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| 1 | Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats显示文摘The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel disease in rats.Naringin(20,40 and 80 mg/kg) was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4%(v/v) acetic acid solution.The degree of colonic mucosal damage was analyzed by examining mucosal damage,ulcer area,ulcer index and stool consistency.Intrarectal administration of 4%acetic acid resulted in significant modulation of serum alkaline phosphatase,lactate dehydrogenase,superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA) and myeloperoxidase(MPO) content along with colonic nitric oxide(NO),xanthine oxidase(XO) level and protein carbonyl content in the colonic tissue as well as in blood.Naringin(40 and 80 mg/kg) exerted a dose dependent(P < 0.05) ameliorative effect,as it significantly increased hematological parameter as well as colonic SOD and GSH.There was a significant(P < 0.05)and dose dependant inhibition of macroscopical score,ulcer area along with colonic MDA,MPO activity by the7 days of pretreatment of naringin(40 and 80 mg/kg).Biochemical studies revealed a significant(P < 0.05) dose dependant inhibition in serum alkaline phosphatase(ALP) and lactate dehydrogenase(LDH) levels by pretreatment of naringin.Increased levels of colonic NO,XO,protein carbonyl content and DNA damage were also significantly decreased by naringin pretreatment.The findings of the present investigation propose that naringin has an anti-inflammatory,anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA,MPO,NO and XO,thus reducing DNA damage. | Venkatashivam Shiva Kumar Anuchandra Ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar | 2014 | The Journal of Biomedical Research2014，28，2： | 8 |
| 2 | Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging显示文摘 | Ana P. Gomes Nathan L. Price Alvin J.Y. Ling Javid J. Moslehi Magdalene K. Montgomery Luis Rajman James P. White Jo?o S. Teodoro Christiane D. Wrann Basil P. Hubbard Evi M. Mercken Carlos M. Palmeira Rafael de Cabo Anabela P. Rolo Nigel Turner Eric L. Bel | 2013 | Cell2013，，7： | 2 |
| 3 | Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury显示文摘 | KANDHARE A D SHIVAKUMAR V RAJMANE A | 2014 | J Nat Med2014，68，3： | 1 |
| 4 | Serial measurements of N-terminal pro-brain natriuretic Peptide in patients with coronary heart disease显示文摘 | Dallmeier D Pencina MJ Rajman I | 2015 | PLoS One2015，10，01： | 1 |
| 5 | Patterned nano- structured arrays for high density magnetic recording显示文摘 | Tofail S A Rahman I Z Rajman M A | 2001 | Appl Orgnenometal Chem2001，15，9： | 1 |
| 6 | Cardioprotective therapeuticsdrugs used in hypertension, hyperlipidaemia, thromboembolism, arrhythmias, the postmenopausal state and as anti-oxidants 显示文摘 | Kendall M J Rajman I Maxwell SR | 1994 | Postgrad Med J1994，70，823： | 1 |
| 7 | High-performance thin-layer chromatographic determination of etoricoxib and thiocolchicoside in combined tablet dosage form显示文摘 | Rajmane VS Gandhi SV Patil UP Sengar MR | 2010 | J AOAC int2010，93，3： | 1 |
| 8 | Serial measurements of N- terminal pro- brain natriuretie peptide in patients with coronary heart disease 显示文摘 | Dallmeier D Peneina MJ Rajman I | 2015 | PLoS One2015，10，01： | 1 |
| 9 | Investigation of low density lipoprotein subfraetions as a coronary risk factor in normotriglyceri- daemic men 显示文摘 | Rajman I Kendall MJ Cramb R | 1996 | Atheroselerosis1996，125，2： | 1 |
| 10 | PK/PD modelling and simulations:utility in drug development显示文摘 | Rajman I | 2008 | Drug Discov Today2008，13，78： | 1 |
| 11 | PK/PD modeling and smxlations: utility in drug development 显示文摘 | Rajman I | 2008 | Drug Discov Today2008，13，78： | 1 |
| 12 | Effect of levamisole on performance and immunomodulation against Ranikhet disease in broilers under stress显示文摘 | Chawak MM Rajmane BV and Ranade AS | 1993 | Indian J Ani Sci1993，63，10： | 1 |
| 13 | Serial measure- ments ofN-terminalpro-brain natriuretic peptidein pa- tients with coronary heart disease 显示文摘 | Dallmeier D Pencina M J Rajman I | 2015 | PLoS One2015，10，01： | 1 |
| 14 | Low-density lipoprotein subfraction profiles in chronic renal failure显示文摘 | Rajman I Harper L McPake D | 1998 | Nephrol Dial Transplant1998，13，9： | 1 |
| 15 | SIM- ULTANEOUS DETERMINATION OF DICLOFENAC SODIUM AND THIOCOLCHICOSIDE IN FIXED DOSE COMBINATION BY SPECTROPHOTOMETRY 显示文摘 | MR Sengar SV Gandhi UP Patil VS Rajmane | 2010 | Asian Journal of Pharmaceu- tical and Clinical Research2010，3，2： | 1 |
| 16 | Estimation of the Long-term Cardiovascular Events Using UKPDS Risk Engine in Metabolic Syndrome Patients 显示文摘 | Shivakumar V Kandhare AD Rajmane AR | 2014 | Indian Journal of Pharmaceutical Sciences2014，76，2： | 1 |
| 17 | Investigation of low density lipoprotein in subfractions as a coronary risk fraction in normotrigly ceridaemic men显示文摘 | Rajman I Kendall M J Gramb R | 1996 | Athrosclerosis1996，125，： | 1 |
| 18 | Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner显示文摘 | Bakos J Hlavacova N Rajman M | 2009 | Neurescience2009，164，2： | 1 |
| 19 | Infant mouse brain passaged Dengue serotype 2 virus induces non-neurological disease with inflammatory spleen collapse in AG129 mice after splenic adaptation显示文摘 | Rajmane Y Shaikh S Basha K | 2013 | Virus Res2013，173，2： | 1 |
| 20 | Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner显示文摘 | Bakos J Hlavacova N Rajman M | | 0，，2： | 1 |
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