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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 3 | Review of Directly Producing Light Olefins via CO Hydrogenation显示文摘Directly making light olefins via CO hydrogenation is a promising process to obtain a non-petroleum based supply of alkenes. Limited by the ASF distribution function of Fischer-Tropsch synthesis,the yield of light olefins (C2-C4) can not reach the desired levels, which is a great challenge to overcome.Beginning with a brief introduction of F-T synthesis, this paper provides a review of current research,including thermodynamic analysis, the ASF distribution function, the reaction performance of CO hydro-genation and slurry reactor studies. The problems currently faced by this research area are presented atthe end of the article. | Chong Wang, Longya Xu, Qingxia WangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China | 2003 | Journal of Natural Gas Chemistry2003，12，1： | 6 |
| 4 | A Study of the Migration and Accumulation Efficiency and the Genesis of Hydrocarbon Natural Gas in the Xujiaweizi Fault Depression显示文摘摘要:为了在 Xujiaweizi 调查迁居和烃天然气的累积效率,并且为它的开始的分类提供新证据,指责消沉,在一个封闭系统的一个来源岩石热分解实验被设计并且执行了。基于这,为描述从有机物的产生和碳同位素分别在这期间处理的气体的运动模型被建立,校准然后外推到由联合 Xushen-1 的热历史数据很好的地质的条件。结果显示在 Xujiaweizi 差错消沉的煤措施是典型高效率的煤气的来源,从他们产生的天然气有高迁居和累积效率,并且因而,大规模天然气累积发生在区域。在 Xujiaweizi 差错消沉的高度 / 过去成熟的煤措施与高 13C1 价值产生 coaliferous 气体(>?20%) 在迟了的阶段,使碳成为器官的链烷气体的同位素作文反常地重。另外,通过天然气的 caprock 混合和驱散能导致否定的碳同位素顺序(13C1 > 13C2 > 13C3 > 13C4 ) 器官的链烷,气体,和驱散罐头也导致器官的链烷气体的反常地重的碳同位素作文。至于无机的 nonhydrocarbon 气体水库的发现,它能是仅仅服务一补助证据而非烃气体是无机的一条直接证据。作为结果,作为无机的气体在 Xujiaweizi 差错消沉分类烃天然气需要更充分的证据。 | LI Jijun LU Shuangfang XUE Haitao HUO Qiuli XU Qingxia | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 5 |
| 5 | The Impact of Aqueous Medium on Gas Yields and Kinetic Behaviors of Hydrogen Isotope Fractionation during Organic Matter Thermal Degradation显示文摘以便在有机物期间在煤气的收益和氢同位素分别的运动行为上认出水的媒介的影响热降级,金试管仪器被用来由与不同性质和比例的水混合 nC18 进行热模拟实验。天然气部件的收益,在每个部件和试验性的温度对加热的率的氢同位素作文之中的关系被获得了,并且结果显示在更高的温度条件下面,含水的实验在煤气的收益,更多什么时候流水上有明显的影响被增加,烃气体和 H2 的更高的数量被产出,并且水的存在显然与重烃气体的存在延长温度间隔。比由无水的实验产生了的,含水的实验产生的烃气体的氢同位素才显然轻,并且与增加的水的增加的数量,烃气体的 D 价值逐渐地减少。与煤气的收益相比, 5D 价值的变化对在热模拟实验的水的媒介更敏感。与增加的水的数量相比,然而,水的中等性质在煤气的收益上有更小的影响,它仍然在水的媒介的氢同位素作文上显示出 inherit 效果。通过模型模拟和同位素分别行为分析,氢同位素分别过程能被化学运动模型很好描述,这被验证。正常甲烷和包含 D 甲烷的反应部分的差别大,相应于一样的激活精力。正常甲烷的内容在有更低的激活精力的部分显然是更高的,当包含 D 甲烷的内容在有更高的激活精力的部分是更高的时。因此,它将导致更大的氢同位素分别振幅,和 D 价值将对成熟的变化更敏感。同时,从在含水的实验的 nC18 的甲烷产生的平均激活精力在无水的实验比那高,并且越增加的水的大数量,越 larger 甲烷产生反应的平均激活精力。这在形成历史和煤气来源的关联的煤气的水库的学习为它的探索申请打了基础,它在这取向显示研究和申请前景。 | LU Shuangfang WANG Min XUE Haitao LI Jijun CHEN Fangwen XU Qingxia | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 5 |
| 6 | Synthesis of ZSM-35 Zeolite and Its Application in Skeletal Isomerization of 1-Hexene显示文摘 | XIE Sujuan, WANG Qingxia, XU Longya, WU Zhihua (State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China) | 2000 | 催化学报2000，21，4： | 3 |
| 7 | Pure organic room-temperature phosphorescent N-allylquinolinium salts as anti-counterfeiting materials显示文摘Pure organic room-temperature phosphorescence (RTP) materials have been attracting much attention recently. Herein, we report a facile approach combining heavy atom effect and external solvent stimuli to realize RTP. N-Allylquinolinium bromide under 365 nm UV exhibited intense green RTP emission with response upon adding chloroform. This interesting phenomenon endowed N-allylquinolinium bromide great potential as an anti-counterfeiting material. | Qingxia Xiong Chao Xu Nianming Jiao Xiang Ma Yanqiang Zhang Suojiang Zhang | 2019 | Chinese Chemical Letters2019，30，7： | 2 |
| 8 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 9 | Effect of Reaction Temperature and Pressure on the Metathesis Reaction between Ethene and 2-Butene to Propene on the WO_3/Al_2O_3-HY Catalyst显示文摘在到丙烯的 ethene 和 2-butene 之间的换位反应上的反应温度和压力的效果在 WO3/| 上被学习 ?-Al2O3-HY 催化剂。这项活动被发现与提高的温度增加并且在 150 ¨ C 到达一个高原 240 ??6 号元素碳的化学符号。在那以后,这项活动经历显著减少在也高温。温度的效果被钨种类的氧化态阐明。评估结果也显示稳定性依赖于这个反应参数。中等压力(0.5 ¨ C 0.8 MPa ) 为稳定性是有利的,当时气压或也高压(> 1.0 MPa ) 败坏稳定性。为解释,紫外力,英尺红外, O2-TPO,和 TG,技术被用来描绘废催化剂。给词调音:换位;氧化钨催化剂;温度;压力;ethene;2-butene; | Shengjun Huang Shenglin Liu Wenjie Xin Sujuan Xie Qingxia Wang Longya Xu | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 10 | Carboncapture and storage using alkaline industrial wastes显示文摘 | Bobicki Erin R Qingxia Liu Zhenghe Xu | 2012 | Progress in Energy and Combustion Science2012，，38： | 1 |
| 11 | Effect of Citric Acid Solution Treatment on Textural Properties and Alkylation Activity of Zeolite Beta Catalyst显示文摘 | HE Shengbao, XIE Sujuan, SHENG Wulin, WANG Qingxia, XU Longya (Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China) | 2003 | 催化学报2003，24，6： | 1 |
| 12 | 显示文摘 | Wang Qingxia Xu Yide | 1995 | Catal Lett1995，31，： | 1 |
| 13 | Regeneration behaviors of Fe/Si‐2 and Fe–Mn/Si‐2 catalysts for C2H6 dehydrogenation with CO2 to C2H4显示文摘 | Longya Xu Jinxiang Liu Hong Yang Yide Xu Qingxia Wang Liwu Lin | 1999 | Catalysis Letters (-)1999，，2： | 1 |
| 14 | Promotion Effect of K2O and MnO Additives on the Selective Production of Light Alkenes via Syngas over Fe/Silicalite-2 Catalysts 显示文摘 | Xu Longya Wang Qingxia Xu Yide | 1995 | Catal Lett1995，31，23： | 1 |
| 15 | The Catalytic Dehydrogenation of c2h6 to c2h4 under non-Oxidative Conditions over the 6cr/g-al2o3Catalyst显示文摘 | Hong Yang Longya Xu Dechun Ji Qingxia Wang Liwu Lin | 2002 | Reaction Kinetics and Catalysis Letters2002，，1： | 1 |
| 16 | Water Role and Its Influence on Hydrogen Isotopic Composition of Natural Gas during Gas Generation显示文摘In order to discuss the role and influence of water during the generation of natural gas,the participation mechanism of water during the evolution of organic matter and its influences were summarized.In addition,we carried out an anhydrous cracking experiment of oil extracted from the Feixianguan Formation source rock in a closed system,which led to the establishment of the kinetic models for describing carbon and hydrogen isotopic fractionation during gas generation from organic matter.The models were c... | Jijun LI Shuangfang LU Wei WU Haitao XUE Qingxia XU Jie GENG Yinghua YU | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 1 |
| 17 | Effect of polycarboxylate ether comb-type polymer on viscosity and interfacial properties of kaolinite clay suspensions显示文摘 | Ling Zhang Qingye Lu Zhenghe Xu Qingxia Liu Hongbo Zeng | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 18 | An effective method to enhance the stability on-stream of butene aromatization: Post-treatment of ZSM-5 by alkali solution of sodium hydroxide显示文摘 | Yueqin Song Xiangxue Zhu Yi Song Qingxia Wang Longya Xu | 2005 | Applied Catalysis A General2005，，1： | 1 |
| 19 | GC-MS Analysis of Volatile Oils in Mango Leaves from Different Producing Areas显示文摘[Objectives]To analyze the composition of volatile oils from mango leaves from different producing areas.[Methods]The volatile oils in mango leaves from different areas was extracted by steam distillation,and the GC-MS method combined with retention index and peak area normalization method was used for qualitative and quantitative analysis.[Results]The volatile oils of mango leaves in southern provinces contained high content of terpenes,such asα-gurjunene(18.39%-34.13%),(+)-viridiflorene(8.95%-16.30%)and(E)-β-ocimene(3.49%-7.63%).The volatile oils components of mango leaves were significantly different in different provinces,for example,mango leaves produced in Hainan Province contained a large amount ofβ-selinene(23.00%),but not in other provinces.[Conclusions]The origin had a great influence on the composition and contents of volatile oils in mango leaves. | Xu FENG Chuanxian QIN Qingxia HUANG Chengzhi DU Chenyan LIANG | 2021 | Medicinal Plant2021，12，3： | 1 |
| 20 | The promotions of MnO and K2O to Fe/silicalite-2 catalyst for the production of light alkenes from CO2 hydrogenation显示文摘 | Xu Longya Wang Qingxia Liang Dongbai | 1998 | Applied Catalysis A1998，173，： | 1 |
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