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| 1 | Cancer incidence,mortality,and burden in China:a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020显示文摘Background:Cancer is one of the leading causes of death and a main economic burden in China.Investigating the differences in cancer patterns and control strategies between China and developed countries could provide reference for policy planning and contribute to improving cancer control measures.In this study,we reviewed the rates and trends of cancer incidence and mortality and disability-adjusted life year(DALY)burden in China,and compared them with those in the United States(US)and the United Kingdom(UK).Methods:Cancer incidence,mortality,and DALY data for China,US and UK were obtained fromtheGLOBOCAN2020 online database,Global Burden of Disease(GBD)2019 study,and Cancer Incidence in Five Continents plus database(CI5 plus).Trends of cancer incidence and mortality in China,US,and UK were analyzed using Joinpoint regression models to calculate annual percent changes(APCs)and identify the best-fitting joinpoints.Results:An estimated 4,568,754 newly diagnosed cancer cases and 3,002,899 cancer deaths occurred in China in 2020.Additionally,cancers resulted in 67,340,309 DALYs in China.Compared to the US and UK,China had lower cancer incidence but higher cancer mortality andDALY rates.Furthermore,the cancer spectrum of China was changing,with a rapid increase incidence and burden of lung,breast,colorectal,and prostate cancer in addition to a high incidence and heavy burden of liver,stomach,esophageal,and cervical cancer.Conclusions:The cancer spectrum of China is changing from a developing country to a developed country.Population aging and increase of unhealthy lifestyles would continue to increase the cancer burden of China.Therefore,the Chinese authorities should adjust the national cancer control program with reference to the practices of cancer control which have been well-established in the developed countries,and taking consideration of the diversity of cancer types by of different regions in China at the same time. | Haibo Qiu Sumei Cao Ruihua Xu | 2021 | Cancer Communications2021，41，10： | 194 |
| 2 | Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination显示文摘Objective: The predictive and prognostic role of prognostic nutritional index(PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination.Methods: A total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yatsen University were retrospectively analyzed. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were analyzed.Results: Compared with PNI-high group, PNI-low group was correlated with advanced age(P=0.036), worse performance status(P<0.001), higher frequency of ascites(P<0.001) and higher frequency of multisite distant metastasis(P<0.001). Kaplan-Meier survival curves showed that PNI-high group had a significantly longer median overall survival than PNI-low group(13.13 vs. 9.03 months, P<0.001). Multivariate survival analysis revealed that Borrmann type IV(P=0.014), presence of ascites(P=0.017) and lower PNI(P=0.041) were independent poor prognostic factors, and palliative surgery(P<0.001) and first-line chemotherapy(P<0.001) were good prognostic factors. For patients receiving palliative surgery, the postoperative morbidity rates in the PNI-low group and PNIhigh group were 9.1% and 9.9%, respectively(P=0.797). The postoperative mortality rate was not significantly different between PNI-low and PNI-high groups(2.3% vs. 0.9%, P=0.362).Conclusions: PNI is a useful and practical tool for evaluating the nutritional status of gastric cancer patients with peritoneal dissemination, and is an independent prognostic factor for these patients. | Runcong Nie Shuqiang Yuan Shi Chen Xiaojiang Chen Yongming Chen Baoyan Zhu Haibo Qiu Zhiwei Zhou Junsheng Peng Yingbo Chen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 19 |
| 3 | Prognostic factors of primary gastrointestinal stromal tumors: a cohort study based on high-volume centers显示文摘Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors(GISTs).Methods: Data from 2,570 consecutive GIST patients from four medical centers in China(January2001–December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors.Results: Of the included patients, 1,375(53.5%) were male, and the patient age range was 18 to 95(median, 58)years. The tumors were mostly found in the stomach(64.5%), small intestine(25.1%) and colorectal region(5.1%).At the time of diagnosis, the median tumor size was 4.0(range: 0.1–55.0) cm, and the median mitotic index per 50 high power fields(HPFs) was 3(range: 0–254). Of the 2,168 resected patients, 2,009(92.7%) received curative resection. According to the modified National Institutes of Health(NIH) classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1(DOG-1), 8.0% for S-100, 31.0% for smooth muscle actin(SMA) and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib(P<0.001), whereas intermediate-risk patients did not(P=0.954).Conclusions: Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies. | Xuechao Liu Haibo Qiu Peng Zhang Xingyu Feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou | 2018 | Chinese Journal of Cancer Research2018，30，1： | 14 |
| 4 | The Cenozoic activities of Yangjiang-Yitongdong Fault: insights from analysis of the tectonic characteristics and evolution processes in western Zhujiang(Pearl) River Mouth Basin显示文摘The Yangjiang-Yitongdong Fault (YJF) is an important NW-trending regional fault, which divides the Zhujiang (Pearl) River Mouth Basin (ZRMB) into western and eastern segments. In Cenozoic, the northern continental margin of the South China Sea (SCS) underwent continental rifting, breakup, seafloor spreading and thermal subsidence processes, and the Cenozoic activities of YJF is one part of this series of complex processes. Two long NW-trending multichannel seismic profiles located on both sides of the YJF extending from the continental shelf to Continent-Ocean Boundary (COB) were used to study the tectonic and sedimentary characteristics of western ZRMB. Using the 2D-Move software and back-stripping method, we constructed the balance cross-section model and calculated the fault activity rate. Through the comprehensive consideration of tectonic position, tectonic evolution history, featured structure, and stress analysis, we deduced the activity history of the YJF in Cenozoic. The results showed that the YJF can be divided into two segments by the central uplift belt. From 65 Ma to 32 Ma, the YJF was in sinistral motion as a whole, inherited the preexisting sinistral motion of Mesozoic YJF, in which, the southern part of YJF was mainly in extension activity, controlling the formation and evolution of Yunkai Low Uplift, coupled with slight sinistral motion. From 32 Ma to 23.8 Ma, the sinistral motion in northern part of YJF continued, while the sinistral motion in southern part began to stop or shifted to a slightly dextral motion. After 23.8 Ma, the dextral motion in southern part of YJF continued, while the sinistral motion in northern part of YJF gradually stopped, or shifted to the slightly dextral motion. The shift of the YJF strike-slip direction may be related to the magmatic underplating in continent-ocean transition, southeastern ZRMB. According to the analysis of tectonic activity intensity and rift sedimentary structure, the activities of YJF in Cenozoic played a regulating role in the rift extension process of ZRMB. | Yuhan Li Rongwei Zhu Hailing Liu Xuelin Qiu Haibo Huang | 2019 | Acta Oceanologica Sinica2019，38，9： | 10 |
| 5 | Optimal Operation for Baoying Pumping Station in East Route Project of South-to-North Water Transfer显示文摘Baoying pumping station is a part of source pumping stations in East Route Project of South-to-North Water Transfer in China.Aiming at the characteristics of head varying, and making use of the function of pump adjustable blade, mathematical models of pumping station optimal operation are established and solved with genetic algorithm.For different total pumping discharge and total pumping volume of water per day, in order to minimize pumping station operation cost, the number and operation duties of running pump units are respectively determined at different periods of time in a day.The results indicate that the saving of electrical cost is significantly effected by the schemes of adjusting blade angles and time-varying electrical price when pumping certain water volume of water per day, and compared with conventional operation schemes(namely, the schemes of pumping station operation at design blade angles based on certain pumping discharge), the electrical cost is saved by 4.73%?31.27%.Also, compared with the electrical cost of conventional operation schemes, the electrical cost is saved by 2.03%?5.79% by the schemes of adjusting blade angles when pumping certain discharge. | FENG Xiaoli QIU Baoyun CAO Haihong WEI Qianglin TENG Haibo | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 7 |
| 6 | Effects of high-frequency oscillatory ventilation and conventional mechanical ventilation on oxygen metabolism and tissue perfusion in sheep models of acute respiratory distress syndrome显示文摘 | Liu Songqiao Huang Yingzi Wang Maohua Chen Qiuhua Liu Ling Xie Jianfeng Tan Li Guo Fengmei Yang Congshan Pan Chun Yang Yi Qiu Haibo | 2014 | Chinese Medical Journal2014，，18： | 6 |
| 7 | Safety and efficacy of toripalimab in advanced gastric cancer:A new clinical trial bringing hope for immunotherapy in gastric cancer显示文摘Epidemiological data indicate that gastric cancer(GC)remains highly prevalent in the world,although its global incidence is declining[1].It is the third leading cause of cancer death and a significant health burden in China[2-4].At the time of diagnosis,around 50%of GC cases are already locally advanced or metastatic[5,6]and can no longer be considered for curative surgical treatment[7].The prognosis for these patients is poor[4].Previous studies efforts have mainly focused on the improvements in chemotherapy and targeted therapy of advanced GC.So far,scientists have only found a few reagents that have shown to be effective against GC.However,the survival of GC patients treated with these reagents is marginal[8].Therefore,novel therapeutic approaches to treat GC are urgently required. | Haibo Qiu | 2020 | Cancer Communications2020，40，4： | 4 |
| 8 | Mechanical ventilation in acute respiratory distress syndrome: past, present and future显示文摘Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants.Mechanical ventilation (MV) is the foundation in the supportive management of patients with ARDS.1 However,it is associated with several complications,such as increased risk of pneumonia and development of lung injury.The improved understanding of ARDS and complications from MV has been considered important in designing lung-protective ventilatory strategies aimed at attenuating or preventing organ dysfunction and improving outcomes. | Xie Jianfeng Qiu Haibo | 2014 | Chinese Medical Journal2014，，10： | 2 |
| 9 | An economic feasibility study of O 2 /CO 2 recycle combustion technology based on existing coal-fired power plants in China显示文摘 | Jie Xiong Haibo Zhao Chuguang Zheng Zhaohui Liu Lingda Zeng Hao Liu Jianrong Qiu | 2008 | Fuel2008，，6： | 2 |
| 10 | An APWM resonant inverter topology for high frequency AC power distribution systems显示文摘 | Qiu Mei Jain P K Zhang Haibo | 2004 | IEEE Transactions on Power Electronics2004，19，1： | 1 |
| 11 | Effects of dexamethasone, ibaprofen,and ligustrazini on lipoposaecharidex - induced tumor necrosis factor alpha production显示文摘 | Qiu Haibo Pan Jiaqi Du Bin | 1997 | Acta Pharmacol Sin1997，18，1： | 1 |
| 12 | Two-dimensional CoNi@mesoporous carbon composite with heterogeneous structure toward broadband microwave absorber显示文摘Constructing composites with heterogeneous structure and dual loss mechanism shows great potential in designing microwave absorbers.In this work,two-dimensional cobalt and nickel alloys@mesoporous carbon(CoNi@MC)composites were constructed via using CoNi layered double hydroxide@mesoporous polydopamine(CoNi LDH@MPDA)as sacrifice template.During the pyrolysis process,the MPDA is transformed into mesoporous carbon coated the surface of CoNi LDH that is further reduced to CoNi alloys.The mesoporous structure is conducive to the multi-reflection of electromagnetic waves and facilitates optimizing impedance matching.Heterogeneous interfaces between CoNi alloys and mesoporous carbon induce interface polarization.Multiple attenuation mechanism promotes the electromagnetic waves conversion.The maximum reflection loss of CoNi@MC composite is−70.86 dB and the widest effective absorption bandwidth is 7.74 GHz covering almost the entire Ku band.This strategy will be a guidance for designing electromagnetic absorbers. | Yun Qiu Haibo Yang Fanfan Hu Ying Lin | 2022 | Nano Research2022，15，9： | 1 |
| 13 | Purifying chylous plasma by precluding triglyceride via carboxylated polyethersulfone microfiltration membrane显示文摘Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation stations.The current centrifugation procedure is high-cost and time-consuming.Herein,we fabricated an anionic microfiltration polyethersulfone(PES)membrane modified by interface swelling and implanting of acrylic acid(AA)for screening out large particle lipoprotein chylomicron(CM)and adsorbing cationic very low-density lipoproteins(VLDL).To improve the separation efficiency,a two-stage filtration through carboxylated polyethersulfone microfiltration membranes with the mean pore size of 0.45 and 0.22μm respectively were conducted.Attenuated total reflection Fourier transform infrared technique(ATR-FTIR),water contact angle(WCA),Zeta potential and scanning electron microscope(SEM)were employed to characterize the modified membrane.To test the effectiveness of this membrane,plasma flux and concentration variation of plasma components were examined to study the purification effectiveness.Furthermore,the hemocompatibility of modified membranes was tested to confirm its practicability on bloodcontacting materials.The carboxylated polyethersulfone microfiltration membrane shows its promising potential application to purify chylous plasma. | Yang Liu Qiu Han Guiliang Li Haibo Lin Fu Liu Gang Deng Dingfeng Lv Weijie Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，9： | 1 |
| 14 | Collective dynamics of two-species Bose-Einstein-condensate mixtures in a double-well potential显示文摘 | Qiu Haibo Tian Jing Fu Libin | | 0，，04： | 1 |
| 15 | Lead‑Carbon Batteries toward Future Energy Storage:From Mechanism and Materials to Applications显示文摘The lead acid battery has been a dominant device in large-scale energy storage systems since its invention in 1859.It has been the most successful commercialized aqueous electrochemical energy storage system ever since.In addition,this type of battery has witnessed the emergence and development of modern electricity-powered society.Nevertheless,lead acid batteries have technologically evolved since their invention.Over the past two decades,engineers and scientists have been exploring the applications of lead acid batteries in emerging devices such as hybrid electric vehicles and renewable energy storage;these applications necessitate operation under partial state of charge.Considerable endeavors have been devoted to the development of advanced carbon-enhanced lead acid battery(i.e.,lead-carbon battery)technologies.Achievements have been made in developing advanced lead-carbon negative electrodes.Additionally,there has been significant progress in developing commercially available lead-carbon battery products.Therefore,exploring a durable,long-life,corrosion-resistive lead dioxide positive electrode is of significance.In this review,the possible design strategies for advanced maintenance-free lead-carbon batteries and new rechargeable battery configurations based on lead acid battery technology are critically reviewed.Moreover,a synopsis of the lead-carbon battery is provided from the mechanism,additive manufacturing,electrode fabrication,and full cell evaluation to practical applications. | Jian Yin Haibo Lin Jun Shi Zheqi Lin Jinpeng Bao Yue Wang Xuliang Lin Yanlin Qin Xueqing Qiu Wenli Zhang | 2022 | Electrochemical Energy Reviews2022，5，3： | 1 |
| 16 | Targeting CDH17 Suppresses tumor progression in gastric cancer by downregulating Wnt /β-catenin signaling 显示文摘 | QIU Haibo ZHANG Li - yi CHAO Ren | 2013 | PLOS ONE2013，8，3： | 1 |
| 17 | Targeting CDH17 Suppresses tumor progression in gastric cancer by downregulating Wnt/b-catenin signaling显示文摘 | QIU Haibo ZHANG Li-yi CHAO Ren | | 0，，03： | 1 |
| 18 | Various approaches to modify biomaterial surfaces for improving hemocompatibility显示文摘 | Mao Chun Qiu Yongzhi Sang Haibo | 2004 | Adv Colloid Interf Sci2004，110，12： | 1 |
| 19 | Adsorption performance of low-cost gelatin-montmorillonite nanocomposite for Cr(Ⅲ) ions显示文摘 | QIU Jinghong DONG Shihua WANG Haibo | 2015 | RSC Advances2015，5，58： | 1 |
| 20 | Dynamic performance of an APWM resonant inverter for high frequency AC power distribution system显示文摘 | Qiu Mei Jain P K Zhang Haibo | 2006 | Power Electronics2006，21，6： | 1 |
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