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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Utilization of sugar cane bagasse hemicellulosic hydrolyzate by Pichia stipitis for the production of ethanol显示文摘 | Roberto I C Lacis L S Barbosa M F S | 1991 | Proc Biochem1991，26，1： | 1 |
| 4 | Thermogravimetric studies on the effect of support in sorbent-materials applied to flue gas desulfurization 显示文摘 | ROBERTO F ARTURO R CINTHYA P YULIANA M XOCHITL M LAURA G | 2008 | Fuel2008，87，： | 1 |
| 5 | Assessment of nutritional status in free living elderly individuals by bioelectrical impedance vector analysis 显示文摘 | Roberto B 6iovanni F Elisabetta M | 2009 | btrition2009，25，： | 1 |
| 6 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Ionic profile of honey as a potential indicator of botanical origin and global environmental pollution显示文摘 | Paola F Gianggiacomo B Roberto M F | 2013 | Environmental pollution2013，178，： | 1 |
| 9 | Effec- tiveness of hydroehlorothiazide in combination with telmisartan and olmesartan in adults with moderate hypertension not controlled with monotherapy: a prospective, randomized, open-label, blinded end point (PROBE), parallel-arm study显示文摘 | Roberto F Annalisa Z Amedeo M | 2008 | Curr Ther Res2008，1，69： | 1 |
| 10 | Utilization of sugar cane baggasse hemicellulose hydrolysate by Pichia stipitis for the production of ethanol显示文摘 | Roberto I C Lacis L S Barbosa M F S | 1991 | Proc Biochem1991，26，1： | 1 |
| 11 | TBD-catalysed solventless synthesis of symmetrically N,N' substituted ureas from primary amines and diethyl carbonate显示文摘 | Roberto B Dennis F Raimondo M | 2003 | Green Chemistry2003，5，： | 1 |
| 12 | Solid- state fermentation for xylanase production by Thermoascus aurantiacus using response surface methodology显示文摘 | Souza M C de O Roberto I C Milagres A M F | 1999 | Appl Microbiol Biotechnol1999，52，6： | 1 |
| 13 | Assessmentof nutritional status in free-living elderlyindividuals by bioelectrical impedance vector analysis显示文摘 | Roberto B Giovanni F Elisabetta M | 2009 | Nutrition2009，25，1： | 1 |
| 14 | Curcumin,an antioxidant and anti-inflammatory agent,induces heme oxygenase-1 and protects endothelial cells against oxidative stress显示文摘 | ROBERTO M ROBERTA F REKHA B C | 2000 | Free Rad Bio Med2000，28，8： | 1 |
| 15 | Implementing lecane quadridentata acute toxicity tests to assess the toxic effects of selected metals(Al,Fe and Zn)显示文摘 | Félix T G Francisco F J Roberto R M | 2010 | Ecotoxicology and Environmental Safety2010，73，28： | 1 |
| 16 | Single solid phaseextraction method for the simultaneous analysis of polar and nonpolarpesticides in urine samples by gas chromatography and ultrahigh pressure liquid chromatography coupled to tandem massspectrometry显示文摘 | Rocío C R JoséL F M Roberto R G | 2011 | Talanta2011，85，18： | 1 |
| 17 | Simultaneous extraction of polycyclic aromatic hydrocarbons and polychlorinated biphenyls in agricultural soils by pressurized liquid extraction显示文摘 | MRT(I)NEZ V J L GARRIDO F A BARCO BONILLA M D L N ROBERTO R G S(A)NCHEZ J A P | 2009 | Anal Bioanal Chem2009，395，5： | 1 |
| 18 | Note on Ranking Fuzzy Triangular Numbers显示文摘 | Gisella F Roberto G Silvia M | 1998 | International Jour- nal of Intelligent Systems1998，13，7： | 1 |
| 19 | Evaluation of a GFP reporter gene construct for environmental arsenic detection显示文摘 | ROBERTO F F BARNES J M BRUHN D F | 2002 | Talanta2002，58，1： | 1 |
| 20 | Glottal source biometricalsignature for voice pathology detection显示文摘 | PEDRO G V ROBERTO F B VICTORIA R B VICTOR N L AGUSTIN A M LUIS M M F RAFAEL M O JUAN I G L | 2009 | Speech Communication2009，51，9： | 1 |
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