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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases显示文摘AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions. | Michael Kinori Narasimhan Jagannathan Anne M Langguth Marjorie A Sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 3 | The interplay of language on execu- tive functions in children with ASD 显示文摘 | Maysa A Rebecca L Rhea P | 2013 | Res Autism Spect Disord2013，7，： | 1 |
| 4 | Mass spectrometric survey of interganglionically transported ppeptides in Aplysia 显示文摘 | LI L J TATIANA P M REBECCA W G | 1998 | Peptides1998，19，8： | 1 |
| 5 | Effect of aquaculture on world fish supplies显示文摘 | ROSAMOND L N REBECCA J G JURGENNE H P | 2000 | Nature2000，405，6790： | 1 |
| 6 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 7 | Polyethylene Glycol-containing Polyurethanes for Biomedical Applications显示文摘 | Siska C Ngoc P L Etienne S Martyn D Alex S Rebecca G Stephen D Mike W Hugh W Simon C | 1998 | Polymer International1998，46，3： | 1 |
| 8 | Three newly isolated plant growth - promoting bacilli facilitate the seedling growth of canola,Brassica campestris显示文摘 | Sibdas G Jon N P Rebecca D L | 2003 | Plant Physiol Biochem2003，41，： | 1 |
| 9 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 10 | Interventions to Support a Palliative Care Approach in Patients with Chronic Obstructive Pulmonary Disease: an Integrative Review 显示文摘 | Rebecca T D David C C Jane L P | 2012 | International Journal of Nursing Studies2012，49，11： | 1 |
| 11 | Drought planning and water alloca- tion:an assessment of local capacity in Minnesota显示文摘 | REBECCA L P ROB C L REID K | 2004 | Journal of Environ- mental Management2004，73，： | 1 |
| 12 | Predicting progeny variance from parental divergence in hard red spring wheat显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 13 | Effect of aquaculture on world fish supplies 显示文摘 | NAYLOR R L REBECCA J G JURGENNE H P et at | 2000 | Nature2000，405，6790： | 1 |
| 14 | Predicting progeny variance from parental divergence in hard spring wheat显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 15 | Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death显示文摘AIM: To investigate the influence of ischemia/reperfusion on arctic ground squirrel(AGS) neuronal progenitor cells(NPCs), we subjected these cultured cells to oxygen and glucose deprivation.METHODS: AGS NPCs were expanded and differentiated into NPCs and as an ischemia vulnerable control, commercially available human NPCs(hNPCs) were seeded from thawed NPCs. NPCs, identified by expression of TUJ1 were seen at 14-21 d in vitro(DIV). Cultures were exposed to control conditions, hypoxia, oxygen and glucose deprivation or glucose deprivation alone or following return to normal conditions to model reperfusion. Cell viability and death were assessed from loss of ATP as well as from measures of alamarB lue~ and lactate dehydrogenase in the media and from counts of TUJ1 positive cells using immunocytochemistry. Dividing cells were identified by expression of Ki67 and phenotyped by double labeling with GFAP, MAP2 ab or TUJ1. RESULTS: We report that when cultured in NeuraLife^(TM), AGS cells remain viable out to 21 DIV, continue to express TUJ1 and begin to express MAP2 ab. Viability of hN PCs assessed by fluorescence alamarB lue(arbitrary units) depends on both glucose and oxygen availability [viability of hNPCs after 24 h oxygen glucose deprivation(OGD) with return of oxygen and glucose decreased from 48151 ± 4551 in control cultures to 43481 ± 2413 after OGD, P < 0.05]. By contrast, when AGS NPCs are exposed to the same OGD with reperfusion at 14 DIV, cell viability assessed by alamar Blue increased from 165305 ± 11719 in control cultures to 196054 ± 13977 after OGD. Likewise AGS NPCs recovered ATP(92766 ± 6089 in control and 92907 ± 4290 after modeled reperfusion; arbitrary luminescence units), and doubled in the ratio of TUJ1 expressing neurons to total dividing cells(0.11 ± 0.04 in control cultures vs 0.22 ± 0.2 after modeled reperfusion, P < 0.05). Maintaining AGS NPCs for a longer time in culture lowered resistance to injury, however, did not impair proliferation of NPCs relative to other cell lineages after oxygen deprivation followed by re-oxygenation.CONCLUSION: Ischemic-like insults decrease viability and increase cell death in cultures of human NPCs. Similar conditions have less affect on cell death and promote proliferation in AGS NPCs. | Kelly L Drew Matthew Wells Rebecca McGee Austin P Ross Judith Kelleher-Andersson | 2016 | World Journal of Biological Chemistry2016，7，1： | 1 |
| 16 | The Influ-ence of Career Planning,Race,and Athletic Injury-on Life Satisfaction Among Recently Retired Colle-giate MaleAthletes 显示文摘 | Frank M P Rebecca L A Leonard Z | 1999 | The Sport Psychologist1999，，13： | 1 |
| 17 | Psychometric analyses of the Test Anxiety Scale for Elementary Students (TAS -E) scores a- mong Singapore primary school students显示文摘 | PATRICIA A L REBECCA P A STEPHEN W L | 2011 | Journal of Psychopathology and Behavioral Assessment2011，33，4： | 1 |
| 18 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
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