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| 1 | Differentiating Crohn's disease from intestinal tuberculosis显示文摘Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. | Saurabh Kedia Prasenjit Das Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja | 2019 | World Journal of Gastroenterology2019，25，4： | 19 |
| 2 | Diffusion weighted imaging: Technique and applications显示文摘Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes. | Vinit Baliyan Chandan J Das Raju Sharma Arun Kumar Gupta | 2016 | World Journal of Radiology2016，8，9： | 18 |
| 3 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 4 | Review on current concepts of myopia and its control strategies显示文摘Myopia poses a significant burden on the healthcare system,economy and quality of life.It is an emerging global public health challenge and requires interventions to delay or stop onset and progression.With changing times and evidence,the concepts of myopia are changing along with the treatment and control strategies.Behavioural modifications including increased outdoors time and reduced near work,optical and pharmaceutical management options are reviewed.This paper presents a current overview on the concepts of myopia,and is expected to summarize updates on myopia control methods. | Raju Kaiti Ranjila Shyangbo Indra Prasad Sharma Manish Dahal | 2021 | International Journal of Ophthalmology(English edition)2021，14，4： | 3 |
| 5 | Amantadine: an antiparkinsonian agent inhibits bovine brain 60<ce:hsp sp='0.25'/>kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme显示文摘 | Rakesh Kakkar Rajala V.S. Raju Ali H. Rajput Rajendra K. Sharma | 1997 | Brain Research1997，，2： | 2 |
| 6 | Man-agement of raised intracranial Pressure 显示文摘 | Sankhyan N Vykunta Raju K N Sharma S | 2010 | Indian J Ped-iatr2010，77，12： | 1 |
| 7 | Diffusion-weighted MRI in assessment of renal dysfunction显示文摘 | Ankur Goyal Raju Sharma Ashu Bhalla Shivanand Gamanagatti Amlesh Seth | 2012 | Indian Journal of Radiology and Imaging2012，，3： | 1 |
| 8 | Renal agenesis and external iliac artery stenosis in an infant with moyamoya disease显示文摘 | Ramesh K Sharma S Raju V | 2011 | Brain Dev2011，33，7： | 1 |
| 9 | Stem cell culture engineering-process scale up and beyond显示文摘 | Sharma S Raju R Sui SG | 2011 | Biotechnol J2011，6，11： | 1 |
| 10 | SEP-E(RCH):Enhanced Stable Election Protocol Based on Redundant Cluster Head Selection for HWSNs显示文摘 | Raju Pal Ritu Sindhu Ajay K Sharma | 2013 | Social Informatics and Telecommunications Engineering2013，115，： | 1 |
| 11 | Preoperative embolization of primary bone tumors:A case control study显示文摘AIM:To study the safety and effectiveness of preoperative embolization of primary bone tumors in relation to intraoperative blood loss,intraoperative blood transfusion volume and surgical time.METHODS:Thirty-three patients underwent preoperative embolization of primary tumors of extremities,hip or vertebrae before resection and stabilization.The primary osseous tumors included giant cell tumors,aneurysmal bone cyst,osteoblastoma,chondroblastoma and chondrosarcoma.Twenty-six patients were included for the statistical analysis(embolization group)as they were operated within 0-48 h within preoperative embolization.A control group(non-embolization group,n = 28)with bone tumor having similar histological diagnosis and operated without embolization was retrieved from hospital record for statistical comparison.RESULTS:The mean intraoperative blood loss was 1300 mL(250-2900 mL),the mean intraoperative blood transfusion was 700 m L(0-1400 m L)and the mean surgical time was 221 ± 76.7 min for embolization group(group Ⅰ,n = 26).Non-embolization group(group Ⅱ,n = 28),the mean intraoperative blood loss was 1800 m L(800-6000 m L),the mean intraoperative blood transfusion was 1400 mL(700-8400 mL)and the meansurgical time was 250 ± 69.7 min.On comparison,statistically significant(P < 0.001)difference was found between embolisation group and non-embolisation group for the amount of blood loss and requirement of blood transfusion.There was no statistical difference between the two groups for the surgical time.No patients developed any angiography or embolization related complications.CONCLUSION:Preoperative embolization of bone tumors is a safe and effective adjunct to the surgical management of primary bone tumors that leads to reduction in intraoperative blood loss and blood transfusion volume. | Roushan Jha Raju Sharma Shishir Rastogi Shah Alam Khan Arvind Jayaswal Shivanand Gamanagatti | 2016 | World Journal of Radiology2016，8，4： | 1 |
| 12 | Lameness in chickens: alliviation by dietary manipulation显示文摘 | Drs S V Rama Rao M V L N Raju R P Sharma | 2003 | Poultry International2003，42，9： | 1 |
| 13 | Man- agement of raised intracranial pressure 显示文摘 | Sankhyan N Vykunta Raju K N Sharma S | 2010 | Indian J Pe- diatr2010，77，12： | 1 |
| 14 | Renal agenesis and external iliac artery stenosis in an infant with moyamoya disease显示文摘 | Ramesh K Sharma S Raju V | 2011 | Brain Dev2011，33，7： | 1 |
| 15 | Assessment of noise level due to vehicular traffic at Warangal city显示文摘 | Sharma P S Raju S G Murali M | 2007 | International Journal of Environment and Pollution2007，30，1： | 1 |
| 16 | New sources of resistance to Fusarium wilt and sterility mosaic disease in a mini-core collection of pigeonpea germplasm显示文摘 | Mamta Sharma Abhishek Rathore U. Mangala Raju Ghosh Shivali Sharma HD Upadhyay Suresh Pande | 2012 | European Journal of Plant Pathology2012，，3： | 1 |
| 17 | MR evaluation of biliary-enteric anastomotic stricture: Does contrast-enhanced T1W MRC provide additional information?显示文摘 | Devasenathipathy Kandasamy Raju Sharma Ashu Seith Bhalla Shivanand R. Gamanagatti Deep N. Srivastava Peush Sahni Rakesh Kumar | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，8： | 1 |
| 18 | TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling 显示文摘 | Zhong J Sharma J Raju R | 2014 | Database (Oxford)2014，2014，： | 1 |
| 19 | Adult and child malaria mortality in India: a nationally representative mortality survey显示文摘 | Neeraj Dhingra Prabhat Jha Vinod P Sharma Alan A Cohen Raju M Jotkar Peter S Rodriguez Diego G Bassani Wilson Suraweera Ramanan Laxminarayan Richard Peto | 2010 | 2010 (9754)2010，，9754： | 1 |
| 20 | Characterization of early repolarization during ajmaline provocation and exercise tolerance testing显示文摘 | Bastiaenen R Raju H Sharma S | | 0，，02： | 1 |
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