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| 1 | Urban sprawl in provincial capital cities in China: evidence from multi-temporal urban land products using Landsat data显示文摘The onset of global urbanization has led to a population shift from rural to urban areas and the expansion of urban development [1-3]. Urban land areas are growing at faster rates than their populations in most parts of the world [4]. The urban sprawl process refers to dispersed land development characterized by low-density, unplanned, and uneven patter ns of growth duri ng urban expansion. This process can result in inefficient use of land resources contradictory to the principle of sustainable development [5]. Additionally, urban sprawl has various environmental, economic, and social consequences, including the following: loss of agricultural land, higher costs for transportation infrastructure, increased landscape fragmentation, degeneration of soil ecological functions, and reduced ecosystem resilience. It is crucial to understand the trends and patterns of urban sprawl to implement a framework for sustainable urban development in developing regions. | Linlin Lu Huadong Guo Christina Corbane Qingting Li | 2019 | Science Bulletin2019，64，14： | 8 |
| 2 | Structural basis for gating mechanism of Pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical analysis,PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However,the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study,we report the cryo-EM structures of full-length and carboxyl-terminal(CT)tail-cleaved human PANX1.Combined with single-channel electrophysiological study,we identified the key residues involved in the gating of PANX1. | Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng | 2020 | Cell Research2020，30，5： | 2 |
| 3 | Prevalence of Congenital Heart Disease at Extremely High Altitudes in Tibet and the Establishment of a New Free Treatment Model显示文摘Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatmentfor the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County,Xigaze City, Tibet from September 2019 to September 2020 were selected for screening. The students were examinedthrough the inquiry of their current medical history and family history, cardiac auscultation and a physicalexamination, in order to screen out the suspected cases of CHD, and then the suspected cases were confirmed bycardiac color ultrasound examinations. After that, positive patients were be transferred to Shandong Province forfree treatment. Results: The prevalence of CHD among children in Ngamring County was 3.70% (83 cases),which is the highest incidence rate ever reported. The most common type of CHD was patent ductus arteriosus(PDA), accounting for 55.42% of the total number of cases screened, followed by atrial septal defect (ASD) andventricular septal defect (VSD), accounting for 28.92% and 12.05%, respectively. The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude. The children with CHD weretransferred to Shandong Province for surgery, the operations were successful and their recoveries went well.Conclusions: The results show that high altitude is closely related to the prevalence of CHD, and the incidencein Ngamring County is much higher than that in previous reports. | Shuting Chang Guanzhao Zhang Nengjun Sun Xinpeng Yuan Qingting Wang Lin Zhu Feiyue Zhang Yu Xiu Yang Dong Yonghong Chen Zhanpeng Zhao Xiao Liu Qiang Shao Xiaofeng Xu Anshun Wang Mengjiao Li Bo Li | 2022 | Congenital Heart Disease2022，17，6： | 1 |
| 4 | Spatio-temporal analysis of forest fire events in the Margalla Hills,Islamabad,Pakistan using socio-economic and environmental variable data with machine learning methods显示文摘Most forest fires in the Margalla Hills are related to human activities and socioeconomic factors are essential to assess their likelihood of occurrence.This study considers both environmental(altitude,precipitation,forest type,terrain and humidity index)and socioeconomic(population density,distance from roads and urban areas)factors to analyze how human behavior affects the risk of forest fires.Maximum entropy(Maxent)modelling and random forest(RF)machine learning methods were used to predict the probability and spatial diffusion patterns of forest fires in the Margalla Hills.The receiver operating characteristic(ROC)curve and the area under the ROC curve(AUC)were used to compare the models.We studied the fire history from 1990 to 2019 to establish the relationship between the probability of forest fire and environmental and socioeconomic changes.Using Maxent,the AUC fire probability values for the 1999 s,2009 s,and 2019 s were 0.532,0.569,and 0.518,respectively;using RF,they were 0.782,0.825,and 0.789,respectively.Fires were mainly distributed in urban areas and their probability of occurrence was related to accessibility and human behaviour/activity.AUC principles for validation were greater in the random forest models than in the Maxent models.Our results can be used to establish preventive measures to reduce risks of forest fires by considering socio-economic and environmental conditions. | Aqil Tariq Hong Shu Saima Siddiqui Iqra Munir Alireza Sharifi Qingting Li Linlin Lu | 2022 | Journal of Forestry Research2022，33，1： | 1 |
| 5 | Immunogenic hydrogel toolkit disturbing residual tumor “seeds” and pre-metastatic “soil” for inhibition of postoperative tumor recurrence and metastasis显示文摘Tumor recurrence and metastasis is the leading cause of mortality for postoperative breast cancer patients. However, chemotherapy intervention after surgery is often unsatisfactory, because residual microtumors are difficult to target and require frequent administration. Here, an all-in-one and oncefor-all drug depot based on in situ-formed hydrogel was applied to fit the irregular surgical trauma, and enable direct contact with residual tumors and sustained drug release. Our immunological analysis after resection of orthotopic breast tumor revealed that postsurgical activation of CXCR4-CXCL12 signal exacerbated the immunosuppression and correlated with adaptive upregulation of PD-L1 in recurrent tumors. Thus, a multifunctional hydrogel toolkit was developed integrating strategies of CXCR4 inhibition,immunogenicity activation and PD-L1 blockade. Our results showed that the hydrogel toolkit not only exerted local effect on inhibiting residual tumor cell “seeds” but also resulted in abscopal effect on disturbing pre-metastatic “soil”. Furthermore, vaccine-like effect and durable antitumor memory were generated, which resisted a secondary tumor rechallenge in 100% cured mice. Strikingly, one single dose of such modality was able to eradicate recurrent tumors, completely prevent pulmonary metastasis and minimize off-target toxicity, thus providing an effective option for postoperative intervention. | Minglu Zhou Qingting Zuo Yuan Huang Lian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 0 |
| 6 | Soil erosion assessment by RUSLE model using remote sensing and GIS in an arid zone显示文摘In this research,we used the Revised Universal Soil Loss Equation(RUSLE)and Geographical Information System(GIS)to predict the annual rate of soil loss in the District Chakwal of Pakistan.The parameters of the RUSLE model were estimated using remote sensing data,and the erosion probability zones were determined using GIs.The estimated length slope(LS),crop management(C),rainfall erosivity(R),soil erodibility(K),and support practice(P)range from 0-68,227,0-66.61%,0-0.58,495.99-648.68 MJ/mm.t.ha^(-1).year^(-1),0.15-0.25 MJ/mm.t.ha^(-1).year^(-1),and 1 respectively.The results indicate that the estimated total annual potential soi loss of approximately 4,67,064.25 t.ha^(-1).year^(-1) is comparable with the measured'sediment ioss of 11,631 t.ha^(-1).year^(-1) during the water year 2020.The predicted soil erosion rate due to an increase in agricultural area is approximately 164,249.31 t.ha^(-1).year^(-1).In this study,we also used,Landsat imagery to rapidly achieve actual land use classification.Meanwhile,38.i3%of the region was threatened by very high soil erosion,where the quantity of soil erosion ranged from 365487.35 t.ha^(-1).year^(-1),Integrating GIS and remote sensing with the RUSLE model helped researchers achieve their final objectives.Land-use planners and decision-makers use the result's spatial distribution of soil erosion in District Chakwal for conservation and management planning. | Pingheng Li Aqil Tariq Qingting Li Bushra Ghaffar Muhammad Farhan Ahsan Jamil Walid Soufan Ayman El Sabagh Mohamed Freeshah | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 7 | Investigation of weight updating modes on oxide-based resistive switching memory synapse towards neuromorphic computing applications显示文摘Dear editor,Memristors, resistive random access memory(RRAM) devices when used in memory applications, have attracted significant interest recently as a promising candidate for neuromorphic computing systems due to their excellent size scalability, fast switching speed and low energy consumption [1].In order to obtain high learning accuracy in neural networks based on back propagation learning rule, the updating behavior of synaptic linear symmetric weights is important [2]. | Qingting DING Tiancheng GONG Jie YU Xiaoxin XU Xiaoyan LI Hangbing LV Jianguo YANG Qing LUO Peng YUAN Feng ZHANG Ming LIU | 2021 | Science China(Information Sciences)2021，64，11： | 0 |
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