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| 1 | Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells显示文摘Aim: To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods: The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3,-8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results: GA inhibited cell growth in a time-and dose-dependent manner. GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting. Conclusions: GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle. | Jingyan Xu Min Zhou Jian Ouyang Jing Wang Qiguo Zhang Yong Xu Yueyi Xu Qian Zhang Xihui Xu Hui Zeng | 2013 | Chinese Journal of Cancer Research2013，25，2： | 18 |
| 2 | Leaching and Redistribution of Nutrients in Surface Layer of Red Soils in Southeast China显示文摘The leaching and redistribution of nutrients in the surface layer of 4 types of red soils in Southeast China were studied with a lysimeter experiment under filed conditions.Results showed that the leaching concentrated in the rainy season(from April to June).Generally,the leaching of soil nutrients from the surface layer of red soils was in the order of Ca>Mg>K>NO3-N,In fertilization treatment,the total amount of soil nutrients leached out of the surface layer in a red soil derived from granite was the highest in all soils.The uptake by grass decreased the leaching of fertilizer ions in surface layer,particularly for No3-N,Soil total N and exchangeable K,Ca and Mg in the surface layer decreased with leaching and grass uptake during the 2 years without new fertilization of urea,Ca(H2PO4)2,KCl,CaCO3 and MgCO3,Ca moved from the application layer(0-5cm) of fertilizer and accumulated in the 10-30cm depth in the soils studied except that derved from quaternary red clay.The deficiency of soil exchangeable K will become a serious degradation process facing the Southeast China. | SUN BO ZHANG TAOLIN and ZHAO QIGUO(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Naniing 210008 China) | 2000 | Pedosphere2000，10，2： | 14 |
| 3 | Predicting As,Cd and Pb uptake by rice and vegetables using field data from China显示文摘Plant uptake factor(PUF),single-variable regression of natural log-transformed concentrations in rice grain/vegetables versus natural log-transformed concentrations in soil and multiple-variable regression with soil concentrations and pH,was derived,validated and compared based on the paired crop and soil data collected from studies regarding As,Cd and Pb contaminated croplands in China.Results showed that the median value of PUF did not present deterministic prediction.But after natural logarithm transformation,the PUF followed Gaussian distribution which could be useful in risk assessment.The single-variable regression models were significant for As,Cd and Pb uptake both by rice and vegetables;however,the standard errors of all the regressions were comparatively large.Soil pH as a variable was generally significant but it only contributed positively to model fit for Cd uptake.After model comparison and selection,the upper 95% prediction limits of the multiple regression model for Cd uptake by rice was recommended to calculate screening value of Cd for paddy soil based on the limit for Cd concentration in rice grain. | Hongzhen Zhang Yongming Luo Jing Song Haibo Zhang Jiaqi Xia Qiguo Zhao | 2011 | Journal of Environmental Sciences2011，23，1： | 12 |
| 4 | Evaluation of the Customer Satisfaction Index for Wellhead Blowout Preventers of China’s Petroleum Industry——A new method based on PLS显示文摘This paper establishes an evaluation model of the customer satisfaction index for the wellhead blowout preventers of China’s petroleum industry based on evaluation models of the customer satisfaction index at home and aboard, and by considering the consuming situation in China and the features of the China’s petroleum industry. For the existence of: (1) multiple correlations among the factors in the model; (2) the variables need to be explained, but that are hard to observe; (3) the customer satisfaction degree of observation variables appears the shape of skewness or two or three peaks, the correlations between the satisfaction index and its factors cannot be described by common multiple regression. This paper uses a partial least squares (PLS) method based on principal components and typical correlative analysis to solve the problem. When PLS is used in the model of the customer satisfaction index of the wellhead blowout preventers, the latent variables and the explanation degree coefficient of the manifest variable to the corresponding latent variables are estimated by PLS path analysis, and the influencing coefficient among the latent variables in the model is estimated by PLS regression analysis. PLS is also be used to calculate and analyze the model and disclose the correlations among the structural variables as well as the correlation between structural variables and its corresponding observation variables, evaluating results of which provide useful information for petroleum industry to improve the product quality and to the enhancement of the customer satisfaction to the product. | Zhang Peng Hu Qiguo Han Xia Zhang Bin | 2005 | Petroleum Science2005，2，3： | 8 |
| 5 | A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China显示文摘Crimean-Congo hemorrhagic fever virus(CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world.Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China.Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents. | Rong Guo Shu Shen Yanfang Zhang Junming Shi Zhengyuan Su Dan Liu Jinliang Liu Juan Yang Qiguo Wang Zhihong Hu Yujiang Zhang Fei Deng | 2017 | Virologica Sinica2017，32，1： | 5 |
| 6 | An efficient algorithm to compute transient pressure responses of slanted wells with arbitrary inclination in reservoirs显示文摘Compared with vertical and horizontal wells, the solution and computation of transient pressure responses of slanted wells are more complex. Vertical and horizontal wells are both simplified cases of slanted wells at particular inclination, so the model for slanted wells is more general and more complex than other models for vertical and horizontal wells. Many authors have studied unsteady-state flow of fluids in slanted wells and various solutions have been proposed. However, until now, few of the published results pertain to the computational efficiency. Whether in the time domain or in the Laplace domain, the computation of integration of complex functions is necessary in obtaining pressure responses of slanted wells, while the computation of the integration is complex and time-consuming. To obtain a perfect type curve the computation time is unacceptable even with an aid of high-speed computers. The purpose of this paper is to present an efficient algorithm to compute transient pressure distributions caused by slanted wells in reservoirs. Based on rigorous derivation, the transient pressure solution for slanted wells of any inclination angle is presented. Assuming an infinite-conductivity wellbore, the location of the equivalent-pressure point is determined. More importantly, according to the characteristics of the integrand in a transient pressure solution for slanted wells, the whole integral interval is partitioned into several small integral intervals, and then the method of variable substitution and the variable step-size piecewise numerical integration are employed. The amount of computation is significantly reduced and the computational efficiency is greatly improved. The algorithm proposed in this paper thoroughly solved the difficulty in the efficient and high-speed computation of transient pressure distribution of slanted wells with any inclination angle. | Wang Haitao Zhang Liehui Guo Jingjing Liu Qiguo He Xinming | 2012 | Petroleum Science2012，9，2： | 3 |
| 7 | Spatial Distribution and Changes of Heavy Metals of Agricultural Lands in Typical Pregrading Coast in Dongtai City,Jiangsu Province,China显示文摘According to the historical changes of coastal lines, seven soil sampling districts, from land to sea, were arranged in Dongtai City, Jiangsu Province to sample soils from surface and profile. Concentrations of seven major heavy metals (HMs), granularity, pH, organic matters and C/N of the soil samples were analyzed. Results show that concentrations of heavy metals in agricultural land present a certain spatial variance, decreasing from land to sea. Pollution assessment indicates that the agricultural soils were not polluted by HMs, but the potential pollution of Cu and Hg needs to be alerted. Different HMs accumulate in the surface and sub-surface of the soil profiles, and concentrations of Hg and Pb decrease significantly with the increment of soil depth. Concentrations of HMs exhibit a significantly negative correlation to pH, but have no significant relation with organic matters in soil. Principle component analysis show that the concentrations of HMs relate to the land use history. Concentrations of Hg, Ni and Cr in soil are closely related with land use history, and concentrations of Pb, Cu and Cr are affected by land use history as well as other factors. However, there is no significant relation between concentration of As and land use history. | LIAO Fuqiang ZHOU Shenglu ZHANG Hongfu WU Shaohua ZHAO Qiguo | 2008 | Chinese Geographical Science2008，18，3： | 3 |
| 8 | N-terminal domains of ARC1 are essential for interaction with the N-terminal region of Exo70A1 in transducing self-incompatibility of Brassica oleracea显示文摘自我障碍(SI ) 是一个重要交配系统阻止使近交并且支持 outcrossing。ARC1 和 Exo70A1 在 Brassica SI 发信号作为 S 地点受体 kinase 和戏保守人士角色的下游的目标工作。基于顺序相同, Exo70A1 被划分成四子域:白氨酸拉链(列伊 128-Leu149), hypervariable 区域(重量的单位 172-Leu197), 相扑修正主题(Glu 260-Ile275), 和 pfamExo70 领域(他的 271-Phe627) 。ARC1 如下包含四个领域:白氨酸拉链(列伊 116-Leu137), 卷卷领域(Thr 210-Val236),U 盒子(毒蛇 282-Trp347) 主题,和手臂(翼 415-Thr611) 领域。生物信息学分析,酵母二混血儿的屏蔽和 ARC1 116-236 的白氨酸拉链和卷卷主题为和 Exo70A1 的相互作用被要求的下拉试金表演,当手臂主题的增加导致和 Exo70A1 的相互作用的损失时。同时,没有任何域的 Exo70A1 的N终端与 ARC1 显示出一个弱相互作用,并且 LacZ 表示的水平与白氨酸拉链的增加增加并且与 hypervariable 区域和相扑修正主题到达最大的值,显示那个 hypervariable 区域和 Exo70A1 172-275的相扑修正主题为有 ARC1 的绑定主要负责,而 pfamExo70 领域为 ARC1 有很少亲密关系。位于 Exo70A1 hypervariable 区域的 Lys 181 可以是调停的 ubiquitination 地点在 ARC1 和 Exo70A1 之间的相互作用。因此,两有 ARC1 116-236, 和 hypervariable 区域和 Exo70A1 172-275 的相扑修正主题的卷卷结构的白氨酸拉链是在 ARC1 和 Exo70A1 之间的核心相互作用领域。影响这些核心领域的任何因素将是调停的 ARC1 的管理者在自我不兼容的系统的 ubiquitin 降级。 | Songmei Shi Qiguo Gao Jing Zeng Xiaohuan Liu Quanming Pu Guixi Liu Hecui Zhang Xiaohong Yang Liquan Zhu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 3 |
| 9 | A mobile polar atmospheric parameter measurement system:Ⅱ. First atmospheric turbulence observation at Antarctic Taishan Station显示文摘This is the second paper of a series devoted to atmospheric optical turbulence C2 n observation using a mobile polar atmospheric parameter measurement system. We present the initial results of C2 n measurement at Antarctic Taishan Station using micro-thermal sensors and a three-dimensional sonic anemometer at height ~2.0 m above the snow surface. The site testing experiments were carried out during the 30 th Chinese National Antarctic Research Expedition(CHINARE). We collected about 1 000 h of data between 30 December 2013 and 10 February 2014. The C2 n curve exhibits clear daily structures, with two peaks around midnight and midday and two troughs around 7:30 and 17:00 local time(UTC+5). The mean C2 n is 2.7×10-15 m-2/3 and the 25 th and 75 th percentiles of the C215 n cumulative distribution are 9.6×10-16 m-2/3 and 6.2×10- m-2/3, respectively. Meteorological parameters such as temperature, relative humidity, wind speed, and air pressure are also presented. | TIAN Qiguo JIANG Peng WU Xiaoqing JIN Xinmiao LU Shan JI Tuo CHAI Bo ZHANG Shaohua ZHOU Hongyan | 2015 | Advances in Polar Science2015，26，2： | 2 |
| 10 | Review of Researches on Advantages of Intercropping显示文摘Intercropping is a very effective cultivation method in the agricultural production with a long history. The use of intercropping to build a niche complementary crop community can not only enhance the stability of farmland ecosystem and the resistance of crop community to environmental stress but also reduce the damage of diseases, insect pests, environmental pollution and improve the efficiency of resource use to finally achieve high and stable yield of crop community. By collecting the intercropping researches at home and abroad, this thesis describes the impact of intercropping on crop nitrogen fixation and nitrogen transfer, accumulation and distribution of soil nitrate nitrogen, soil microorganism, crop diseases and insect pests, ventilation and light transmission, quality, yield and nutrient absorption, draws a conclusion on intercropping advantages and points out the sections requiring further study in the future. | ZHANG Xiang-qian HUANG Guo-qin BIAN Xin-min JIANG Xue-hai ZHAO Qiguo | 2012 | Asian Agricultural Research2012，4，12： | 2 |
| 11 | Effects of multiple heavy metal contamination and repeated phytoextraction by Sedum plumbizincicola on soil microbial properties显示文摘 | Jinping Jiang Longhua Wu Na Li Yongming Luo Ling Liu Qiguo Zhao Lei Zhang Peter Christie | 2009 | European Journal of Soil Biology2009，，1： | 1 |
| 12 | The interwell interference effect on numerical well test curve of oil-water phase显示文摘 | Zhang Liehui Xiang Zuping Li Yun Li Xiaoping Liu Qiguo | 2006 | Journal of Hydrodynamics (Series A)2006，21，6： | 1 |
| 13 | Response of ^(210)Pb_(ex) inventory to changes in soil erosion rates on uncultivated land显示文摘This analysis studies changes in the variation 210Pbex inventory in soil in response to soil erosion on uncultivated land.A model was created to fit the response of 210 Pb ex inventory to variations in soil erosion rates on uncultivated land using the principle of mass balance.By numerical simulation of the variation in the soil erosion rate in soil of uncultivated land,we prove:(1) past use of what has long been considered the best method of determining 210 Pb ex levels over the past 100 to 200 years is not scientifically accurate;(2) the model shows that variation in 210 Pb ex inventory as a function of time varies according to the index law after variation of soil erosion rates in uncultivated land is considered;and(3) the time needed for the variation in 210 Pb ex inventory to reach a steady-state is affected by changes in the rate of soil erosion and the quality and depth of relaxation in soil of uncultivated land.The results of this research can guide efforts to measure soil erosion rates. | SUN Wei YANG Hao ZHAO QiGuo ZHANG MingLi XU LiangJiang | 2013 | Chinese Science Bulletin2013，58，15： | 1 |
| 14 | Effect of silicon carbide particles on properties of Al/Sip + SiCp显示文摘 | Zhang Qiguo Gu Mingyuan | 2006 | Materials Science and Engineering A2006，19，4： | 1 |
| 15 | Interference well testing analysis when responding well is producing显示文摘 | Li Chengyong Zhang Ran Liu Qiguo Zhang Liehui | 2005 | Well Testing and Production Technology2005，26，2： | 1 |
| 16 | Thermogravimetric analysis of co-combustion of biomass and biochar显示文摘 | Qiguo Yi Fangjie Qi Gong Cheng Yongguang Zhang Bo Xiao Zhiquan Hu Shiming Liu Haiyan Cai Shan Xu | 2013 | Journal of Thermal Analysis and Calorimetry2013，，3： | 1 |
| 17 | Shear strength of surface soil as affected by soil bulk density and soil water content显示文摘 | ZHANG Bin ZHAO Qiguo HORN R | 2001 | Soil &Tillage Research2001，59，： | 1 |
| 18 | Rheological properties and gelcasting of concentrated aqueous silicon suspension显示文摘 | GU Mingyuan | 2005 | Materials Science and Engineering2005，399，2005： | 1 |
| 19 | A well test model for stress-sensitive and heterogeneous reservoirs with non-uniform thicknesses显示文摘In view of the anisotropy,heterogeneity and stress-sensitive permeability in low permeability reservoirs,an analytical well test model was established by introducing the concept of permeability modulus.This model considered the permeability stress-sensitivity,wellbore storage effect,and the skin effect.The perturbation technique and Laplace transformation were used to solve the mathematical model analytically in Laplace space,and the bottom-hole pressure type curves were plotted and analyzed in real space by using the Stehfest numerical inversion. | Zhang Liehui Guo Jingjing Liu Qiguo | 2010 | Petroleum Science2010，7，4： | 1 |
| 20 | Studies on the fracture and flexural strength of A1/Sip composite 显示文摘 | Qiguo Zhang Hongxiang Zhang Mingyuan Gu | 2004 | Materials Letters2004，58，2728： | 1 |
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