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| 1 | Naringenin reduces lung metastasis in a breast cancer resection model显示文摘Metastasis is the main cause of death in cancer patients. To improve the outcomes of patients undergoing a surgery, new adjuvant therapies that can effectively inhibit metastases have to be developed. Studies have shown that flavonoid naringenin, a natural product that is mainly present in grapes and citrus, may contribute to cancer prevention. It has many advantages compared to traditional chemotherapeutic drugs, such as low toxicity. To determine whether naringenin can also inhibit metastases, a breast cancer resection model that mimics clinical situations was established. We found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells. In vitro studies further demonstrated that relief of immunosuppression caused by regulatory T cells might be the fundamental mechanism of metastasis inhibition by naringenin. These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients. | Lei Qin Lingtao Jin Linlin Lu Xiaoyan Lu Chunling Zhang Fayun Zhang Wei Liang | 2011 | Protein & Cell2011，2，6： | 12 |
| 2 | Arab/c/opste N^(6)-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies显示文摘The biological functions of the epitranscriptomic modification N^(6)-methyladenosine(m^(6)A)in plants are not fully understood.CPSF30-L is a predominant isoform of the polyadenylation factor CPSF30 and consists of CPSF30-S and an m^(6)A-binding YTH domain.Little is known about the biological roles of CPSF30-L and the molecular mechanism underlying its m^(6)A-binding function in alternative polyadenylation.Here,we charac-terized CPSF30-L as an Arabidopsis m^(6)A reader whose m^(6)A-binding function is required for the floral tran-sition and abscisic acid(ABA)response.We found that the m^(6)A-binding activity of CPSF30-L enhances the formation of liquid-like nuclear bodies,where CPSF30-L mainly recognizes m*A-modified far-upstream elements to control polyadenylation site choice.Deficiency of CPSF30-L lengthens the 3'untranslated region of three phenotypes-related transcripts,thereby accelerating their mRNA degradation and leading to late flowering and ABA hypersensitivity.Collectively,this study uncovers a new molecular mechanism for m^(6)A-driven phase separation and polyadenylation in plants. | Peizhe Song Junbo Yang Chunling Wang Qiang Lu Linqing Shi Subiding Tayier Guifang Jia | 2021 | Molecular Plant2021，14，4： | 12 |
| 3 | On the Systematic Position of Eosipterus yangi Ji et Ji,1997 among Pterodactyloids显示文摘A comparison of the new specimen with the holotype of Eosipterus from western Liaoning Province indicates that Eosipterus is a valid genus,which belongs to the family Ctenochasmatidae.The revised diagnosis of Eosipterus includes the wing span is less than 1.25 meters,the length of the ulna is nearly equal to these of wing phalanx 2 and the tibia,humerus is longer than tibia,and the ratio of metatarsal to tibia is approximately 0.40. | LU Junchang GAO Chunling MENG Qingjin LIU Jinyuan JI Qiang | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 4 |
| 4 | Effects of Nutritional Factors on the Growth and Heterotrophic Eicosapentaenoic Acid Production of Diatom Nitzschia laevis显示文摘The effects of several nutritional factors on the growth and eicosapentaenoic acid(EPA) production of diatom Nitzschia laevis were studied. 4 LDM(quadrupled concentration of the nutrient salt) was the optimal concentration of nutrient salt for the growth and EPA production of N. laevis. The growth of N. laevis was inhibited when the glucose concentration was either lower than 10 gL-1 or higher than 15 gL-1. Both sodium nitrate and urea were good nitrogen sources for the growth and EPA production,while ammonium chloride seriously decreased the dry cell weight(DW) and the EPA content. Silicate seriously influenced the growth of N. laevis. The maximum DW of 2.34 gL-1 was obtained in the presence of 150 mgL-1 Na2SiO3· 9H2O. The EPA content remained almost the same when the silicate concentration was lower than 150 mgL-1;however,higher silicate concentrations resulted in a steady de-crease of EPA content. Low medium salinity(≤29) did not seem to influence the DW of N. laevis,and high salinity resulted in a decrease of DW. The highest EPA content(4.08%) and yield(110 mgL-1) were observed at the salinity of 36 and 29,respectively. | CAO Xiaohong LI Songyao WANG Chunling LU Meifang | 2008 | Journal of Ocean University of China2008，7，3： | 3 |
| 5 | Expression of Pseudorabies Virus gE Core Epitopes in Escherichia coli Strain BL21 and Utilization of Indirect PRV gE-ELISA显示文摘Pseudorabies virus glycoprotein E( PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. In order to produce gE antigen in large quantities and at low cost,a gene fragment encoding PRV gE core epitopes was expressed in E. coli BL21 expression system. SDS-PAGE and Western Blotting revealed that the expression product in culture supernatant of E. coli BL21 was a recombinant protein,approximately 51. 8 Kd. At 5 h post-induction,protein concentration assay showed that the expression product amounted to 1. 65 mg /ml,accounting for 24. 17% of total proteins in the culture supernatant. An indirect PRV gE-ELISA was established by using the recombinant expression product as a coating antigen. Cross-reactivity assay showed that this antigen was PRV specific. In addition,the assay was consistently reproducible. Comparison of detection results of 240 serum samples between PRV gE-ELISA and a commercially available PRV diagnostic kit showed that there was no significant difference between these two methods( P > 0. 05). | Guangjun GUO Sufang LU Guanggang QU Feng LI Lin DONG Yanli BI Jinliang WANG Feng WEI Na TANG Chunling ZHANG Zhuang DING Zhiqiang SHEN | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 6 | A graphene platform for sensing biomolecules显示文摘 | Lu Chunhua Yang Huanghao Zhu Chunling | 2009 | Angew Chem Int Ed2009，48，26： | 1 |
| 7 | Urinary TNF?α and NGAL are correlated with the progression of nephropathyin patients with type 2 diabetes显示文摘 | Jian Wu Yaqing Ding Chunling Zhu Xiaohong Shao Xin Xie Kan Lu Rui Wang | 2013 | Experimental and Therapeutic Medicine2013，，6： | 1 |
| 8 | Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spotl4 and Cyp2e1 expression levels显示文摘Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involved in vitamin A metabolism in both humans and mice. We previously generated Rdh13 knockout mice and showed that Rdh13 deficiency causes severe acute retinal light damage. In this study, considering that Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injury induced by carbon tetrachloride (CC14). Although Rdh13 deficiency showed no significant effect on liver histology and physiological functions under regular culture, the Rdh13^-/- mice displayed an attenuated response to CCl4-induced liver injury. Their livers also exhibited less histological changes and contained lower levels of liver-related metabolism enzymes compared with the livers of wild-type (WT) mice. Furthermore, the Rdhl3 1 mice had Rdh13 deficiency and thus their liver cells were protected from apoptosis, and the quantity of their proliferative cells became lower than that in WT after CC14 exposure. The ablation of Rdhl3 gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2el) in the liver, especially after CC14 treatment for 48 h. These data suggested that the alleviated liver damage induced by CC14 in Rdh13^-/- mice was caused by Cyp2el enzymes, which promoted reductive CC14 metabolism by altering the status of thyroxine metabolism. This result further implicated Rdhl3 as a potential drug target in preventing chemically induced liver injury. | Xiaofang Cui Benting Ma Yan Wang Yan Chen Chunling Shen Ying Kuang Jian Fei Lungen Lu Zhugang Wang | 2019 | Frontiers of Medicine2019，13，1： | 1 |
| 9 | Optimization of Heterogeneous Databases Data Synchronization In WAN By Virtual Log Compression显示文摘 | ]Lu Zhengyu Zhang Chunling Liu Zunfeng | 2010 | ICFN2010，，： | 1 |
| 10 | Prepa ration of two kinds of chloromethylated polystyrene particle u sing 1,4-bis (chloromethoxy) butane as chloromethylation rea gent显示文摘 | Lu Chunling Gao Baojiao Liu Qing Qi Changsheng | 2008 | Colloid Polymer Science2008，286，： | 1 |
| 11 | COVID-19-associated gastrointestinal and liver injury:clinical features and potential mechanisms显示文摘Coronavirus disease-2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The infection is spreading globally and poses a huge threat to human health.Besides common respiratory symptoms,some patients with COVID-19 experience gastrointestinal symptoms,such as diarrhea,nausea,vomiting,and loss of appetite.SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2(ACE2)and there is increasing evidence of a possible fecal–oral transmission route.In addition,there exist multiple abnormalities in liver enzymes.COVID-19-related liver injury may be due to drug-induced liver injury,systemic inflammatory reaction,and hypoxia–ischemia reperfusion injury.The direct toxic attack of SARS-CoV-2 on the liver is still questionable.This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19. | Peijie Zhong Jing Xu Dong Yang Yue Shen Lu Wang Yun Feng Chunling Du Yuanlin Song Chaomin Wu Xianglin Hu Yangbai Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 12 | Reduction of Escherichia coli O157:H7 and Salmonella enteritidis on mung bean seeds and sprouts by slightly acidic electrolyzed water显示文摘 | Chunling Zhang Zhanhui Lu Yongyu Li Yuchao Shang Gong Zhang Wei Cao | 2010 | Food Control2010，，5： | 1 |
| 13 | EEMD and bidimensional RLS to suppress physiological interference for heterogeneous distribution in fNIRS study显示文摘Near-infrared spectroscopy(NIRS)can provide the hemodynamics information based on the hemoglobin concentration representing the blood oxygen metabolism of the cerebral cortical,which can be deployed for the cerebral function study.However,NIRS-based cerebral function detection accuracy can be signi¯cantly in°uenced by the physiological activities such as cardic cycle,respiration,spontaneous low-frequency oscillation and ultra-low frequency oscillation.The distribution difference of the capillary,artery and vein leads to the heterogeneity feature of the cerebral tissues.In the case that the heterogeneity is not serious,good detection accuracy and stable performance can be achieved through the regression analysis as the reference signal can well represent the interference in the measurement signal when conducting the multi-distance measurement approach.The direct use of the reference signal to estimate the interference is not able to achieve good performance in the case that the heterogeneity is serious.In this study,the cerebral function activity signal is extracted using recursive least square(RLS)method based on the multi-distance measurement method in which the reference signal is processed by ensemble empirical mode decomposition(EEMD)algorithm.The temporal and dimensional correlation of the neighboring sampling values are applied to estimate the interference in the measurement signal.Monte Carlo simulation based on a heterogeneous model is adopted here to investigate the effectiveness of this methodology.The results show that this methodology can effectively suppress the physiological interference and improve the detection accuracy of cerebral activity signal. | Yan Zhang Dan Liu Qisong Wang Xin Liu Chunling Yang Jinwei Sun Jingyang Lu Peter Rolfe | 2018 | Journal of Innovative Optical Health Sciences2018，，6： | 1 |
| 14 | Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson' s disease显示文摘 | Lu LL Chunl LZ Yu JL | 2005 | Brain Research Protocols2005，15，4： | 1 |
| 15 | Reduction of escherichia coli O157:H7 and Salmonella enteritidis on mung bean seeds and sprouts by slightly acidic electrolyzed water显示文摘 | Zhang Chunling Lu Zhanhui Li Yongyu | | 0，，05： | 1 |
| 16 | A grapheneplatformforsensingbiomolecules显示文摘 | LU CHUNHUA YANG HUANGHAO ZHU CHUNLING | 2009 | Angewandte Chemic International Edition2009，121，26： | 1 |
| 17 | Healing Effect and Underlying Mechanism of Silver Nanoparticles Prepared Using Carboxymethyl Chitosan under Solar Irradiation显示文摘In our previous study,silver nanoparticles were prepared using AgNO_(3) and carboxymethyl chitosan(CMCS)which is commercially available with solar irradiation.In this study,the efficacy and safety of silver nanoparticles prepared by this method were evaluated for healing wounds in rats with diabetes.We also attempted to determine the underlying mechanism and influencing factors of the silver nanomaterial preparation method.Compared with growth factors,silver nanoparticles exhibit better healing effects for rats with diabetes.No remnant silver ions were detected in the major organs of these rats after the application of silver nanoparticles.Silver nanoparticles prepared using CMCS are less toxic than those prepared from the conventional method,promote the proliferation of skin fibroblasts,and are promising as a topical medication for infected wounds.An obvious breakage process of the particles is observed during the growth of nanocrystalline silver in CMCS.In this study,we also attempted to determine whether this method is suitable for synthesizing silver nanoparticles using N-trimethyl chitosan chloride and sodium alginate were used in this particular experiment.The characteristic UV-vis absorbance peak of silver nanoparticles was found only in the reaction mixture containing N-trimethyl chitosan chloride.Our study demonstrates that free radicals are the key factor in this silver nanoparticle preparation method. | Yi Long Chunling Zhang Lan Chen Tietao Di Lu Chen Lisha Tang Kaizhong Luo Yu Yan Pingzhen Tong Jie Xiang | 2021 | Journal of Renewable Materials2021，9，6： | 0 |
| 18 | Transition metal embedded in nonmetal-doped T-carbon [110]: A superior synergistic trifunctional electrocatalyst for HER, OER and ORR显示文摘The design of efficient and low-cost multifunctional electrocatalysts for hydrogen evolution reaction(HER), oxygen evolution reaction(OER) and oxygen reduction reaction(ORR) is critical for the development of clean energy. Two-dimensional(2D) carbon-based nano-materials are becoming more and more popular in heterogeneous catalysis due to their cost-effective and multi-scale tunability as single-atom catalysis(SACs) substrates. In this paper, by using first-principles calculation, we designed and demonstrated a novel macropore T-carbon [110](TC) monolayer as 2D electrocatalyst substrate for HER/OER/ORR, and the synergistic modification of the transition metal and nonmetal atoms(TM-X) were investigated to enhance the multifunctional electrocatalytic performance. We screened out the Co embedded in N-doped TC(Co3@N-TC) from 30 TM@X-TC monolayers as a trifunctional electrocatalysts, which exhibits superior performance for HER/ORR/OER on both thermodynamic and kinetic scales, and with excellent thermal and electrochemical stability. Then, the TC monolayer is naturally macropore with a diameter of 5.36 A and exhibits excellent adsorption capacity for the intermediates and products of the redox reactions. Moreover, we revealed the origin of the electrocatalytic activity using the crystal orbital Hamilton population(COHP) and the molecular orbitals(MOs). The d orbital of Co3@N-TC is significantly hybridized with the p orbital of the intermediates, so that the lone electrons initially occupied in the antibonding state pair up and occupy the downward bonding state, allowing *OH to be appropriately adsorbed onto the TC monolayer. This work not only demonstrates that the TM@X-TC monolayer is a superior synergistic trifunctional electrocatalyst, but also reveals a macropore monolayer material with potential applications in electrocatalysis. | Zhengqin Zhao Jinbo Hao Baonan Jia Xinhui Zhang Ge Wu Chunling Zhang Long Li Shuli Gao Yirong Ma Yuanzi Li Pengfei Lu | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 19 | Organochlorine pesticides in eco-geochemical survey, China显示文摘 | Shihua QI Gan ZHANG Xiangdong LI Qiuke SU Xianyi GONG Chunling LU Jun LI Julia Burnet E | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 20 | Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division显示文摘细菌的房间分割严格地在相等的女儿房间的形成被调整。这个过程被一系列空间、时间的管理者管理,并且这块地感兴趣的几个新因素最近被识别了。这里,我们在 zoonotic 病原体链球菌 suis 的房间分割报导 gluconate 5 脱氢酶(Ga5DH ) 的要求。Ga5DH 催化 5-ketogluconate 的可逆减小到 D-gluconate 并且对房间分割的地点局部性。在 S 的 Ga5DH 的删除。suis 与加入子孙的异常 septa 导致了丰满的形态学。重要增加也在房间长度被观察。这些缺点决心是在 S 的 Ga5DH 剥夺的后果。引起 FtsZ delocalization 的 suis。另外,有在 vitro 的 Ga5DH 的 FtsZ 的相互作用被蛋白质相互作用试金证实。这些结果显示 Ga5DH 可以工作在 S 期间阻止宫外的 Z 戒指的形成。suis 房间分割。 | Zhongyu Shi Chunling Xuan Huiming Han Xia Cheng Jundong Wang Youjun Feng Swaminath Srinivass Guangwen Lu George F. Gao | 2014 | Protein & Cell2014，5，10： | 0 |
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