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| 1 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 2 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 3 | NOD2 和 TLR2 ligands 由在遗传性过敏症的像皮炎的皮肤发炎与真皮的成纤维细胞交往触发 basophils 和嗜曙红血球的激活显示文摘有遗传性过敏症的皮炎(广告) 的病人的皮肤由葡萄球菌 aureus 为殖民有唯一的倾向(S。aureus ) ,它贡献发炎和广告的冷酷的预后。尽管位于 S 下面的机制。不清楚的、最近的研究在在 S 调整煽动性的回答为模式识别受体发现了一个枢轴的角色的广告遗体的导致 aureus 的恶化。aureus 感染。在现在的学习,我们使用了像广告的皮肤发炎的一个典型老鼠模型并且发现了那 S。联系 aureus 的核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 并且像使用费的受体 2 (TLR2 ) ligands 加重了像广告的症状,它进一步被败坏由在里面 basophils 和嗜曙红血球的 vivo 扩大。随后的组织学的分析表明真皮的成纤维细胞在像广告的皮肤损害是弥漫的。有 basophils 和嗜曙红血球的人的真皮的成纤维细胞的合作文化在真皮的成纤维细胞上导致了对 NOD2/TLR2 ligands 和细胞间的粘附 molecule-1 的提高的表示的精力旺盛的 cytokine/chemokine 回答。Basophils 和嗜曙红血球为在合作文化的广告相关的 cytokine/chemokine 表示主要负责。直接细胞间的接触为在 basophils 和真皮的成纤维细胞之间的串音是必要的,当可溶的调停人是足够的调停时嗜曙红血球成纤维细胞相互作用。而且,细胞内部的 p38 激活 mitogen 的蛋白质 kinase,细胞外的调整信号的 kinase,和表明小径的原子 factor-kappa B 为在广告相关的发炎的 basophils,嗜曙红血球,和真皮的成纤维细胞的 NOD2/TLR2 调停 ligand 的激活是必要的。这研究通过天生的有免疫力的房间的激活提供广告的 NOD2/TLR2-mediated 恶化的证据因此使一条新奇机械学的小径由清楚些哪个 S。aureus 贡献广告的 pathophysiology。 | Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 4 | Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma显示文摘AIM: To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC).METHODS: Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression difference in HCC tissues and surrounding non-neoplastic liver tissue. FGFR3 expression levels were further determined by immunohistochemical study in 43 cases of HCC.RESULTS: Northern blot results showed the significant over-expression of FGFR3 in HCC tissues, which was consistent with that from DNA microarray. Quantitative real-time PCR demonstrated that the mean ratio of FGFR3 mRNA to glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA in HCC tissue was 0.250, whereas the ratio in non-neoplastic liver tissue was 0.014. Statistical analyses of 43 cases of HCC revealed that HCC scored higher than the matched non-neoplastic liver tissues.Examination of clinicopathological features revealed a strong correlation of over-expression of FGFR3 with poor tumor differentiation and high nuclear grade.CONCLUSION: Over-expression of FGFR3 may play an important role in liver carcinogenesis. FGFR3 may be an ideal candidate as a molecular marker in the diagnosis of HCC and a potential therapeutic target. | Wei-Hua Qiu Bing-Sen Zhou Peiguo G. Chu Wen-Gang Chen Christopher Chung Jennifer Shih Paul Hwu Christopher Yeh Richard Lopez Yun Yen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 5 | NOD-like receptors mediated activation of eosinophils interacting with bronchial epithelial cells: a link between innate immunity and allergic asthma显示文摘对细菌的感染的天生的免疫的关键 intracytosolic 模式识别受体是象受体(NLR ) 一样的核苷酸绑定 oligomerization 领域(点头) 。我们阐明了 NOD1 和人的嗜曙红血球的调停 NOD2 的激活,为过敏发炎的主要受动器房间,在在过敏气喘与人的支气管的上皮的 BEAS-2B 房间交往之上。嗜曙红血球组成地表示了 NOD1,2,但是展出了不重要的回答由 NOD1 ligand γ 在刺激之上释放 chemokines; -D-glutamyl-meso-diaminopimelic 酸(即弹跳) 和 NOD2 ligand muramyl dipeptide (MDP ) 。然而,即弹跳和 MDP 能显著地 CD18 的 upregulate 房间表面表示和细胞间的粘附分子(ICAM ) 嗜曙红血球上的 -1 和 BEAS-2B 房间上的 ICAM-1,以及在 coculture 系统导致 chemokines CCL2 和 CXCL8 版本(所有 P < 0.05 ) 。嗜曙红血球和 BEAS-2B 房间在在即弹跳或 MDP 刺激之上的 coculture 系统是为 CXCL8 和 CCL2 版本的主要来源。在嗜曙红血球和 BEAS-2B 房间之间的直接相互作用为 CCL2 版本负责,并且可溶的调停人在 CXCL8 版本被含有。英皇家空军之阶级最低之兵和 NF-κ B 玩为在 coculture 的粘附分子和 chemokines 的表示的规章的角色。有 NOD1,2 ligand 的处理能导致 subepithelial 纤维变性并且显著地提高全部的 IgE,为嗜曙红血球的 chemokine CCL5 和 T 助手类型的浆液集中 2 (Th2 )在 敏化ovalbumin 的过敏气喘的老鼠的 bronchoalveolar lavage 液体的房间和气喘 Th2 cytokine IL-13 (所有 P < 0.05 )。这研究在经由在煽动性的航线与支气管的上皮的房间交往的嗜曙红血球的激活触发过敏气喘提供 NOD1,2 的细菌的调停感染的激活的进一步的证据。 | Churl Kwok Wong Shuiqing Hu Karen Ming-Lam Leungt Jie Dong Lan He Yi Jun Chu Ida Miu-Ting Chu Huai-Na Qiu Kelly Yan-Ping Liu ChristopherWai-Kei Lam | 2013 | Cellular & Molecular Immunology2013，10，4： | 7 |
| 6 | Effects of Heyan Kuntai Capsule(和颜坤泰胶囊)on Follicular Development and Oocyte Cohesin Levels in Aged Mice显示文摘Objective: To evaluate the effect of Heyan Kuntai Capsule(和颜坤泰胶囊, HYKT) on the ovarian function of aged mice and expressions of cohesion complexes in oocytes. Methods: Twenty-five 9-month-old female C57BL/6J mice were randomly divided into 5 groups by block randomization method(n=5 per group), including the control group(saline), 17β-estradiol group [E_2, 100 μg/(kg·d)], and low-, medium-, and highdose of HYKT groups [0.3, 0.9, 2.7 g/(kg·d), respectively]. All mice were treated by intragastric administration for 4 weeks. Hematoxylin and eosin staining and anti-VASA staining were used to detect the amounts of follicles. The apoptosis of follicles was measured by anti-gamma H_2A histone family member X(γH_2AX) staining and Td T-mediated d UTP Nick-End Labeling(TUNEL) assay. The density of cohesin subunits, REC8 meiotic recombination protein(REC8), structural maintenance of chromosome(SMC) 1β and SMC3 in oocytes were evaluated by immunofluorescent staining. Results: After administration of E_2 and high-dose of HYKT, the total number of follicles as well as the number of primordial and primary follicles were significantly increased(P<0.05). Anti-γH_2AX staining and TUNEL assay demonstrated that high-dose of HYKT and E_2 partly suppressed the apoptosis of follicles(P<0.05). Furthermore, it showed an increased trend in the levels of REC8 and SMC1β, after administration with E_2 and HYKT, and no obvious change in the level of SMC3. Conclusion: HYKT could enhance the number of follicles, suppress apoptosis of oocytes and have a trend to elevate the meiotic-specific cohesin subunits(REC8 and SMC1β) in oocytes of aged mice, indicating a beneficial effect on the ovarian function in terms of the quantity and quality of follicles. | ZHANG Bin CHU Nan QIU Xue-min TANG Wei Hans-Jorgen Gober LI Da-jin WANG Ling | 2018 | Chinese Journal of Integrative Medicine2018，24，10： | 7 |
| 7 | Improvement cues of lesion absorption using the adjuvant therapy of traditional Chinese medicine Qinbudan tablet for retreatment pulmonary tuberculosis with standard anti-tuberculosis regimen显示文摘Background:China is the second highest pulmonary tuberculosis(PTB)burden country worldwide.However,retreatment of PTB has often developed resistance to at least one of the four first-line anti-TB drugs.The cure rate(approximately 50.0–73.3%)and management of retreatment of PTB in China needs to be improved.Qinbudan decoction has been widely used to treat PTB in China since the 1960s.Previously clinical studies have shown that the Qinbudan tablet(QBDT)promoted sputum-culture negative conversion and lesion absorption.However,powerful evidence from a randomized controlled clinical trial is lacking.Therefore,the aim of this study was to compare the efficacy and safety of QBDT as an adjunct therapy for retreatment of PTB.Methods:We conducted a multicenter,randomized,double-blind,placebo-controlled clinical trial in China.People diagnosed with PTB were enrolled who received previous anti-TB treatment from April 2011 to March 2013.The treatment group received an anti-TB regimen and QBDT,and the control group was administered an anti-TB regimen plus placebo.Anti-TB treatment options included isoniazid,rifampicin,pyrazinamide,ethambutol,streptomycin for 2 months(2HRZES),followed by isoniazid,rifampicin,ethambutol for 6 months(6HRE),daily for 8 months.Primary outcome was sputum-culture conversion using the MGIT 960 liquid medium method.Secondary outcomes included lung lesion absorption and cavity closure.Adverse events and reactions were observed after treatment.A structured questionnaire was used to record demographic information and clinical symptoms of all subjects.Data analysis was performed by SPSS 25.0 software in the full analysis set(FAS)population.Results:One hundred eighty-one cases of retreatment PTB were randomly divided into two groups:the placebo group(88 cases)and the QBDT group(93 cases).A total of 166 patients completed the trial and 15 patients lost to follow-up.The culture conversion rate of the QBDT group and placebo group did not show a noticeable improvement by using the covariate sites to correct the rate differences(79.6%vs 69.3%;rate difference=0.10,95%confidence interval(CI):-0.02–0.23;F=2.48,P=0.12)after treatment.A significant 16.6%increase in lesion absorption was observed in the QBDT group when compared with the placebo group(67.7%vs 51.1%;rate difference=0.17,95%CI:0.02–0.31;χ2=5.56,P=0.02).The intervention and placebo group did not differ in terms of cavity closure(25.5%vs 21.1%;rate difference=0.04,95%CI:-0.21–0.12;χ2=0.27,P=0.60).Two patients who received chemotherapy and combined QBDT reported pruritus/nausea and vomiting.Conclusions:No significant improvement in culture conversion was observed for retreatment PTB with traditional Chinese medicine plus standard anti-TB regimen.However,QBDT as an adjunct therapy significantly promoted lesion absorption,thereby reducing lung injury due to Mycobacterium tuberculosis infection.Trial registration:This trial is registered at ClinicalTrials.gov,NCT02313610. | Shao-Yan Zhang Ji-You Fu Xiao-Yan Guo Ding-Zhong Wu Tong Zhang Cui Li Lei Qiu Chang-Rong Shao He-Ping Xiao Nai-Hui Chu Qun-Yi Deng Xia Zhang Xiao-Feng Yan Zhao-Long Wang Zhi-Jie Zhang Xin Jiang Yue-Juan Zheng Pei-Yong Zheng Hui-Yong Zhang Zhen-Hui Lu | 2020 | Infectious Diseases of Poverty2020，9，3： | 7 |
| 8 | Selective laser melting of near-α titanium alloy Ti-6Al-2Zr-1Mo-1V:Parameter optimization, heat treatment and mechanical performance显示文摘This paper presents a comprehensive study conducted to optimize the selective laser melting(SLM)parameters and subsequent heat-treatment temperatures for near-α high-temperature titanium alloy Ti-6 Al-2 Zr-1 Mo-1 V(TA15),which is widely used in the aerospace industry.Based on the surface morphology and relative density analysis,the optimized process parameters were:laser power from 230 W to 380 W,scan speed from 675 mm/s to 800 mm/s,scan spacing of 0.12 mm,and layer thickness of0.03 mm.The effects of the laser power and the layer thickness on the phase constitutions,microstructure features,as well as room-temperature and high-temperature(500℃) tensile properties,were then studied to obtain an in-depth understanding of SLM-built TA15.Six typical temperatures(650,750,850,950,1000 and 1100℃) covering three representative temperature ranges,i.e.,martensite partial decomposition temperature range,martensite complete decomposition temperature range and above βtransus temperature,were subsequently selected as heat-treatment temperatures.The heat treatmentmicrostructure-mechanical property relationships of SLM-built TA15 were elucidated in detail.These results provide valuable information on the development of SLM-built TA15 alloy for industrial applications,and these findings are also beneficial to additive manufacturing of other near-α Ti alloys with desirable high-temperature properties. | Chao Cai Xu Wu Wan Liu Wei Zhu Hui Chen Jasper Chu Dong Qiu Chen-Nan Sun Jie Liu Qingsong Wei Yusheng Shi | 2020 | Journal of Materials Science & Technology2020，54，22： | 7 |
| 9 | Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress显示文摘Previous studies have shown that resveratrol,a bioactive substance found in many plants,can reduce early brain injury after subarachnoid hemorrhage,but how it acts is still unclear.This study explored the mechanism using the experimental subarachnoid hemorrhage rat model established by injecting autologous blood into the cerebellomedullary cistern.Rat models were treated with an intraperitoneal injection of 60 mg/kg resveratrol 2,6,24 and 46 hours after injury.At 48 hours after injury,their neurological function was assessed using a modified Garcia score.Brain edema was measured by the wet-dry method.Neuronal apoptosis in the prefrontal cortex was detected by terminal deoxyribonucleotidyl transferase-mediated biotin-16-dUTP nick-end labeling assay.Levels of reactive oxygen species and malondialdehyde in the prefrontal cortex were determined by colorimetry.CHOP,glucose-regulated protein 78,nuclear factor-erythroid2-related factor 2 and heme oxygenase-1 mRNA expression levels in the prefrontal cortex were measured by reverse transcription polymerase chain reaction.Tumor necrosis factor-alpha content in the prefrontal cortex was detected by enzyme linked immunosorbent assay.Immunohistochemical staining was used to detect the number of positive cells of nuclear factor-erythroid 2-related factor 2,heme oxygenase 1,glucose-regulated protein 78,CHOP and glial fibrillary acidic protein.Western blot assay was utilized to analyze the expression levels of nuclear factor-erythroid 2-related factor 2,heme oxygenase 1,glucose-regulated protein 78 and CHOP protein expression levels in the prefrontal cortex.The results showed that resveratrol treatment markedly alleviated neurological deficits and brain edema in experimental subarachnoid hemorrhage rats,and reduced neuronal apoptosis in the prefrontal cortex.Resveratrol reduced the levels of reactive oxygen species and malondialdehyde,and increased the expression of nuclear factor-erythroid 2-related factor 2,heme oxygenase-1 mRNA and protein in the prefrontal cortex.Resveratrol decreased glucose-regulated protein 78,CHOP mRNA and protein expression and tumor necrosis factor-alpha level.It also activated astrocytes.The results suggest that resveratrol exerted neuroprotective effect on subarachnoid hemorrhage by reducing oxidative damage,endoplasmic reticulum stress and neuroinflammation.The study was approved by the Animals Ethics Committee of Shandong University,China on February 22,2016(approval No.LL-201602022). | Yun-Kai Xie Xin Zhou Hong-Tao Yuan Jie Qiu Dan-Qing Xin Xi-Li Chu Da-Chuan Wang Zhen Wang | 2019 | Neural Regeneration Research2019，14，10： | 6 |
| 10 | Short-term safety and efficacy of the biodegradable iron stent in mini-swine coronary arteries显示文摘 | WU Chao QIU Hong HU Xiao-ying RUAN Ying-mao TIAN Yi CHU Yan XU Xin-lin XU Liang TANG Yue GAO Run-lin | 2013 | Chinese Medical Journal2013，，24： | 5 |
| 11 | Diversity,bioactivities,and metabolic potentials of endophytic actinomycetes isolated from traditional medicinal plants in Sichuan,China显示文摘The present study was designed to determine the taxonomic diversity and metabolic activity of the actinomycetes community, including 13 traditional medicinal plants collected in Sichuan province, China, using multiple approaches such as morphological and molecular identification methods, bioactivity assays, and PCR screening for genes involved in antibiotics biosynthesis. 119 endophytic actinomycetes were recovered; 80 representative strains were chosen for 16 S r RNA gene partial sequence analyses, with 66 of them being affiliated to genus Streptomyces and the remaining 14 strains being rare actinomycetes. Antimicrobial tests showed that 12(15%) of the 80 endophytic actinomycetes displayed inhibitory effects against at least one indicator pathogens, which were all assigned to the genus Streptomyces. In addition, 87.5% and 58.8% of the isolates showed anticancer and anti-diabetic activities, respectively. Meanwhile, the anticancer activities of the isolates negatively correlated with their anti-diabetic activities. Based on the results of PCR screening, five genes, PKS-I, PKS-II, NRPS, ANSA, and oxy B, were detected in 55.0%, 58.8%, 90.0%, 18.8% and 8.8% of the 80 actinomycetes, respectively. In conclusion, the PCR screening method employed in the present study was conducive for screening and selection of potential actinomycetes and predicting potential secondary metabolites, which could overcome the limitations of traditional activity screening models. | QIU Peng FENG Zhi-Xiang TIAN Jie-Wei LEI Zu-Chao WANG Lei ZENG Zhi-Gang CHU Yi-Wen TIAN Yong-Qiang | 2015 | Chinese Journal of Natural Medicines2015，13，12： | 5 |
| 12 | Corrosion resistance and hydrophobicity of myristic acid modified Mg-AI LDH/Mg(OH)2 steam coating on magnesium alloy AZ31显示文摘A hydrophobic surface was successfully fabricated on the Mg-Al-layered double hydroxide(Mg-Al LDH)/Mg(OH)2-coated AZ31 magnesium alloy via an in-situ steam coating(SC)process and a subsequent surface modification with environment-friendly myristic acid(MA).The microstructure,composition and hydrophobicity of SC/MA composite coating were investigated by XRD,SEM,EDS,FTIR,and contact angle(CA)measurement.The corrosion behavior of the hybrid coating was evaluated by potentiodynamic polarization,EIS and hydrogen evolution test in 3.5 wt.%NaCl solution.The results showed that the LDH coating had nano-flake microstructure,which remained unchanged after modification with MA.The CA of the MA-modified coating surface reached up to 129°±3.5°,and the corrosion current density of SC/MA-2 coating decreased about three orders of the magnitude compared to that of the substrate.It is proven that the modified surface has an effective anti-corrosion effect on AZ31 alloy.The formation mechanism and the corrosion mechanism of the coating were also discussed. | Zai-Meng Qiu Fen Zhang Jun-Tong Chu Yu-Chao Li Liang Song | 2020 | Frontiers of Materials Science2020，14，1： | 5 |
| 13 | A pure blue light emitting binaphthyl derivative:Synthesis and properties显示文摘有 3 和 3 个′位置上的分核的联萘衍生物被综合并且经由铃木描绘了偶合反应。在答案最大的排放被作为参考拿 9,10-diphenyl 蒽与 68% 的量子效率在 390 nm 定位,当它与从聚集状态导致固态膜的 104 nm 的 FWHM 被转移到 450 nm 时。玻璃化转变温度(Tg ) 和分解温度被测量分别地,由 DSC 和 TGA 是 184 和 447 ° C。不同于它的光致发光光谱,电镀物品发光光谱在大约 460 nm 和表演达到顶点相应于纯蓝排出物的 69 nm 的 FWHM。刺激电压,发光性和效率最大值是有并列的 CIE 颜色的 5 V, 2953 cd/m2 和 1.37 cd/A (0.16, 0.15 ) ,在 ITO/NPB (40 nm ) 的设备结构 /PY-BN-PY (15 nm )/BPhen (40 nm )/Mg :47 号元素银的化学符号。 | Qing Guo He Zeng Ze Chu Gang Tie Lei An Jun Qin Hong Zhen Lin Feng Lian Bai Jian Gong Cheng Yong Qiu | 2008 | Chinese Chemical Letters2008，19，4： | 4 |
| 14 | Primary malignant lymphoma of the glans penis: a rare :ase report and review of the literature显示文摘 | Li Chu Wei Mao Kim Curran Vikramsingh Xi Liu Hui-Min Qiu jun-Hua Zheng Yi Wang Gen-Pei Yu Qing Xu | 2013 | Asian Journal of Andrology2013，15，4： | 4 |
| 15 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 16 | Effects of precipitation on soil organic carbon fractions in three subtropical forests in southern China显示文摘Aims The aim of this study was to investigate the effects of precipitation changes on soil organic carbon(SOC)fractions in subtropical forests where the precipitation pattern has been altered for decades.Methods We conducted field manipulations of precipitation,including ambient precipitation as a control(CK),double precipitation(DP)and no precipitation(NP),for 3 years in three forests with different stand ages(broadleaf forest[BF],mixed forest[MF]and pine forest[PF])in subtropical China.At the end of the experiment,soil samples were collected to assay SOC content,readily oxidizable organic carbon(ROC)and non-readily oxidizable organic carbon(NROC),as well as soil microbial biomass carbon(MBC),pH and total nitrogen content.Samples from the forest floors were also collected to analyze carbon(C)functional groups(i.e.alkyl C,aromatic C,O-alkyl C and carbonyl C).Furthermore,fine root biomass was measured periodically throughout the experiment.Important Findings Among the forests,ROC content did not exhibit any notable differences,while NROC content increased significantly with the stand age.This finding implied that the SOC accumulation observed in these forests resulted from the accumulation of NROC in the soil,a mechanism for SOC accumulation in the mature forests of southern China.Moreover,NP treatment led to significant reductions in both ROC and NROC content and therefore reduced the total SOC content in all of the studied forests.Such decreases may be due to the lower plant-derived C inputs(C quantity)and to the changes in SOC components(C quality)indicated by C functional groups analyses under NP treatment.DP treatment in all the forests also tended to decrease the SOC content,although the decreases were not statistically significant with the exception of SOC and ROC content in PF.This finding indicated that soils in MF and in BF may be more resistant to precipitation increases,possibly due to less water limitations under natural conditions in the two forests.Our results therefore highlight the different responses of SOC and its fractions to precipitation changes among the forests and suggest that further studies are needed to improve our understanding of SOC dynamics in such an important C sink region. | Xiaomei Chen Deqiang Zhang Guohua Liang Qingyan Qiu Juxiu Liu Guoyi Zhou Shizhong Liu Guowei Chu Junhua Yan | 2016 | Journal of Plant Ecology2016，9，1： | 4 |
| 17 | High‐sensitivity distributed dynamic strain sensing by combining Rayleigh and Brillouin scattering显示文摘The phase-sensitive optical time-domain reflectometry(φ-OTDR)is a good candidate for distributed dynamic strain sensing,due to its high sensitivity and fast measurement,which has already been widely used in intrusion monitoring,geophysical exploration,etc.For the frequency scanning basedφ-OTDR,the phase change manifests itself as a shift of the intensity distribution.The correlation between the reference and measured spectra is employed for relative strain demodulation,which has imposed the continuous measurement for the absolute strain demodulation.Fortunately,the Brillouin optical time domain analysis(BOTDA)allows for the absolute strain demodulation with only one measurement.In this work,the combination of theφ-OTDR and BOTDA has been proposed and demonstrated by using the same set of frequency-scanning optical pulses,and the frequency-agile technique is also introduced for fast measurements.A 9.9 Hz vibration with a strain range of 500 nεhas been measured under two different absolute strains(296.7μεand 554.8με)by integrating the Rayleigh and Brillouin information.The sub-micro strain vibration is demonstrated by theφ-OTDR signal with a high sensitivity of 6.8 nε,while the absolute strain is measured by the BOTDA signal with an accuracy of 5.4με.The proposed sensor allows for dynamic absolute strain measurements with a high sensitivity,thus opening a door for new possibilities which are yet to be explored. | Benzhang Wang Dexin Ba Qi Chu Liqiang Qiu Dengwang Zhou Yongkang Dong | 2020 | Opto-Electronic Advances2020，3，12： | 3 |
| 18 | Spacing graphene and Ni-Co layered double hydroxides with polypyrrole for high-performance supercapacitors显示文摘The urgent need of high-performance of energy storage devices triggers us to design newly class of materials.Generally,the materials feature with high conductivity,abundant pore s and excellent stability.Here,a sandwiched hybrid composite containing reduced graphene oxide,polypyrrole and Ni-Co layered double hydroxides(RGO/PPy/NiCo-LDH) was prepared in a facile way.The polypyrrole was incorporated in the two dimensional(2D) nanosheets,which not only serve as the spacer to increase the surface area,but also enhance the conductivity of the nanocomposite.The obtained architecture was employed as an advanced electrode in a supercapacitor.The electrode shows an ultrahigh specific capacitance(2534 F g^-1 at 1 A g^-1) and good cycling efficiency(78 % after 5000 cycles).Moreover,an asymmetric cell based RGO/PPy/NiCo-LDH composite demonstrates excellent electrochemical properties and good prospect of practical use. | Jing Liang Cuili Xiang Yongjin Zou Xuebu Hu Hailiang Chu Shujun Qiu Fen Xu Lixian Sun | 2020 | Journal of Materials Science & Technology2020，52，20： | 3 |
| 19 | The Colour Reaction of Mercury with 1-(6-Ethoxyl-2-benzothiazolyl)-3-(4-Nitrophenyl)-Triazene and its Application显示文摘A new triazene reagent 1-(6-ethoxyl-2-benzothiazolyl )-3-(4-nitrophenyl)-triazene(EtOBTNPT) has been synthesized. The colour reaction of EtOBTNPT with Hg(II) has beenstudied. At pH=10. 1-- 10. 7, in the presence of Triton X-100, the reagent with Hg(II) forms anorange-yellow complex with high sensitivity. The molar absorptivity is 2.38 × 105 L. mol-1. cm-1 .Beer’s law is obeyed for Hg(II) in the range of 0-7 μg/25 ml. | Chuan Ming JIN Ming Hua YANG Chu Ru GONG Zhong Qiu HU(Department of chemistry,Hubei Normal University, Huangshi 435002) | 1998 | Chinese Chemical Letters1998，9，3： | 3 |
| 20 | Lactam Triterpenoids from the Bark of Toona sinensis显示文摘Three new limonoid-type triterpenoids,namely toonasins A–C(1–3)with a rare lactam E ring,along with six known compounds(4–9)were isolated from the barks of Toona sinensis.The structures of new compounds were elucidated by interpretation of spectroscopic data,and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses.The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines(HL-60,SMMC-7721,A-549,MCF-7 and SW480),and compounds 3 and 5 showed weak cytotoxicities. | Qian-Qian Meng Xing-Rong Peng Shuang-Yang Lu Luo-Sheng Wan Xia Wang Jin-Run Dong Rui Chu Lin Zhou Xiao-Nian Li Ming-Hua Qiu | 2016 | Natural Products and Bioprospecting2016，6，5： | 3 |
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