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| 1 | Effects of material of metallic frame on the penetration resistances of ceramic-metal hybrid structures显示文摘The effects of metallic material on the penetration resistances of ceramic-metal hybrid structures against vertical long-rod tungsten projectiles were studied by artillery-launched experiments and numerical simulation.Hybrid structures with rectangular cores in transverse orthogonal arrangement and slidefitting ceramic inserts of zirconia toughened alumina prisms were fabricated with titanium alloy TC4(Ti6 Al4 V),AISI 4340 steel and 7075 aluminum alloy panels,respectively.The results showed that the hybrid structure of Ti6A14V exhibited the highest penetration resistance,followed by that of 7075 aluminum alloy with the same area density.The penetration resistance of the hybrid structure of AISI4340 steel was the lowest.The underlying mechanisms showed that the metallic material of a ceramicmetal hybrid structure can directly affect its energy absorption from the impact projectile,which further affects its penetration resistance.Different metallic frames exhibited different failure characteristics,resulting in different constraint conditions or support conditions for ceramic prisms.The high penetration resistance of the Ti6Al4V hybrid structure was due to its stronger back support to ceramic prisms as compared with that of AISI 4340 steel hybrid structure,and better constraint condition for ceramic prisms by metallic webs as compared with that of 7075 aluminum alloy hybrid structure.The results of mass efficiency and thickness efficiency showed that the Ti6Al4V hybrid structure has advantages in reducing both the thickness and the mass of protective structure.In addition,because the ceramic-metal hybrid structures in the present work were heterogeneous,impact position has slight influence on their penetration resistances. | Xuanyi An Chao Tian Qitian Sun Yongxiang Dong | 2020 | Defence Technology(防务技术)2020，16，1： | 6 |
| 2 | Syn-tectonic sedimentation and its linkage to fold-thrusting in the region of Zhangjiakou, North Hebei, China显示文摘The timing of the 'Yanshanian Movement' and the tectonic setting that controlled the Yanshan fold-and-thrust belt during Jurassic time in China are still matters of controversy. Sediments that filled the intramontane basins in the Yanshan belt perfectly record the history of 'Yanshanian Movement' and the tectonic background of these basins. Recognizing syn-tectonic sedimentation, clarifying its relationship with structures, and accurately defining strata ages to build up a correct chronostratigraphic framework are the key points to further reveal the timing and kinematics of tectonic deformation in the Yanshan belt from the Jurassic to the Early Cretaceous. This paper applies both tectonic and sedimentary methods on the fold-and-thrust belt and intramontane basins in the Zhangjiakou area, which is located at the intersection between the western Yanshan and northern Taihangshan. Our work suggests that the pre-defined 'Jurassic strata' should be re-dated and sub-divided into three strata units: a Late Triassic to Early Jurassic unit, a Middle Jurassic unit, and a Late Jurassic to early Early Cretaceous unit. Under the control of growth fold-and-thrust structures, five types of growth strata developed in different growth structures: fold-belt foredeep type,thrust-belt foredeep type, fault-propagation fold-thrust structure type, fault-bend fold-thrust structure type, and fault-bend foldthrust plus fault-propagation fold composite type. The reconstructed 'source-to-sink' systems of Late Triassic to Early Jurassic,Middle Jurassic and Late Jurassic to early Early Cretaceous times, which are composed of a fold-and-thrust belt and flexure basins, imply that the 'Yanshanian Movement' in our study area started in the Middle Jurassic. During Middle Jurassic to early Early Cretaceous times, there have been at least three stages of fold-thrust events that developed 'Laramide-type' basementinvolved fold-thrust structures and small-scale intramontane broken 'axial basins'. The westward migration of a 'pair' of basement-involved fold-thrust belt and flexure basins might have been controlled by flat subduction of the western Paleo-Pacific slab from the Jurassic to the Early Cretaceous. | Shaofeng LIU Chengfa LIN Xiaobo LIU Qitian ZHUANG | 2018 | Science China Earth Sciences2018，61，6： | 6 |
| 3 | 基于最佳鉴别变换的HMM手写数字字符识别显示文摘基于隐马尔可夫模型 (HMM)的手写字符识别方法是近年来的一个研究热点 ,针对 HMM编码稳定性和建模过程复杂的问题 ,提出了一种新方法 ,即采用统计不相关最佳鉴别变换对模式进行特征抽取和降维 ,获得最佳鉴别特征向量 ,并在此基础上对各最佳鉴别方向的投影结果进行编码 ,作为 HMM的观测值序列 ,由于统计不相关最佳鉴别变换保证了变换特征向量集类内散布最小 ,类间散布最大的条件 ,使 HMM编码的稳定性和模式的可分性得到明显改善 ,通过对美国国家邮政局 | 芮挺 沈春林 丁健 QiTIAN | 2004 | 中国图象图形学报(A辑)2004，9，8： | 3 |
| 4 | Investigation on the Influence of Refrigerant Charge Amount on the Cooling Performance of Air Conditioning Heat Pump System for Electric Vehicles显示文摘The application of air conditioning heat pump(ACHP) in electric vehicles could lead to significant electrical power saving effect. As for an air conditioning heat pump system for electric vehicles, the influence of refrigerant charge amount should be investigated during the design phase. In this study, experimental method was employed to investigate the influence of the refrigerant charge amount on the performance of the ACHP system. The results showed that the refrigerant charge amount had different influence on the refrigerant properties at various locations within the system. The coefficient of performance and pressure-enthalpy diagram were calculated, and showed a close relationship with refrigerant charge amount under different compressor speeds. The degree of subcooling and the degree of superheating were recorded and the critical charge amount was determined by a typical practical test method. In addition, the critical refrigerant charge amount determined by the experimental method was also compared with two typical void fraction correlation models, and the model with consideration of two phase stream reaction of the refrigerant showed a good estimation accuracy on the critical charge amount. | LI Kang LAN Jiao ZHOU Guoliang TANG Qitian CHENG Qia FANG Yidong SU Lin | 2019 | Journal of Thermal Science2019，28，2： | 3 |
| 5 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 6 | An Efficient Attack-Resistant Trust Model for P2P Networks 显示文摘 | Chun Qitian Zou Shihong Wang Wendong | 2006 | International Journal of Computer Science and Network Security2006，6，11： | 1 |
| 7 | Discussion on Dehydration Process of Crude Oilin High Water Cut Stage of Oil Field 显示文摘 | Yuan Qitian | 2008 | Neijiang Keji2008，29，4： | 1 |
| 8 | The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells显示文摘 | Zhuo Zhihong Zhang Leming Mu Qitian Lou Yanru Gong Zhaohui Shi Yijiu Ouyang Guifang Zhang Yi | 2009 | In Vitro Cellular & Developmental Biology . 2009 (1/2)2009，，1： | 1 |
| 9 | Experimental infection of Bama miniature pigs with a highly virulent classical swine fever virus显示文摘 | SUN Y JIANG QITIAN D Y | 2011 | Virol J2011，8，： | 1 |
| 10 | Haploidentical stem cell transplantation used in treating primary plasma cell leukemia: a case report显示文摘Here we report a successful protocol in treatment of a patient with primary plasma cell leukemia (PPCL) using haploidentical stem cell transplantation (hi-HSCT). During first complete remission after routine chemotherapy, the patient received autologous blood stem cell transplantation, but he had relapse later. He gained a second CR after chemotherapy and underwent hi-HSCT from his daughter, who had HLA mismatched at three loci. Recovery of hemopoiesis was found at day 14 and complete donor chimerism was confirmed by PCR-STR on day 34, 95 and 238. The patients have survived disease-free for 56 months since hi-HSCT, without serious graft-versus-host-disease. | Ouyang Guifang Zhu Huiling Hong Yongwei Xu Kaihong Mu Qitian Le Jing Wu Wenmiao Lu Ying Gu Xuewei Ni Lifeng | 2010 | Journal of Medical Colleges of PLA(China)2010，25，1： | 0 |
| 11 | Robust Stabilization of Discrete-time Constrained Singular Piecewise-affine Systems with Norm-bounded Uncertainties显示文摘In this paper,the problem of designing robust H-infinity output feedback controller and l2-gain controller are investigated for a class of discrete-time singular piecewise-affine systems with input saturation and state constraints. Based on a singular piecewise Lyapunov function combined with S-procedure and some matrix inequality convexifying techniques,the H-infinity stabilization condition is established and the l2-gain controller is investigated,and meanwhile,the input saturation disturbance tolerance condition is proposed. Under energy bounded disturbance,the domain of attraction is well estimated and the l2-gain controller is designed in some restricted region. It is shown that the controller gains can be obtained by solving a family of LMIs parameterized by one or two scalar variables. Meanwhile,by using the corresponding optimization methods,the domain of attraction and the disturbance tolerance level is maximized,and the H-infinity performance γ is minimized.Finally,numerical examples are given to illustrate the effectiveness of the proposed design methods. | Zhenhua Zhou Mao Wang Qitian Yin | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，1： | 0 |
| 12 | Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms显示文摘Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(Ⅰ) complex with tetraphenylethylene(TPE) modification(RePyTPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of ^(1)O_(2) generation in a biological aqueous solution. The produced ^(1)O_(2) and released CO killed mycobacterium smegmatis(M. smegmatis) and Escherichia coli(E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. | Yue Li Haobing Wang Qitian Lin Xinyu Yu Huaiyi Huang Pingyu Zhang | 2023 | Science China Chemistry2023，66，9： | 0 |
| 13 | Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor显示文摘Carbon monoxide(CO)gas therapy,a novel anti-tumor technique based on the cytotoxicity from the CO released in situ,has become one of the hot topics in cancer treatment.Since the technique is oxygenindependent,it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration depth.To fully address these limitations of PDT,we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic tumor.In this work,two rhenium(Ⅰ)tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO release.Our results indicated that the electron-donating NMe2-substituted complex(Re-NMe2)exhibits stronger luminescence intensity and generates more singlet oxygen(1O2)than the electron-withdrawing NO2-substituted complex(Re-NO2).In addition,Re-NMe2displays release of CO triggered by US,thus showing high sono-cytotoxicity to tumor cells in-vitro and in-vivo.The strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe2has made it a powerful tool for the efficient treatment of hypoxic tumor. | Yue Li Nong Lu Qitian Lin Haobing Wang Zhuoming Liang Yujuan Lu Pingyu Zhang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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