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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | A deep learning-enabled portable imaging flow cytometer for cost-effective, highthroughput, and label-free analysis of natural water samples显示文摘We report a deep learning-enabled field-portable and cost-effective imaging flow cytometer that automatically captures phase-contrast color images of the contents of a continuously flowing water sample at a throughput of 100 mL/h.The device is based on partially coherent lens-free holographic microscopy and acquires the diffraction patterns of flowing micro-objects inside a microfluidic channel.These holographic diffraction patterns are reconstructed in real time using a deep learning-based phase-recovery and image-reconstruction method to produce a color image of each micro-object without the use of external labeling.Motion blur is eliminated by simultaneously illuminating the sample with red,green,and blue light-emitting diodes that are pulsed.Operated by a laptop computer,this portable device measures 15.5 cm×15 cm×12.5 cm,weighs 1 kg,and compared to standard imaging flow cytometers,it provides extreme reductions of cost,size and weight while also providing a high volumetric throughput over a large object size range.We demonstrated the capabilities of this device by measuring ocean samples at the Los Angeles coastline and obtaining images of its micro-and nanoplankton composition.Furthermore,we measured the concentration of a potentially toxic alga(Pseudo-nitzschia)in six public beaches in Los Angeles and achieved good agreement with measurements conducted by the California Department of Public Health.The cost-effectiveness,compactness,and simplicity of this computational platform might lead to the creation of a network of imaging flow cytometers for largescale and continuous monitoring of the ocean microbiome,including its plankton composition. | Zoltán Gӧrӧcs Miu Tamamitsu Vittorio Bianco Patrick Wolf Shounak Roy Koyoshi Shindo Kyrollos Yanny Yichen Wu Hatice Ceylan Koydemir Yair Rivenson Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 14 |
| 3 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 4 | 生物相容性量子点的表征及其在细胞标记中的应用显示文摘利用无机低温水相合成法制备表面包覆L-半胱氨酸的CdTe/ZnTe核壳型量子点,测量不同溶液以及激发功率激光作用下该量子点的光谱特性。结果表明,该量子点吸收谱和荧光光谱峰值位置不随pH值变化,而荧光光强随pH值升高呈近似线性上升趋势;不同缓冲液对该量子点荧光光强无影响,但随孵育时间延长,荧光强度略有下降;在强激光照射下QDs会被快速光漂白,选择适当的激光功率(<100μW),可降低漂白速率,实现长时间稳定测量。因此,该量子点具有较好的生物稳定性和光稳定性,将其与血铁蛋白相连形成靶向共轭纳米粒,可成功用于HeLa细胞标记。细胞内量子点光漂白实验表明,细胞微环境会影响量子点的光稳定性,加速量子点的光漂白。 | 刘夏 陈丹妮 屈军乐 杨坚泰 罗永祥 Roy Indrajit 王晓梅 林晓潭 钟磊 Prasad N Paras 许改霞 牛憨笨 | 2010 | 光谱学与光谱分析2010，30，5： | 4 |
| 5 | Atmospheric pressure gliding arc discharge plasma treatments for improving germination, growth and yield of wheat显示文摘Wheat(Triticum aestivum) seeds were treated with atmospheric pressure gliding arc discharge plasmas to investigate the effects on water absorption, seed germination rate, seedling growth and yield in wheat. The surface architectures and functionalities of the seeds were found to modify due to plasma treatments. 6 min treatment was provided 95%–100% germination rate.For the treatment duration of 3 and 9 min the growth activity, dry matter accumulation, leaves chlorophyll contents, longest spikes, number of spikes/spikelet and total soluble protein content in shoots were improved. The grain yield of wheat was increased ~20% by 6 min treatment with H_2O/O_2 plasma with respect to control. | N C ROY M M HASAN A H KABIR M A REZA M R TALUKDER A N CHOWDHURY | 2018 | Plasma Science and Technology2018，20，11： | 2 |
| 6 | Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites显示文摘 | Marie Vos Bénédicte Vroey Béatrice Garcia Garcia Clothilde Roy Fran?ois Kidd Jean Henrion Pierre Deltenre | 2013 | Liver Int2013，，9： | 2 |
| 7 | Expression of human gelatinase B in Pichia pastoris显示文摘 | Roy N Padmanabhan S Smith M | 1999 | Protein Expression Purefication1999，16，： | 2 |
| 8 | Surgical and psychosocial outcomes in the rural injured: a follow-up study of the 2001 earthquake victims 显示文摘 | Roy N Shah H Pard V | 2005 | Injury2005，36，8： | 1 |
| 9 | Flow and particle paths at a natural river confluence with coarse bed material显示文摘 | Roy A G Bergeron N | 1990 | Geomorphology1990，3，1： | 1 |
| 10 | Impact of trimalleolar an- kle fractures: how do patients fare post -operatively显示文摘 | Hong CC Nashi N Prosad Roy S | 2014 | Foot An- kle Surg2014，20，1： | 1 |
| 11 | Function to form mapping:model,representation and applications in design synthesis显示文摘 | Roy U Pramanika N Sudarsanb R etal | 2001 | Computer Aided Design2001，33，10： | 1 |
| 12 | Spatial analysis of trace element contamination in sediments of Tamir- aparani estuary, southeast coast of India 显示文摘 | MAGESH N S CHANDRASEKAR N VETHA ROY D | 2011 | Estuarine Coastal and Shelf Science2011，92，4： | 1 |
| 13 | Modifications of carbon for polymer composites and nanocomposites显示文摘 | Roy N Sengupta R Bhowmick A K | | 0，，6： | 1 |
| 14 | Cancer-induced alterations of NK mediated target recognition: current and investigational pharmacological strategies aiming at restoring NK-mediated anti- tumor activity显示文摘 | Chretien AS Le Roy A Vey N | 2014 | Front Immunol2014，20，5： | 1 |
| 15 | Boundary Shear Distribution inOpen Channel Flow显示文摘 | GHOSH S N ROY N | 1970 | Journal of Hydraulics Division ASCE1970，96，4： | 1 |
| 16 | Congenital Heart Surgery Nomencla- ture and Database Project: Pulmonary Atresia-Ventrieular Septal Defect显示文摘 | Tehervenkov CI Roy N | 2000 | Ann Thorac Surg2000，69，： | 1 |
| 17 | Role of graphene/metal oxide composites as photocatalysts , adsorbents and disinfectants in water treatment: a review显示文摘 | Upadhyay R K Soin N Roy S S | 2014 | RSC Adv2014，4，： | 1 |
| 18 | Non-thermal effects of microwaves on protease-catalyzed esterifi cation and transesteri? cation 显示文摘 | Roy I Munishwar N G | 2003 | Tetrahedron2003，59，： | 1 |
| 19 | Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicin-resistant human hepatocellular-carcinoma cell line HepG2显示文摘 | ROY K R ARUNASREE K M REDDY N P | 2007 | Biotcclmol Appl Biochem2007，47，3： | 1 |
| 20 | Toward the development of an objective index ofdysphonia severity:a four-factor acoustic model显示文摘 | Awan SN Roy N | 2006 | Clin LinguistPhon2006，20，1： | 1 |
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