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| 1 | Polymorphisms of three gene-derived STS on pig chromosome 13q41 are associated with susceptibility to enterotoxigenic Escherichia coli F4ab/ac in pigs显示文摘Neonatal diarrhea caused by enterotoxigenic Escherichia coli(ETEC)F4 is a common and serious disease,resulting in significant economical loss in the pig industry.The locus encoding ETEC F4 receptor has been mapped to pig chromosome(SSC)13q41,and one of the most significantly linked markers is S0075.In this study,we selected three genes including SLC12A8,MYLK and KPNA1 from a chromosomal region flanking S0075 on SSC13 to develop pig specific sequence tagged sites(STS). Seven single nucleotide polymorphisms were identified in the three pig STS using DNA of four full-sib susceptible and resistant animals in a White Duroc×Erhualian intercross.All grandparents,parents and 755 offspring in the intercross were genotyped for three polymorphisms,including SLC12A8 g.159A>G,MYLK g.1673A>G and KPNA1 g.306A>G.Family-based transmission disequilibrium test(TDT) revealed that all polymorphisms and the corresponding haplotypes are significantly associated with ETEC F4ab/ac(especially F4ac)brush border adhesion phenotypes,indicating that these polymor- phism are in linkage disequlibrium with causal mutation(s)of the gene encoding ETEC F4ab/ac receptor. Our results strengthen the evidence for the involvement of SSC13q41 in high acquiring risk of ETEC F4ab/ac infection,and provide novel polymorphic markers for fine mapping of the ETEC F4ab/ac receptor locus. | HUANG Xiang 1 ,REN Jun 1 ,YAN XueMing 1,2 ,PENG QiuLing 1 ,TANG Huan 1 ,ZHANG Bo 1 ,JI HuaYuan 1 , YANG ShuJin1&HUANG LuSheng 1 1Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China,Jiangxi Agricultural University, Nanchang 330045,China 2Department of Biology,Nanchang University of Science and Technology,Nanchang 330038,China | 2008 | Science China(Life Sciences)2008，51，7： | 8 |
| 2 | Energy-saving PPM schemes for WSNs显示文摘Energy conservation is a critical problem in recently-emerging wireless sensor networks (WSNs). Pulse position modulation (PPM), as an exploring-worthy modulation format for energy efficiency, is tailored for WSNs into two schemes, mono-mode PPM and multi-mode PPM, in this paper. Resorting to an idealized system model and a practical system model, which combine the power consumptions in transmission and reception modules of nodes with the idealized and realistic battery characteristics, the battery energy efficiencies of mono-mode PPM and multi-mode PPM are evaluated and compared. To minimize the battery energy consumption (BEC), these schemes are further optimized in terms of constellation size M for a link in path-loss channels. Our analytical and numerical results show that considerable energy can be saved by multi-mode PPM; and the optimization performances of these schemes are noticeable at various communication distances though their optimization properties are different. | TANG QiuLing YANG LiuQing QIN TuanFa ZHANG ShuYi | 2008 | Science in China(Series F)2008，51，5： | 7 |
| 3 | Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2显示文摘Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction.Protocatechuic aldehyde(PCA)is a major phenolic acid in Chinese herb Danshen(Salvia miltiorrhiza root).This study investigated whether PCA regulated nuclear pyruvate kinase isoform M2(PKM2)function to protect cardiomyocytes.In rats subjected to isoprenaline,PCA attenuated heart injury and protected cardiomyocytes from apoptosis.Through DARTS and CETSA assays,we identified that PCA bound and promoted PKM2 nuclear translocation in cardiomyocytes exposed to oxygen/glucose deprivation(OGD).In the nucleus,PCA increased the binding of PKM2 to β-Catenin via preserving PKM2 acetylation,and the complex,in cooperation with T-cell factor 4(TCF4),was required for transcriptional induction of genes encoding anti-apoptotic proteins,contributing to rescuing cardiomyocyte survival.In addition,PCA ameliorated mitochondrial dysfunction and prevented mitochondrial apoptosis dependent on PKM2.Consistently,PCA increased the binding of PKM2 to β-Catenin,improved heart contractive function,normalized heart structure and attenuated oxidative damage in mice subjected to artery ligation,but the protective effects were lost in Pkm2-deficient heart.Together,we showed that PCA regulated nuclear PKM2 function to rescue cardiomyocyte survival via β-Catenin/TCF4 signaling cascade,suggesting the potential of pharmacological intervention of PKM2 shuttle to protect the heart. | Xunxun Wu Lian Liu Qiuling Zheng Haiping Hao Hui Ye Ping Li Hua Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 4 | Significance and strategies in developing delivery systems for bio-macromolecular drugs显示文摘 | Huining HE Qiuling LIANG Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU Jingkang WANG Victor YANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 2 |
| 5 | Research on delay and packet loss control mechanism in wireless Mesh networks 显示文摘 | YANG Qiuling JIN Zhigang HUANG Xiangdang | 2014 | Journal of networks2014，9，4： | 1 |
| 6 | Bat- tery power efficiency of PPM and FSK in wireless sensor networks显示文摘 | Tang Qiuling Yang Liuqing Giannakis G B | 2007 | IEEE Transactions on Wireless Communi- cation2007，6，4： | 1 |
| 7 | Synthesis of anti-vicinal diboronates from diarylethynes and B2pin2显示文摘Anti-vicinal diboronates were fabricated from easily available diarylethynes and B2pin2via a basecatalyzed domino-borylation-protodeboronation(DBP)strategy under transition-metal-free conditions.Under the standard conditions,reactants with a range of different classes of functional groups on the rings,such as Me O,Me S,CF3O,Me2N,TMS,I,Br,Cl,F,and the thiophene ring,were tolerated.Downstream transformation of the vicinal diboronates provided a facile pathway for obtaining vicinal diols by mild oxidation with Na BO3,and a new deuteriation technique was developed in order to acquire1,2-diarylethanes-1,2-d2and 1,2-diarylethanes-1,1,2,2-d4.The new deuteriation strategy developed in this study may provide a new research direction for deuteriation chemistry. | Zhijie Kuang Shaoyu Mai Kai Yang Qiuling Song | 2019 | Science Bulletin2019，64，22： | 1 |
| 8 | Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS显示文摘Ischemic preconditioning(IPC)is a potential intervention known to protect the heart against ischemia/reperfusion injury,but its role in the no-reflow phenomenon that follows reperfusion is unclear.Dihydrotanshinone I(DT)is a natural compound and this study illustrates its role in cardiac ischemic injury from the aspect of IPC.Pretreatment with DT induced modest ROS production and protected cardiomyocytes against oxygen and glucose deprivation(OGD),but the protection was prevented by a ROS scavenger.In addition,DT administration protected the heart against isoprenaline challenge.Mechanistically,PKM2 reacted to transient ROS via oxidization at Cys423/Cys424,leading to glutathionylation and nuclear translocation in dimer form.In the nucleus,PKM2 served as a co-factor to promote HIF-1a-dependent gene induction,contributing to adaptive responses.In mice subjected to permanent coronary ligation,cardiac-specific knockdown of Pkm2 blocked DT-mediated preconditioning protection,which was rescued by overexpression of wild-type Pkm2,rather than Cys423/424-mutated Pkm2.In conclusion,PKM2 is sensitive to oxidation,and subsequent glutathionylation promotes its nuclear translocation.Although IPC has been viewed as a protective means against reperfusion injury,our study reveals its potential role in protection of the heart from no-reflow ischemia. | Xunxun Wu Lian Liu Qiuling Zheng Hui Ye Hua Yang Haiping Hao Ping Li | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 1 |
| 9 | Deep reinforcement learning for optimal denial-of-service attacks scheduling显示文摘We consider an optimal denial-of-service(DoS)attack scheduling problem of N independent linear time-invariant processes,where sensors have limited computational capability.Sensors transmit measurements to the remote estimator via a communication channel that is exposed to DoS attackers.However,due to limited energy,an attacker can only attack a subset of sensors at each time step.To maximally degrade the estimation performance,a DoS attacker needs to determine which sensors to attack at each time step.In this context,a deep reinforcement learning(DRL)algorithm,which combines Q-learning with a deep neural network,is introduced to solve the Markov decision process(MDP).The DoS attack scheduling optimization problem is formulated as an MDP that is solved by the DRL algorithm.A numerical example is provided to illustrate the efficiency of the optimal DoS attack scheduling scheme using the DRL algorithm. | Fangyuan HOU Jian SUN Qiuling YANG Zhonghua PANG | 2022 | Science China(Information Sciences)2022，65，6： | 1 |
| 10 | Determination of cadmium and copper in water and food samples by dispersive liquid–liquid microextraction combined with UV–vis spectrophotometry显示文摘 | Xiaodong Wen Qiuling Yang Zhidong Yan Qingwen Deng | 2010 | Microchemical Journal2010，，2： | 1 |
| 11 | Battery power efficiency of PPM and FSK in wireless sensor networks显示文摘 | Tang Qiuling Yang Liuqing Giannakis G B | 2007 | IEEE Transactions on Wireless Communications2007，6，4： | 1 |
| 12 | Phase quantification of two chlorothalonil polymorphs by X-ray powder diffraction显示文摘 | LU Qiuling YANG Guang GU Hao | 2005 | Analytica Chimica Acta2005，538，7： | 1 |
| 13 | Determining the in vitro Anti-Aging Effect of the Characteristic Components from Eucommia ulmoides显示文摘To evaluate the potential anti-aging ability of Eucommia ulmoides,four characteristic components(chlorogenic acid,geniposidic acid,aucubin,quercetin)were selected to assess their effects on H_(2)O_(2)-induced oxidative damage model of human umbilical vein endothelial cell(HUVEC).Oxidative damage indexes,inflammatory factors,cell cycle,cell apoptosis,cell senescence,and their related proteins were analyzed by methyl thiazolyl tetrazolium(MTT)assay,enzyme-linked immunosorbent assay(ELISA),propidium iodide(PI)staining,annexin V-FITC/PI double staining,SAβ-galactosidase staining,and western blotting(WB).The results showed that H_(2)O_(2)-induced cell growth inhibition rate decreased as supplementation with characteristic components when compared to H_(2)O_(2) group.Meanwhile,the contents of antioxidant indexes(reactive oxygen species,lactate dehydrogenase,molondialdehyde,superoxide dismutase,glutathione),inflammatory factors(nuclear factor kappa-B,intercellular cell adhesion molecule-1,vascular cell adhesion protein 1),and functional factors(NO,Endothelin-1)in characteristic components treated groups improved if comparison with H_(2)O_(2) group,suggesting the characteristic components of E.ulmoides could alleviate H_(2)O_(2)-induced oxidative damage.Moreover,cell cycle,cell apoptosis,cell senescence,and their related proteins under characteristic components treatment exhibited a better effect than under H_(2)O_(2) treatment,implying the characteristic components could participate in anti-aging via multiple pathways.These results manifested that the characteristic components of E.ulmoides posses the capacity of anti-aging,which provided a basis for investigating the anti-aging ability of E.ulmoides itself. | Xuesong Wang Zhihong Wang Qiuling Yang Sheng Peng Mijun Peng | 2022 | Journal of Renewable Materials2022，10，12： | 1 |
| 14 | Stimuli-responsive gel-micelles with flexible modulation of drug release for maximized antitumor efficacy显示文摘设计的刺激应答的药交货设备由于他们的最大化的治疗学的功效为疾病处理在生物应用保持广阔诺言。在这研究,一篇小说,稳定地, cross-linked ,和pH敏感的可被细菌破坏的 gel-micelle 与 amphiphilic 被构造 trimethylene dipiperidine甲基丙烯结合酐玻尿的 acid-stearylamine ( TMDP-MA-HA-SA , TMHS )改善与 paclitaxel ( PTX )的灵活细胞内部的交货指向肿瘤 .The cross-linked methacrylate 契约显著地改进了 TMHS gel-micelle 的 biostability (~ 200 nm )在上在生理的条件下面交叉结合得非,当玻尿的酸玩时cross-linked 的渐渐的降级玻尿的酸壳被集中的玻尿酸酵素触发。同时,在酸的条件下面(pH < 6.5 ) , pH 敏感的 TMDP 一半的第三级的胺是 protonated 并且从而 solubilized gel-micellar 核心部分。结果的被触发 pH 的内部核心的空格很快面对主要降级了的多重 cytosolic 酶推动了 PTX 版本仍然保持恐水病 stearylamine 核心。在期间在里面 vitro cytotoxicity 试金,装载 PTX 的 TMHS 胶化微粒(CLTMHSPTX ) 与 1.42 g/mL (PTX 集中) 的 IC 50 对人的 hepatocellular 癌 HepG2 房间揭示了 anticancer 功效,比另外的组显著地低。在平行,在里面 CL TMHS 对 BALB/c 异种皮移植肿瘤动物模型的 PTX 胶化微粒表明了 72.06% 的更大的肿瘤生长抑制能力,与在安全集中的另外的处理组相比。因而, cross-linked 和刺激应答的 CL TMHS PTX 胶化微粒抓住为有最大化的 antitumor 功效的恐水病的 anticancer 药的细胞内部的交货的灵活调整的一个大潜力。 | Djamila Aouameur Hao Cheng Yaw Opoku-Damoah Bo Sun Qiuling Dong Yue Han Jianping Zhou Yang Ding | 2018 | Nano Research2018，11，8： | 1 |
| 15 | Ultrasound diagnosis about branchial cyst in parotid显示文摘 | Shi Qiuling Hui Luo Yang Jiao Tao Liu Jun Lu | 2014 | International English Education Research2014，，2： | 0 |
| 16 | Research Overview on Occurrence and Control of Tetranychus urticae Koch in China显示文摘Tetranychus urticae Koch;Insecticide resistance;Chemical control This paper elaborates the occurrence factors and damage characteristics of Tetranychus urticae Koch in China,and emphatically summarizes three main control strategies of T.urticae,namely agricultural control,chemical control and biological control,as well as research progress in its resistance mechanisms.The problems existing in controlling T.urticae and its resistance management strategies are put forward,to provide a theoretical basis for the resistance management and comprehensive control of T.urticae. | Yang HAN Tingmi YANG Jingcheng WU Qiuling PANG Xiaowen LIANG Binghai LOU | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
| 17 | An Olefinic 1,2-α-Boryl Migration Enables 1,2-Bis(boronic esters)via Radical-Polar Crossover Reaction显示文摘A radical-induced 1,2-α-boryl migration through radical polar crossover reactions has been described.In this work,in situ formed vinyldiboron“ate”complexes from alkenyl Grignard reagent and diborylalkanes react with commercial radical precursors under light initiation.This three-component process enables diborylation of alkene.This protocol features high atom economy,a broad substrate scope as well as good functional group toleration with mild conditions. | Feng Zhang Shangteng Liao Lu Zhou Kai Yang Chenglan Wang Yixian Lou Cece Wang Qiuling Song | 2022 | Chinese Journal of Chemistry2022，40，5： | 0 |
| 18 | A chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood显示文摘Dracaena,a remarkably long-lived and slowly maturing species of plant,is world famous for its ability to produce dragon’s blood,a precious traditional medicine used by different cultures since ancient times.However,there is no detailed and high-quality genome available for this species at present;thus,the molecular mechanisms that underlie its important traits are largely unknown.These factors seriously limit the protection and regeneration of this rare and endangered plant resource.Here,we sequenced and assembled the genome of Dracaena cochinchinensis at the chromosome level.The D.cochinchinensis genome covers 1.21 Gb with a scaffold N50 of 50.06 Mb and encodes 31619 predicted protein-coding genes.Analysis showed that D.cochinchinensis has undergone two whole-genome duplications and two bursts of long terminal repeat insertions.The expansion of two gene classes,cis-zeatin O-glucosyltransferase and small auxin upregulated RNA,were found to account for its longevity and slow growth.Two transcription factors(bHLH and MYB)were found to be core regulators of the flavonoid biosynthesis pathway,and reactive oxygen species were identified as the specific signaling molecules responsible for the injuryinduced formation of dragon’s blood.Our study provides high-quality genomic information relating to D.cochinchinensis and significant insight into the molecular mechanisms responsible for its longevity and formation of dragon’s blood.These findings will facilitate resource protection and sustainable utilization of Dracaena. | Yanhong Xu Kaijian Zhang Zhonglian Zhang Yang Liu Feifei Lv Peiwen Sun Shixi Gao Qiuling Wang Cuicui Yu Jiemei Jiang Chuangjun Li Meifang Song Zhihui Gao Chun Sui Haitao Li Yue Jin Xinwei Guo Jianhe Wei | 2022 | Plant Communications2022，3，6： | 0 |
| 19 | Curcumin based combination therapy for anti-breast cancer: from in vitro drug screening to in vivo efficacy evaluation显示文摘当药抵抗看起来是在 monotherapy 的越来越多的 anticancer 药的一个不可避免的问题时,联合药治疗成为了一个繁荣的方法减少管理的全部的药剂量以及克服癌房间的药抵抗。Curcumin,考虑了作为 chemoresistance 的一块压板根据它的多重反肿瘤的机制在癌症治疗拥有 multifaceted 角色,能显著地便于它的反癌症功能并且改进经由联合用法与的治疗学的效果许多有不同反应机制的另外的药。探索这可能性,四反癌症都拥有药抵抗问题的某个度的化学疗法的代理人,包括三个酷氨酸 kinase 禁止者( erlotinib , sunitinib 和 sorafenib ),那对不同房间小径和典型 anticancer 药 doxorubicin 正在起作用,个别地与 curcumin 被相结合在 vitro 并且在 vivo 检验 synergistic 反肿瘤效果。结果表明在 0.46 的臼齿的比率与 curcumin 相结合的 sunitinib 在 vitro 产出大多数有势力 synergistic 效果,并且因此为进一步的动物评估被选择。为了推进,提高 anticancer 效果,牛的浆液白朊(BSA ) nanoparticles 作为一个搬运人被利用在 situ 交付选择的药联合。在证实的 vivo 调查结果初步我们能由我们的途径在测试动物为延长时间时期维持类似的注射的药比率的假设,从而最大化还最小化这些药的毒性的治疗学的力量。这个工作能在联合药治疗和实现上开创一条新大街如此的药的临床的用途。 | Sunhui Chen Qiuling Liang Shuping Xie Ergang Liu Zhili Yu Lu Sun Meong Cheol Shin Seung Jin Lee Huining He Victor C. Yang | 2016 | Frontiers of Chemical Science and Engineering2016，10，3： | 0 |
| 20 | IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis显示文摘Background and Aims:Liver cirrhosis can lead to liver failure and eventually death.Macrophages are the main contributors to cirrhosis and have a bidirectional role in regulating matrix deposition and degradation.Macrophage-based cell therapy has been developed as an alternative to liver transplantation.However,there is insufficient evidence regarding its safety and efficacy.In this study,we aimed to explore the effect of combining insulin-like growth factor 2(IGF2)with bone marrow-derived macrophages(BMDMs)to treat mice with liver cirrhosis.Methods:We assessed liver inflammation,fibrosis regression,liver function,and liver regeneration in mice with CCl4-induced cirrhosis and treated with BMDM only or IGF2+BMDM.We performed in vitro experiments in which activated hepatic stellate cells(HSCs)were co-cultured with macrophages in the presence or absence of IGF2.The polarity of macrophages and the degree of inhibition of HSCs were examined.The effect of IGF2 on macrophages was also verified by the overexpression of IGF2.Results:Combining IGF2 with BMDM reduced liver inflammation and fibrosis and increased hepatocyte proliferation.Combining IGF2 with BMDM was more effective than using BMDM alone.In vitro experiments demonstrated that IGF2 inhibited HSCs activation by upregulating NR4A2 to promote the anti-inflammatory macrophages phenotype.IGF2 also increased the synthesis of matrix metalloproteinases(MMPs)by macrophages,which may explain why administering IGF2 combined with BMDM was more effective than administering BMDM only.Conclusions:Our study provides a theoretical basis for the future use of BMDM-based cell therapy to treat liver cirrhosis. | Lichao Yao Xue Hu Mengqin Yuan Qiuling Zhang Pingji Liu Lian Yang Kai Dai Yingan Jiang | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 0 |
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