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| 1 | Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine显示文摘Dear Editor,COVID-19 vaccination campaigns are being conducted in countries worldwide,and 47.4% of the world population has received at least one dose of a COVID-19 vaccine.1 Although vaccination has shaped COVID-19 epidemic curves,waning antibody levels and relatively short-duration protection provided by current COVID-19 vaccines have been observed,especially against SARS-CoV-2 variants of concern(VOCs)and among older individuals. | Yunlong Cao Xiaohua Hao Xi Wang Qianhui Wu Rui Song Dong Zhao Weiliang Song Yao Wang Ayijiang Yisimayi Wei Wang Juan Du Hongjie Yu Xiaoliang Sunney Xie Ronghua Jin | 2022 | Cell Research2022，32，1： | 8 |
| 2 | Latent fingerprint enhancement on conductive substrates using electrodeposition of copper显示文摘We presented a novel method for the development of a latent fingerprint by selective electrodeposition of a copper thin film from sulfate solution onto the conductive substrate between fingerprint ridges to generate a negative image of the fingerprint deposit. After optimizing the parameters(deposition time, deposition potential, and copper concentration), the preferential electrodeposition of copper films allowed latent fingerprints on six kinds of conductive surfaces(indium/tin oxide-coated glass, silver sheet, platinum sheet, gold sheet, copper sheet, and a stainless steel coin) to be successfully developed with high resolution. In addition, this technique could also be exploited to visualize latent fingerprints on rough and dirty surfaces. The quality of the developed fingerprints was estimated visually and the morphology of the copper film was characterized by field emission scanning electron microscopy. | Meiqin Zhang Xi Yu Gang Qin Yu Zhu Meiling Wang Qianhui Wei Yang Zhang Xueji Zhang | 2015 | Science China Chemistry2015，58，7： | 5 |
| 3 | Research Progress on Estimation of the Atmospheric Boundary Layer Height显示文摘Atmospheric boundary layer height(ABLH)is an important parameter used to depict characteristics of the planetary boundary layer(PBL)in the lower troposphere.The ABLH is strongly associated with the vertical distributions of heat,mass,and energy in the PBL,and it is a key quantity in numerical simulation of the PBL and plays an essential role in atmospheric environmental assessment.In this paper,various definitions and methods for deriving and estimating the ABLH are summarized,from the perspectives of turbulent motion,PBL dynamics and thermodynamics,and distributions of various substances in the PBL.Different methods for determining the ABLH by means of direct observation and remote sensing retrieval are reviewed,and comparisons of the advantages and disadvantages of these methods are presented.The paper also summarizes the ABLH parameterization schemes,discusses current problems in the estimation of ABLH,and finally points out the directions for possible future breakthroughs in the ABLHrelated research and application. | Hongsheng ZHANG Xiaoye ZHANG Qianhui LI Xuhui CAI Shaojia FAN Yu SONG Fei HU Huizheng CHE Jiannong QUAN Ling KANG Tong ZHU | 2020 | Journal of Meteorological Research2020，34，3： | 3 |
| 4 | 2-Diphenylphosphinoyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis ofβ-Glycosides显示文摘Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate molecules.However,their stereochemistry control in glycosylation represents one of the most challenging tasks in carbohydrate chemistry. | Xianglai Liu Yetong Lin Ao Liu Qianhui Sun Huiyong Sun Peng Xu Guolong Li Yingying Song Weijia Xie Haopeng Sun Biao Yu Wei Li | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 5 | Evaluation of Cell Type Annotation R Packages on Single-cell RNA-seq显示文摘Annotating cell types is a critical step in single-cell RNA sequencing(scRNA-seq)data analysis.Some supervised or semi-supervised classification methods have recently emerged to enable automated cell type identification.However,comprehensive evaluations of these methods are lacking.Moreover,it is not clear whether some classification methods originally designed for analyzing other bulk omics data are adaptable to scRNA-seq analysis.In this study,we evaluated ten cell type annotation methods publicly available as R packages.Eight of them are popular methods developed specifically for single-cell research,including Seurat,scmap,SingleR,CHETAH,SingleCellNet,scID,Garnett,and SCINA.The other two methods were repurposed from deconvoluting DNA methylation data,i.e.,linear constrained projection(CP)and robust partial correlations(RPC).We conducted systematic comparisons on a wide variety of public scRNA-seq datasets as well as simulation data.We assessed the accuracy through intra-dataset and inter-dataset predictions;the robustness over practical challenges such as gene filtering,high similarity among cell types,and increased cell type classes;as well as the detection of rare and unknown cell types.Overall,methods such as Seurat,SingleR,CP,RPC,and SingleCellNet performed well,with Seurat being the best at annotating major cell types.Additionally,Seurat,SingleR,CP,and RPC were more robust against downsampling.However,Seurat did have a major drawback at predicting rare cell populations,and it was suboptimal at differentiating cell types highly similar to each other,compared to SingleR and RPC.All the code and data are available from http://gffzz188fe103f8f1460asofwv6kcqccw06wuk.ffgz.tsg.suse.edu.cn/qianhuiSenn/scRNA_cell_deconv_benchmark. | Qianhui Huang Yu Liu Yuheng Du Lana X.Garmire | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 1 |
| 6 | Housing Market Speculation and Firm Productivity:Evidence from China显示文摘An appreciation in the price of housing could generate speculation opportunities for enterprises.Many firms try to seize these opportunities for quick returns.This may harm their productivity.We use the real estate boom and the investment activities of Chinese manufacturing firms during 2006–2017 to examine the processes and the net effect of housing market speculation on firm productivity.We find that housing market speculation negatively affects firm productivity by crowding out investments in research and development and productive fixed assets,and the positive effect brought about by a strengthened balance sheet and better financing capacity is outweighed by the crowding-out effect.This negative impact is more evident in state-owned firms,but is mitigated in regions and periods with better business environments.Set in the overheated housing market in China,our study contributes to the existing literature by exploring how firms’investments outside of their main business influence firm behavior and productivity. | Qianhui Yu Yanying Chen Feng Helen Liang | 2021 | China & World Economy2021，29，5： | 0 |
| 7 | MFSD7c functions as a transporter of choline at the blood–brain barrier显示文摘Mutations in the orphan transporter MFSD7c(also known as Flvcr2),are linked to Fowler syndrome.Here,we used Mfsd7c knockout(Mfsd7c–/–)mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood–brain barrier(BBB).We performed comprehensive metabolomics analysis and detected differential changes of metabolites in the brains and livers of Mfsd7c–/–embryos.Particularly,we found that choline-related metabolites were altered in the brains but not in the livers of Mfsd7c–/–embryos.Thus,we hypothesized that MFSD7c regulates the level of choline in the brain.Indeed,expression of human MFSD7c in cells significantly increased choline uptake.Interestingly,we showed that choline uptake by MFSD7c is greatly increased by choline-metabolizing enzymes,leading us to demonstrate that MFSD7c is a facilitative transporter of choline.Furthermore,single-cell patch clamp analysis showed that the import of choline by MFSD7c is electrogenic.Choline transport function of MFSD7c was shown to be conserved in vertebrates,but not in yeasts.We demonstrated that human MFSD7c is a functional ortholog of HNM1,the yeast choline importer.We also showed that several missense mutations identified in patients exhibiting Fowler syndrome had abolished or reduced choline transport activity.Mice lacking Mfsd7c in endothelial cells of the central nervous system suppressed the import of exogenous choline from blood but unexpectedly had increased choline levels in the brain.Stable-isotope tracing study revealed that MFSD7c was required for exporting choline derived from lysophosphatidylcholine in the brain.Collectively,our work identifies MFSD7c as a choline exporter at the BBB and provides a foundation for future work to reveal the disease mechanisms of Fowler syndrome. | Xuan Thi Anh Nguyen Thanh Nha Uyen Le Toan Q.Nguyen Hoa Thi Thuy Ha Anna Artati Nancy C.P.Leong Dat T.Nguyen Pei Yen Lim Adelia Vicanatalita Susanto Qianhui Huang Ling Fam Lo Ngah Leong Isabelle Bonne Angela Lee Jorge L.Granadillo Catherine Gooch Dejie Yu Hua Huang Tuck Wah Soong Matthew Wook Chang Markus R.Wenk Jerzy Adamski Amaury Cazenave-Gassiot Long N.Nguyen | 2024 | Cell Research2024，34，3： | 0 |
| 8 | 盐摄入通过PPARδ/脂联素介导的SGLT2通路调控糖稳态显示文摘高盐摄入是糖尿病发生高血压的主要危险因素.促进肾脏盐排泄可减少糖尿病的心血管损害,但摄盐与糖稳态的相互作用尚不清楚。 | Yu Zhao Peng Gao Fang Sun Qiang Li Jing Chen Hao Yu Li Li Xing Wei Hongbo He Zongshi Lu Xiao Wei Bin Wang Yuanting Cui Shiqiang Xiong Qianhui Shang Aimin Xu Yu Huang Daoyan Liu 祝之明 | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | GranatumX:A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis显示文摘We present GranatumX,a next-generation software environment for single-cell RNA sequencing(scRNA-seq)data analysis.GranatumX is inspired by the interactive webtool Granatum.GranatumX enables biologists to access the latest scRNA-seq bioinformatics methods in a web-based graphical environment.It also offers software developers the opportunity to rapidly promote their own tools with others in customizable pipelines.The architecture of GranatumX allows for easy inclusion of plugin modules,named Gboxes,which wrap around bioinformatics tools written in various programming languages and on various platforms.GranatumX can be run on the cloud or private servers and generate reproducible results.It is a community-engaging,flexible,and evolving software ecosystem for scRNA-seq analysis,connecting developers with bench scientists.GranatumX is freely accessible at http://gffzz6e31a05dc69b4ca4hofwv6kcqccw06wuk.ffgz.tsg.suse.edu.cn/granatumx/app. | David G.Garmire Xun Zhu Aravind Mantravadi Qianhui Huang Breck Yunits Yu Liu Thomas Wolfgruber Olivier Poirion Tianying Zhao Cédric Arisdakessian Stefan Stanojevic Lana X.Garmire | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 0 |
| 10 | Screening of nanobody against Microcystis from a human phage display nanobody library显示文摘Microcystis species identification is essential for ecological studies and water bloom control.Immunoassays are more specific and convenient and several approaches have been used to develop for diagnosing harmful red tide algae.Howeve r,inve stigations onMicrocystis identification using immunological approaches are still in the initial stage.In this study.Microcystis aeruginosa PCC7806 lysates were utilized as coated antigens to enrich and screen specific Microcystis nanobodies from a human domain antibody display library.After three rounds of enrichment,10 positive monoclonal particles were isolated from the library and the most two positive nanobodies(DAb2 and Dab3)were effectively produced in Escherichia coli BL21.Finally,the DAb2 showed specific immune binding to different Microcystis by the immuno-dot blot assay.This antibody could be used to establish an immunological method to identify Microcystis. | Yao ZU Wenjie MIAO Yu LUO Chen XU Qianhui PAN Siyu CHEN Jianhong LI | 2022 | Journal of Oceanology and Limnology2022，40，5： | 0 |
| 11 | Immunogenicity and Safety of Homologous Booster Doses of CoronaVac COVID-19 Vaccine in Elderly Individuals Aged 60 Years and Older:A Dosing Interval Study—Yunnan Province,China,2021–2022显示文摘Summary What is already known about this topic?Neutralization levels induced by inactivated vaccines rapidly wane after primary immunization,and a homologous booster can recall specific immune memory,resulting in a remarkable increase in antibody concentration.The optimal interval between primary and booster doses has yet to be determined. | Haitao Yang Xing Meng Tingyu Zhuang Cangning Wang Zhongliang Yang Taotao Zhu Mei Li Yan Zheng Qianhui Wu Yaling Hu Hongjie Yu Xiaoqiang Liu Gang Zeng | 2023 | China CDC weekly2023，5，6： | 0 |
| 12 | COATS:Comprehensive observation on the atmospheric boundary layer three-dimensional structure during haze pollution in the North China Plain显示文摘The North China Plain(NCP)is troubled by severe haze pollution and the evolution of haze pollution is closely related to the atmospheric boundary layer(ABL).However,experimental and theoretical studies on the physical-chemical processes of the ABL in the NCP are lacking,with many scientific problems to be addressed.To solve these problems,the Comprehensive Observation on the Atmospheric boundary layer Three-dimensional Structure(COATS)during haze pollution was carried out in the NCP from 2016 to 2020.The COATS experiment adopted a'point-line-surface'spatial layout,obtaining both spatial-temporal profiles of the meteorological and environmental elements in the ABL and the turbulent transport data of fine particulate matter(PM_(2.5))in winter and summer.The research achievements are as follows.The spatial-temporal distribution characteristics of the ABL structure and PM_(2.5)concentrations in NCP were determined.The typical thermal structure of persistent heavy haze events and the pollutant removal mechanism by low-level jets were revealed.It was determined that the spatial structure of the ABL adjusted by the Taihang Mountains is responsible for the heterogeneous distribution of haze pollution in the NCP,and that mountain-induced vertical circulations can promote the formation of elevated pollution layers.The restraints of the atmospheric internal boundaries on horizontal diffusion of pollutants were emphasized.The contribution of the ABL to haze pollution in winter and summer was qualitatively compared and quantitatively estimated.The turbulent transport nature behind the relationship between the atmospheric boundary layer height(ABLH)and surface PM_(2.5)concentrations was analyzed.The concept of'aerosol accumulation layer'was defined,and the applicability of the material method in determining ABLH was clarified.A measurement system for obtaining the turbulent flux of PM_(2.5)concentrations was developed,and the turbulence characteristics of PM_(2.5)concentrations were demonstrated.The COATS experiment is of great theoretical significance for thoroughly understanding the physical mechanisms of the ABL during haze pollution and filling the knowledge gap on the impacts of the ABL three-dimensional structure on haze pollution.The results of this study are conducive to the improvement and development of ABL parameterization schemes and serve as a scientific basis for formulating regional pollution prevention and control measures. | Qianhui LI Hongsheng ZHANG Xiaoye ZHANG Xuhui CAI Xipeng JIN Lu ZHANG Yu SONG Ling KANG Fei HU Tong ZHU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
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