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| 1 | Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling显示文摘Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury,but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes(CMs) for driving the differentiation of cardiac stem cells(CSCs).Forced hypoxia-inducible factor 1α(HIF-1α) expression and physical hypoxia(5% O_2) treatment could induce Jagged1 expression in neonatal rat CMs. Pharmacological inhibition of HIF-1α by YC-1 attenuated hypoxia-promoted Jagged1 expression in CMs. An ERK inhibitor(PD98059), but not inhibitors of JNK(SP600125), Notch(DAPT), NF-κB(PTDC), JAK(AG490), or STAT3(Stattic) suppressed hypoxiainduced Jagged1 protein expression in CMs. c-Kit^+ CSCs isolated from neonatal rat hearts using a magnetic-activated cell sorting method expressed GATA4, SM22α or vWF, but not Nkx2.5 and cTnI.Moreover, 87.3% of freshly isolated CSCs displayed Notch1 receptor expression. Direct co-culture of CMs with BrdU-labeled CSCs enhanced CSCs differentiation, as evidenced by an increased number of BrdU^+/Nkx2.5^+ cells, while intermittent hypoxia for 21 days promoted co-culture-triggered differentiation of CSCs into CM-like cells. Notably, YC-1 and DAPT attenuated hypoxia-induced differentiation.Our results suggest that hypoxia induces Jagged1 expression in CMs primarily through ERK signaling,and facilitates early cardiac lineage differentiation of CSCs in CM/CSC co-cultures via HIF-1α/Jagged1/Notch signaling. | Keke Wang Ranran Ding Yanping Ha Yanan Jia Xiaomin Liao Sisi Wang Rujia Li Zhihua Shen Hui Xiong Junli Guo Wei Jie | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 7 |
| 2 | Average time synchro- nization in wireless sensor networks by pairwise messages 显示文摘 | Wu Jianshe Jiao Licheng Ding Ranran | 2012 | Computer Communications2012，35，2： | 1 |
| 3 | Mechanical and biocompatible properties of polymer-infiltrated-ceramic-network materials for dental restoration显示文摘Dental restorative materials with high mechanical properties and biocompatible performances are promising.In this work,polymer-infiltrated-ceramic-network materials(PICNs)were fabricated via infiltrating polymerizable monomers into porous ceramic networks and incorporated with hydroxyapatite nano-powders.Our results revealed that the flexural strength can be enhanced up to 157.32 MPa,and elastic modulus and Vickers hardness can be achieved up to 19.4 and 1.31 GPa,respectively,which are comparable with the commercial computer-aided design and computer-aided manufacturing(CAD/CAM)blocks.Additionally,the adhesion and spreading of rat bone marrow mesenchymal stem cells(r BMSCs)on the surface of such materials can be improved by adding hydroxyapatite,which results in good biocompatibility.Such PICNs are potential applicants for their application in the dental restoration. | Bencang CUI Ranran ZHANG Fengbo SUN Qian DING Yuanhua LIN Lei ZHANG Cewen NAN | 2020 | Journal of Advanced Ceramics2020，9，1： | 1 |
| 4 | Average time synchronization in wireless sensor networks by pairwise messages 显示文摘 | Wu Jianshe Jiao Licheng Ding Ranran | 2012 | Computer Communications2012，35，2： | 1 |
| 5 | Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer显示文摘Objective The aim of the present study was to investigate the effect of dendritic cell(DC)/cytokine-induced killer cell(CIK) immunobiological cancer therapy in patients with triple-negative breast cancer(TNBC) who underwent adjuvant chemotherapy. Methods From January 2010 to October 2013, 120 patients with postoperative TNBC were recruited and included in the study. Patients were enrolled in one of two groups according to whether they accepted DC/CIK immunobiological cancer therapy during adjuvant chemotherapy; the patients in the DC/CIK group underwent adjuvant chemotherapy combined with DC/CIK immunobiological cancer therapy, and the control group underwent adjuvant chemotherapy alone. When six cycles of adjuvant chemotherapy and six cycles of DC/CIK immunobiological cancer therapy had been completed, differences between the two groups with regard to quality of life(Qo L), immunological indicators(CD3, CD4, CD8, and NK cell levels), disease-free survival(DFS), and side effects of chemotherapy and DC/CIK treatment were evaluated.Results In the DC/CIK group, the proportion of NK cells and CD3+ and CD4+ T-cell subgroups significantly increased, and the proportion of CD8+ cells decreased when they were compared before and after DC/CIK therapy(P < 0.05). However, there were no significant changes in the control group. By the final follow-up, DFS of the treatment group and the control group was 38.4 and 34.2 months, respectively. The Qo L improved in the patients treated with chemotherapy plus DC/CIK therapy compared with the patients treated with chemotherapy alone, and the difference between groups was significant(P < 0.05). The side effects of two groups were tolerable and not significantly different between the two groups.Conclusion The DC/CIK treatment had potential benefits for patients with TNBC compared with the control group, and was not associated with any obvious side effects. Therefore, DC/CIK therapy is a safe and effective method for the treatment of TNBC. | Ranran Zhang Wanqing Xie Tao Han Yongye Liu Zhaozhe Liu Fang Guo Yaling Han Zhenyu Ding Yinghui Sun Dongchu Ma Xiaodong Xie | 2015 | The Chinese-German Journal of Clinical Oncology2015，14，1： | 1 |
| 6 | Average time synchroniza- tion in wireless sensor networks by pairwise messages 显示文摘 | WU Jianshe JIAO Licheng DING Ranran | 2012 | Computer Communications2012，35，2： | 1 |
| 7 | A significant quantitative trait locus on chromosome Z and its impact on egg production traits in seven maternal lines of meat-type chicken显示文摘Background:Egg production is economically important in the meat-type chicken industry.To better understand the molecular genetic mechanism of egg production in meat-type chicken,genetic parameter estimation,genome-wide association analyses combined with meta-analyses,Bayesian analyses,and selective sweep analyses were performed to screen single nucleotide polymorphisms(SNPs)and other genetic loci that were significantly associated with egg number traits in 11,279 chickens from seven material lines.Results:Yellow-feathered meat-type chickens laid 115 eggs at 43 weeks of age and white-feathered chickens laid 143 eggs at 60 weeks of age,with heritability ranging from 0.034–0.258.Based on meta-analyses and selective sweep analyses,one region(10.81–13.05 Mb)on chromosome Z was associated with egg number in all lines.Further analyses using the W2 line was also associated with the same region,and 29 SNPs were identified that significantly affected estimation of breeding value of egg numbers.The 29 SNPs were identified as having a significant effect on the egg number EBV in 3194 birds in line W2.There are 36 genes in the region,with glial cell derived neurotrophic factor,DAB adaptor protein 2,protein kinase AMP-activated catalytic subunit alpha 1,NAD kinase 2,mitochondrial,WD repeat domain 70,leukemia inhibitory factor receptor alpha,complement C6,and complement C7 identified as being potentially affecting to egg number.In addition,three SNPs(rs318154184,rs13769886,and rs313325646)associated with egg number were located on or near the prolactin receptor gene.Conclusion:Our study used genomic information from different chicken lines and populations to identify a genomic region(spanning 2.24 Mb)associated with egg number.Nine genes and 29 SNPs were identified as the most likely candidate genes and variations for egg production.These results contribute to the identification of candidate genes and variants for egg traits in poultry. | Jiqiang Ding Fan Ying Qinghe Li Gaomeng Zhang Jin Zhang Ranran Liu Maiqing Zheng Jie Wen Guiping Zhao | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 1 |
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