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| 1 | Heavy metals in rice and garden vegetables and their potential health risks to inhabitants in the vicinity of an industrial zone in Jiangsu, China显示文摘Contamination of soil and agricultural products by heavy metals resulting from rapid industrial development has caused major concern. In this study, we investigated heavy metal (Cu, Zn, Pb, Cr, Hg and Cd) concentrations in rice and garden vegetables, as well as in cultivated soils, in a rural-industrial developed region in southern Jiangsu, China, and estimated the potential health risks of metals to the inhabitants via consumption of locally produced rice and garden vegetables. A questionnaire-based survey on dietary consumption rates of foodstuffs showed that rice and vegetables accounted for 64% of total foodstuffs consumed, and over 60% of rice and vegetables were grown in the local region. Average concentrations of Cr, Cu, Zn, Cd, Hg and Pb were 0.75, 2.64, 12.00, 0.014, 0.006 and 0.054 mg/kg dw (dry weight) in rice and were 0.67, 1.18, 4.34, 0.011, 0.002 and 0.058 mg/kg fw (fresh weight) in garden vegetables, respectively. These values were all below the maximum allowable concentration in food in China except for Cr in vegetables. Leafy vegetables had higher metal concentrations than solanaceae vegetables. Average daily intake of Cr, Cu, Zn, Cd, Hg and Pb through the consumption of rice and garden vegetables were 5.66, 16.90, 74.21, 0.10, 0.04 and 0.43 μg/(kg·day), respectively. Although Hazard Quotient values of individual metals were all lower than 1, when all six metal intakes via self-planted rice and garden vegetables were combined, the Hazard Index value was close to 1. Potential health risks from exposure to heavy metals in self-planted rice and garden vegetables need more attention. | Hongbin Cao Jianjiang Chen Jun Zhang Hui Zhang Li Qiao Yi Men | 2010 | Journal of Environmental Sciences2010，22，11： | 61 |
| 2 | Comparison of Chlorophyll and Photosynthesis Parameters of Floating and Attached Ulva prolifera显示文摘In mid-May 2008 a serious green tide caused mainly by floating Ulva prolifera(Mller) J.Agardh(Chlorophyta,Ulvales) thalli struck the coastal area of Qingdao,China.To understand the present physiological conditions of the floating alga,in this work both laboratory and field investigations were conducted on the floating U.prolifera thalli in comparison with the attached U.prolifera thalli collected from the area.The floating thalli of three distinctively different colors and attached thalli at three different stages of sporangium formation process were characterized under a microscope,while their photosynthetic parameters were determined with chlorophyll fluorescence technology.On the other hand,the sporangium formation status of the floating U.prolifera thalli was surveyed both in the laboratory and in the field.Comparisons showed that both of the paired morphological characteristics and the paired physiological parameters of the floating and attached U.prolifera thalli were consistent.Furthermore,some spores were confirmed in the field and some motile particles were found within the floating thalli.These results suggest that the floating U.prolifera thalli with different colors could be at different stages of sporangium formation.However,our results also showed that the floating alga thalli have only a limited reproductive potential.This might limit the duration and the further geographic expansion of the green algal bloom. | Apeng Lin Songdong Shen Guangce Wang Qianqian Yi Hongjin Qiao Jianfeng Niu Guanghua Pan | 2011 | Journal of Integrative Plant Biology2011，53，1： | 20 |
| 3 | Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis显示文摘Background:Critical patients with the coronavirus disease 2019(COVID-19),even those whose nucleic acid test results had turned negative and those receiving maximal medical support,have been noted to progress to irreversible fatal respiratory failure.Lung transplantation(LT)as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.Methods:From February 10 to March 10,2020,three male patients were urgently assessed and listed for transplantation.After conducting a full ethical review and after obtaining assent from the family of the patients,we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.Results:Two of the three recipients survived post-LT and started participating in a rehabilitation program.Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved.The pathological results of the explanted lungs were concordant with the critical clinical manifestation,and provided insight towards better understanding of the disease.Government health affair systems,virology detection tools,and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.Conclusions:LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis.If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT,LT provided the final option for these patients to avoid certain death,with proper protection of transplant surgeons and medical staffs.By ensuring instant seamless care for both patients and medical teams,the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained. | Jing-Yu Chen Kun Qiao Feng Liu Bo Wu Xin Xu Guo-Qing Jiao Rong-Guo Lu Hui-Xing Li Jin Zhao Jian Huang Yi Yang Xiao-Jie Lu Jia-Shu Li Shu-Yun Jiang Da-Peng Wang Chun-Xiao Hu Gui-Long Wang Dong-Xiao Huang Guo-Hui Jiao Dong Wei Shu-Gao Ye Jian-An Huang Li Zhou Xiao-Qin Zhang Jian-Xing He | 2020 | Chinese Medical Journal2020，，12： | 19 |
| 4 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 5 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 6 | Impact of Residual SYNTAX Score and Its Derived Indexes on Clinical Outcomes after Percutaneous Coronary Intervention:Data from a Large Single Center显示文摘 | Ying Song Zhan Gao Xiao-Fang Tang Ping Jiang Jing-Jing Xu Yi Yao Jian-Xin Li Xue-Yan Zhao Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan | 2018 | Chinese Medical Journal2018，，12： | 11 |
| 7 | Exploratory Precipitation in North-Central China during the Past Four Centuries显示文摘Two robust precipitation reconstructions were conducted by combining tree-ring chronologies, dryness/wetness indices from historical documents, and climate data from the global grid. It was found that the recurrent drought history of a region can help us understand the variability of precipitation. Several dry/wet periods during the past four centuries and potential cycles of precipitation variation were determined. Furthermore, the reconstructions are not only consistent well with each other in North-central China, but also in good agreement with variations of precipitation in northeastern Mongolia, the Longxi area in Gangsu Province and the Dulan area of Qinghai Province, and the snow accumulation of the Guliya glacier. These synchronous variations indicate that it is valuable to study various climate records, find common information and determine the driving force of climate change. | YI Liang YU Hongjun XUXingyong YAO Jing SU Qiao GE Junyi | 2010 | Acta Geologica Sinica(English Edition)2010，84，1： | 11 |
| 8 | Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance显示文摘Objective: Vascular-targeted therapy is gradually becoming more appealing for patients with lung cancer. It is unclear whether vascular endothelial growth factor receptor 2(VEGFR2) and neuropilin-1(NRP-1) can be biomarkers for clinical treatment. We aimed to investigate the expression levels of VEGFR2 and NRP-1 in human non-small cell lung cancer(NSCLC) and their clinical significance by observing patient prognosis. Methods: VEGFR2 and NRP-1 were assessed by immunohistochemistry(IHC) in 40 patients with NSCLC and in 10 patients with benign lesions of lung; kinase insert domain receptor(KDR) and NRP-1 copy number gain(CNG) was assessed by fluorescence in situ hybridization(FISH). The distributions of overall survival(OS) and progression-free survival(PFS) were estimated using the Kaplan-Meier method and compared between groups by log-rank test.Results: Rates of positive immunostaining for VEGFR2 and NRP-1 were 58% and 55%, respectively. KDR and NRP-1 CNG(+) were detected in 32.5% and 30% of tumors, respectively. Levels of both VEGFR2 and NRP-1 in lung tumors were significantly different than in the control tissue(χ2=11.22, P=0.001; χ2=9.82, P=0.001, respectively); similar results were obtained using CNGs(χ2=4.39, P=0.036; χ2=3.95, P=0.046, respectively). Statistically significant correlations were observed with histological grade, clinical TNM stage and the lymph node status(P<0.05), but not age, gender or pathology type(P>0.05). VEGFR2 showed a strong correlation with NRP-1(Rs=0.68, P=0.00); similar results were observed with KDR and NRP-1 CNG(Rs=0.32, P=0.04). Significant differences in OS and PFS were observed between the groups with higher VEGFR2 and NRP-1 and those with lower expression(P<0.05). Conclusions: According to these data, VEGFR2 and NRP-1 are highly expressed in NSCLC. We can conclude that they play a key role in NSCLC occurrence, development and metastasis and are associated with patient prognosis(P<0.05 for OS and PFS). This information will be beneficial for clinical antiangiogenic treatment in NSCLC. | Manhua Ding Liang Liu Chengxi Hu Yi Liu Yun Qiao Xiaodong Jiang | 2014 | Chinese Journal of Cancer Research2014，26，6： | 11 |
| 9 | Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema显示文摘 | Ye Qiao Huang Kewu Ding Yi Lou Baohui Hou Ziliang Dai Huaping Wang Chen | 2014 | Chinese Medical Journal2014，，3： | 10 |
| 10 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 11 | Low-Dimensional Halide Perovskites and Their Advanced Optoelectronic Applications显示文摘Metal halide perovskites are crystalline materials originally developed out of scientific curiosity. They have shown great potential as active materials in optoelectronic applications. In the last 6 years, their certified photovoltaic efficiencies have reached 22.1%. Compared to bulk halide perovskites, low-dimensional ones exhibited novel physical properties. The photoluminescence quantum yields of perovskite quantum dots are close to 100%. The external quantum efficiencies and current efficiencies of perovskite quantum dot light-emitting diodes have reached 8% and 43 cd A^(-1),respectively, and their nanowire lasers show ultralow-threshold room-temperature lasing with emission tunability and ease of synthesis. Perovskite nanowire photodetectors reached a responsivity of 10 A W^(-1)and a specific normalized detectivity of the order of 10^(12 )Jones. Different from most reported reviews focusing on photovoltaic applications, we summarize the rapid progress in the study of low-dimensional perovskite materials, as well as their promising applications in optoelectronic devices. In particular, we review the wide tunability of fabrication methods and the state-of-the-art research outputs of low-dimensional perovskite optoelectronic devices. Finally, the anticipated challenges and potential for this exciting research are proposed. | Jian Zhang Xiaokun Yang Hui Deng Keke Qiao Umar Farooq Muhammad Ishaq Fei Yi Huan Liu Jiang Tang Haisheng Song | 2017 | Nano-Micro Letters2017，9，3： | 10 |
| 12 | Simultaneous determination of 14β-lactam antibiotics in cosmetic products by liquid chromatography tandem mass spectrometry method显示文摘在这研究,一个简单、快速的高效的液体 chromatographytandem 团 spectrometry ( HPLCMS/MS )方法被建立并且验证了在化妆产品决定 14 酮抗菌素,包括 1 ( ceftazidime ), 2 ( cefaclor ), 3 ( cefdinir ), 4 (氨比西林), 5 ( cefalexin ), 6 ( ceftezole ), 7 ( cefotaxim ), 8 ( cefradine ), 9 ( cefuroxime ), 10 ( cephazoline ), 11 ( cefathiamidine ), 12 ( cefoperazone ), 13 ( cafalotin ), 14 ( piperacillin )。 | Cai Sheng Wu Jin Lan Zhang Yan Ling Qiao Yi Lin Wang Zhi Rong Chen | 2011 | Chinese Chemical Letters2011，22，3： | 10 |
| 13 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 14 | Synthesis of CNT film on the surface of micro-pyramid array and its intense pulsed emission characteristics显示文摘We developed a new scheme to suppress the electric-field-screening effect in high growth density of a carbon nanotube(CNT) film during its intense pulsed emission.We synthesize the CNT film on a tridimensional surface(t-CNT film).The tridimensional surface includes wet etched silicon pyramids,and the Ni layer is electroless plated thereon.The intense pulsed emission characteristics of the t-CNT and planar-grown CNT(p-CNT) films were measured using a diode structure in single-pulse mode.The even turn-on field decreased from 5.5 V/μm for p-CNTs to 2.8 V/m for t-CNTs,and the peak emission current increased from 232 A for p-CNTs to 324 A for t-CNTs at a peak field intensity ~12.2 V/m.The peak current of the t-CNT film increased by ~39.7% over the p-CNT film.It is clear that the micro-pyramid array can effectively suppress the field screening effect to improve the electron-emission of CNT films. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2012 | Chinese Science Bulletin2012，57，14： | 10 |
| 15 | Studies on Reducing Nitrogen Excretion: Ⅰ. Net Energy Requirement of Finishing Pigs Maximizing Performance and Carcass Quality Fed Low Crude Protein Diets Supplemented with Crystalline Amino Acids显示文摘Two experiments were conducted to investigate the effects of net energy (NE) level on the performance and carcass traits of finishing pigs fed low crude protein (CP) diets supplemented with crystalline amino acids (CAA). A total of 216 (Exp.1) and 360 (Exp.2) barrows (Yorkshire×Landrace×Duroc) were allotted to one of six treatments (n=6). The experimental diets were based on corn and soybean meal, and consisted of a highCP diet that contained approximately 16% CP and 2.50 Mcal/kg of NE as well as five lowCP diets in which the CP level of the diet was reduced by approximately four percentage units but was supplemented with crystalline lysine, methionine, threonine, and tryptophan. The low CP diets provided 2.64, 2.58, 2.50, 2.42, or 2.36 Mcal/kg in Exp.1 as well as 2.45, 2.40, 2.35, 2.30, or 2.25 Mcal/kg in Exp.2. In Exp.1, a linear (P=0.03) increase in weight gain was observed with decreasing NE level while the ratio of gain to feed was unaffected (P>0.05) by NE level. There was a linear increase (P=0.01) in the percentage of fatfree lean and a linear decrease (P=0.03) in the percentage of total fat with decreasing NE levels. In Exp.2, a significant quadratic (P=0.03) effect of NE level was observed for weight gain. The ratio of gain to feed demonstrated a significant (P<0.01) quadratic effect with pigs fed 2.35 and 2.40 Mcal/kg of NE. Pigs fed the diet containing 2.40 Mcal/kg of NE had the lowest percentage of total fat (36.95%) and the highest percentage of fatfree lean (49.36%). The overall results of these experiments indicate that feeding either a surplus or a deficiency of NE is detrimental to both pig performance and carcass composition when low CP diets supplemented with CAA are fed. Our results indicate that when the CP content of the diet is reduced by four percentage units and the diet is properly supplemented with CAA, maximum performance and carcass quality will be obtained if the diet provides approximately 2.42 Mcal/kg of NE. | Hongyu Chen Xuewu Yi Guijie Zhang Ning Lu Licui Chu P. A. Thacker Shiyan Qiao | 2011 | Journal of Animal Science and Biotechnology2011，2，2： | 9 |
| 16 | Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao,China显示文摘Objective To determine whether elevated serum uric acid(UA)levels are associated with type 2 diabetes diagnosed using Hb A1 c levels among Chinese adults.Methods We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009.A total of 6894(39.4% men)subjects aged 35-74 years were included in the data analysis.Newly diagnosed diabetes was defined as Hb A1 c level of ≥6.5%,and prediabetes was classified as Hb A1 c level between 5.7% and 6.4% according to the International Diabetes Federation criteria.Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c(Hb A1 c levels.Results Subjects with prediabetes had higher UA levels than those with normal glucose tolerance,newly diagnosed diabetes,and known diabetes,with corresponding values of 325.1(82.5)μmol/L,310.9(84.2)μmol/L,291.3(81.7)μmol/L,305.2(83.6)μmol/L,respectively(P<0.001 for all comparisons).Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using Hb A1 c levels,and the second quartile of UA levels had a higher odds ratio(OR:4.088;95% CI:2.900-5.765)for Hb A1 c than the other quartiles after adjusting for age,body mass index,sex,marital status,education,income,alcohol consumption,smoking,and cardiometabolic parameters.Conclusion Serum UA is significantly associated with type 2 diabetes diagnosed using Hb A1 c levels,independent of other cardiometabolic parameters. | XUE Bai TAN Ji Bin NING Feng SUN Jian Ping ZHANG Ke Yi LIU Li WANG Shao Jie ZHANG Dong Feng QIAO Qing PANG Zeng Chang | 2015 | Biomedical and Environmental Sciences2015，28，12： | 9 |
| 17 | Establishment and reliability evaluation of the design space for HPLC analysis of six alkaloids in Coptis chinensis(Huanglian) using Bayesian approach显示文摘Coptis chinensis(Huanglian) is a commonly used traditional Chinese medicine(TCM) herb and alkaloids are the most important chemical constituents in it. In the present study, an isocratic reverse phase high performance liquid chromatography(RP-HPLC) method allowing the separation of six alkaloids in Huanglian was for the first time developed under the quality by design(Qb D) principles. First, five chromatographic parameters were identified to construct a Plackett-Burman experimental design. The critical resolution, analysis time, and peak width were responses modeled by multivariate linear regression. The results showed that the percentage of acetonitrile, concentration of sodium dodecyl sulfate, and concentration of potassium phosphate monobasic were statistically significant parameters(P < 0.05). Then, the Box-Behnken experimental design was applied to further evaluate the interactions between the three parameters on selected responses. Full quadratic models were built and used to establish the analytical design space. Moreover, the reliability of design space was estimated by the Bayesian posterior predictive distribution. The optimal separation was predicted at 40% acetonitrile, 1.7 g·m L-1of sodium dodecyl sulfate and 0.03 mol·m L-1 of potassium phosphate monobasic. Finally, the accuracy profile methodology was used to validate the established HPLC method. The results demonstrated that the Qb D concept could be efficiently used to develop a robust RP-HPLC analytical method for Huanglian. | DAI Sheng-Yun XU Bing ZHANG Yi LI Jian-Yu SUN Fei SHI Xin-Yuan QIAO Yan-Jiang | 2016 | Chinese Journal of Natural Medicines2016，14，9： | 9 |
| 18 | Effects of Dietary Net Energy Density and Standardized Ileal Digestible Lysine: Net Energy Ratio on the Performance and Carcass Characteristic of Growing-Finishing Pigs Fed Low Crude Protein Supplemented with Crystalline Amino Acids Diets显示文摘Two 3×3 factorial design trials with 1080 of Yorkshire×Landrace×Duroc barrows were conducted to investigate the effectsof dietary net energy (NE) density and standardized ileal digestible (SID) lysine:NE ratio on the performance of growing-finishing pigs and carcass characteristic of finishing pigs fed low crude protein (CP) supplemented with crystalline aminoacids (CAA) diets. Low CP corn-soybean meal basal diets (14% for Exp. 1 and 11% for Exp. 2) supplemented withcrystalline lysine, methionine, threonine, and tryptophan were formulated. Nine treatments with increasing NE densityand SID lysine:NE ratiowereused in each trial(Exp. 1: 9.66, 9.87, and 10.08 MJ kg-1 NE, 0.89, 0.96,and 1.03 g MJ-1 SID lysine:NE; Exp. 2: 9.83, 10.04, and 10.25 MJ kg-1 NE, 0.69, 0.76, and 0.83 g MJ-1 SID lysine:NE). In Exp. 1, we observed that theaverage daily gain (ADG) for barrows that received the diet containing 9.87 MJ kg-1 NE was significantly higher than thatof barrows fed a 9.66 MJ kg-1 NE diet (P<0.05), but no difference was observed when compared with barrows that receiveda diet containing 10.08 MJ kg-1 NE (P>0.05). TheADG was affected both linearly (P<0.05) and quadratically(P<0.05) as theSID lysine:NE ratio increased. The NE density or SID lysine:NE ratio and their interaction had no effect on the averagedaily feed intake (ADFI) and serum urea nitrogen (SUN) (P>0.05). The feed to gain ratio (F:G) decreased (linearly, P<0.05;quadratically, P<0.05) as the NE density or SID lysine:NE ratio increased, but no interaction of NE density and SID lysine:NE ratio on the F:G. In Exp. 2, the dietary NE density both linearly (P<0.05) and quadratically (P<0.05) affected the ADGand F:G. Barrows that received a diet containing 10.04 MJ kg-1 NE had a greater ADG (P<0.05) than barrows that receiveda 9.83 MJ kg-1 diet, but there was no difference (P>0.05) as compared with barrows that received a diet containing 10.25 MJkg-1 NE. F:G was significantly higher (P<0.05) for barrows that received a 9.83 MJ kg-1 diet when compared with barrowsthat received the other two diets. The ADG was significantly decreased (P<0.05) for pigs that received a diet containing0.69 g MJ-1 SID lysine:NE ratio when compared with pigs fed a diet containing 0.76 or 0.83 g MJ-1 SID lysine:NE ratio. TheNE density or SID lysine:NE ratio and their interaction had no effect on the average daily feed intake, SUN, and carcasscharacteristic for finishing barrows (P>0.05). The overall results of the two experiments indicated that barrows thatreceived the diet with the dietary CP level reduced 4 percentage units compared the NRC (1998) recommendations.Maximized the best performance with NE density and SID lysine:NE ratio were 9.87 MJ kg-1, 1.03 g MJ-1 NE for 20-50 kgpigs, and 10.04 MJ kg-1, 0.76 g MJ-1 NE for 60-100 kg pigs, respectively. | ZHANG Gui-jie YI Xue-wu CHU Li-cui LU Ning Htoo John QIAO Shi-yan | 2011 | Agricultural Sciences in China2011，10，4： | 8 |
| 19 | Age-related changes of the redox state of glutathione in plasma显示文摘Glutathione (GSH) is the principal non-protein thiol responsible for maintaining intracellular redox status and protecting cells against oxidative/nitrosative stresses. In the biological system, some GSH is bound to proteins, and others exist freely, including the reduced glutathione and oxidized glutathione (GSSG). Generally it is in a steady redox state for GSH/GSSG couple to participate in a variety of physiological functions. Earlier studies showed that chemically induced oxidative stress in vivo in rats resulted in increased GSSG and decreased GSH/GSSG ratio.1 The impairment of the glutathione homeostasis represents an indicator of tissue oxidative stresss status in human subjects. The “free radical theory of aging” considers that aging resulted from the accumulation of oxidative lesions mediated by free radicals. In the present study, we therefore investigated the effect of aging on the redox state of GSH/GSSG redox couple, which integrates the GSH concentration and the redox potential for GSSG/GSH couple. | WANG Qiu-lin WANG Shu-ren DING Yi PENG Ke-jun LIN Xia QIAO Xiao-rong LIU Yi-lun WU Chen-heng | 2005 | Chinese Medical Journal2005，，18： | 8 |
| 20 | A New Hemiterpene Derivative from Prinsepia utilis显示文摘A new hemiterpenoid, (+)-(2R,3S)-2-chloro-3-hydroxy-3-methyl-γ-buty-rolactone wasisolated from the leaves of Prinsepia utilis Royle. Its structure was elucidated by spectroscopicmethods and X-ray crystallographic analysis. | Jun Yi HU Wei QIAO Yoshihisa TAKAISHI Hong Quart DUAN | 2006 | Chinese Chemical Letters2006，17，2： | 8 |
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