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| 1 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 2 | Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization显示文摘在细胞分裂期间,染色体分离被和着丝点的锭子微导管的相互作用安排。进在分开的染色单体之间的一支组织中央锭子的 interpolarmicrotubules 的戏剧的改变为胞质分裂的开始和实行被要求。中央锭子组织要求有丝分裂的 kinesins, chromosomal 旅客蛋白质建筑群,和微导管捆绑蛋白质 PRC1。由在 Thr470 和 Thr481 的 Cdc2 的 PRC1 isphosphorylated 在有丝分裂期间。然而,在 Thr470 的功能的关联 ofPRC1 磷酸化留下了逃犯。这里,我们证明 thenon-phosphorylatable 异种 PRC1 (T470A ) 然而并非 phospho-mimicking 异种 PRC1 (T470E ) 的那表情引起中央锭子的异常组织。Immunoprecipitation 实验与野类型的 PRC1 显示那 bothPRC1 (T470A ) 和 PRC1 (T470E ) 突变蛋白质伙伴,建议 Thr470 的 thatphosphorylation 不改变 PRC1 自我协会。另外,在 vitroco 沉积,实验证明 PRC1 绑在独立于 Thr470 的 phosphorylationstate 的微导管。胶化过滤实验建议了 PRC1 的 Thr470 promotesoligomerization 的那磷酸化。给 Thr470 磷酸化的那预防禁止 PRC1oligomerization 试管内并且引起中央锭子体内的一个异常组织的事实,我们建议这 phosphorylation 依赖的 PRC1 oligomerization 保证中央锭子汇编在房间周期发生在适当时间。 | Chuanhai Fu Feng Yan Fang Wu Quan Wu Joseph Whittaker Haiying Hu Renming Hu Xuebiao Yao | 2007 | Cell Research2007，17，5： | 3 |
| 3 | Effects of berberine on glucose metabolism in vitro显示文摘 | Jun Yin Renming Hu Mingdao Chen Jinfeng Tang Fengying Li Ying Yang Jialun Chen | 2002 | Metabolism2002，，11： | 2 |
| 4 | EMC10 governs male fertility via maintaining sperm ion balance显示文摘Infertility is a severe public health problem worldwide that prevails up to 15% in reproductive-age couples,and male infertility accounts for half of total infertility.Studies on genetically modified animal models have identifed lots of genes involved in the pathogenesis of male infertility.The underlying causes,however,remain largely unclear.In this study,we provide evidence that EMCIO,one subunit of endoplasmic reticulum (ER)membrane protein complex (EMC),is required for male fertility.EMC10 is significantly decreased in spermatozoa from patients with asthenozoospermia and positively associated with human sperm motility. Male mice lacking Emc10 gene are completely sterile.Emc10-null spermatozoa exhibit multiple defects including abnormal morphology,decreased motility,impaired capacitation,and impotency of acrosome reaction,thereby which are incapable of fertilizing intact or ZP-free oocytes.However,intracytoplasmic sperm injection could rescue this defect caused by EMC10 deletion. Mechanistically,EMC10 deficiency leads to inactivation of Na/K-ATPase,in turn giving rise to an increased level of intraceltutar Na^+ in spermatozoa,which contributes to decreased sperm motility and abnormal morphology.Other mechanistic investigations demonstrate that the absence of EMC10 results in a reduction of HCO3^- entry and subsequent decreases of both cAMP-dependent protein kinase A substrate phosphorylation and protein tyrosine phosphorytation.These data demonstrate that EMC10 is indispensable to mate fertility via maintaining sperm ion balance of Na^+ and HCO3^-,and also suggest that EMC10 is a promising biomarker for male fertility and a potential pharmaceutical target to treat male infertility. | Yuchuan Zhou Fei Wu Man Zhang Zuquan Xiong Qianqian Yin Yanfei Ru Huijuan Shi Jinsong Li Shanhua Mao Yanliang Li Xinyi Cao Renming Hu Chong Wee Liew Qiang Ding Xuanchun Wang Yonglian Zhang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 2 |
| 5 | High prevalence of diabetic neuropathy in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown显示文摘 | Bin Lu Zhihong Yang Mei Wang Zhen Yang Wei Gong Yehong Yang Jie Wen Zhaoyun Zhang Naiqing Zhao Xixing Zhu Renming Hu | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 6 | Aspirin reduces the apoptotic effect of etoposide via Akt activationand up-regulation of p21cip显示文摘 | Xiaocheng Feng Bin Lu Yingying Xu Qin Li Wenbai Zhou Zhihong Yang Zeng Yang Weiwei Zhao Zonghou Shen Renming Hu | 2011 | International Journal of Molecular Medicine2011，，4： | 1 |
| 7 | Effects of berberine on glucose metabolism in vitro显示文摘 | Yin Jun Hu Renming Chen Mingdao | 2002 | Metabolism2002，51，11： | 1 |
| 8 | Efects ofberberine on glucose metabolism in vitro显示文摘 | Jun Y Renming HU | 2002 | Metabolism2002，51，： | 1 |
| 9 | The anorexic effect of Ex4/Fc through GLP-1 receptor activation in high-fat diet fed mice显示文摘Exendin-4 (Ex4 ) ,肽开始在 Gila 怪物的口水发现了,能通过 GLP-1 受体(GLP-1R ) 激活 incretinhormone 象 glucagon 一样 peptide-1 (GLP-1 ) 的发信号的小径。我们以前报导 Ex4 和鼠标 IgG 重链常数区域(Ex4/Fc ) 的怪物 proteinconsisting 能施加 GLP-1 的生物效果,例如在糖尿病的鼠标的 improvingglycemic 控制和改善表明。这研究的目的是决定是否在在老鼠的 modulating 精力动态平衡的 Ex4/Fc iseffective。我们的结果证明在 vivo,由编码 Ex4/Fc 的 plasmid 的肌内的注射的 Ex4/Fc 的表示在喂的高脂肪的节食(HFD ) 在老鼠由本地 electroporation effectivelydecreased 食物吸入列在后面。另外,减少的精力吸入是从 Ex4/Fc-treated HFD 鼠标然而并非 Fc 的减少的排泄物控制的联系 withthe 鼠标。显著地,显示的 Ex4/Fc-treated HFDmice 显著地降低 triglyceride (TG ) 层次什么时候与控制老鼠相比。有趣地,当 theleptin 层次没被改变时,传播 ghrelin 层次比在建议的 Fc 控制 mice.These 结果的那些在 Ex4/Fc 鼠标是更高的那 Ex4/Fc 能在 excessivenutrition 条件下面在鼠标通过 GLP-1R 改进精力新陈代谢和类脂化合物新陈代谢。 | Rui Liu Duan Ma Yiming Li Renming Hu Yongde Peng Qinghua Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 0 |
| 10 | Effects of Y_(2)O_(3) and transition-metal nitrates on phase,microstructures and PL properties of N-containing Ce_(2)Si_(2.5)Al_(0.5)O_(3.5)N_(3.5) melilite显示文摘N-containing Ce_(2)Si_(2.5)Al_(0.5)O_(3.5)N_(3.5)(CeSiAlON) melilite was synthesized at 1550 and 1600℃ for 5 h from CeO_(2),Si,Al,and Al_(2)O_(3) in nitrogen by using Y_(2)O_(3) and transition-metal nitrates(Co(NO_(3))_(2)·6 H_(2) O and Ni(NO_(3))_(2)·6 H_(2)O) as additives.The effects of Y_(2)O_(3) and transition-metal nitrates on the phase,microstructures and photoluminescence properties of CeSiAlON melilite were studied.The incorporation of Y_(2)O_(3) can promote the reaction of raw materials to a low degree,and results in a unit cell shrinkage of CeSiAlON due to the smaller radius of Y atom than that of Ce atom.The transition-metal nitrates can accelerate the reaction clearly and facilitate the formation of CeSiAlON fibers.The photoluminescence(PL) properties of CeSiAlON melilite presents a board violet emission band because of the 5 d-4 f transitions of Ce^(3+),and the additives can enhance the PL emission intensities of specimen significantly. | Meng Zhang Zhihui Hu Zhi Chen Juntong Huang Qingming Xiong Renming Shuai Zhijun Feng Xibao Li | 2021 | Journal of Rare Earths2021，39，10： | 0 |
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