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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Intesti- nal peptide transporter PepTl is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection 显示文摘 | BARBOT L WINDSOR E ROME S | 2003 | Parasitology Research2003，89，： | 1 |
| 4 | Stress analysis of occlusal forces in canine teeth and their role in the development of non cari- ous cervical lesions:abfraction显示文摘 | ROMEED S A MALIK R DUNNE S M | 2012 | Int j dent2012，，8： | 1 |
| 5 | Micrearray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp 显示文摘 | Rome S Clement K Rabasa-Lhoret R | 2003 | J Biol Chem2003，278，18： | 1 |
| 6 | Seasonal phenology of Bactrocera minax (Diptera:Tephritidae) in western Bhutan显示文摘 | Dorji C Clark A R Drew R A I Fletcher B S Loday P Mahat K Raghu S and Roming M C | | 0，，： | 1 |
| 7 | Linking temperature and salinity tolerance to winter mortality of Chesapeake Bay blue crabs (Callinectes sapidus)显示文摘 | ROME M S YOUNG-WILLIAMS A C DAVIS G R | 2005 | Journal of Experimental Marine Biology and Ecology2005，319，： | 1 |
| 8 | Preventing pa- tients from slippering显示文摘 | Rome S Tinetti ME Sweting HL | 2002 | Am J Nurs2002，102，6： | 1 |
| 9 | Computational visual attention systems and their cognitive foundations:a survey显示文摘 | Frintrop S Rome E Christensen H I | | 0，，01： | 1 |
| 10 | Fibrin glue apphca- tion in the management of refractory chylous ascites in children 显示文摘 | Zeidan S Delarue A Rome A | 2008 | J Pediatr Gastroenterol Nutr2008，46，4： | 1 |
| 11 | Mobility and safety in the multiple myeloma survivor:survivorship care plan of the International Myeloma Foundation Nurse Leadership Board 显示文摘 | Sandra I Rome H Bonnie S | 2011 | Clinical Journal of Oncolo- gy Nursing2011，12，15： | 1 |
| 12 | Dysfunctional voiding in women显示文摘 | Carlson KV Rome S Nitti VW | 2001 | J Urol2001，165，1： | 1 |
| 13 | Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects显示文摘 | Meugnier E Faraj M Rome S | | 0，，04： | 1 |
| 14 | Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells显示文摘 | Guay C Menoud V Rome S | 2014 | Cell Cornmun & Signal2014，13，： | 1 |
| 15 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 16 | Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells显示文摘 | Guay C Menoud V Rome S | 2015 | Cell Commun Signal2015，19，： | 1 |
| 17 | Combination of ring-opening polymerization and 'click chemistry':Toward functional ization and grafting of poly(ε-caprolactone)显示文摘 | R Riva Schmeits S Jérome C | 2007 | Macromolecules2007，40，： | 1 |
| 18 | A comparison of 2 D and 3 D finite element analysis of a restored tooth 显示文摘 | ROMEED S A FOK S L WILSONN H F | 2006 | J Oral Rehabil2006，33，3： | 1 |
| 19 | Aptamer affinity chromatograph: combinatorial chemistry applied to protein purification显示文摘 | ROMING T S BELL C DROLET D W | 1999 | J Chromatogr B1999，731，： | 1 |
| 20 | The ubiquitin-proteasome pathway is a new partner for the control of insulin signaling显示文摘 | Rome S Meugnier E Vidal H | 2004 | Curr Opin Clin Nutr Metab Care2004，7，： | 1 |
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