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| 1 | Blockchain-Based Secure Distributed Control for Software Defined Optical Networking显示文摘Software defined optical networking(SDON)is a critical technology for the next generation network with the advantages of programmable control and etc.As one of the key issues of SDON,the security of control plane has also received extensive attention,especially in certain network scenarios with high security requirement.Due to the existence of vulnerabilities and heavy overhead,the existing firewalls and distributed control technologies cannot solve the control plane security problem well.In this paper,we propose a distributed control architecture for SDON using the blockchain technique(BlockCtrl).The proposed BlockCtrl model introduces the advantages of blockchain into SDON to achieve a high-efficiency fault tolerant control.We have evaluated the performance of our proposed architecture and compared it to the existing models with respect to various metrics including processing rate,recovery latency and etc.The numerical results show that the BlockCtrl is capable of attacks detection and fault tolerant control in SDON with high performance on resource utilization and service correlation. | Hui Yang Yongshen Liang Qiuyan Yao Shaoyong Guo Ao Yu Jie Zhang | 2019 | China Communications2019，16，6： | 5 |
| 2 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 3 | tRNA-derived small RNAs:Mechanisms and potential roles in cancers显示文摘Transfer RNAs(tRNAs)are essential for protein synthesis.Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs(tsRNAs).tsRNAs,divided into tRNA-derived stress-induced RNA(tiRNAs)and tRNA-derived fragments(tRFs),play versatile roles in a number of fundamental biological processes.tsRNAs not only play regulatory roles in gene silencing,RNA stability,reverse transcription,and translation,but are also closely related to cell proliferation,migration,cell cycle,and apoptosis.Their abnormal expression is associated with the occurrence and development of various human diseases,especially cancer.This paper reviews the classification,biogenesis,and mechanism of action of tsRNAs,and the research progress to date on tsRNAs in cancers.These findings provide new opportunities for diagnostic biomarkers and treatment targets of several types of cancers including gastric cancer,colorectal cancer,hepatocellular carcinomas,pancreatic cancer,breast cancer,prostate cancer,renal cell carcinoma,ovarian cancer,lung cancer,bladder cancer,thyroid cancer,oral cancer,and leukemia. | Yao Wang Qiuyan Weng Jiaxin Ge Xinjun Zhang Junming Guo Guoliang Ye | 2022 | Genes & Diseases2022，9，6： | 2 |
| 4 | Intent defined optical network with artificial intelligence-based automated operation and maintenance显示文摘Traditionally,the operation and maintenance of optical networks rely on the experience of engineers to configure network parameters,involving command-line interface,middle-ware scripting,and troubleshooting.However,with the emerging of newly B5 G applications,the traditional configuration cannot meet the requirement of real-time automatic configuration.Operators need a new configuration way without manual intervention at an underlying optical transport network.To cope with this issue,we propose an intent defined optical network(IDON)architecture toward artificial intelligence-based optical network automated operation and maintenance against service objective,by introducing a self-adapted generation and optimization(SAGO)policy in a customized manner.The IDON platform has three key innovations including intent-orient configuration translation,self-adapted generation and optimization policy,and close-loop intent guarantee operation.Focusing specifically on communication requirements,the IDON uses natural language processing to construct semantic graphs to understand,interact,and create the required network configuration.Then,deep reinforcement learning(DRL)is utilized to find the composition policy that satisfies the requirement of intent through the dynamic integration of fine-grained policies.Finally,the deep neural evolutionary network(DNEN)is introduced to achieve the intent guarantee at the milliseconds level.The feasibility and efficiency are verified on enhanced SDN testbed.Finally,we discuss several related challenges and opportunities for unveiling a promising upcoming future of intent defined optical network. | Hui YANG Kaixuan ZHAN Qiuyan YAO Xudong ZHAO Jie ZHANG Young LEE | 2020 | Science China(Information Sciences)2020，63，6： | 2 |
| 5 | Localized-domains staging structure and evolution in lithiated graphite显示文摘Intercalation provides to the host materials a means for controlled variation of many physical/chemical properties and dominates the reactions in metal‐ion batteries.Of particular interest is the graphite intercalation compounds with intriguing staging structures,which however are still unclear,especially in their nanostructure and dynamic transition mechanism.Herein,the nature of the staging structure and evolution of the lithium(Li)‐intercalated graphite was revealed by cryogenic‐transmission electron microscopy and other methods at the nanoscale.The intercalated Li‐ions distribute unevenly,generating local stress and dislocations in the graphitic structure.Each staging compound is found macroscopically ordered but microscopically inhomogeneous,exhibiting a localized‐domains structural model.Our findings uncover the correlation between the long‐range ordered structure and short‐range domains,refresh the insights on the staging structure and transition of Li‐intercalated/deintercalated graphite,and provide effective ways to enhance the reaction kinetic in rechargeable batteries by defect engineering. | Suting Weng Siyuan Wu Zepeng Liu Gaojing Yang Xiaozhi Liu Xiao Zhang Chu Zhang Qiuyan Liu Yao Huang Yejing Li Mehmet NAteş Dong Su Lin Gu Hong Li Liquan Chen Ruijuan Xiao Zhaoxiang Wang Xuefeng Wang | 2023 | Carbon Energy2023，5，1： | 1 |
| 6 | Targeting CC Chemokine Ligand 2 (CCL2) for Cancer Skeletal Metastasis显示文摘Prostate, breast, and lung cancer preferentially metastasize to bone resulting in bone lesions and thus high mortality. However, the | Yi LU Cai ZHONG Qiuyan CHEN Eva COREY Zhi YAO Atsushi MIZOKAMI Qinghua ZHOU Evan T. KELLER Kenneth J. PIENTA Jian ZHANG | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 7 | Application and Research of Meteorological Data in Lightning Protection Technical Service of Oil Depot显示文摘In this paper,lightning protection technical service of oil depot is taken as research object. It is proposed using various meteorological data to carry out multiple lightning protection technical services( risk assessment,potential forecast,monitoring and early warning of lightning disasters) based on conventional detection of lightning protection system,to improve technical content of lightning protection service and benefits of disaster prevention and mitigation. It mainly analyzes the application of lightning monitoring data in pre-assessment of lightning disaster,to guide site selection of new oil depot; guidance of lightning disaster status assessment on regular inspection of lightning protection system,to determine lightning protection detection time and update and maintenance time of lightning protection system; potential prediction and early warning of lightning,to guide daily operation of oil depot. | Liu Fengjiao He Qiuyan Tang Yao Su Kai Liu Yueyu | 2019 | Meteorological and Environmental Research2019，10，1： | 0 |
| 8 | Characterizing Human Collective Behaviors During COVID-19 — Hong Kong SAR, China, 2020显示文摘Summary What is already known about this topic?People are likely to engage in collective behaviors online during extreme events,such as the coronavirus disease 2019(COVID-19)crisis,to express awareness,take action,and work through concerns. | Zhanwei Du Xiao Zhang Lin Wang Sidan Yao Yuan Bai Qi Tan Xiaoke Xu Sen Pei Jingyi Xiao Tim K.Tsang Qiuyan Liao Eric H.YLau Peng Wu Chao Gao Benjamin J.Cowling | 2023 | China CDC weekly2023，5，4： | 0 |
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