous area are water resources,tourism resources,position resources,geographical environment and soil erosion environment.(2)Data on cultivated land,construction land,minerals,transportation,water conservancy,ecosystem services,topography,soil erosion and rocky desertification can be obtained from RS data.GIS techniques integrate the information into the RECC results.The data extraction and processing methods are feasible on evaluating RECC.(3)The RECC of Guangnan County was in the mid-carrying level in 2018.The midcarrying and low-carrying levels were the main types,accounting for more than 80.00%of the total study area.The areas with high carrying capacity were mainly distributed in the northern regions of the northwest-southeast line of the county,and other areas have a low carrying capacity comparatively.The coordination between regional resource-environment status and socioeconomic development is the key to improve RECC.This study explores the evaluation index system of RECC in karst mountainous area and the application of multisource RS data and GIS techniques in the comprehensive evaluation.The methods can be applied in related fields to provide suggestions for data/information extraction and integration,and sustainable development.PU Jun-wei ZHAO Xiao-qing MIAO Pei-pei LI Si-nan TAN Kun WANG Qian TANG Wei 2020Journal of Mountain Science2020,17,10:6
4An Integrated Approach to Hypersonic Entry Attitude Control显示文摘This paper presents an integrated approach based on dynamic inversion(DI)and active disturbance rejection control(ADRC)to the entry attitude control of a generic hypersonic vehicle(GHV).DI is frstly used to cancel the nonlinearities of the GHV entry model to construct a basic attitude controller.To enhance the control performance and system robustness to inevitable disturbances,ADRC techniques,including the arranged transient process(ATP),nonlinear feedback(NF),and most importantly the extended state observer(ESO),are integrated with the basic DI controller.As one primary task,the stability and estimation error of the second-order nonlinear ESO are analyzed from a brand new perspective:the nonlinear ESO is treated as a specifc form of forced Li′enard system.Abundant qualitative properties of the Li′enard system are utilized to yield comprehensive theorems on nonlinear ESO solution behaviors,such as the boundedness,convergence,and existence of periodic solutions.Phase portraits of ESO estimation error dynamics are given to validate our analysis.At last,three groups of simulations,including comparative simulations with modeling errors,Monte Carlo runs with parametric uncertainties,and a six degrees-of-freedom reference entry trajectory tracking are executed,which demonstrate the superiority of the proposed integrated controller over the basic DI controller.Zhi-Qiang Pu Ru-Yi Yuan Xiang-Min Tan Jian-Qiang Yi 2014International Journal of Automation and computing2014,11,1:5
5Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates显示文摘Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In addition to the canonical C-terminal full-length huntingtin(htt) nuclear export signal,a cytoplasmic localization-related domain(CLRD) in the N-terminus of htt has recently been reported.Here,we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal htt protein and subsequently monitored htt expression,aggregation and subcellular localization by immunocytochemistry and Western blot analysis.We demonstrated that Htt4-17 was the essential sequence for htt cytoplasmic localization.We also found that the subcellular distribution of htt was altered when Htt1-17 was mutated to contain amino acids of different charges,suggesting a structural requirement of Htt1-17 for the cytoplasmic localization of htt. Deletion of the first three amino acids did not affect its association with mitochondria.We observed that defective cytoplasmic localization resulted in a reduction of total htt aggregates and increased nuclear aggregates,indicating that the subcellular distribution of the protein might influence the aggregation process.These studies provide new insight into the molecular mechanism of htt aggregation in HD.YAN YaPing PENG DanTao TIAN Jun CHI JingWei TAN JieQiong YIN XinZhen PU JiaLi XIA Kun ZHANG BaoRong 2011Science China(Life Sciences)2011,54,4:4
6Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1/VEGFA pathway and promoting PEDF expression显示文摘AIM:To evaluate the protective mechanisms of piperine in the retina of mice with streptozotocin-induced diabetes.METHODS:In experiments in vitro,stimulation by chemical hypoxia was established in ARPE-19 cells.Then,the expression of hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor A(VEGFA),and pigment epithelium-derived factor(PEDF)was assessed at the m RNA and protein levels.In experiments in vivo,diabetes mellitus was established by intraperitoneally injecting 150 mg/kg streptozotocin once.After 3 wk of the onset of diabetes,15 mg/kg piperine was intraperitoneally injected once daily for 1 or 3 wk.Then,the retinal morphology and m RNA and protein expression were assessed.RESULTS:In hypoxia,1-100μmol/L piperine significantly decreased the expression of VEGFA m RNA and increased the expression of PEDF m RNA without affecting HIF-1αm RNA.Meanwhile,100μmol/L piperine substantially decreased the protein level of VEGFA and increased the protein level of PEDF.The HIF-1αprotein level was also hampered by piperine.In the diabetic retina of mice,the morphological damage was alleviated by piperine.Likewise,the retinal vascular leakage was substantially decreased by piperine.Further,the protein levels of HIF-1αand VEGFA were significantly reduced by piperine.Moreover,the level of the antiangiogenic factor of PEDF dramatically increased by piperine.CONCLUSION:Piperine may exert protective effects on the retina of mice with diabetes via regulating the pro-antiangiogenic homeostasis composed of HIF-1/VEGFA and PEDF.Pu Zhang Yan-Dan Zhou Yao Tan Ling Gao 2021International Journal of Ophthalmology(English edition)2021,14,5:4
7Phylogenetic diversity stabilizes community biomass显示文摘Aims The relationship between biodiversity and ecological stability is a long-standing issue in ecology.Current diversity–stability studies,which have largely focused on species diversity,often report an increase in the stability of aggregate community properties with increasing species diversity.Few studies have examined the linkage between phylogenetic diversity,another important dimension of biodiversity,and stability.By taking species evolutionary history into account,phylogenetic diversity may better capture the diversity of traits and niches of species in a community than species diversity and better relate to temporal stability.In this study,we investigated whether phylogenetic diversity could affect temporal stability of community biomass independent of species diversity.Methods We performed an experiment in laboratory microcosms with a pool of 12 bacterivorous ciliated protist species.To eliminate the possibility of species diversity effects confounding with phylogenetic diversity effects,we assembled communities that had the same number of species but varied in the level of phylogenetic diversity.Weekly disturbance,in the form of short-term temperature shock,was imposed on each microcosm and species abundances were monitored over time.We examined the relationship between temporal stability of community biomass and phylogenetic diversity and evaluated the role of several stabilizing mechanisms for explaining the influence of phylogenetic diversity on temporal stability.Important Findings Our results showed that increasing phylogenetic diversity promoted temporal stability of community biomass.Both total community biomass and summed variances showed a U-shaped relationship with phylogenetic diversity,driven by the presence of large,competitively superior species that attained large biomass and high temporal variation in their biomass in both low and high phylogenetic diversity communities.Communities without these species showed patterns consistent with the reduced strength of competition and increasingly asynchronous species responses to environmental changes under higher phylogenetic diversity,two mechanisms that can drive positive diversity–stability relationships.These results support the utility of species phylogenetic knowledge for predicting ecosystem functions and their stability.Zhichao Pu Poonim Daya Jiaqi Tan Lin Jiang 2014Journal of Plant Ecology2014,7,2:4
8Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients.Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang 2021Stroke & Vascular Neurology2021,6,2:3
9Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR显示文摘Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families.Yu-Jia Wang Ayidana Kaierdebieke Si-Yuan Fan Rui-Feng Zhang Meng-Jie Huang Han Li Xiao-Nan Sun Qi-Yu Li Wen-Jia Meng Wen-Yu Wu Zhi Lin Jing-Yao Liu Xin-Pei Wang Yun-Chou Wu Jing-Qi Tang Yi-Ke Sun Ke Chen Pu Ge Wai-Kit Ming Casper Zhang Zheng Feei Ma Lei Feng Xin-Yue Zhang Yu-Yao Niu Yu-Pei Yan Yi-Le Jin Guang-Ze Gao Shuang Dai Yu-Liu Li Yue Tan Yi-Wei Wu Qi Zhang Gui Gui Xian-Li Pan Yan-Ming Liao Xian-Qi Zhao Ya-Ting Zhang Hui-Yi Chen Yue-Wei Qiu Xiao-Min Fu Jiang-Ling Zhou Dan Li Ke-Han Li Meng-Wei Xu Zhe Wang Yue-Qi Wang Yong Ma Xin-Ying Sun Yi-Bo Wu 2022Psychosomatic Medicine Research2022,4,3:3
10Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu 2014Cell2014,,:3
11Swansea criteria score in acute fatty liver of pregnancy显示文摘To the Editor:Acute fatty liver of pregnancy(AFLP)is an uncommon but potentially fatal disease unique to pregnancy that typically occurs in the third trimester and is one of the leading causes of maternal mortality in critically ill patients.^([1])The Swansea diagnostic criteria have been widely used in the diagnosis of AFLP worldwide since their proposal.The Swansea criteria include clinical symptoms and laboratory tests,imaging,and pathological examination results.Jianbo Tan Fei Hou Haofeng Xiong Lin Pu Pan Xiang Chuansheng Li 2022Chinese Medical Journal2022,,7:2
12The HuaBiao project:whole-exome sequencing of 5000 Han Chinese individuals显示文摘Next-generation sequencing technologies have significantly accelerated the identification of disease-causing mutations and facilitated the emergence of personalized medicine(Genomes Project Consortium et al.,2015;Goodwin et al.,2016;Sirugo et al.,2019).In comparison with whole-genome sequencing,whole-exome sequencing(WES),which covers the coding regions of the genome,offers a cost-efficacy balance.WES provides deeper sequencing depth(>100)and allows the more accurate detection of rare variants that are tailored for clinical applications(Lek et al.,2016).Meng Hao Weilin Pu Yi Li Shaoqing Wen Chang Sun Yanyun Ma Hongxiang Zheng Xingdong Chen Jingze Tan Guoqing Zhang Menghan Zhang Shuhua Xu Yi Wang Hui Li Jiucun Wang Li Jin 2021Journal of Genetics and Genomics2021,48,11:2
13Fourier-domain optical coherence tomography-guided phototherapeutic keratectomy for the treatment of anterior corneal scarring显示文摘AIM:To evaluate the safety,visual and anatomic outcomes of fourier-domain optical coherence tomography(FD-OCT)-guided excimer laser phototherapeutic keratectomy(PTK)combined with photorefractive keratectomy(PRK)surgery in treating anterior corneal scarring.METHODS:Clinical data of 23 eyes of 21 patients with anterior corneal scarring underwent FD-OCT-guided PTK and PRK from Dec.2014 to Jul.2016 were reviewed.Patients were assessed for preoperative and postoperative uncorrected visual acuity(UCVA),best spectacle-corrected visual acuity(BSCVA),contrast sensitivity(CS),FD-OCT,corneal topography and colour figures of anterior segments.RESULTS:The preoperative corneal pathologic conditions included viral keratitis(7 patients,7 eyes),band keratopathy(2 patients,4 eyes),corneal dystrophy(4 patients,4 eyes),traumatic corneal disease(2 patients,2 eyes)and corneal chemical injury(6 patients,6 eyes).Mean follow-up time was 10.65(range,3-19)mo.UCVA(in IogMAR)improved from a mean of 0.79(95%Cl,0.28­1.29)preoperatively to a mean of 0.45(95%Cl,0.29-0.62)postoperatively(P=0.021).BSCVA(in IogMAR)improved from 0.57(95%Cl,0.27-0.88)preoperatively to a mean of 0.28(95%Cl,0.15-0.41)postoperatively(P=0.001).Corneal topographic indices postoperatively showed significant improvement in corneal cylinder(P=0.009),the surface regularity index(P=0.007)and surface asymmetry index(P=0.00).Postoperative spherical equivalent averaged-0.53 diopters(-1.49 to 0.42).No complications were associated with the treatment.CONCLUSION:FD-OCT-guided PTK combined with PRK is safe and effective for the treatment of anterior corneal scarring by eliminating or reducing corneal opacities.Yu-Li Yang Qian Jian Bo Liu Ke Wang Yu-Juan Chen Lian Tan Mei-Jun Pu Yong Liu 2020International Journal of Ophthalmology(English edition)2020,13,11:2
14A Review of the Application of Additive Manufacturing in Prosthetic and Orthotic Clinics from a Biomechanical Perspective显示文摘Prostheses and orthoses are common assistive devices to meet the biomechanical needs of people with physical disabilities.The traditional fabrication approach for prostheses or orthoses is a materialwasting,time-consuming,and labor-intensive process.Additive manufacturing(AM)technology has advantages that can solve these problems.Many trials have been conducted in fabricating prostheses and orthoses.However,there is still a gap between the hype and the expected realities of AM in prosthetic and orthotic clinics.One of the key challenges is the lack of a systematic framework of integrated technologies with the AM procedure;another challenge is the need to design a prosthetic or orthotic product that can meet the requirements of both comfort and function.This study reviews the current state of application of AM technologies in prosthesis and orthosis fabrication,and discusses optimal design using computational methods and biomechanical evaluations of product performance.A systematic framework of the AM procedure is proposed,which covers the scanning of affected body parts through to the final designed adaptable product.A cycle of optimal design and biomechanical evaluation of products using finite-element analysis is included in the framework.A mature framework of the AM procedure and sufficient evidence that the resulting products show satisfactory biomechanical performance will promote the application of AM in prosthetic and orthotic clinics.Yan Wang Qitao Tan Fang Pu David Boone Ming Zhang 2020Engineering2020,6,11:2
15Association of human leukocyte antigen-DR-DQ-DP haplotypes with the risk of hepatitis B virus-related hepatocellular carcinoma显示文摘Aim:Genetic polymorphisms of human leukocyte antigen(HLA)class II molecules are associated with chronic hepatitis B virus(HBV)infection.We aimed to investigate the impacts of HLA-II haplotypes on viral evolution and the risks of HBV-caused liver diseases.Methods:HLA-DR-DQ-DP haplotypes were estimated in 1210 healthy controls,296 HBV clearance subjects,301 asymptomatic hepatitis B surface antigen carriers,770 chronic hepatitis B patients,443 HBV-related liver cirrhosis(LC)patients,and 1037 HBV-related hepatocellular carcinoma(HCC)patients.HBV mutations were determined by sequencing.The associations of HLA-DR-DQ-DP haplotypes with viral mutations and the risks of liver diseases were assessed by multivariate logistic regression.Results:Compared to HBV-free subjects,the haplotypes CCAACG,CCGACG,TCAATA,and TCGATA were associated with decreased HCC risk,with an odds ratio(OR)[95%confidence interval(CI)]of 0.62(0.40-0.95),0.60(0.39-0.92),0.73(0.54-0.98),and 0.58(0.42-0.78),respectively.CCAACG,CCGACG,and TCAATA were significantly associated with decreased frequencies of the HCC-risk HBV mutations:preS1 deletion,APOBECsignature HBV mutations in the core promoter and preS regions,A51C/T,G104C/T,and G146C/T.TCGATA and TTAACG were associated with increased LC risk,with an OR(95%CI)of 1.54(1.03-2.30)and 2.23(1.50-3.33),respectively.However,TCGATA and TTAACG were not consistently associated with the cirrhosis-risk HBV mutations.Conclusion:CCAACG,CCGACG,and TCAATA are inversely associated with HCC risk,possibly because they are involved in creating an immune microenvironment attenuating the generation of HCC-risk HBV mutations.TCGATA and TTAACG might predispose the polarity of immunity towards Th17 isotype related to LC.Yifan Chen Jiansheng Lin Yang Deng Wenbin Liu Zishuai Li Xinyu Zhou Shiliang Cai Rui Pu Jianhua Yin Xiaojie Tan Jun Zhao Xue Han Guangwen Cao 2022Hepatoma Research2022,8,1:2
16Comparisons of inhibin B versus antimtlllerian hormone in poor ovarian responders undergoing in vitro fertilization 显示文摘Tan R Pu D Liu L 2011Fertil Steril2011,96,4:1
17Multi-objective optimization of cassava based fuel ethanol used as an alternative automotive fuel in Guangxi,China显示文摘Zhiyuan Hu Piqiang Tan Gengqiang Pu 2006Applied Energy2006,38,:1
18Multi-Modality Video Representation for Action Recognition显示文摘Nowadays,action recognition is widely applied in many fields.However,action is hard to define by single modality information.The difference between image recognition and action recognition is that action recognition needs more modality information to depict one action,such as the appearance,the motion and the dynamic information.Due to the state of action evolves with the change of time,motion information must be considered when representing an action.Most of current methods define an action by spatial information and motion information.There are two key elements of current action recognition methods:spatial information achieved by sampling sparsely on video frames’sequence and the motion content mostly represented by the optical flow which is calculated on consecutive video frames.However,the relevance between them in current methods is weak.Therefore,to strengthen the associativity,this paper presents a new architecture consisted of three streams to obtain multi-modality information.The advantages of our network are:(a)We propose a new sampling approach to sample evenly on the video sequence for acquiring the appearance information;(b)We utilize ResNet101 for gaining high-level and distinguished features;(c)We advance a three-stream architecture to capture temporal,spatial and dynamic information.Experimental results on UCF101 dataset illustrate that our method outperforms other previous methods.Chao Zhu Yike Wang Dongbing Pu Miao Qi Hui Sun Lei Tan 2020Journal on Big Data2020,2,3:1
19Impact of obesity on hypogonadism in the andropansep显示文摘 Pu SJ 2002Int J Androl2002,25,4:1
20Is it andropause?Recognizing androgen deficiency in aging men显示文摘Tan RS Pu SJ 2004Postgrad Med2004,115,1:1
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