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| 1 | 国际生物样本库和网络系统:成功因素和主要预算方案显示文摘概述了分布在欧洲、北美、澳大利亚以及亚洲的16个最大的生物样本库与生物样本信息网络在人类生物样本收集、分发,以及资金的科学运转等方面所采用的方法。这些生物样本库的运转和经济模式取决于他们所在国家和研究所的医学和研究宗旨。生物样本库模式的成功运作取决于各种因素,包括明确的目标,可靠的经营计划,以及具有严格质量控制和操作规范的生物样本收集。 | Jim Vaught Andrea Kelly Robert Hewitt 孙孟红 倪淑娟 杜祥 | 2011 | 医学与哲学(A)2011，32，7： | 8 |
| 2 | Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E.coli显示文摘Background: This experiment was conducted to test the hypothesis that vitamin E(Vit E) and acetylsalicylic acid(ASA), a cyclooxygenase-2(COX-2) inhibitor, will additively reduce the production of the immunosuppressive molecule prostaglandin E_2(PGE_2) and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E. coli.Methods: The experiment was conducted in a research facility with 192 individually-housed male weaner pigs(Landrace × Large White) weighing 6.6 ± 0.04 kg(mean ± SEM). The pigs were experimentally infected with an enterotoxigenic strain of E. coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels of Vit E supplementation(50, 100 or 200 IU/kg diet, dl-α-tocopheryl acetate).Results: Acetylsalicylic acid supplementation improved average daily gain(P < 0.05) and tended to improve feed:gain ratio(P < 0.10) during the first 14 d after weaning. Acetylsalicylic acid supplementation also improved(P < 0.001) amino acid utilization efficiency(as assessed by plasma urea level) and tended to decrease(P < 0.10) PGE_2 production in the liver without affecting smal intestinal histology and tight junction protein mR NA expression in the jejunal epithelium. Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration(P < 0.001) and plasma haptoglobin content(P < 0.001) after weaning. However, there was no additive effects of the combined supplementation of ASA and Vit E on performance, intestinal barrier function and inflammatory responses of weaned pigs.Conclusions: Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses, ASA and vitamin E did not additively reduce production of PGE_2 and inflammatory responses in weaner pigs experimental y infected with an enterotoxigenic strain of E. coli. | Jae Cheol Kim Bruce P. Mullan John L. Black Robert J. E. Hewitt Robert J. van Barneveld John R. Pluske | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 3 | Anopheline vectors and malaria transmission in eastern Afghanistan显示文摘 | Mark Rowland Nasir Mohammed Hameed Rehman Sean Hewitt Chandana Mendis Mushtaq Ahmad Mohammed Kamal Robert Wirtz | 2002 | Transactions of the Royal Society of Tropical Medicine and Hygiene2002，，6： | 1 |
| 4 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME显示文摘 | Patricio Godoy Nicola J. Hewitt Ute Albrecht Melvin E. Andersen Nariman Ansari Sudin Bhattacharya Johannes Georg Bode Jennifer Bolleyn Christoph Borner Jan B?ttger Albert Braeuning Robert A. Budinsky Britta Burkhardt Neil R. Cameron Giovanni Camussi Chong | 2013 | Archives of Toxicology2013，，8： | 1 |
| 5 | A direct synthsis of 2'-deoxyadenosine and its anomer through 2-deoxy-d-ribose deriatives显示文摘 | Robert K Ness Hewitt G Fletcher JR | 1960 | J Am Chem Soc1960，82，： | 1 |
| 6 | An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers显示文摘 | Lee Terence K Murthy Saravana R K Cawley Niamh X Dhanvantari Savita Hewitt Stephen M Lou Hong Lau Tracy Ma Stephanie Huynh Thanh Wesley Robert A Ng Irene O Pacak Karel Poon Ronnie T Loh Y Peng | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 7 | Wheat leaf rust resistance gene Lr13 is a specific Ne2 allele for hybrid necrosis显示文摘Dear Editor,Wheat leaf rust,caused by Puccinia triticina(Pt),is a destructive fungal disease of wheat globally.Host resistance(R)genes are widely studied as a means to combat disease.Lr13 is regarded as one of the most widely distributed leaf rust R genes in wheat(McIntosh et al.,1995).Researchers observed that lines carrying Lr13 consistently gave hybrid necrosis in specific crosses. | Timothy Hewitt Jianping Zhang Li Huang Narayana Upadhyaya Jianbo Li Robert Park Sami Hoxha Robert McIntosh Evans Lagudah Peng Zhang | 2021 | Molecular Plant2021，14，7： | 0 |
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