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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 3 | Addressing durability of asphalt concrete by self-healing mechanism显示文摘 | Raquel Casado Barrasaa Víctor Blanco Lópeza Carlos MartínPortugués Montoliua | 2014 | Procedia-Social and Behavioral Sciences2014，，162： | 1 |
| 4 | Respirometric assays at fixed and process temperatures to monitor composting process 显示文摘 | Raquel B G Felicitas V L Bolasell F G | 2005 | Bioresour Technol2005，96，10： | 1 |
| 5 | Lessons from the genomes of ex- tremely acidophilic bacteria and archaea with special emphasis on bioleach- ing microorganisms 显示文摘 | Juan P C Jorge V Raquel Q | 2010 | Applied Microbiology and Biotechnology2010，88，3： | 1 |
| 6 | A new method to prepare porous silk fibroin Membranes suitable for' tissue scaffolding applications 显示文摘 | GRINIA M N RAQUEL W WELLINGTON C V | 2009 | Journal of Applied Polymer Science2009，114，1： | 1 |
| 7 | Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells 显示文摘 | Pilar V Genoveva B Raquel A | 2008 | Exp Cell Res2008，314，5： | 1 |
| 8 | Carbon nanofibers allow foaming of semicrystalline poly(ether ether ketone)显示文摘 | Werner Raquel V Frank W | 2005 | Adv Mater2005，17，： | 1 |
| 9 | Tuberculosis in pediatric solid organ and hematopoietic stem cell transplant percipients显示文摘 | Raquel V Bego(n)a S Femando BA | | 0，，7： | 1 |
| 10 | Funetionalized graphene sheet filled silicone foam nanoeomposites 显示文摘 | Raquel V Fabienne B Miguel A R | 2008 | Journal of Materials Chemistry2008，18，19： | 1 |
| 11 | 2,4-Dichlorophenoxyacetic Acid (2,4-D) Degradation Promoted by Nanoparticulate Zero Valent Iron (nZVI) in Aerobic Suspensions显示文摘 | ADR/ANA C V RAQUEL F P | 2013 | Journal of Environmental Management2013，121，： | 1 |
| 12 | Natural melanin: A potential pH-responsive drug release device 显示文摘 | MARCO A RAQUEL V TIAGO R | 2014 | Int J Pharm2014，469，1： | 1 |
| 13 | Functionalized graphene sheet filled silicone foam nanocomposites 显示文摘 | Raquel V Fabienne B Miguel A R | 2008 | Journal of Materials Chemistry2008，18，19： | 1 |
| 14 | IL-6 induces MUC4 expression through gpl30/STAT3 pathway in gastric cancer cell lines显示文摘 | Raquel M L Sandra P Audrey V | 2008 | Biochim Biophys Acta2008，1783，： | 1 |
| 15 | Physical properties of silicone foams filled with carbon nanotubes and functionalized graphene sheets显示文摘 | Raquel V Cristina S A | 2008 | Eur Polym J2008，44，6： | 1 |
| 16 | Conservative treatment with transurethral resection, neoadjuvant chemotherapy followed by radiochemotherapy in stage T2-3 transitional bladder cancer显示文摘 | Manuel Cobo Raquel Delgado Silvia Gil Ismael Herruzo Víctor Baena Francisco Carabante Pilar Moreno José Luis Ruiz Juan José Bretón M. José Rosal Carlos Fuentes Paloma Moreno Emilio García Esther Villar Jorge Contreras Inmaculada Alés Manuel Benavides | 2006 | Clinical and Translational Oncology2006，，12： | 1 |
| 17 | Evaluation of the ecotoxicity of model nanoparticles显示文摘 | Raquel Barrena Eudald Casals Joan Colón Xavier Font Antoni Sánchez Víctor Puntes | 2009 | Chemosphere2009，，7： | 1 |
| 18 | Tuberculosis in pediatric solid organ and hematopoietic stem cell transplant percipients显示文摘 | Raquel V Begona S Fernando BA | | 0，，7： | 1 |
| 19 | Electrospin- ning of preceramic polymers for the preparation of SiBNC felts and their modification with semiconductor nanowires 显示文摘 | JAKOB W ROBIN V H RAQUEL F | 2012 | J Mater Sci2012，22，5： | 1 |
| 20 | Frequencies of GSTM1, GSTT1, and GSTP 1 polymorphisms in a Brazilian population显示文摘 | Ana Rossinil Davy C M Rapozol Lidia M F Amorim2 Jacyara M B Macedo1 Raquel Medina1 Jose F N Neto3 Claudia V M Gallol and Luis F R Pintol | 2002 | Genetics and Molecular Research2002，1，3： | 1 |
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