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| 1 | The subducted slab of Yangtze Continental block beneath the Tethyan orogen in western Yunnan显示文摘The western Yunnan area is a natural laboratory with fully developed and best preserved Tethyan orogen in the world. Seismic tomography reveals a slab-like high velocity anomaly down to 250 km beneath the western Yunnan Tethyan orogen, to its west there is a low-velocity column about 300 km wide. in the region from Lancangjiang to Mojiang an obvious low velocity in the lower crust and uppermost mantle overlies on the slab. Synthesizing the available geological and geochemical results, the present paper demonstrates that this slab-like high velocity anomaly is a part of the subducted plate of Yangtze Continental segment after the closure of Paleotethys. The collision of India and Eurasia continent starting from 50-60 MaBP might trigger thermal disturbance in the upper mantle and cause the uprising of asthenosphere, in that case the subducted Yangtze plate could be broken off, causing Cenozoic magmatic activities and underplating in the Lancangjiang-Mojiang region. | Futian Liu Jianhua Liu Dalai Zhong Jiankun He Qingyu You | 2000 | Chinese Science Bulletin2000，45，5： | 28 |
| 2 | Analgesic effect of different moxibustion durations in rheumatoid arthritis rats显示文摘OBJECTIVE:To observe the influence of different moxibustion durations on hypothalamic pro-opiomelanocortin(POMC)and prodynorphin(PDYN)mRNA expressions and plasmaβ-endorphin(β-EP)content in rheumatoid arthritis(RA)rats,to understand the mechanism of moxibustion analgesia and its dose-effect relationship.METHODS:Twelve male Wistar rats were randomly selected from 48 male Wistar rats as a normal control group.The RA model was created by raising rats in a windy(blowing with electric fan),cold(6℃±2℃),and wet(80%-90%humidity)environment for 20 days,12 h each day.This was followed byinjectionofFreund'scompleteadjuvant(0.15 mL)into the ankle.Then,rats were randomly divided into a model group,moxibustion groupⅠ,and moxibustion groupⅡ,with 12 rats in each group.In moxibustion groupsⅠandⅡ,moxibustion was given at Shenshu(BL 23)and Zusanli(ST 36)for 20and 40 min,respectively,once daily for 15 days.Hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content were determined.RESULTS:Compared with the normal group,the pressure pain threshold decreased,while the hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content increased in the moxibustion groups(P<0.01).Compared with the model group,the pressure pain threshold,hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content in the moxibustion groups increased significantly(P<0.01).Compared the moxibustion groupⅠ,the pain threshold,hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content in moxibustion groupⅡsignificantly increased(P<0.01).CONCLUSION:Moxibustion has an analgesic effect and increases hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content inRArats.TheanalgesiceffectinmoxibustiongroupⅡisbetterthanthatinmoxibustiongroupⅠ. | Baozhu Zheng Ling Hu Xiaoge Song ZijianWu Ronglin Cai Lu He Cheng Zhang QingYu | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 10 |
| 3 | Circular cladding waveguides in Pr:YAG fabricated by femtosecond laser inscription:Raman,luminescence properties and guiding performance显示文摘We report on the fabrication of circular cladding waveguides with cross-section diameters of 60−120μm in Pr:YAG crystal by applying femtosecond laser inscription.The fabricated waveguides present 2D guidance on the cross-section and fairly low propagation losses.Multiple high-order guiding modes are observed in waveguides with different diameters.Corresponding simulation results reveal the origin of a specific kind of guiding modes.Confocal micro-Raman(μ-Raman)experiments demonstrate the modification effects in femtosecond laser affected areas and ascertain the refractive index induced guiding mechanism.In addition,luminescence emission properties of Pr3+ions at waveguide volume are well preserved during the femtosecond laser inscription process,which may result in a potential high-power visible waveguide laser. | Quanxin Yang Hongliang Liu Shan He Qingyu Tian Bin Xu Pengfei Wu | 2021 | Opto-Electronic Advances2021，4，2： | 4 |
| 4 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 5 | In-situ observation of electrical tree evolution in epoxy dielectrics with internal cracks显示文摘Gas-filled internal crack might appear in thermoset materials like epoxy resin during the equipment manufacturing,which would become a vulnerable local region to initiate the electrical tree,thus prone to cause insulation failure.The withstand voltage test was carried on epoxy samples with artificial cracks based on a rod-plane electrode arrange-ment.Simultaneously,surface state variation and tree evolution with crack were observed by an optical microscope in conjunction with a charge-coupled device camera.The changes in morphology and chemical status of the crack surface were characterized by scanning electron microscopy,laser Raman spectrometer and energy dispersive spec-trometer,respectively.It was found that the erosion and tree started from the borderline of crack under a relatively low electric field strength;however,the area near the electrode had relatively little damage.The breaking of epoxy molecular chains coarsens the crack surface and further forms deep channels on a micro-level,which is the forerunner of the electrical tree inception.Based on these,the initiation mechanisms of the crack-induced electrical tree and the reasons for the erosion near the borderline have been revealed.This study provides a train thought for the polymer degradation opening up into the initial tree channel during tree evolution processes. | Zehua Wu Huidong Tian Sijia Zhu He Li Qingyu Wang Zongliang Xie Peng Liu Zongren Peng | 2021 | High Voltage2021，6，2： | 3 |
| 6 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 7 | Identification of Ubiquitinated Proteins from Human Multiple Myeloma U266 Cells by Proteomics显示文摘Objective To identify ubiquitinated proteins from complex human multiple myeloma (MM) U266 cells,a malignant disorder of differentiated human B cells.Methods Employing a globally proteomic strategy combining of immunoprecipitation,LC-MS/MS and SCX-LC-MS analysis to identified ubiquitination sites,which were identified by detecting signature peptides containing a GG-tag (114.1 Da) and an LRGG-tag (383.2 Da).Results In total,52 ubiquitinated proteins containing 73 ubiquitination sites of which 14 and 59 sites contained LRGG-tag and GG-tag were identified,respectively.Conclusion Classification analysis by of the proteins identified in the study based on the PANTHER showed that they were associated with multiple functional groups.This suggested the involvement of many endogenous proteins in the ubiquitination in MM. | JIA HongLing LIU ChaoWu GE Feng XIAO ChuanLe LU ChunHua WANG Tong HE QingYu | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 8 | Measurement of hydrogen peroxide and organic hydroperoxide concentrations during autumn in Beijing, China显示文摘Gaseous peroxides play important roles in atmospheric chemistry. To understand the pathways of the formation and removal of peroxides, atmospheric peroxide concentrations and their controlling factors were measured from 7:00 to 20:00 in September, October, and November 2013 at a heavily trafficked residential site in Beijing, China, with average concentrations of hydrogen peroxide(H_2O_2) and methyl hydroperoxide(MHP) at 0.55 ppb and 0.063 ppb, respectively. H_2O_2 concentrations were higher in the afternoon and lower in the morning and evening, while MHP concentrations did not exhibit a regular diurnal pattern. Both H_2O_2 and MHP concentrations increased at dusk in most cases. Both peroxides displayed monthly variations with higher concentrations in September. These results suggested that photochemical activity was the main controlling factor on variations of H_2O_2 concentrations during the measurement period. Increasing concentrations of volatile organic compounds emitted by motor vehicles were important contributors to H_2O_2 and MHP enrichment. High levels of H_2O_2 and MHP concentrations which occurred during the measurement period probably resulted from the transport of a polluted air mass with high water vapor content passing over the Bohai Bay, China. | Qingyu Zhang Jiaoyu Liu Youjiang He Jiaying Yang Jian Gao Houfeng Liu Wei Tang Yizhen Chen Wenhao Fan Xuan Chen Fahe Chai Shiro Hatakeyama | 2018 | Journal of Environmental Sciences2018，30，2： | 2 |
| 9 | Magnetoacoustic tomograhpy with magentic indction: a rigorous theory 显示文摘 | Ma Qingyu He Bin | 2008 | IEEE Transactions on Biomedical Engineerng2008，55，2： | 1 |
| 10 | Magnetoacoustic Tomograhpy with Magentic Indction: A Rigorous Theory 显示文摘 | Qingyu Ma Bin He | 2008 | IEEE Transactions on Biomedical Engineerng2008，55，2： | 1 |
| 11 | How to discover new proteins——translatome profiling显示文摘According to the Central Dogma,genes in genome can be transcribed and translated into proteins to perform a variety of biological functions.Since proteins are the actual functional molecules in almost all physiological processes,discovering new proteins is essential to understand the nature of various biological phenomena.So far,the Human Genome Project and many transcriptomic analyses have defined about 20300 genes that can be transcribed into mRNA.These genes,comprising only 2%of human genome,are considered as coding genes that may be translated into proteins. | ZHANG Gong WANG Tong HE QingYu | 2014 | Science China(Life Sciences)2014，57，3： | 1 |
| 12 | The critical role of m^(6)A methylation in the pathogenesis of Graves'ophthalmopathy显示文摘Purpose:To investigate the role of N6-methyladenosine(m^(6)A)RNA modification in the pathogenesis of Graves'ophthalmopathy(GO).Methods:Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without GO were used.The global m^(6)A levels in the specimens were determined using an m^(6)A RNA methylation quantification kit.RNA sequencing(RNA-seq)was used to analyze the molecules involved in the regulation of m^(6)A RNA methylation and the differential expression of mRNAs between the two groups(4 eyes,respectively).The expression of m^(6)A RNA modification genes was evaluated by real-time PCR.The functional implications of the gene alterations between the GO and control specimens were determined by Gene Ontology analysis.Results:The m^(6)A level was significantly increased in the specimens of GO patients compared to the control specimens(P<0.05).The expression of m^(6)A methylation regulators,such as WT1 associated protein(WTAP),alkylation repair homolog protein 5(ALKBH5),E74 like ETS transcription factor 3(ELF3),YTH N6-methyladenosine RNA binding protein 2(YTHDF2),YTHDF3 and YTH domain containing 2(YTHDC2),was significantly upregulated(P<0.05).Gene Ontology enrichment analysis showed that the most highly upregulated genes and biological pathways were related to the immune response and inflammatory processes such as lymphocyte activation,leukocyte differentiation,cytokine production and cytokine-mediated signaling pathways.Conclusions:Our results suggest that m^(6)A methylation may play a critical role in the pathogenesis of GO and that targeting genes that regulate m^(6)A methylation may provide a new therapeutic approach for GO. | Li Zhu Siyan Li Shikun He Qizhe Tong Lejin Wang Xiaohua Li Xi Wu Qingyu Meng Enzhong Jin Chuan Zhang Tianyuan Li Ningda Xu Lvzhen Huang Yi Wang Mingwei Zhao | 2020 | Eye and Vision2020，7，1： | 1 |
| 13 | A robust polyacrylic acid/chitosan cryogel for rapid hemostasis显示文摘Currently,it is a challenge to develop hemostatic materials with high water absorption capacity and anti-fatigue properties for quickly preventing massive hemorrhage from arteries and visceral organs.A series of polyacrylic acid/chitosan(PAA/CS)cryogels were prepared by a cryostructurization technique to improve mechanical performance and hemostatic efficiency of chitosan(CS).In this system,the chemically cross-linked PAA network was used as a framework to improve water absorption behaviors and mechanical strength.The CS network was co-blended by hydrogen bonding and electrostatic interactions,both of which synergistically promoted hemostasis.These cryogels had high porosity(>94%),rapid water absorption rate(<3 s),high blood absorption capacity(>2000%),outstanding mechanical strength,and fatigue resistance.Moreover,the results of cytotoxicity and hemolysis demonstrated that the cryogels had good biocompatibility.Notably,the PAA/CS cryogels exhibited superior whole blood coagulation ability and red blood cell and platelet adhesion ability compared to those of commercial hemostatic dressing(gauze,gelatin sponges,and CS sponges).Based on these results,mouse femoral artery hemorrhage models and liver hemorrhage models were prepared to investigate the hemostatic ability of the prepared PAA/CS cryogels.Results suggested that the hemostatic ability of PAA5/CS cryogels was superior to that of commercial hemostatic materials.Therefore,the PAA/CS cryogels showed potential application in preventing massive hemorrhage from arteries and visceral organs. | SHI MingYue JIANG LiJie YU ChaoJie DONG XiaoRu YU QingYu YAO MengMeng HE ShaoShuai YUE ZhiWei YAO FangLian ZHANG Hong SUN Hong LI JunJie | 2022 | Science China(Technological Sciences)2022，65，5： | 1 |
| 14 | Investigation on magnetoacoustic signal generaition with magnetic induction and its application to electrical conductivity reconstruction 显示文摘 | Ma Qingyu He Bin | 2007 | Phys Med Bio2007，52，： | 1 |
| 15 | Interfacial enhancement of carbon fiber composites by poly(amido amine) functionalization显示文摘 | Qingyu Peng Yibin Li Xiaodong He Hongzhen Lv Pingan Hu Yuanyuan Shang Chao Wang Rongguo Wang Thirumany Sritharan Shanyi Du | 2013 | Composites Science and Technology2013，，： | 1 |
| 16 | Investigation on magnetoacoustic signal generation with magnetic induction and its application to electrical conductivity reconstruction显示文摘 | Ma Qingyu He Bin | 2007 | Phys Med Biol2007，52，： | 1 |
| 17 | Study of seismic tomography in Panxi paleorift area of southwestern China显示文摘 | Jianhua Liu Futian Liu Jiankun He Hui Chen Qingyu You | 2001 | Science in China Series D: Earth Sciences2001，，3： | 1 |
| 18 | Magnetoacoustic Tomograhpy with Magentic Indction: A Rigorous Theory 显示文摘 | Qingyu Ma Bin He | 2008 | IEEE Transactions on Biomedical Engineerng2008，55，2： | 1 |
| 19 | Magnetoacoustic Tomograhpy with Magentic Indction: A Rigorous Theory 显示文摘 | Qingyu Ma Bin He | 2008 | IEEE Transactions on Biomedical Engineerng2008，55，2： | 1 |
| 20 | Study of seismic tomography in Panxi paleorift area of southwestern China显示文摘 | Jianhua Liu Futian Liu Jiankun He Hui Chen Qingyu You | 2001 | Science in China Series D: Earth Sciences2001，，3： | 1 |
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