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| 1 | Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma显示文摘AIM: To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC).METHODS: Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression difference in HCC tissues and surrounding non-neoplastic liver tissue. FGFR3 expression levels were further determined by immunohistochemical study in 43 cases of HCC.RESULTS: Northern blot results showed the significant over-expression of FGFR3 in HCC tissues, which was consistent with that from DNA microarray. Quantitative real-time PCR demonstrated that the mean ratio of FGFR3 mRNA to glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA in HCC tissue was 0.250, whereas the ratio in non-neoplastic liver tissue was 0.014. Statistical analyses of 43 cases of HCC revealed that HCC scored higher than the matched non-neoplastic liver tissues.Examination of clinicopathological features revealed a strong correlation of over-expression of FGFR3 with poor tumor differentiation and high nuclear grade.CONCLUSION: Over-expression of FGFR3 may play an important role in liver carcinogenesis. FGFR3 may be an ideal candidate as a molecular marker in the diagnosis of HCC and a potential therapeutic target. | Wei-Hua Qiu Bing-Sen Zhou Peiguo G. Chu Wen-Gang Chen Christopher Chung Jennifer Shih Paul Hwu Christopher Yeh Richard Lopez Yun Yen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 2 | Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery显示文摘 | Jonathan Wang Christopher Poon Deborah Chin Sarah Milkowski Vivian Lu Kenneth R. Hallows Eun Ji Chung | 2018 | Nano Research2018，11，10： | 3 |
| 3 | Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors显示文摘 | Daniela C. Kroy Donatella Ciuffreda Jennifer H. Cooperrider Michelle Tomlinson Garrett D. Hauck Jasneet Aneja Christoph Berger David Wolski Mary Carrington E. John Wherry Raymond T. Chung Kenneth K. Tanabe Nahel Elias Gordon J. Freeman Rosemarie H. de Kru | 2014 | Gastroenterology2014，，2： | 2 |
| 4 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 5 | 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction显示文摘 | Patrick T. O’Gara Frederick G. Kushner Deborah D. Ascheim Donald E. Casey Mina K. Chung James A. de Lemos Steven M. Ettinger James C. Fang Francis M. Fesmire Barry A. Franklin Christopher B. Granger Harlan M. Krumholz Jane A. Linderbaum David A. Morrow L. | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 6 | Genetic Algorithm Approach to Aircraft Gate Reassignment Problem显示文摘 | Yu Gu Christopher A. Chung | 1999 | Journal of Transportation Engineering1999，，5： | 1 |
| 7 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 8 | Dysnatremias and Survival in Adult Burn Patients: A Retrospective Analysis显示文摘 | Stewart Ian J Morrow Benjamin D Tilley Molly A Snow Brian D Gisler Christopher Kramer Keith W Aden James K Renz Evan M Chung Kevin K | 2013 | American Journal of Nephrology2013，，1： | 1 |
| 9 | Results of the Predictors of Response to CRT (PROSPECT) Trial显示文摘 | Eugene S. Chung Angel R. Leon Luigi Tavazzi Jing-Ping Sun Petros Nihoyannopoulos John Merlino William T. Abraham Stefano Ghio Christophe Leclercq Jeroen J. Bax Cheuk-Man Yu John Gorcsan Martin St John Sutton Johan De Sutter Jaime Murillo | 2008 | Circulation2008，，： | 1 |
| 10 | Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer 显示文摘 | Michael A.S. Jewett Kamal Mattar Joan Basiuk Christopher G. Morash Stephen E. Pautler D. Robert Siemens Simon Tanguay Ricardo A. Rendon Martin E. Gleave Darrel E. Drachenberg Raymond Chow Hannah Chung Joseph L. Chin Neil E. Fleshner Andrew J. Evans Brenda | 2011 | European Urology2011，，： | 1 |
| 11 | Vereckei criteria as a diagnostic tool amongst emergency medicine residents to distinguish between ventricular tachycardia and supra-ventricular tachycardia with aberrancy显示文摘 | Rupen P. Baxi Kimberly W. Hart András Vereckei John Miller Sora Chung Wendy Chang Brent Gottesman Meagan Hunt Ginger Culyer Thomas Trimarco Christopher Willoughby Guillermo Suarez Christopher J. Lindsell Sean P. Collins | 2012 | Journal of Cardiology2012，，3： | 1 |
| 12 | 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction显示文摘 | Patrick T. O’Gara Frederick G. Kushner Deborah D. Ascheim Donald E. Casey Mina K. Chung James A. de Lemos Steven M. Ettinger James C. Fang Francis M. Fesmire Barry A. Franklin Christopher B. Granger Harlan M. Krumholz Jane A. Linderbaum David A. Morrow L. | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 13 | Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content显示文摘 | Arijeet K. Gattu E. Scott Swenson Yasuko Iwakiri Varman T. Samuel Nancy Troiano Ryan Berry Christopher D. Church Matthew S. Rodeheffer Thomas O. Carpenter Chuhan Chung | 2013 | The FASEB Journal2013，，11： | 1 |
| 14 | Abdominal Complications after Severe Burns显示文摘 | Katharine W. Markell Evan M. Renz Christopher E. White Michael E. Albrecht Lorne H. Blackbourne Myung S. Park David A. Barillo Kevin K. Chung Rosemary A. Kozar Joseph P. Minei Stephen M. Cohn David N. Herndon Leopoldo C. Cancio John B. Holcomb Steven E. W | 2009 | Journal of the American College of Surgeons2009，，5： | 1 |
| 15 | Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells显示文摘 | Perry Mark M Hui Christopher K Whiteman Matthew Wood Mark E Adcock Ian Kirkham Paul Michaeloudes Charalambos Chung Kian Fan | 2011 | EN2011，，4： | 1 |
| 16 | Thoracoabdominal aneurysm repair: Hybrid versus open repair显示文摘 | Rajendra Patel Mark F. Conrad Vikram Paruchuri Christopher J. Kwolek Thomas K. Chung Richard P. Cambria | 2009 | Journal of Vascular Surgery2009，，1： | 1 |
| 17 | Pretreatment Total Testosterone Level Predicts Pathological Stage in Patients With Localized Prostate Cancer Treated With Radical Prostatectomy显示文摘 | JASON C. MASSENGILL LEON SUN JUDD W. MOUL HONGYU WU DAVID G. McLEOD CHRISTOPHER AMLING RAYMOND LANCE JOHN FOLEY WADE SEXTON LEO KUSUDA ANDREW CHUNG DOUGLAS SODERDAHL TIMOTHY DONAHUE | 2003 | The Journal of Urology2003，，5： | 1 |
| 18 | A Genetic Screen Identifies Interferon-α Effector Genes Required to Suppress Hepatitis C Virus Replication显示文摘 | Dahlene N. Fusco Cynthia Brisac Sinu P. John Yi–Wen Huang Christopher R. Chin Tiao Xie Hong Zhao Nikolaus Jilg Leiliang Zhang Stephane Chevaliez Daniel Wambua Wenyu Lin Lee Peng Raymond T. Chung Abraham L. Brass | 2013 | Gastroenterology2013，，7： | 1 |
| 19 | Results of the Predictors of Response to CRT (PROSPECT) Trial显示文摘 | Eugene S. Chung Angel R. Leon Luigi Tavazzi Jing-Ping Sun Petros Nihoyannopoulos John Merlino William T. Abraham Stefano Ghio Christophe Leclercq Jeroen J. Bax Cheuk-Man Yu John Gorcsan Martin St John Sutton Johan De Sutter Jaime Murillo | 2008 | Circulation2008，，20： | 1 |
| 20 | Comparison of Magnetic Resonance Feature Tracking for Strain Calculation With Harmonic Phase Imaging Analysis显示文摘 | Kan N. Hor William M. Gottliebson Christopher Carson Erin Wash James Cnota Robert Fleck Janaka Wansapura Piotr Klimeczek Hussein R. Al-Khalidi Eugene S. Chung D. Woodrow Benson Wojciech Mazur | 2010 | JACC: Cardiovascular Imaging2010，，： | 1 |
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