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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Caloric equivalent of live weight loss of dairy cattle显示文摘 | Th Bath D L Ronning M Meyer J H | 1965 | J Dairy Sci1965，48，： | 1 |
| 3 | A fractal-based algorithm for detecting first arrivals on seismic traces显示文摘 | Mike D D Ron D L | 1993 | Geophysics1993，61，4： | 1 |
| 4 | Heightened stress respouse in primary, fihroblasts expressing mutant elF2B genes from CACH/VWM leukodystrophy patients 显示文摘 | Kantor L Harding HP Ron D | 2005 | Hum Genet2005，118，： | 1 |
| 5 | Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress显示文摘 | Tabas l Ron D | 2011 | Nat Cell Bi ol2011，13，3： | 1 |
| 6 | Recent progress in under standing and controlling bacterial canker of tomato in eastern north America显示文摘 | Gleason M L Gitaitis Ron D Ricker Mark D | 1993 | Plant Disease1993，77，： | 1 |
| 7 | A fractal-based algorithm for detecting first arrivals on seismic traces显示文摘 | FABIO B MIKE D D RON D L | 1996 | Geophysics1996，，61： | 1 |
| 8 | Male breast cancer incidence among atomic bomb survivors显示文摘 | Ron E Ikeda T Preston D L | 2005 | J Natl Cancer Inst2005，97，8： | 1 |
| 9 | Effect of time of feeding concentrates and ground, pelleted aifalfa hay on milk fat percentage and fatty acid eonlposition显示文摘 | Palmquist D L Smith L M Ronning M | 1964 | Journal of Dairy Science1964，47，： | 1 |
| 10 | Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses显示文摘 | Berlanga J J Ventoso I Harding H P Deng J Ron D Sonenberg N Carrasco L de Haro C | 2006 | The EMBO Journal2006，25，： | 1 |
| 11 | Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients显示文摘 | Kantor L Harding HP Ron D | 2005 | Hum Genet2005，118，： | 1 |
| 12 | 查看详情显示文摘 | Ron I Sepunaru L Itzhakov S Belenkova T Friedman N Pecht I Sheves M Cahen D | | 0，，： | 1 |
| 13 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 显示文摘 | Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A Garcla JL Garcia MJ Goble A Goldman GH Gomi K Griffith- Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jim6nez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Latgo JP Li W Lord A Lu C Majoros WH May GS Miller BL Mohamoud Y Molina M Monod M Mouyna I Mulligan S Murphy L O'Neil S Paulsen I Pefialva MA Pertea M Price C Pritchard BL Quail MA Rabbinowitsch E Rawlins N Rajandream MA Reichard U Renauld H Robson GD Rodriguez de Cordoba S Rodriguez-Pefia JM Ronning CM Putter S Salzberg SL Sanchez M Sfnchez-Ferrero JC Saunders D Seeger K Squares R Squares S Takeuchi M Tekaia F Turner G Vazquez de Aldana CR Weidman J White O Woodward J Yu JH Fraser C Galagan JE Asai K Machida M Hall N Barrell B Denning DW | 2005 | Nature2005，438，7071： | 1 |
| 14 | Wurtzite ZnS nanosaws produced by polar surfaces 显示文摘 | MOORE D RONNING C MA C WANG Z L | 2004 | Chem Phys Lett2004，385，： | 1 |
| 15 | Coordinated movement of RACK1 with activated betaⅡ PKC显示文摘 | Ron D Jiang Z Yao L | 1999 | J Biol Chem1999，274，27： | 1 |
| 16 | Serum uric acidas a harbinger of metabolic outcome in subjects with impaired glucose tolerance显示文摘 | Niskanen L Laaksonen D E Lindst ron J | 2006 | Diabetes Care2006，29，： | 1 |
| 17 | Global Minimum for Active Contour Models:A Minimal Path Approach显示文摘 | L D Cohen Ron Kimmel | 1997 | International Journal of Computer Vision1997，24，1： | 1 |
| 18 | Impact of body mass in-dex on atrial fibrillation recurrence: a meta-analysis of observationalstudies显示文摘 | Guijian L Jinchuan Y Ron gzeng D | 2013 | Pacing Clin Electrophysiol2013，36，6： | 1 |
| 19 | Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants显示文摘 | Ron D Juhani E Claudo L | 1998 | Infect Immun1998，66，5： | 1 |
| 20 | Solid cancer incidence in atomic bomb survivors : 1958-1998 显示文摘 | Preston D L Ron E Tokuoka S ot al | 2007 | Radiation Research2007，168，1： | 1 |
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