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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 3 | CYCLIC VOLTAMMETRY STUDY ON ANTIMALARIAL MECHANISM OF ARTEMISININ(QINGHAOSU)DERIVATIVES显示文摘CYCLICVOLTAMMETRYSTUDYONANTIMALARIALMECHANISMOFARTEMISININ(QINGHAOSU)DERIVATIVES￥HuaLiangJIANG;KaiXianCHEN;YunTANG;JianZhongC... | Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK | 1996 | Chinese Chemical Letters1996，7，7： | 2 |
| 4 | Thoracic endovascular aortic repair for retrograde type A aortic dissection with an entry tear in the descending aorta 显示文摘 | Shu C Wang T Li QM | 2012 | J Vasc Interv Radiol2012，23，4： | 1 |
| 5 | Differentation of mesenehymal stem cells into dopaminergic neuron - like cells in vitro 显示文摘 | Li G Fei Y Hong QM | 2005 | Biomed Envivon Sci2005，18，5： | 1 |
| 6 | Ginsenoside R(e)increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase显示文摘 | Zhou QM Li XD Xie Y Duan X Min FL | 2006 | Arch Pharm Res2006，29，： | 1 |
| 7 | Frequency and allele burden of CALR mutations in Chinese with essential thrombocythemia and primary myelofibrosis without JAK2 (V617F) or MPL mutations 显示文摘 | Li N Yao QM Gale RP | 2015 | Leuk Res2015，39，5： | 1 |
| 8 | Ginsenoside R(e), increases fertileand asthenozoospermic infertile human sperm motility by inductionof nitric oxide synthase显示文摘 | Zhang H Zhou QM Li XD | 2006 | Arch Pharm Res2006，29，2： | 1 |
| 9 | A novel hepatitis B virus X-interactive protein: cytochrome C oxidase III显示文摘 | Wang XZ Li D Tao QM | 2006 | J Gastroenterol Hepatol2006，21，： | 1 |
| 10 | Antiviral Matrine-Type alkaloids from the rtlizomes of sophora tonkinensis显示文摘 | Pan QM Li YH Hua J | 2015 | J Nat Prod2015，78，7： | 1 |
| 11 | A convenient synthesis of novel thi- azolidin-4-one-linked pseudodisaceharides by tandem Staudinger/ aza-Wittig/cyclization and their biological evaluation 显示文摘 | Li XL Yin QM Jiao LY | 2011 | Carbohydr Res2011，346，3： | 1 |
| 12 | Early results of left carotid chimney technique inendovascular repair of acute non-a-non-B aortic dissections显示文摘 | Shu C Luo MY Li QM | 2011 | J Endovasc Ther2011，18，4： | 1 |
| 13 | Efficacy and safety comparisonbetween liraglutide as add-on therapy to insulin and insulin dose- increase in Chinese subjects with poorly controlled type 2 diabetes and abdominal obesity显示文摘 | Li CJ Li J Zhang QM | 2012 | Cardiovascular Diabetology2012，11，： | 1 |
| 14 | Efficacy and safety comparison between liraglufide as add-on therapy to insulin and insulin dose-increase in Chinese subjects with poorly conlrolled type 2 diabetes and abdominal obesity显示文摘 | Li C J Li J Zhang QM | 2012 | Cardiovasc Diabetol2012，11，： | 1 |
| 15 | A new strategy for prenatal di- agnosis of homozygous α0 - thalassemia 显示文摘 | Leung KY Liao C Li QM | 2006 | Ultrasound Obstet Gynecol2006，28，2： | 1 |
| 16 | Alternative concession model for build operate transfer contract projects 显示文摘 | Shen LY Li QM | 2002 | Journal of Construction Engineering and Management2002，128，4： | 1 |
| 17 | Association study of IFNAR2and IL10RB genes with the susceptibility and interferon response in HBV infection显示文摘 | Gong QM Kong XF Yang ZT Xu J Wang L Li XH Jin GD Gao J Zhang DH Jiang JH Lu ZM Zhang XX | 2009 | J Viral Hepat2009，16，9： | 1 |
| 18 | Efficacy and safety comparison be-tween liraglutide as add-on therapy to insulin and insulin dose-in- crease in Chinese subjects with poorly controlled type 2 diabetes and abdominal obesity显示文摘 | Li CJ Li J Zhang QM | 2012 | Cardiovasc Diabetol2012，15，11： | 1 |
| 19 | A new strategy for prenatal diagnosis of homozygousα0-thalassaemia显示文摘 | Leung KY Liao C Li QM | 2006 | Ultrasound Obstet Gynecol2006，28，2： | 1 |
| 20 | Synthesis of C-Pseudonucleosides bearing thiazolidin-4-one as a novel potential immunostimulating agent显示文摘 | Chen H Yin QM Li CX | 2011 | ACS Med Chem Lett2011，2，11： | 1 |
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