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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 3 | Placental angiogenesis in sheep models of compromised pregnancy 显示文摘 | Reynolds L P Borowicz P P Vonnahme K A | 2005 | The Journal of Physiology2005，，： | 1 |
| 4 | Placental angiogensis in sheep sodels of compromised pregnancy显示文摘 | Reynolds L P Borowicz P P Vonnahme K A | 2005 | The Journal of Physology2005，565，1： | 1 |
| 5 | Fumigation of table grapes with acetic acid to prevent post-harvest decay显示文摘 | Sholberg P L Reynolds A G Gaunce A P | | 0，，12： | 1 |
| 6 | User-Driven acquisitions : Allowing patron requests to drive collection development in an academic library 显示文摘 | Reynolds L Carmelita P vanDuinkerken W | 2010 | Collection Management2010，35，3： | 1 |
| 7 | Expression of the angiogenic factors, basic fibroblast growth factor and vascular endothelial growth factor: inthe ovary显示文摘 | Reynolds L P Redmer D A | 1998 | Anita Sci1998，76，： | 1 |
| 8 | Analytical methods for determining ascorbic acid in biological samples,food products and pharmaceuticals显示文摘 | Reynolds D L Kissinger P T | 1985 | J Assoc Off Anal Chem1985，68，1： | 1 |
| 9 | Plant breeding and drought in C3 cereals:What should we breed for显示文摘 | Araus J L Slafer G A Reynolds M P | 2002 | Ann Bot2002，89，： | 1 |
| 10 | Environmen- tal and genetic risk factors for childhood leukemia: appraising the evidence显示文摘 | BUFFLER P A KWAN M L REYNOLDS P | 2005 | Cancer Invest2005，23，1： | 1 |
| 11 | Character- ization of a divergent VanD-type resistance element from the first glyco- peptide-resistant strain of Enterococcus faecium isolated in Brazil 显示文摘 | DALLA COSTA L M REYNOLDS P E SOUZA H A | 2000 | Antimicrob Agents Chemother2000，44，12： | 1 |
| 12 | Impacts of maternal selenium and nutritional level on growth, adiposity, and glucose tolerance in female offspring in sheep 显示文摘 | Vonnahme K A Luther J S Reynolds L P Hammer C J Carlson D B Redmer D A Caton J S | 2010 | Domestic Animal Endocrinology2010，39，4： | 1 |
| 13 | Advanced subscriber authentication approaches for third generation mobile systems显示文摘 | N L Clarke S M Furnell P L Reynolds | 2002 | IEE 3G mobile communication technologles2002，489，： | 1 |
| 14 | Gap junctional intercellular communication of bovine granulose and thecal cells from antral follicles:effects of luteinizing hormone and follicle-stimulating hormone显示文摘 | Johnson M L Redmer D A Reynolds L P | 2002 | Endocrine2002，18，3： | 1 |
| 15 | Thyroid hormones and cortisol concentrations in offspring are influenced by maternal supranutritional selenium and nutritional plane in sheep 显示文摘 | Vonnahme K A Neville T L Lekatz L A Reynolds L P Hammer C J Redmer D A Caton J S | 2013 | Nutrition and Metabolic Insights2013，6，4： | 1 |
| 16 | Effects of dietary fiber on intestinal growth,cell proliIeration,and morphology in growing pigs显示文摘 | Jin L Reynolds L P Redmer D A | 1994 | J Anim Sci1994，72，： | 1 |
| 17 | Drug interactions evaluation : an integrated part of risk assessment of therapeutics 显示文摘 | Zhang L Reynolds KS Zhao P | 2010 | Toxicol Appl Pharmaco12010，243，2： | 1 |
| 18 | Impacts of maternal selenium supply and nutritional plane on visceral tissues and intestinal biology in 180 - day-old offspring in sheep 显示文摘 | Yuuusova R D Neville T L Vonnahme K A Hammer C J Reed J J Taylor J B Redmer D A Reynolds L P Eaton J S | 2013 | Journal of Animal Science2013，91，5： | 1 |
| 19 | Biodiversity mediates top-down control in eelgrass ecosystems: a global comparative- experimental approach 显示文摘 | Duffy J E Reynolds P L Bostr~Sm C | 2015 | Ecology Letters2015，，8： | 1 |
| 20 | Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of rapamyein (roTOR) signaling pathway in aged skeletal muscle显示文摘 | Reynolds T H 4th Reid P Larkin L M | 2004 | Exp Gerontol2004，39，3： | 1 |
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