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| 1 | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy显示文摘The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 18 |
| 2 | Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes显示文摘We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor. | ZHANG Li LIU QingHua LIU ChengFang ZHAI XuWen FENG QiLong XU RuiLing CUI XiangLi ZHAO ZhiQing CAO JiMin WU BoWei | 2013 | Science China(Life Sciences)2013，56，9： | 7 |
| 3 | The three-dimensional structure and seasonal variation of the North Pacific meridional overturning circulation显示文摘The three-dimensional structure and the seasonal variation of the North Pacific meridional overturning circulation (NPMOC) are analyzed based on the Simple Ocean Data Assimilation data and Argo profiling float data.The NPMOC displays a multi-cell structure with four cells in the North Pacific altogether.The TC and the STC are a strong clockwise meridional cell in the low latitude ocean and a weaker clockwise meridional cell between 7°N and 18°N,respectively, while the DTC and the subpolar cell are a weaker anticlockwise meridional cell between 3°N and 15°N and a weakest anticlockwise meridional cell between 35°N and 50°N,respectively. The DTC,the TC and the STC are all of very strong seasonal variations.As to the DTC, the southward transport is strongest in fall and weakest in spring.For the TC,the northward transport is strongest in winter and weakest in spring,while the southward transport is strongest in fall and weakest in spring, which is associated with the strong southward flow of the DTC in fall.As the STC,the northward transport is strongest in winter and weakest in summer,while the southward transport is strongest in summer and weakest in spring. This seasonal difference may be associated with the DTC.The zonal wind stress and the east-west slope of sea level play important roles in the seasonal variations of the TC,the STC and the DTC. | LIU Hongwei ZHANG Qilong DUAN Yongliang HOU Yijun | 2011 | Acta Oceanologica Sinica2011，30，3： | 7 |
| 4 | The study on seasonal characteristics of water masses in the western East China Sea shelf area显示文摘On the basis of the CTD data and the modeling results in the winter and summer of 2009, the seasonal characteristics of the water masses in the western East China Sea shelf area were analyzed using a cluster analysis method. The results show that the distributions and temperature-salinity characteristics of the water masses in the study area are of distinct seasonal difference. In the western East China Sea shelf area, there are three water masses during winter, i.e., continental coastal water(CCW), Taiwan Warm Current surface water(TWCSW) and Yellow Sea mixing water(YSMW), but four ones during summer, i.e., the CCW, the TWCSW, Taiwan Warm Current deep water(TWCDW) and the YSMW. Of all, the CCW, the TWCSW and the TWCDW are all dominant water masses. The CCW, primarily characterized by a low salinity, has lower temperature, higher salinity and smaller spatial extent in winter than in summer. The TWCSW is warmer, fresher and smaller in summer than in winter, and it originates mostly from the Kuroshio surface water(KSW) northeast of Taiwan, China and less from the Taiwan Strait water during winter, but it consists of the strait water and the KSW during summer. The TWCDW is characterized by a low temperature and a high salinity, and originates completely in the Kuroshio subsurface water northeast of Taiwan. | ZHANG Qilong LIU Hongwei QIN Sisi YANG Dezhou LIU Zhiliang | 2014 | Acta Oceanologica Sinica2014，33，11： | 7 |
| 5 | Carbon-Selective Difluoromethylation of Soft Carbon Nucleophiles with Difluoromethylated Sulfonium Ylide显示文摘A highly carbon-selective difluoromethylation of soft carbon nucleophiles including ^-ketoesters, malonates, oxindoles, benzofuranones andketene silyl acetals with a difluoromethylated sulfonium ylide under mild conditions was described. Mechanistic studies suggest that these difluorometh-ylating reactions proceed via a difluorocarbene pathway. | Jiansheng Zhu Hanliang Zheng Xiao-Song Xue Yisa Xiao Yafei Liu Qilong Shen | 2018 | Chinese Journal of Chemistry2018，36，11： | 7 |
| 6 | An optimal one-way cooperative strategy for two defenders against an attacking missile显示文摘This paper investigates a cooperative strategy for protecting an aerial target.The problem is solved as a game among four players(a target,two defenders,and a missile).In this scenario,the target launches two defenders(defender-1 and defender-2)simultaneously,to establish a oneway cooperation system(OCS)against an attacking missile.A new optimal evasion strategy for the target is also derived.During the engagement,the target takes into account the reaction of the attacking missile,and guides defender-1 to the interception point by receiving information from defender-1.Depending on the control effort of the target,defender-2 can choose appropriate launch conditions and use very limited maneuvering capability to intercept the missile.For adversaries with first-order dynamics,simulation results show that the OCS allows two defenders to intercept the missile.During the engagement,even if one defender or communication channel is broken,the OCS still allows an interception to be made,thus increasing the target’s survivability. | Qilong SUN Naiming QI Zheyao XU Yanfang LIU Yong ZHANG | 2017 | Chinese Journal of Aeronautics2017，30，4： | 6 |
| 7 | Enhanced Reversible Zinc Ion Intercalation in Deficient Ammonium Vanadate for High-Performance Aqueous Zinc-Ion Battery显示文摘Ammonium vanadate with bronze structure(NH_(4)V_(4)O_(10))is a promising cathode material for zinc-ion batteries due to its high specific capacity and low cost.However,the extraction of NH^(+)_(4) at a high voltage during charge/discharge processes leads to irreversible reaction and structure degradation.In this work,partial NH^(+)_(4) ions were pre-removed from NH_(4)V_(4)O_(10) through heat treatment;NH_(4)V_(4)O_(10) nanosheets were directly grown on carbon cloth through hydrothermal method.Defi-cient NH_(4)V_(4)O_(10)(denoted as NVO),with enlarged interlayer spacing,facilitated fast zinc ions transport and high storage capacity and ensured the highly reversible electrochemical reaction and the good stability of layered structure.The NVO nanosheets delivered a high specific capac-ity of 457 mAh g^(−1) at a current density of 100 mA g^(−1) and a capacity retention of 81%over 1000 cycles at 2 A g^(−1).The initial Coulombic efficiency of NVO could reach up to 97%compared to 85%of NH_(4)V_(4)O_(10) and maintain almost 100%during cycling,indicating the high reaction reversibility in NVO electrode. | Quan Zong Wei Du Chaofeng Liu Hui Yang Qilong Zhang Zheng Zhou Muhammad Atif Mohamad Alsalhi Guozhong Cao | 2021 | Nano-Micro Letters2021，13，8： | 4 |
| 8 | Interannual variability in the Mindanao Eddy and its impact on thermohaline structure pattern显示文摘The major feature,interannual variability and variation cause of the Mindanao Eddy and its impact on the thermohaline structure are analyzed based on the Argo profiling float data,the history observed data and the SODA data.The analysis results show that the Mindanao Eddy is a permanent cyclonic meso-scale eddy and spreads vertically from about 500 m depth upward do about 50 m depth.In addition to its strong seasonal variability,the Mindanao Eddy displays a remarkable interannual variability associated with ENSO.It strengthens and expands eastward during El Nin o while it weakens and retreats westward during La Nin a.The interannual variability in the Mindanao Eddy may be caused by the North Equatorial Counter Current,the North Equatorial Current,the Mindanao Current and the Indonesian Through Flow.The eddy variability can have a great influence on the thermohaline structure pattern in the local upper ocean.When the eddy is strong,the cold and low salinity water inside the eddy moves violently upward from deep layer,the thermocline depth greatly shoals,and the subsurface high salinity water largely decreases,with the upper mixed layer becoming thinner,and vice versa. | ZHANG Qilong ZHOU Hui LIU Hongwei | 2012 | Acta Oceanologica Sinica2012，31，6： | 4 |
| 9 | Maize MS2 encodes an ATP-binding cassette transporter that is essential for anther development显示文摘The anther cuticle and pollen exine play a critical role in male gametophyte development. The sporopollenin precursors and cuticular lipid monomers are transported to the surface of the microspores and the epidermis by lipid transport proteins(LTPs) and ATP-binding cassette G(ABCG) transporters for the formation of the pollen wall and anther cuticle, respectively. However, the function of ABCG transporters in maize anther development is unclear. Here, we cloned the MS2 gene from the maize male sterile2 mutant using map-based cloning and determined that it encodes an ABCG transporter. MS2 protein was experimentally confirmed to be located on the cell membrane. The quantitative real-time PCR(qRT-PCR)results showed that MS2 was ubiquitously expressed in all vegetative and reproductive tissues, whereas a high transcriptional level of MS2 was observed in anthers, especially at the young microspore stage. Gas chromatography-mass spectrometry(GC–MS) analysis showed decreased accumulation of cutin and wax components in ms2 anthers, indicating that MS2 plays a role in the transport of lipid molecules to anther cuticle and pollen exine. To our knowledge, MS2 is the first reported ABCG transporter gene that participates in anther development in maize. | Qilong Xu Li Yang Dan Kang Zhenjing Ren Yunjun Liu | 2021 | The Crop Journal2021，9，6： | 4 |
| 10 | Guidance laws for attacking defended target显示文摘In this paper,two new guidance laws based on differential game theory are proposed and investigated for the attacker in an attacker-defender-target scenario.The conditions for the attacker winning the game are analyzed when the target and defender using the differential game guidance law based on the linear model.The core ideas underlying the two guidance laws are the attacker evading to a critical safe boundary from the defender,and then maintaining a critical miss distance.The guidance law more appropriate for the attacker to win the game differs according to the initial parameters.Unlike other guidance laws,when using the derived guidance laws there is no need to know the target and the defender’s control efforts.The results of numerical simulations show that the attacker can evade the defender and hit the target successfully by using the proposed derived guidance laws. | Qilong SUN Chenfeng ZHANG Ning LIU Weixue ZHOU Naiming QI | 2019 | Chinese Journal of Aeronautics2019，32，10： | 4 |
| 11 | Porous-hollow nanorods constructed from alternate intercalation of carbon and MoS2 monolayers for lithium and sodium storage显示文摘Weak ion diffusion and electron transport due to limited interlayer spacing and poor electrical conductivity have been identified as critical roadbacks for fast and abundant energy storage of both MoS2-based lithium ion batteries (LIBs) and sodium ion batteries (SIBs). In this work, MoS2 porous-hollow nanorods (MoS2/m-C800) have been designed and synthesized via an annealing-followed chemistry-intercalated strategy to solve the two issues. They are uniformly assembled from ultrathin MoS2 nanosheets, deviated to the rod-axis direction, with expanded interlayer spacing due to alternate intercalation of N-doped carbon monolayers between the adjacent MoS2 monolayers. Electrochemical studies of the MoS2/m-C800 sample, as an anode of LIBs, demonstrate that the superstructure can deliver a reversible discharge capacity of 1,170 mAh·g^-1 after 100 cycles at 0.2 A·g^-1 and maintain a reversible capacity of 951 mAh·g^-1 at 1.25 A·g^-1 after 350 cycles. While for SIBs, the superstructure also delivers a reversible discharge capacity of 350 mAh·g^-1 at 0.5 A-g-1 after 500 cycles and exhibits superior rate capacity of 238 mAh·g^-1 at 15 A·g^-1 .The excellent electrochemical performance is closely related with the hierarchical superstructures, including expanded interlayer spacing, alternate intercalation of carbon monolayers and mesoporous feature, which effectively reduce ion diffusion barrier, shorten ion diffusion paths and improve electrical conductivity. | Laiying Jing Gang Lian Junru Wang Mingwen Zhao Xizheng Liu Qilong Wang Deliang Cui Ching-Ping Wong | 2019 | Nano Research2019，12，8： | 3 |
| 12 | Key CO_(2)capture technology of pure oxygen exhaust gas combustion for syngas-fueled high-temperature fuel cells显示文摘Integrated gasification fuel cells(IGFCs)integrating high-temperature solid oxide fuel cell technology with CO_(2)capture processes represents highly-efficient power systems with negligible CO_(2)emissions.Flame burning with pure oxygen is an ideal method for fuel cell exhaust gas treatment,and this report describes experimental and numerical studies regarding an oxy-combustor for treating the exhaust gas of a 10 kW IGFC system anode.The applied simulation method was verified based on experiments,and the key performance indices of the combustor were studied under various conditions.It was determined that 315 K was the ideal condensation temperature to obtain flame stability.Under these pure oxygen flame burning conditions,CO was almost completely converted,and the dry mole fraction of CO_(2)after burning was C 0.958 when there was up to 5%excess O_(2).Overall,5%excess O_(2)was recommended to maximize CO_(2)capture and promote other environmental considerations.Additionally,the optimal tangential fuel jet angle to control the liner temperature was approximately 25°.The total fuel utilization had to be high enough to maintain the oxygen flame temperature of the anode exhaust gas below 1800 K to ensure that the system was environmentally friendly.The results presented herein have great value for designing IGFCs coupled with CO_(2)capture systems. | Hanlin Wang Qilong Lei Pingping Li Changlei Liu Yunpeng Xue Xuewei Zhang Chufu Li Zhibin Yang | 2021 | International Journal of Coal Science & Technology2021，8，3： | 3 |
| 13 | Rational Design and Development of Low-Price, Scalable, Shelf-Stable and Broadly Applicable Electrophilic Sulfonium Ylide-Based Trifluoromethylating Reagents显示文摘The development of two highly reactive electrophilic trifluoromethylating reagents(trifluoromethyl)(4-nitrophenyl)bis(carbometh-oxy)methylide(1g)and(trifluoromethyl)(3-chlorophenyl)bis(carbomethoxy)methylide(1j)through structure-activity study was described.Under mild conditions,reagent 1g reacted with β-ketoesters and silyl enol ethers to give α-trifluoromethylated-β-ketoesters or α-trifluoromethylated ketones in high yields.In addition,reagent 1g could serve as a trifluoromethyl radical for a variety of trifluo-romethylative transformations under visible light irradiation,including radical trifluoromethylation of electron-rich indoles and pyrroles and sodium aryl sulfinates as well as trifluoromethylative difunctionalization with styrene derivatives.On the other hand,as a complimentary,under reductive coupling conditions,reagent 1j reacted with a variety of(hetero)aryl iodides for the formation of tri-fluoromethylated(hetero)arenes. | Yafei Liu Yijing Ling Hangming Ge Long Lu Qilong Shen | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 14 | Effect of Elevated CO2 on the Growth and Macronutrient (N, P and K) Uptake of Annual Wormwood (Artemisia annua L.)显示文摘Annual wormwood(Artemisia annua L.) is the only viable source of artemisinin,an antimalarial drug.There is a pressing need to optimize production per cultivated area of this important medicinal plant;however,the effect of increasing atmospheric carbon dioxide(CO_2) concentration on its growth is still unclear.Therefore,a pot experiment was conducted in a free-air CO2 enrichment(FACE) facility in Yangzhou City,China.Two A.annua varieties,one wild and one cultivated,were grown under ambient(374μmol mol^(-1)) and elevated(577 μmol mol^(-1)) CO_2 levels to determine the dry matter accumulation and macronutrient uptake of aerial parts.The results showed that stem and leaf yields of both A.annua varieties increased significantly under elevated CO_2 due to the enhanced photosynthesis rate.Although nitrogen(N),phosphorus(P),and potassium(K) concentrations in leaves and stems of both varieties decreased under elevated CO_2,total shoot N,P,and K uptake of the two varieties were enhanced and the ratios among the concentrations of these nutrients(N:P,N:K,and P:K) were not affected by elevated CO_2.Overall,our results provided the evidence that elevated CO_2 increased biomass and shoot macronutrient uptake of two A.annua varieties. | ZHU Chunwu ZENG Qilong YU Hongyan LIU Shengjin DONG Gangqiang ZHU Jianguo | 2016 | Pedosphere2016，26，2： | 2 |
| 15 | Criterions for identifying H-tensors显示文摘 | Ruijuan ZHAO Lei GAO Qilong LIU Yaotang LI | 2016 | Frontiers of Mathematics in China2016，11，3： | 2 |
| 16 | Annual and interannual variations of the Western Pacific Warm Pool volume and sources of warm water revealed by Argo data显示文摘Based on gridded Argo profile data from January 2004 to December 2010, together with the P-vector inverse method, the three-dimensional structure, annual and inter-annual variations in volume of the Western Pacific Warm Pool(WPWP) are studied. The variations of latitudinal and longitudinal warm water flowing into and out of the WPWP and the probable mechanism of warm water maintenance are also discussed. From the surface to the bottom, climatic WPWP tilts southward and its area decreases. The maximum depth could extend to 120 m, such that its volume could attain 1.86×1015 m3. Annual variation of the WPWP volume shows two obvious peaks that occur in June and October, whereas its inter-annual variations are related to ENSO events. Based on a climatic perspective, the warm water flowing latitudinally into the pool is about 52 Sv, which is mainly through upper layers and via the eastern boundary. Latitudinally, warm water flowing outward is about 49 Sv, and this is mainly through lower layers and via the western boundary. In contrast, along the latitude, warm water flowing into and out of the pool is about 28 Sv and 23 Sv, respectively. Annual and inter-annual variations of the net transportation of the warm water demonstrate that the WPWP mainly loses warm water in the west-east direction, whereas it receives warm water from the north-south direction. The annual variation of the volume of WPWP is highly related to the annual variation of the net warm water transportation, however, they are not closely related on inter-annual time scale. On the inter-annual time scale, influences of ENSO events on the net warm water transportation in the north-south direction are much more than that in the west-east direction. Although there are some limitations and simplifications when using the P-vector method, it could still help improve our understanding of the WPWP, especially regarding the sources of the warm water. | WU XiaoFen ZHANG QiLong LIU ZengHong | 2014 | Science China Earth Sciences2014，57，9： | 2 |
| 17 | Rapid determination of phthalate esters in alcoholic beverages by conventional ionic liquid dispersive liquid–liquid microextraction coupled with high performance liquid chromatography显示文摘 | Yingying Fan Shuhui Liu Qilong Xie | 2014 | Talanta2014，，： | 2 |
| 18 | Biomass-derived hard carbon microtubes with tunable apertures for high-performance sodium-ion batteries显示文摘Sodium-ion batteries(SIBs)are considered the most up-and-coming complements for large-scale energy storage devices due to the abundance and cheap sodium.However,due to the bigger radius,it is still a great challenge to develop anode materials with suitable space for the intercalation of sodium ions.Herein,we present hard carbon microtubes(HCTs)with tunable apertures derived from low-cost natural kapok fibers via a carbonization process for SIBs.The resulted HCTs feature with smaller surface area and shorter Na+diffusion path benefitting from their unique micro-nano structure.Most importantly,the wall thickness of HCTs could be regulated and controlled by the carbonization temperature.At a high temperature of 1,600℃,the carbonized HCTs possess the smallest wall thickness,which reduces the diffusion barrier of Na+and enhances the reversibility Na+storage.As a result,the 1600HCTs deliver a high initial Coulombic efficiency of 90%,good cycling stability(89.4%of capacity retention over 100 cycles at 100 mA·g^(−1)),and excellent rate capacity.This work not only charts a new path for preparing hard carbon materials with adequate ion channels and novel tubular micro-nano structures but also unravels the mechanism of hard carbon materials for sodium storage. | Pin Song Shiqiang Wei Jun Di Jun Du Wenjie Xu Daobin Liu Changda Wang Sicong Qiao Yuyang Cao Qilong Cui Pengjun Zhang Liaobo Ma Jiewu Cui Yan Wang Yujie Xiong | 2023 | Nano Research2023，16，4： | 1 |
| 19 | Sehiff base compound as a corrosion inhibitor for mild steel in 1 M HCI 显示文摘 | Hong Liu Lin Zhu Qilong Zhao | 2015 | Research on Chemical Intermediates2015，41，： | 1 |
| 20 | Monofluoromethyl-Substituted Sulfonium Ylides:Preparation,Structure-Reactivity Study and Substrate Scope显示文摘of main observation and conclusion Structure-reactivity study of a family of electrophilic monofluoromethylating reagents based on sulfonium ylide skeleton with different steric hindrance and electron-withdrawing properties was described.These studies led us to discover two highly reactive reagents 3 with a cyclic malonate backbone and 6 with an electron-poor 1,1,1,5,5,5-hexafluoropentane-2,4-dione backbone.The high reactivity of reagent 6 allowed to highly selectively access either C-monofluoromethylated or O-monofluoromethylated p-ketoesters in high yields by the use of different bases.In addition,reactions of reagent 3 with a variety of nucleophiles including phenols,carboxylic acids,thiophenols or heteroaryl nucleophiles occurred in full conversion within 10 min at room temperature and the scopes for these reactions were reported in detail. | Xin Hong Yafei Liu Long Lu Qilong Shen | 2020 | Chinese Journal of Chemistry2020，38，11： | 1 |
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