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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy显示文摘AIM: To investigate the characteristics of mucosal le-sions and their relation to laboratory data and long-term follow up in breast-fed infants with allergic colitis. METHODS: In this study 31 breast-fed infants were prospectively evaluated (mean age, 17.4 wk) whose rectal bleeding had not ceased after a maternal elimi-nation diet for cow's milk. Thirty-four age-matched and breast-fed infants (mean age, 16.9 wk) with no rectal bleeding were enrolled for laboratory testing as con-trols. Laboratory findings, colonoscopic and histological characteristics were prospectively evaluated in infants with rectal bleeding. Long-term follow-up with differ-ent nutritional regimes (L-amino-acid based formula or breastfeeding) was also included. RESULTS: Iron deficiency, peripheral eosinophilia andthrombocytosis were significantly higher in patients with allergic colitis in comparison to controls (8.4±3.2 μmol/L vs 13.7±4.7 μmol/L, P<0.001; 0.67±0.49 G/L vs 0.33±0.17 G/L, P<0.001; 474±123 G/L vs 376±89 G/L, P<0.001, respectively). At colonosco-py, lymphonodular hyperplasia or aphthous ulceration were present in 83% of patients. Twenty-two patients were given L-amino acid-based formula and 8 contin-ued the previous feeding. Time to cessation of rectal bleeding was shorter in the special formula feeding group (mean, 1.4 wk; range, 0.5-3 wk) when com-pared with the breast-feeding group (mean, 5.3 wk; range, 2-9 wk). Nevertheless, none of the patients ex-hibited rectal bleeding at the 3-mo visit irrespective of the type of feeding. Peripheral eosinophilia and cessa-tion of rectal bleeding after administration of elemental formula correlated with a higher density of mucosal eosinophils. CONCLUSION: Infant hematochezia, after cow's milk allergy exclusion, is generally a benign and probably self-limiting disorder despite marked mucosal abnor-mality. Formula feeding results in shorter time to cessa-tion of rectal bleeding; however, breast-feeding should not be discouraged in long-lasting hematochezia. | Kriszta Molnár Petra Pintér Hajnalka Gyrffy ron Cseh Katalin Eszter Müller András Arató Gábor Veres | 2013 | World Journal of Gastroenterology2013，19，24： | 3 |
| 3 | Pathogen- induced programmed cell death in tobacco 显示文摘 | Ron M Lee S Eric L | 1997 | Joumal of Ceil Science1997，110，： | 1 |
| 4 | Influence of high temperature on development of flower buds from the visible bud stage to anthesis of Lilium longiflorum Thunb显示文摘 | RON M S | 1973 | Holt Science1973，，： | 1 |
| 5 | The prevalence of treatable left ventricular systolic dysfunction in patients who present with noncardiac vascular episodes:a case-control study显示文摘 | Anthony S Ron M W | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 6 | Mechanistic virtual modeling: coupling a plant simulation model with a three-dimensional plant architecture component显示文摘 | ERIC J RON S PIERRE M | 2009 | Environmental Modeling and Assessment2009，14，1： | 1 |
| 7 | Genetic study of the CD36 gene In a French diabetic population显示文摘 | F Leprêtre KJ Linton C Lacquemant V Vatin C Samson C Dina M Chikri S Ali P Scherer K Séron F Vasseur T Aitman P Froguel | 2004 | Diabetes and Metabolism2004，，5： | 1 |
| 8 | Spotlight Synthetic Aperture Radar Signal Processing Algorithms显示文摘 | Walter G Goodman C Ron S Majewski R M | 1995 | Artech House1995，，： | 1 |
| 9 | Calcium Distribution in the Vessel Wall and Intima-Media Thickness of the Human Carotid Arteries显示文摘 | Mária Tünde Magyar Zita Szikszai Zsófia Kertész Sándor Molnár Imre Uzonyi Gusztáv áron Szíki László Csiba | 2007 | Ultrasound in Medicine & Biology2007，，8： | 1 |
| 10 | Methotrexate in chronic active ulcerative colitis: A double-blind, randomized, Israeli multicenter trial显示文摘 | R Oren N Arber S Odes M Moshkowitz D Keter I Pomeranz Y Ron I Reisfeld E Broide A Lavy A Fich R Eliakim J Patz E Bardan Y Villa T Gilat | 1996 | Gastroenterology1996，，： | 1 |
| 11 | Seed germination of Lilium × formolongi as influenced by temperature and plant growthregulators显示文摘 | Ron M S Yong G S | 1996 | ActaHort1996，414，： | 1 |
| 12 | Real Exchange Rate Effects on the Balance of Trade:Cointegration and the Marshall-Lerner Condition显示文摘 | BOYD D CAPORALE G M RON S | | 0，，03： | 1 |
| 13 | Event specific real-time quantitative PCR for genetically modified Bt11 maize (Zea mays)显示文摘 | ROnning S B Vatilingom M Berdal K G | 2003 | European Food Research Technology2003，216，： | 1 |
| 14 | Additional aroma components of honeydew melon显示文摘 | RON G B RICHARD M S LOUISA C | 1982 | J Agric Food Chem1982，30，6： | 1 |
| 15 | Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas 显示文摘 | Ben T G G Colin F M Ron M S | 2002 | Mar Environ Res2002，54，： | 1 |
| 16 | The binding mode of human nucleoside diphosphate kinase B to single-strand DNA显示文摘 | Agou F Raveh S Véron M | 2000 | J Bioenerg Biomembr2000，32，3： | 1 |
| 17 | Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo显示文摘 | Cousin B Ravet E Poglio S De Toni F Bertuzzi M Lulka H Touil I André M Grolleau JL Péron JM Chavoin JP Bourin P Pénicaud L Casteilla L Buscail L Cordelier P | | 0，，： | 1 |
| 18 | Event specific real-time quantitative PCR for genetically modified Bt11 maize ( Zea mays ) 显示文摘 | Ronning S B Vaitilingom M Berdal K G | 2003 | Euro Food Res Technol2003，216，4： | 1 |
| 19 | Event specific real-time quantitative PCR for genetically modified Btll maize ( Zea mays) 显示文摘 | Ronning S B Vaitilingom M Berdal K G | 2003 | European Food Research and Technology2003，216，： | 1 |
| 20 | 查看详情显示文摘 | Ron I Sepunaru L Itzhakov S Belenkova T Friedman N Pecht I Sheves M Cahen D | | 0，，： | 1 |
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