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| 1 | Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems显示文摘Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ways.Consumption,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth System.Changes in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious consequences.However,current models do not incorporate these critical feedbacks.We argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real systems.In particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population projections.his makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current models.he importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations. | Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.Yakovenko Ning Zeng | 2016 | National Science Review2016，3，4： | 34 |
| 2 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 3 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 4 | Antibody response to Epstein-Barr virus Rta protein in patients with nasopharngeal carcinoma显示文摘 | Feng P Chan SH Rachel Soo MY | 2001 | Cancer2001，92，7： | 1 |
| 5 | Automated system for power measurement in the silent discharge显示文摘 | Rachel Feng Shesha Jayaram | 1998 | IEEE Transactions on Industry Applications1998，34，3： | 1 |
| 6 | Antibody response to Epstein-Barr virus Rta protein in patients with nasopharn geal carcinoma显示文摘 | Feng P Chan SH Rachel Soo MY | 2001 | Cancer2001，92，7： | 1 |
| 7 | Antibody response to Epstci- tearr virus Rta protein in patients with nasopharngcal carcinoma 显示文摘 | Feng P Chan SH Rachel SM | 2001 | Cancer2001，92，7： | 1 |
| 8 | Blood Pressure Is a Major Risk Factor for Renal Death: An Analysis of 560 352 Participants From the Asia-Pacific Region显示文摘 | Conall M. O?Seaghdha Vlado Perkovic Tai Hing Lam Stella McGinn Federica Barzi Dong Feng Gu Alan Cass Il Suh Paul Muntner Graham G. Giles Hirotsugu Ueshima Mark Woodward Rachel Huxley | 2009 | Hypertension2009，，3： | 1 |
| 9 | Automated System for Power Measurement in the Silent Discharge显示文摘 | RACHEL FENG SHESHA JAYARAM | 1998 | IEEE Transactions on Industry Applications1998，34，3： | 1 |
| 10 | Automated System for Power Measurement in the Silent Discharge 显示文摘 | Rachel Feng and Shesha Jayaram | 1998 | IEEE Transactions on Industry Applications1998，34，3： | 1 |
| 11 | MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing显示文摘 | Guillaume Moissiard Shawn J. Cokus Joshua Cary Suhua Feng Allison C. Billi Hume Stroud Dylan Husmann Ye Zhan Bryan R. Lajoie Rachel Patton McCord Christopher J. Hale Wei Feng Scott D. Michaels Alison R. Frand Matteo Pellegrini Job Dekker John K. Kim Steve | 2012 | Science . 2012 (6087)2012，，6087： | 1 |
| 12 | Antibody response to Epstei-Barr virus Rta protein in patients with nasopharngeal carcinoma显示文摘 | Feng P Chan SH Rachel Soo MY | | 0，，07： | 1 |
| 13 | Computational approaches to understanding protein aggregation in neurodegeneration显示文摘有毒的外国人蛋白质 conformers 的产生作为一个统一线程出现在象 Alzheimer'sdisease, Parkinson 的疾病,和 amyotrophic 那样的混乱之中侧面的硬化。关于动态变化的原子水平的详细那 facilitateprotein 聚集,以及大规模订的总数和可溶的外国人 oligomers 的结构的特征,将为细胞毒素的种类的 inhibitingformation 显著地作出贡献到这些复杂现象和提议潜力策略的当前的理解。然而,试验性的限制经常预防高分辨率的 structuraland 的获得为聚集系统的机械学的信息。计算方法,特别地,那些联合所有原子和 coarse-grainedsimulations 盖住大量时间和长度规模,因此为调查 proteinaggregation 作为关键工具出现了。这里,我们为蛋白质的学习考察计算方法论的当前的状态自己组装,与向在人的 neurodegenerative 混乱的蛋白质总数的理解的这些方法的申请上的 afocus。 | Rachel L. Redler David Shirvanyants Onur Dagliyan Feng Ding Doo Nam Kim Pradeep Kota Elizabeth A. Proctor Srinivas Ramachandran Arpit Tandon Nikolay V. Dokholyan | 2014 | Journal of Molecular Cell Biology2014，8，2： | 0 |
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