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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 3 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 4 | Conflict and Power-Dependence Relations in Retailer-Supplier Channels 显示文摘 | James R Brown Robert F Lusch and Darrel D Muehling | 1983 | Journal of Retailing1983，59，4： | 1 |
| 5 | A rapid pulsed-field gel electrophoresis method for analysis of Bifidobacterio 显示文摘 | BRICZINSKI E P ROBERTS R F | 2006 | J Dairy Sci2006，89，： | 1 |
| 6 | 显示文摘 | Ruxandra F R Robert A | 1997 | polymer international1997，42，： | 1 |
| 7 | Local synthesis and dual actions of progesterone in the nervous system: neuropro- tection and myelination 显示文摘 | Schumacher M Guennoun R Robert F | 2004 | Growth Horm IGF Res2004，14，： | 1 |
| 8 | Volatile constituenis of Asina Pear (Pyrus serotin)显示文摘 | Takeoka G R Butteyry Robert A F | 1992 | J Agric Food Chem1992，，40： | 1 |
| 9 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 10 | Conditions for stability of the extended Kalman filter and their application to the frequency trackingproblem显示文摘 | Barbara F Scala L Robert R B | 1995 | Mathematics of Control Signals and Systems1995，8，1： | 1 |
| 11 | An aspect-based approach to modeling access control concerns 显示文摘 | lndrakshi R Robert B F Li Na | 2004 | Information & Software Technology2004，46，9： | 1 |
| 12 | Thermal Expansion by a Pulse Heating Method:Niobium in the Range 1 000-2 600 K显示文摘 | Roberts R B Rosso A | 1999 | High Temp-High Press1999，18，： | 1 |
| 13 | Peak discharge of a Pleistocene lava-dam outburst floods in Grand Canyon,Arizona,USA显示文摘 | CASSANDRA R F ROBERT H W THURE E C | 2006 | Quaternary Research2006，，7： | 1 |
| 14 | In search of environmental spillovers 显示文摘 | ALBORNOZ F MATYHEW C A ROBERT R J | 2009 | The world economy2009，32，1： | 1 |
| 15 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 16 | Power and Relationship Commitment: Their Impact on Marketing Channel Member Perfomance 显示文摘 | JAMES R BROWN ROBERT F LUSCH CAROLYN Y NICHOLSON | 1995 | Journal of Retailing1995，，4： | 1 |
| 17 | Techniques for the study and development of microbial fuel cells: an electrochemical perspective 显示文摘 | Zhao F Robert C T S John R V | 2009 | Chem Soc Rev2009，38，： | 1 |
| 18 | Diurnal and seasonal variability in the radial distribution of sap flow:Predicting total stem flow in Pinus taeda trees显示文摘 | Chelcy R F Carol E G Robert J M | 2004 | Tree Physiology2004，24，： | 1 |
| 19 | High-angle reverse faults, fluid-pressure cycling, and mesothermal gold-quartz de- posits显示文摘 | Sibson R H Robert F Poulsen K H | 1988 | Geology1988，16，： | 1 |
| 20 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
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