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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 3 | The effect of central loops inmiRNA:MRE duplexes on the efficiency of miRNA-mediatedgene regulation显示文摘 | Ye W Lv Qing Wong CK | 2008 | PLoS ONE2008，3，： | 1 |
| 4 | Antioxidative activity of natural isorhapontigenin显示文摘 | Qing L W Mao L Geng T L | 2001 | Jpn J Pharmacol2001，87，： | 1 |
| 5 | Identification and characterization of lactic acid bacteria isolated from traditional pickles in Sichuan, China显示文摘 | Yu J Gao W Qing M | 2012 | The Journal of general and applied microbiology2012，58，3： | 1 |
| 6 | Alar flap combined with free auricular composite flap for the reconstruction of nasal alar defect 显示文摘 | Lin W Qing Y Liu J | 2015 | J Craniofac Surg2015，26，2： | 1 |
| 7 | Formation of coarsely crystalline,hydrothermal dolomite reservoirs in the Presquile barrier,Western Canada sedimentary basin显示文摘 | Qing Hairuo Mountjoy E W | 1994 | AAPG Bulletin1994，78，： | 1 |
| 8 | Improvement in fretting wear and fatigue re-sistance of Ti - 6A1 - 4V by application of several surfacetreatments and coatings显示文摘 | YONG QING FU NEE LAM LOH ANDREW W BATCH-ELOR | 1998 | Surface and Coatings Technol-ogy1998，，106： | 1 |
| 9 | Rare earth element geochemistry of dolomites in the Middle Devonian Presqulle barrier, Western Canada Sedimentary Basin: implications for fluid-rock ratios during dolomitization 显示文摘 | Qing H Mountjoy E W | 1994 | Sedimentology1994，41，4： | 1 |
| 10 | Distributed module of intrusion detection system based on Agent 显示文摘 | Ma H T Qing S H Chen W F | 2001 | Journal of software2001，11，10： | 1 |
| 11 | Synthesis of 4,6- disubstituted pyrimidines via suzuki and kumada coupling reaction of 4,6-dichloropyrimidine 显示文摘 | Qing F L Wang R W Li B H | 2003 | J Fluorine Chem2003，120，1： | 1 |
| 12 | Selective drug delivery to the colon using pectin-coated pellets 显示文摘 | HE W QING D CAO D Y | 2008 | PDA J Pharm Sci Technol2008，62，4： | 1 |
| 13 | A meta modeling approach to workflow management systems supporting exception handling显示文摘 | CHIN Dickson K W LI Qing KARLAPALEM Kamalakar | 1999 | Information Systems1999，24，2： | 1 |
| 14 | p21-activated Kinase 5 inhibits camptothecin-induced apoptosis in colorectal car- cinoma cells显示文摘 | Wang X Gong W Qing H | 2010 | Tumour Bio12010，31，6： | 1 |
| 15 | Insulator contamination forecasting based on fractal analysis of leakage current显示文摘 | Weigen C Wanping W Qing X | 2012 | Energies2012，5，7： | 1 |
| 16 | Statins; multiple neuroproteetive mechanisms in neurodegenerative diseases显示文摘 | Qing W Junqiang Y Xiaohong C | 2011 | Exp Neurol2011，230，1： | 1 |
| 17 | Adrenal ganglioneuromas:a 10-year experience in a Chinese population显示文摘 | Qing Y Bin X Jian W | | 0，，： | 1 |
| 18 | Ethanol-diesel fuel blends:A review显示文摘 | Hansen Alan C Zhang Qing Lyne Peter W L | 2005 | Bioresource Technology2005，96，： | 1 |
| 19 | Effects of film-mulched and dry-farm-ing on lodging resistance of medium hybrid rice显示文摘 | YANG Y DENG W QING XG | 2010 | Agricultural Science&Technology2010，11，97： | 1 |
| 20 | Establishment and char- acteristics of immortal goat endometrial epithelial cells and stromal cells with hTERT 显示文摘 | Yan Y J AI H W Qing X W | 2010 | J Anim Vet Adv2010，9，21： | 1 |
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