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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Appendicitis in children less than five years old:A challenge for the general practitioner显示文摘Acute appendicitis is one of the most common indications for abdominal surgery in pediatrics with peak incidence in the second decade of life. Acute appendicitis in the first years of life is an uncommon event. The clinical presentation is often varied and the diagnosis may be overshadowed by other medical conditions.Gastroenteritis is the most common misdiagnosis, with a history of diarrhea present in 33% to 41% of patients. Pain is the most common presenting symptom in children less than 5 years old, followed by vomiting, fever, anorexia and diarrhea. The most common physical sign is focal tenderness(61% of the patients) followed by guarding(55%), diffuse tenderness(39%), rebound(32%), and mass(6%). Neonatal appendicitis is a very rare disease with high mortality; presenting symptoms are nonspecific with abdominal distension representing the main clinical presentation. The younger the patient, the earlier perforation occurs: 70% of patients less than 3 years develop a perforation within 48 h of onset of symptoms. A timely diagnosis reduces the risk of complications. We highlight the epidemiology, pathophysiology, clinical signs and laboratory clues of appendicitis in young children and suggest an algorithm for early diagnosis. | Pierluigi Marzuillo Claudio Germani Baruch S Krauss Egidio Barbi | 2015 | World Journal of Clinical Pediatrics2015，4，2： | 10 |
| 3 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 4 | GABA receptor antagonists and insecticides:common structural features of 4-alkyl-1-phenyIpyrazoles and 4-alkyl-1-phenyltrioxabicyclooctanes显示文摘 | Robert E S Pierluigi C Kathleen A D | 2004 | Casida Bioorganic & Medicinal Chemistry2004，12，： | 1 |
| 5 | Effect of the addition of Au in zirconia and ceria supported Pd catalysts for the direct synthesis of hydrogen peroxide显示文摘 | Fedefica M Pierluigi B Michela S | 2008 | Journal of Catalysis2008，257，： | 1 |
| 6 | Muhi-ohjective scheduling of electric vehicles in smart distribution显示文摘 | ALIREZA Z SHAHRAM J PIERLUIGI S | 2014 | Energy Conversion and Management2014，，79： | 1 |
| 7 | Constituents of Shashen ( Adenophora axilliflora ) 显示文摘 | DU S J PIERLUIGI G GIANCARLO J | 1986 | Planta Med1986，52，4： | 1 |
| 8 | Cold single-strand conformation polymorphism analysis:Optimization for detection of APC gene mutations in patients with familial adenomatous polyposis显示文摘 | Pierluigi S Silvia S Renato S | 2001 | Int Int J Mol2001，8，： | 1 |
| 9 | A double-blind,randomized parallel-group,efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder显示文摘 | PAOLO P PIERLUIGI S ROBERTO D C | 2002 | International J of Neuropsychopharmacology2002，5，： | 1 |
| 10 | An improved method for the detection of Down's syndrome aneuploidy in uncultured aminocytes 显示文摘 | Pierluigi M Perfumo C Cavani S | 1996 | Clin Genet1996，49，： | 1 |
| 11 | Liquid chromatography- tandem mass spectrometric ion - switching determination of ehlorantraniliprole and flubendiamide in fruits and vegetables 显示文摘 | Pierluigi C Giorgia S Alberto A | 2008 | Journal of Agricultural & Food Chemistry2008，56，17： | 1 |
| 12 | Phenylpyrazole Insecticide Photochemistry, Metabolism, and GABAergic Action: Ethiprole Compared with Fipronil 显示文摘 | Pierluigi C Robert E S John E C | 2003 | J Agric Food Chem2003，51，24： | 1 |
| 13 | Internet traffic modeling by means of hidden Markov models 显示文摘 | ALBERTO D ANTONIO P PIERLUIGI S R et at | 2008 | Computer Networks2008，52，14： | 1 |
| 14 | A modeling language to support the interoperability of global navigation satellite sys tems显示文摘 | Daniele G Joachim F Pierluigi D S | 2013 | GPSSoiutions2013，17，1： | 1 |
| 15 | Expression of T cell receptor alpha gene(TCRA) in human rhabdomyosarcoma and other musculo-skeletal sarcomas 显示文摘 | Stefania C Pierluigi S Laura B | 2005 | Gene2005，353，1： | 1 |
| 16 | Demand Response and Smart Grids-A Survey显示文摘 | PIERLUIGI S | 2014 | Renewable and Sustainable Energy Reviews2014，30，2： | 1 |
| 17 | Fast and Versatile Multiresidue Method for the Analysis of Botanical Insecticides on Fruits and Vegetables by HPLC/DAD/MS显示文摘 | PIERLUIGI C GIORGIA S ALBERTO A | 2005 | Agric Food Chem2005，53，22： | 1 |
| 18 | Liquid chromatography-tandem mass spectrometric ion-switching determination of chlorantraniliprole and flubendiamide in fruits and vegetables显示文摘 | PIERLUIGI C GIORGIA S ALBERTO A | 2008 | Journal of Agricultural and Food Chemistry2008，56，17： | 1 |
| 19 | An improved for the detetion of Down,s syndrome aneuploidy in uncultured aminocytes显示文摘 | Pierluigi M Perfumo C Cavani S | 1996 | Clin Genet1996，49，： | 1 |
| 20 | Constituents of shashen(Adenophora axilliflora) 显示文摘 | DU S J PIERLUIGI G GIANCARLO J | 1986 | Planta Medica1986，4，： | 1 |
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