|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway显示文摘Background Salmonella typhimurium(S.T),as an important foodborne bacterial pathogen,can cause diarrhea and gastroenteritis in humans and animals.Numerous studies have confirmed that exopolysaccharides(EPSs)have various biological functions,but the mechanism through which EPSs improve the immunity of animals against the invasion of pathogenic bacteria is unclear.Here,we explored the protective effect of EPSs of Lactobacillus rhamnosus GG(LGG)on the S.T-infected intestine.Methods Mice received adequate food and drinking water for one week before the start of the experiment.After 7 d of prefeeding,2×108 CFU/mL S.T solution and an equivalent volume of saline(control group)were given orally for 1 d.On the fourth day,the mice were treated with 0.5 mg/mL EPSs,1.0 mg/mL EPSs,2.0 mg/mL EPSs,or 2.0 mg/mL penicillin for 7 d.Finally,the body and relative organ weight,histological staining,and the levels of antioxidant enzyme activity and inflammatory cytokines were determined.Results The S.T-infected mice exhibited symptoms of decreased appetite,somnolence,diarrhea and flagging spirit.Treatment with EPSs and penicillin improved the weight loss of the mice,and the high dose of EPSs showed the best therapeutic effect.EPSs significantly ameliorated S.T-induced ileal injury in mice.High-dose EPSs were more effective than penicillin for alleviating ileal oxidative damage induced by S.T.The mRNA levels of inflammatory cytokines in the ileum of mice showed that the regulatory effects of EPSs on inflammatory cytokines were better than those of penicillin.EPSs could inhibit the expression and activation of key proteins of the TLR4/NF-κB/MAPK pathway and thereby suppress the level of S.T-induced ileal inflammation.Conclusions EPSs attenuate S.T-induced immune responses by inhibiting the expression of key proteins in the TLR4/NF-κB/MAPK signaling pathway.Moreover,EPSs could promote bacterial aggregation into clusters,which may be a potential strategy for reducing the bacterial invasion of intestinal epithelial cells. | Jinze Li Qiuke Li Qianhui Wu Nan Gao Zhihua Wang Yang Yang Anshan Shan | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 0 |
| 2 | Tolerance Comparison Among Selected Spirulina Strains Cultured Under High Carbon Dioxide and Coal Power Plant Flue Gas Supplements显示文摘In order to explore the changes in the growth and protein contents of Spirulina and obtain a proper strain for the fixation of carbon dioxide(CO2 from flue gas,the strains isolated from the Spirulina farms and the strain 208 were cultured under different aeration conditions including no CO2,10%CO2 and coal power plant flue gas supplements.The physiological indexes including filament length,biomass yield and chlorophyll a,soluble protein and phycocyanin contents were determined,respectively.When cultured without CO2 supplement,the strain 4-5 exhibited the highest biomass yield(1.880 g L^(−1)and a specific growth rate(0.367 d−1.However,the specific growth rate of all strains decreased significantly when they were cultured under 10%CO2 and unfiltered coal power plant flue gas supplements.Considerable differences were noted in the performance of the experimental microalgal strains under different contemporaneous conditions.The strain 7-8 achieved the highest biomass yield(1.603 g L^(−1)and relatively high phycocyanin content(7.1%)under 10%CO2 supplement.We noted that strain 4-5 had the highest specific growth rate(0.182 d−1 and biomass yield(0.43 g L^(−1)under coal power plant flue gas supplement.Strain 6-10 displayed the highest soluble protein content(66.02%),and strain 7-8 showed the highest phycocyanin content(9.28%)under coal power plant flue gas supplement. | ZHAO Qianqian JIN Guiyong LIU Qiuke PAN Kehou ZHU Baohua LI Yun | 2021 | Journal of Ocean University of China2021，20，6： | 0 |
| 3 | Organochlorine pesticides in marine environment of Quanzhou Bay, Southeast China显示文摘 | Qiuke SU Shihua QI Chengxi WU Julia E. Burnet Huafeng LIU Min FANG Jun LI Gan ZHANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 4 | Organochlorine pesticides in eco-geochemical survey, China显示文摘 | Shihua QI Gan ZHANG Xiangdong LI Qiuke SU Xianyi GONG Chunling LU Jun LI Julia Burnet E | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员