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| 1 | Rare SNP Identified a TCP Transcription Factor Essential for Tendril Development in Cucumber显示文摘稀罕基因变体充满染色体,但是少些在染色体宽的协会学习易控制。这里,我们利用稀罕变化印射在黄瓜(Cucumis sativus L.) 为卷须开发发现基因必需品的策略。在里面许多 > 3000 根线,我们发现形成的一根唯一的卷须更少线分叉而不是卷须并且因此,失去它的爬的能力。我们假设了那这不平常的显型被一个稀罕变化引起并且随后识别了原因的单个核苷酸多型性。影响基因十编码一个 TCP 抄写因素在葫芦以内保存了并且在卷须明确地被表示,代表新机关身份基因。变化在对葫芦唯一的一个蛋白质主题以内发生并且作为 transcriptional 使活跃之物损害它的功能。从 near-isogenic 线的 transcriptomes 的分析识别了要求让卷须的能力察觉到并且爬支持的下游的基因。这研究提供一个例子在植物染色体探索稀罕功能的变体。 | Shenhao Wang Xueyong Yang Mengnan Xu Xingzhong Lin Tao Lin Jianjian Qi Guangjin Shao Nana Tian QingYang Zhonghua Zhang Sanwen Huang | 2015 | Molecular Plant2015，8，12： | 12 |
| 2 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 3 | Technical Perspective of Carbon Capture,Utilization,and Storage显示文摘Carbon dioxide(CO_(2))is the primary greenhouse gas contributing to anthropogenic climate change which is associated with human activities.The majority of CO_(2) emissions are results of the burning of fossil fuels for energy,as well as industrial processes such as steel and cement production.Carbon capture,utilization,and storage(CCUS)is a sustainable technology promising in terms of reducing CO_(2) emissions that would otherwise contribute to climate change.From this perspective,the discussion on carbon capture focuses on chemical absorption technology,primarily due to its commercialization potential.The CO_(2) absorptive capacity and absorption rate of various chemical solvents have been summarized.The carbon utilization focuses on electrochemical conversion routes converting CO_(2) into potentially valuable chemicals which have received particular attention in recent years.The Faradaic conversion efficiencies for various CO_(2) reduction products are used to describe efficiency improvements.For carbon storage,successful deployment relies on a better understanding of fluid mechanics,geomechanics,and reactive transport,which are discussed in details. | Qingyang Lin Xiao Zhang Tao Wang Chenghang Zheng Xiang Gao | 2022 | Engineering2022，8，7： | 6 |
| 4 | Alteration and Reformation of Hydrocarbon Reservoirs and Prediction of Remaining Potential Resources in Superimposed Basins显示文摘复杂的烃水库在从在早阶段形成的烃水库的多重结构的改变,改革和破坏形成的中国的附加的盆广泛地发展了。他们被陷井调整,部件变化,阶段变换,和规模改革当前描绘。这为由在烃水库形成以后并且为预言揭示进化机制指导当前的烃探索是重要的仍然是潜在的资源。基于很多座复杂的烃水库的分析,有四个地质的特征,控制在早阶段形成的烃水库的破坏的度:在构造进化期间为油和气体封上的构造事件紧张,频率,时间和 caprock。研究看那越大构造事件紧张,越多经常构造事件,以后的最后构造事件,越多更弱为油和气体封上的 caprock,并且更大在早阶段的破坏的烃的体积。基于关于烃水库破坏机制,构造重迭的一个地质的模型和评估潜在的留下的复杂的烃水库的一个数学模型的主要控制因素的研究被建立了。断言方法和技术过程在 Tarim 盆的 Tazhong 区域被使用,在烃累积的四个阶段和烃改变的三个阶段发生了的地方。Geohistorical 烃累积到达了 31.84 亿吨, 12.71 亿吨被破坏。仍然是为探索可得到的资源的全部的体积是 19 亿吨。 | PANG Hong PANG Xiongqi YANG Haijun LIN Changsong MENG Qingyang WANG Huaijie | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 4 |
| 5 | Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis显示文摘TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5,cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with specific primers,and then inserted into a prokaryotic expression vector pET-30a. The recombinant plasmid was expressed in Escherichia coli strain BL21 (DE3),and sDR5 was purified by nickel affinity chromatography. As an antigen,sDR5 was used to immunize mice. Hybridomas secreting antibodies against sDR5 were identified. One positive clone was selected to produce antibody,WD1. ELISA and immunofluorescence demonstrated that WD1 could bind recombinant sDR5 and membrane-bound DR5 (mDR5) on Jurkat and Molt-4 cells. ATPLite assays showed that Jurkat and Molt-4 cells were sensitive to the antibody in a dose dependent manner. The Annexin V/PI assays and Giemsa's staining both showed that WD1 could induce Jurkat cell apoptosis efficiently. Transient transfection of 293T cells and indirect immunofluorescence assay demonstrated that mAb (WD1) couldn't cross-react with DR4. Our findings indicated that the novel antibody,WD1 could act as a direct agonist,bind DR5 characteristically,and initiate efficient apoptotic signaling and tumor regression. Thus,WD1 would be a leading candidate for potential cancer therapeutics. | Jing Wang Zhou Lin Chunxia Qiao Ming Lv Ming Yu He Xiao Qingyang Wang Liyan Wang Jiannan Feng Beifen Shen Yuanfang Ma Yan Li | 2008 | Cellular & Molecular Immunology2008，5，1： | 4 |
| 6 | All-optical computing based on convolutional neural networks显示文摘The rapid development of information technology has fueled an ever-increasing demand for ultrafast and ultralow-en-ergy-consumption computing.Existing computing instruments are pre-dominantly electronic processors,which use elec-trons as information carriers and possess von Neumann architecture featured by physical separation of storage and pro-cessing.The scaling of computing speed is limited not only by data transfer between memory and processing units,but also by RC delay associated with integrated circuits.Moreover,excessive heating due to Ohmic losses is becoming a severe bottleneck for both speed and power consumption scaling.Using photons as information carriers is a promising alternative.Owing to the weak third-order optical nonlinearity of conventional materials,building integrated photonic com-puting chips under traditional von Neumann architecture has been a challenge.Here,we report a new all-optical comput-ing framework to realize ultrafast and ultralow-energy-consumption all-optical computing based on convolutional neural networks.The device is constructed from cascaded silicon Y-shaped waveguides with side-coupled silicon waveguide segments which we termed“weight modulators”to enable complete phase and amplitude control in each waveguide branch.The generic device concept can be used for equation solving,multifunctional logic operations as well as many other mathematical operations.Multiple computing functions including transcendental equation solvers,multifarious logic gate operators,and half-adders were experimentally demonstrated to validate the all-optical computing performances.The time-of-flight of light through the network structure corresponds to an ultrafast computing time of the order of several picoseconds with an ultralow energy consumption of dozens of femtojoules per bit.Our approach can be further expan-ded to fulfill other complex computing tasks based on non-von Neumann architectures and thus paves a new way for on-chip all-optical computing. | Kun Liao Ye Chen Zhongcheng Yu Xiaoyong Hu Xingyuan Wang Cuicui Lu Hongtao Lin Qingyang Du Juejun Hu Qihuang Gong | 2021 | Opto-Electronic Advances2021，4，11： | 3 |
| 7 | Influence of the alkyl side chain length on the room-temperature phosphorescence of organic copolymers显示文摘Pure organic room-temperature phosphorescence(RTP)materials have attracted wide attention owing to their excellent luminescent properties and great potential in various applications.In this work,iminostilbene and its analogues are applied to realize RTP emission by copolymerizing with acrylamide.It can be concluded that the growth of alkane chain in monomers can enhance the lifetime and photoluminescence quantum yield of RTP emission,and polymers with the larger conjugated structure of the monomer show a longer RTP emission wavelength.This work provides a series of new pure organic RTP materials and might provide new thoughts for designing more advanced and superior RTP materials. | Qingyang Xu Liangwei Ma Xiaohan Lin Qiaochun Wang Xiang Ma | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 8 | The evolution and present status of the study on peak oil in China显示文摘Peak oil theory is a theory concerning long-term oil reserves and the rate of oil production. Peak oil refers to the maximum rate of the production of oil or gas in any area under consideration. Its inevitability is analyzed from three aspects. The factors that influence peak oil and their mechanisms are discussed. These include the amount of resources, the discovery maturity of resources, the depletion rate of reserves and the demand for oil. The advance in the study of peak oil in China is divided into three stages. The main characteristics, main researchers, forecast results and research methods are described in each stage. The progress of the study of peak oil in China is summarized and the present problems are analyzed. Finally three development trends of peak oil study in China are presented. | Pang Xiongqi Zhao Lin Feng Lianyong Meng Qingyang Tang Xu LiJunchen | 2009 | Petroleum Science2009，6，2： | 2 |
| 9 | Two Translations of Ji Yun's Close Scrutiny: the Translator, the Reader and the Settings of Translation显示文摘 | Lynn Qingyang Lin | 2017 | Fudan Journal of the Humanities and Social Sciences2017，10，1： | 1 |
| 10 | Flow in Porous Media in the Energy Transition显示文摘1.Historical context Flow in porous media is encountered in a wide variety of natural and engineered settings,including gas exchange in lungs and blood vessels,water extraction from underground aquifers,hydrocarbon production,and microfluidics in drug delivery and food manufacturing.Underground rock is a porous medium that holds water and hydrocarbons,and is a potential storage site for carbon dioxide(CO_(2))and hydrogen.Many manufactured devices also contain porous media to allow the transport of gases and water,including fuel cells,electrolyzers,and electrocatalysts for CO_(2) reduction.Their performance is limited by how rapidly two fluid phases can flow through a porous layer. | Martin J.Blunt Qingyang Lin | 2022 | Engineering2022，8，7： | 1 |
| 11 | The Different Perception and Reaction of Customers Toward Traditional Marketing and Influencer Marketing in Food显示文摘This research paper is aimed at investigating the consumer preference for traditional marketing and influencer marketing in food industry.To accomplish this,the researchers set two questionnaire surveys to collect data.These two questionnaires investigated consumers’different attitudes and reaction toward two rose-cake brands(Holiland and LI ZI QI),by showing them the two different types of advertisements:one for traditional marketing and the other for influencer marketing.After a detailed analysis of the data collected,it was discovered that both influencer marketing and traditional marketing have the capability to deliver the persuasive product information and make consumers desirable to purchase the products;however,consumers tend to pay more creditably and trust to LI ZI QI’s brand,which is the brand using influencer marketing,and are willing to spend more money on it. | REN Qingyang ZHOU Lin LIU Fengyang | 2022 | Management Studies2022，10，2： | 0 |
| 12 | Facile access to chiral 4-substituted chromanes through Rh-catalyzed asymmetric hydrogenation显示文摘Rh/ZhaoPhos-catalyzed asymmetric hydroge nation of a series of(E)-2-(chro man-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities(up to 99%yield,98%ee).Moreover,the gram-scale hydrogenation could be performed well in the presence of 0.02 mol%catalyst loading(TON=5000),the hydrogenation product was easily converted to access other important compounds,which demonstrated the synthetic utility of this asymmetric catalytic methodology. | Lin Tao Qingyang Zhao Xumu Zhang Xiu-Qin Dong | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 13 | LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p显示文摘Background:Renalfibrosis is an important process in the development of chronic kidney disease.Understanding the pathogenesis andfinding effective treatments for renalfibrosis is crucial.This study aims to investigate whether a newly discovered long non-coding RNA(lncRNA)called LOC103694972 could be a potential target for treatingfibrosis of NRK-49F cells.Methods:LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal cells.The dual-luciferase assay confirmed the binding between miR-29c-3p and signal transducer and activator of transcription(STAT3),as well as between miR-29c-3p and lncRNA LOC103694972.Si-LOC103694972 and miR-29c-3p mimic were then transfected into TGF-β1-induced NRK-49F cells.Results:The study found that LOC103694972 was highly expressed in TGF-β1-induced NRK-49F cells.These cells exhibited increased cell length and activity compared to the control group.The expression levels of Collagen I,α-Smooth muscle actin(α-SMA),and tissue inhibitor of metalloproteinase(TIMP-1)were increased,while matrix Metalloproteinase 2(MMP2)and matrix Metalloproteinase 9(MMP9)expression was decreased.However,transfection with si-LOC103694972 and miR-29c-3p mimics restored cell morphology and reduced cell viability.This led to a decrease in the levels of Collagen I,α-SMA,and TIMP-1,as well as an increase in MMP2 and MMP9 expression.Additionally,TGF-β1-induced NRK-49F cells transfected with miR-29c-3p mimics activated the STAT3-Smad3/CTGF pathway.Conclusion:Based on thesefindings,lncRNA LOC103694972 shows promise as a target for treating renalfibrosis.It negatively regulates miR-29c-3p and activates the STAT3-Smad3/CTGF pathway. | YAN LI HUZHI CAI XIAOLING PENG YOUHUI LIU QINGYANG CHEN XIANGDONG LIN XINYU CHEN | 2024 | BIOCELL2024，48，3： | 0 |
| 14 | Oxide formation mechanism of a corrosion-resistant CZ1 zirconium alloy显示文摘Tailoring microstructure and microchemistry by altering elemental compositions and thermomechanical treatment parameters enables superior corrosion performance in zirconium alloys for nuclear applications.However,our understanding of the relationship between various defects and the corrosion process remains limited in the newly developed zirconium alloys.Here we report the oxide formation mechanism of a CZ1 zirconium alloy with corrosion resistance surpassing many other zirconium alloy systems,such as Zircaloy-4 and Zr-1Nb-1Sn alloys.Autoclave experiments of CZ1 alloy and Zr1Nb-1Sn model alloy were performed in 360°C water for up to 820 d.We quantitively determined oxide phases by transmission Kikuchi diffraction(TKD)and examined lateral cracks,nano-porosity,and second-phase particles in oxide scales by transmission electron microscopy(TEM).Compared to the Zr-1Nb-1Sn model alloy,CZ1 alloy with lower Nb and Sn concentrations has shown smaller and lower-density lateral cracks but slightly larger oxide grains,reducing the diffusion route for oxidating species.Using analytical scanning and transmission electron microscopy,we demonstrate that due to the lower content of Sn(∼0.9 wt.%),there is less tetragonal ZrO_(2) phase formed in the oxide,and the level of tetragonal to the monoclinic phase transition is reduced.Although the Nb content(0.1 wt.%–0.3 wt.%)is lower than the solid solution limit of Nb in Zr,by introducing minor elements such as Fe,Cr,and Cu,there are still a reasonable number of second-phase particles to relieve the high stress associated with the metal-to-oxide transformation.These mechanisms have substantially changed the density and distribution of lateral cracks in the oxide,thus reducing the corrosion rate of zirconium alloys. | Jing Hu Weitong Lin Qingyang Lv Changyuan Gao Jun Tan | 2023 | Journal of Materials Science & Technology2023，，16： | 0 |
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