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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | 人工全膝关节置换后股骨假体角度的CT影像学评估:股骨外上髁线参照与间隙平衡技术的对比研究(英文)显示文摘[目的]虽然人工全膝关节置换术中假体旋转定位的重要性已得到公认,但术中以哪条轴线为参照能够更加精确的保证股骨假体的旋转定位,目前尚存争议。研究表明股骨外上髁线(TEA)与膝关节屈曲轴线平行,但这一轴线术中难以精确确定。本文采用间隙平衡技术(BG),对比TEA技术在股骨假体实际旋转角度测量的差异。[方法]30例人工全膝关节置换分为2组(每组15膝),分别采用TEA和BG技术,术后行CT扫描测量股骨假体旋转角度并行膝关节学会评分(KSS)。[结果]BG组中股骨假体平均外旋角度为2.7°±1.1°,TEA组为5.6°±1.6°(P=0.001)。术后KSS功能评分改善BG组高于TEA组(P=0.002),但两组的KSS膝评分无显著性差异(P=0.39)。[结论]研究表明,与BG技术相比,术中应用TEA参照确定股骨假体的旋转定位可导致股骨假体的过度外旋,其术后KSS功能评分亦较差。 | Shrinand V Vaidya Aditya V Maheshwari Rajesh M Gadhiya Vaibhav Bagaria Amar S Ranawat Chitranjan S Ranawat | 2008 | 中国矫形外科杂志2008，16，12： | 2 |
| 4 | Dramatic influence of the orientation of linker between hydrophilic and hydrophobic lipid moiety in liposomal gene delivery显示文摘 | RAJESH M SEN J SRUJAN M | 2007 | J Am Chem Soc2007，129，11： | 1 |
| 5 | Poly ( ADP-ri- bose) polymerase inhibition decreases angiogenesis显示文摘 | Rajesh M Mukhopadhyay P Godlewski G | 2006 | Biochem Biophys Res Commun2006，350，4： | 1 |
| 6 | Simultaneous detection of apoptosis and mitoehondrial superoxide production in live cells by flow cytometry and confocal microscopy显示文摘 | Mukhopadhyay P Rajesh M Haskó G | 2007 | Nat Protoc2007，2，9： | 1 |
| 7 | Role of superoxide, nitric oxide,and peroxynitrite in doxorubicin-in-duced cell death in vivo and in vitro显示文摘 | Mukhopadhyay P Rajesh M Batkai S | 2009 | Am J Physiol Heart Circ Physiol2009，296，5： | 1 |
| 8 | Numerical simulation of dry particle coating processes by the discrete element method 显示文摘 | RAJESH D CHEN Wenliang AJIT M | 2003 | Advanced Powder Technology2003，34，： | 1 |
| 9 | A geometrically sound technique of vermilion repair in unilateral cleft lip显示文摘 | Rajesh S Powar Sandeep M | 2006 | Journal of Plastic Reconstructive & Aesthetic Surgery In Press2006，12，： | 1 |
| 10 | CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes显示文摘 | MUKHOPADHYAY P RAJESH M BATKAI S | 2010 | Cardiovascular Research2010，85，4： | 1 |
| 11 | Combined Location-routing Problems:A Synthesis and Future Research Directions显示文摘 | Hokey M Vaidyanathan J Rajesh S | 1998 | European J of Operational Research1998，108，1： | 1 |
| 12 | Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death显示文摘 | Mukhopadhyay P Rajesh M Horvoth B | 2011 | Free Radic Biol Med2011，50，10： | 1 |
| 13 | Role of superoxide, ni- tric oxide, and peroxynitrite in doxorubicin - induced cell death in rive and in vitro 显示文摘 | Mukhopadhyay P Rajesh M B6tkai S | 2009 | Am J Physiol Heart Circ Physiol2009，296，5： | 1 |
| 14 | Uranium Immobilization by Sulfate-Reducing Biofilms 显示文摘 | Beyenal H Rajesh K S Brent M P | 2004 | Environmental Science and Technology2004，38，7： | 1 |
| 15 | Species identification in sev en small millet species using polymerase chain reaction restriction fragment length polymorphism of trnS-psbC gene region显示文摘 | PARANI M RAJESH K LAKSHMIM | 2001 | Genome2001，44，： | 1 |
| 16 | Low-k damage re- duction using a modified plasma strip process 显示文摘 | RAJESH M BING J STEVE S | 2010 | Solid-State- Technology2010，53，5： | 1 |
| 17 | Acoustic and Ion Sensing of Lean Blowout in an Aircraft Combustor Simulator显示文摘 | SURAJ N RAJESH R ANDREW J M | 2005 | American Institute of Aeronautics and Astronautics2005，32，5： | 1 |
| 18 | CBI cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes 显示文摘 | Mukhopadhyay P Rajesh M Batkai S | 2010 | Cardiovasc Res2010，85，4： | 1 |
| 19 | Hyperglycemia, insu- lin, and acute ischemic stroke; A mechanistic justification for a trial of insulin infusion therapy显示文摘 | Rajesh G Ajaychudhllri Frederick M | 2006 | Stroke2006，37，： | 1 |
| 20 | Muhidrug resistance ( MDR ) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs显示文摘 | Rajesh K Lawrence D M | 2000 | European Journal of Pharmaceutical Sciences2000，11，4： | 1 |
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