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| 1 | Thermally reconfigurable quantum photonic circuits at telecom wavelength by femtosecond laser micromachining显示文摘The importance of integrated quantum photonics in the telecom band is based on the possibility of interfacing with the optical network infrastructure that was developed for classical communications.In this framework,femtosecond laser-written integrated photonic circuits,which have already been assessed for use in quantum information experiments in the 800-nm wavelength range,have great potential.In fact,these circuits,being written in glass,can be perfectly mode-matched at telecom wavelength to the in/out coupling fibers,which is a key requirement for a low-loss processing node in future quantum optical networks.In addition,for several applications,quantum photonic devices must be dynamically reconfigurable.Here,we experimentally demonstrate the high performance of femtosecond laser-written photonic circuits for use in quantum experiments in the telecom band,and we demonstrate the use of thermal shifters,which were also fabricated using the same femtosecond laser,to accurately tune such circuits.State-of-the-art manipulation of single-and two-photon states is demonstrated,with fringe visibilities greater than 95%.The results of this work open the way to the realization of reconfigurable quantum photonic circuits based on this technological platform. | Fulvio Flamini Lorenzo Magrini Adil S Rab Nicolo Spagnolo Vincenzo D’Ambrosio Paolo Mataloni Fabio Sciarrino Tommaso Zandrini Andrea Crespi Roberta Ramponi Roberto Osellame | 2015 | Light(Science & Applications)2015，4，1： | 5 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCl solution显示文摘 | Vanessa Vasconcelos Torres Roberto Salgado Amado Camila Faia de Sá Tatiana Lopez Fernandez Carlos Alberto da Silva Riehl Alexandre Guedes Torres Eliane D’Elia | 2011 | Corrosion Science2011，，7： | 1 |
| 4 | Pathobiology of secondary immune thrombocytopenia显示文摘 | Cines D B Howard L Roberto S | 2009 | Semin Hematol2009，46，1： | 1 |
| 5 | A new route for the preparation of flexible skin-core poly(ethylene-co-acrylic acid)/polyaniline functional hybrids显示文摘 | Roberto S Giada L R Clelia D | 2011 | Functional Polymers2011，71，12： | 1 |
| 6 | On the interharmonic conpenents generated by adjustable speed drivers显示文摘 | Francesco D R Roberto L Adolfo S | 2005 | IEEE Transactions on Power Delivery2005，20，4： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Friction factor and Nusselt number in flat tubes with rounded edges显示文摘 | Marco S Roberto D O | 1995 | International Journal of Heat and Fluid Flow1995，16，4： | 1 |
| 9 | Milbemectin Resistance in Tetranychus urticae(Acari: Tetranychidag): Selection, Stabilityand Cross-resistance to Abamectin显示文摘 | ROBERTO L N MA'RIO E S MARCOS Z D | 2010 | J Exp Appl Acarol2010，50，： | 1 |
| 10 | Friction factor and Nusselt number in flat tubes with rounded edges 显示文摘 | MARCO S ROBERTO D O | 1995 | Int J Heat Fluid Flow1995，16，4： | 1 |
| 11 | On the interharmonic conpenents generated by adjustable speed drivers显示文摘 | FRANCESCO D R ROBERTO L ADOLFO S | 2005 | IEEE Transactions on Power Delivery2005，20，4： | 1 |
| 12 | Friction factor and Nusselt number in flat tubes with rounded edges显示文摘 | MARCO S ROBERTO D O | 1995 | Int J Heat and Fluid Flow1995，16，4： | 1 |
| 13 | Grain-size effects on diffuse phase transitions of sol-gel prepared barium titante ceramic 显示文摘 | Lobe R P S M Mohallem Nelcy D S Moreira Roberto L | 1995 | J Am Ceram Soc1995，78，： | 1 |
| 14 | Stable plasma- deposited acrylic acid surfaces for cell culture applications 显示文摘 | LOREDANA D ROBERTO G SENESI G S | 2005 | Biomaterials2005，26，18： | 1 |
| 15 | Carbohydrate synthesis by two Navicula strains isolated from benthic and pelagic mucilages in the Tyrrhenian Sea (Tuscan Archipelago)显示文摘 | Cecilia F Roberto D P Claudio S | 2003 | Applied Phycology2003，，15： | 1 |
| 16 | Alternative synthesis of a dialkylimidazolium tetrafuoroborate ionic liquid mixture and its use in poly hydrogenation显示文摘 | Roberto de S Viviane R Jairton D | 2002 | Advanced Synthesis and Catalysis2002，344，2： | 1 |
| 17 | A double-blind,randomized parallel-group,efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder显示文摘 | PAOLO P PIERLUIGI S ROBERTO D C | 2002 | International J of Neuropsychopharmacology2002，5，： | 1 |
| 18 | Marine pharmacology in 2007--8: Marine compotmds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antipmtozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action显示文摘 | ALEJANDRO M S M ABIMAEL D R ROBERTO G S B | 2011 | Comparative Biochemistry and Physiology: Part C2011，153，2： | 1 |
| 19 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCI solution 显示文摘 | VANESSA V T ROBERTO S A CAMILA F TATIANA L F CARLOS R ALEXANDRE G T ELIANE D | 2011 | Corrosion Science2011，53，： | 1 |
| 20 | Simultaneous extraction of polycyclic aromatic hydrocarbons and polychlorinated biphenyls in agricultural soils by pressurized liquid extraction显示文摘 | MRT(I)NEZ V J L GARRIDO F A BARCO BONILLA M D L N ROBERTO R G S(A)NCHEZ J A P | 2009 | Anal Bioanal Chem2009，395，5： | 1 |
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