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| 1 | The divergent roles of autophagy in ischemia and preconditioning显示文摘 | Rui SHENG Zheng-hong QIN | 2015 | Acta Pharmacologica Sinica2015，36，4： | 25 |
| 2 | Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway显示文摘Our previous study shows that nicotinamide adenine dinucleotide phosphate(NADPH)plays an important role in protecting against cerebral ischemia injury.In this study we investigated whether NADPH exerted cardioprotection against myocardial ischemia/reperfusion(I/R)injury.To induce myocardial I/R injury,rats were subjected to ligation of the left anterior descending branch of coronary artery for 30 min followed by reperfusion for 2 h.At the onset of reperfusion,NADPH(4,8,16 mg·kg?1·d?1,iv)was administered to the rats.We found that NADPH concentrations in plasma and heart were signi?cantly increased at 4 h after intravenous administration.Exogenous NADPH(8?16 mg/kg)signi?cantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase(LDH)and cardiac troponin I(cTn-I).Exogenous NADPH signi?cantly decreased the apoptotic rate of cardiomyocytes,and reduced the cleavage of PARP and caspase-3.In addition,exogenous NADPH reduced mitochondrial vacuolation and increased mitochondrial membrane protein COXIV and TOM20,decreased BNIP3L and increased Bcl-2 to protect mitochondrial function.We conducted in vitro experiments in neonatal rat cardiomyocytes(NRCM)subjected to oxygen–glucose deprivation/restoration(OGD/R).Pretreatment with NADPH(60,500 nM)signi?cantly rescued the cell viability and inhibited OGD/R-induced apoptosis.Pretreatment with NADPH signi?cantly increased the phosphorylation of AMPK and downregulated the phosphorylation of mTOR in OGD/R-treated NRCM.Compound C,an AMPK inhibitor,abolished NADPH-induced AMPK phosphorylation and cardioprotection in OGD/R-treated NRCM.In conclusion,exogenous NADPH exerts cardioprotection against myocardial I/R injury through the activation of AMPK/mTOR pathway and inhibiting mitochondrial damage and cardiomyocyte apoptosis.NADPH may be a potential candidate for the prevention and treatment of myocardial ischemic diseases. | Jiang Zhu Yi-fei Wang Xiao-ming Chai Ke Qian Ling-wei Zhang Peng Peng Pei-min Chen Jian-fang Cao Zheng-hong Qin Rui Sheng Hong Xie | 2020 | Acta Pharmacologica Sinica2020，41，4： | 19 |
| 3 | The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning显示文摘 | Bo GAO Xiang-yang ZHANG Rong HAN Tong-tong ZHANG Cheng CHEN Zheng-hong QIN Rui SHENG | 2013 | Acta Pharmacologica Sinica2013，34，5： | 19 |
| 4 | Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘 | Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun | 2018 | Asian Journal of Andrology2018，20，5： | 18 |
| 5 | Curcumin improves learning and memory ability and its neuroprotective mechanism in mice显示文摘背景增加证据建议许多神经原可以在 Alzheimer 的疾病(广告) 通过 apoptosis 死 .Mitochondrial 机能障碍在 neuronal 房间死亡的这个过程被含有。为阻止广告的一条有希望的途径在 anti-apoptosis 之上被基于到神经细胞的减少死亡。在这研究,我们观察了在老鼠改进 curcumin 的性质的记忆并且 intraperitoneally 在 vitro 并且在老鼠口头上地被给 AlCl3 的 vivo.Methods 和 D 半乳糖的注射调查了 curcumin 的 neuroprotective 效果 90 天建立 AD 动物模型。从白天 45, curcumin 组与 curcumin 被对待 45 天。随后,走彻底地测试,在马头鱼尾的怪兽的 neuropathological 变化和 Bax 和 Bcl-2 的表达式被执行在 AD 模型鼠标上评估 curcumin 的效果。在有教养的 PC12 房间, AlCl3 暴露导致了 apoptosis。MTT 试金被用来测量房间生存能力;流动 cytometric 分析将调查房间 apoptosis 的率;观察原子核的DNA有约束力的 fluorochrome Hoechst 33258 在 apoptotic 房间和 Bax 的西方的污点分析变化,调查 curcumin 显著地由保护房间免受 toxicity.Results Curcumin 的伤害的机制的 Bcl-2 在走彻底地测试改进了广告老鼠的记忆能力,是由走彻底地错误的减少的数字显示了( P < 0.05 )并且延长走彻底地潜伏( P < 0.05 )。Curcumin 也稀释了在马头鱼尾的怪兽和禁止的 apoptosis 的变化由 Bcl-2 水平的增加伴随了的 neuropathological (P < 0.05 ) ,但是 Bax 的活动没变化(P > 0.05 ) 。AlCl3 显著地减少了 PC12 房间的生存能力(P < 0.01 ) 。Curcumin 面对 AlCl3 增加了房间生存能力(P < 0.01 ) 。apoptosis 的率在 curcumin 组显著地减少了(P < 0.05 ) 当由流动 cytometric 分析测量了时。Curcumin 由增加 Bcl-2 水平保护了房间(P < 0.05 ) ,但是 Bax 的水平没变化(P > 0.05 ) 这研究表明的 .Conclusions curcumin 改进广告鼠标的存储器能力并且在有教养的 PC12 房间禁止 apoptosis,这由 AlCl3 导致了。它的机制可以涉及提高 Bcl-2 的水平。 | PAN Rui QIU Sheng LU Da-xiang DONG Jun | 2008 | Chinese Medical Journal2008，，9： | 14 |
| 6 | Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities. | LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 7 | Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation显示文摘目的: 由禁止白细胞 adhesion.Methods 调查白果树 biloba 叶子(PGBL ) 的多糖的反煽动性的机制: 不平的 PGBL 被孤立并且净化。净化的 PGBL (p-PGBL ) 的反煽动性的效果是由混合二甲苯和急性腹膜炎模型在老鼠导致的耳朵浮肿的 assayed。禁止在 P-selectin 和它的 ligands 之间的相互作用上的 p-PGBL 的效果被流动血细胞计数调查,流动 chamber.Results:p-PGBL 能有效地处于静态的条件与对 P-selectin 的 HL-60 房间,一根人的白血球过多症房间线,或 neutrophils 的粘附在老鼠和interfere 禁止急性炎,象到在一个剂量家属处于流动条件表示人的 P-selectin 和人的脐的静脉 endothelial 的中国仓鼠卵巢房间的 neutrophils 的粘附一样, manner.Conclusions:p-PGBL 能通过防碍在 P-selectin 和它的 ligands 之间的相互作用禁止煽动性的过程。 | Rui EEI Yu EEI Sheng ZHENG Yan-guang GAO Hong-xia SUN Xian-lu ZENG | 2008 | Acta Pharmacologica Sinica2008，29，4： | 12 |
| 8 | Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia显示文摘瞄准:热吃惊蛋白质(HSP ) 是细胞的幸存的重要管理者并且对服的局部缺血施加 neuroprotective 效果。前列腺素 El (PGE1 ) 和锂被报导了保护神经原免于是化学家损害。如果锂能加强,现在的学习被承担检验对服的局部缺血的 PGE1 的 neuroprotection,并且如果合作效果发生在 HSP 的水平。方法:大脑局部缺血被永久中间的服的动脉吸藏(pMCAO ) 在老鼠导致。老鼠立即是有为 2 d 和 PGE1 的一个单个静脉内的政府的锂的下的注射的 pretreated 在以后化学家侮辱。每个组的 Cerebrocortical 血流动仔细在外科的操作以后在局部缺血, 5 min, 15 min, 30 min 和 60 min 的发作以前被监视。身体温度以前被测量,在 pMCAO 的发作以后的 5 min, 2 h 和 24 h。梗塞体积,大脑浮肿和马达行为赤字被分析 24 h 在以后化学家侮辱。Cytoprotective HSP70 并且他我在 ipsilateral 半球的条纹弦音器的 oxygenase-1 (HO-1 ) 被弄污的免疫检测。从 ipsilateral 半球的条纹弦音器的大脑节是有 anti-HSP70 抗体和 4,6-diamidino-2-phenylindole (DAPI ) 的双 labeled。结果:有 PGE1 的处理(8 和 16 μg/kg, iv ) 或锂(0.5 mEq/kg, sc ) 独自减少的梗塞体积,神经病学的赤字和大脑浮肿在老鼠由焦点的服的局部缺血导致了。而且,当 PGE1 和锂一起被给时,更大的 neuroprotection 被观察。显著地,在调整 cytoprotective 上面, HSP70 和 HO-1 蛋白质铺平的 PGE1 和锂的合作管理。结论:锂和 PGE1 可以在服的局部缺血的处理施加 synergistic 效果并且可以因此为击的处理有潜在的临床的价值。 | Rong HAN Bo GAO Rui SHENG Li-sha ZHANG Hui-lin ZHANG Zhen-lun GU Zheng-hong QIN | 2008 | Acta Pharmacologica Sinica2008，29，10： | 10 |
| 9 | Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells显示文摘目的:从鼠尾草植物 miltiorrhiza 和 Paeoniae radix.Methods 的水溶性的混合物调查 Chi-Shenextract ( CSE )的 antihepatocellular 癌效果: HepG2 房间( hepatocellular 癌房间线)的生长上的 CSE 的 Theeffect 被学习by3-( 4,5 ) -2,5-diphenyltetrazohum 溴化物 assay.Apoptosis 通过氮蒽橘子( AO )被检测并且染色的乙烯 dibromide ( EB )和 DNA 破碎试金。房间周期 ofHepG2 房间上的 CSE 的效果被染色方法的 propidium 碘化物学习。caspases-3 的激活, -8and-9 被免疫分析工具包检验。Bcl-2 家庭和 p53 的抄写是检测 byRT-PCR.Results : 我们的数据表明 CSE 强烈在导致 manner.CSE 的房间死亡被考虑是由观察 typicalapoptotic 的 apoptotic 的 dose-andtime-dependent 导致了 HepG2 房间死亡由 AO/EB 染色和 DNA 破碎试金的词法变化。 HepG2cell 死亡的正式就职被 apoptosis 的正式就职为 sub-G1 比例增加引起, Bcl-2 的 thedownregulation ,起来 Bax 和 p53 的规定,并且 caspases-3 and-9pathways.Conclusion 的激活:这些结果清楚地证明 CSE 能禁止 HepG2 房间和原因 apoptosis.Moreover 的增长, CSE 的反癌症效果与 Bcl-2 家庭小径和在 HepG2 房间的 caspases-3 and-9 的激活有关。 | Sheng HU Shi-min CHEN Xiao-kuan LI Rui QIN Zhi-nan MEI | 2007 | Acta Pharmacologica Sinica2007，28，8： | 10 |
| 10 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 11 | EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats显示文摘为了在 pressureoverload 和氢过氧化物( H_2O_2 )上调查 epigallocatechin gallate ( EGCG )的效果,导致了心脏的 myocyte apoptosis.Methods : Cardiachypertrophy 被腹的大动脉的 constriction.EGCG 在老鼠建立 25,50 和 100 mg/kg wereadministered intragastrically ( ig ) .Cultured 新生儿老鼠 cardiomyocytes 是 preincubated withEGCG ,并且氧化压力损害被 H_2O_2.Results 导致:在 ACin 老鼠导致的心脏的肥大相对模型组, EGCG 25,50 和 100 | Rui SHENG Zhen-lun GU Mei-lin XIE Wen-xuan ZHOU Ci-yi GUO | 2007 | Acta Pharmacologica Sinica2007，28，2： | 9 |
| 12 | Clinical Application of Loewenstein Occupational Therapy Cognitive Assessment Battery-Second Edition in Evaluating of Cognitive Function of Chinese Patients with Post-stroke Aphasia显示文摘Objective To investigate the clinical application value of Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)battery in Chinese patients with post-stroke aphasia.Methods Cognitive functions of 59 Chinese patients with aphasia following a stroke were assessed with the Chinese version of the second edition of LOTCA battery and their linguistic functions were tested with the Western Aphasia Battery(WAB)Scale,respectively.The results of LOTCA were analyzed and compared across different groups,in the light of gender,age,educational background,the length of illness,and the degree of aphasia.Results Neither the score of subtests of the LOTCA nor the overall scores of LOTCA of aphasia patients with different gender and educational background differed(all P>0.05).In different age groups,apart from thinking operation(F=3.373,P=0.016),visuomotor organization(F=3.124,P=0.022),attention(F=3.729,P=0.009)and the total score(F=2.683,P=0.041),there was no difference in terms of the other subtest scores of LOTCA(all P>0.05).In the groups of different length of time with illness,apart from orientation(F=2.982,P=0.039)and attention(F=3.485,P=0.022),the score of other subtests and the total score of LOTCA were not different(all P>0.05).In the groups of different degree of aphasia,apart from attention(F=2.061,P=0.074),both the score of other subtests and the total score of LOTCA differed(all P<0.05).Conclusion LOTCA might be suitable to assessing the cognitive ability of post-stroke Chinese patients with aphasia. | Zeng-zhi Yu Shu-jun Jiang Jun Li Sheng Bi Fei Li Tao Xie Rui Wang Xiao-tan Zhang | 2013 | Chinese Medical Sciences Journal2013，28，3： | 9 |
| 13 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 14 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 15 | Distribution characteristics of poly-and perfluoroalkyl substances in the Yangtze River Delta显示文摘In this work, a method was developed and optimized for the analysis of polyfluoroalkyl and/or perfluoroalkyl substances(PFASs) content in surface water and sediment samples with high instrumental response and good separation. Surface water and sediment samples were collected from the Yangtze River Delta(YRD) to analyze the distribution characteristics of perfluoroalkyl carboxylic acids(PFCAs), perfluoroalkane sulfonic acids(PFSAs), perfluoroalkyl phosphonic acids(PFPAs), perfluoroalkyl phosphinic acids(PFPiAs), and polyfluoroalkyl phosphoric acid diesters(di PAPs). The results showed that the total concentrations of PFCAs and PFSAs in YRD varied from 31 to 902 ng/L. PFCAs(≥ 11 carbons) and PFSAs(≥ 10 carbons atoms) were not detected in any surface water samples. The mean concentrations of all PFCAs and PFSAs in surface water from the sampling areas decreased in the following order:Yangtze river(191 ng/L) ≈ Taihu lake(189 ng/L) > Huangpu river(122 ng/L) ≈ Qiantang river(120 ng/L) > Jiaxing urban river(100 ng/L). Strong significant(p < 0.05) correlations between the concentrations of many of the compounds were found in the sampling areas, suggesting a common source for these compounds. Only perfluorooctanoic acid(PFOA) was observed in all sediment samples, at concentrations varying from 0.02 to 1.35 ng/g. Finally, detection rates of two di PAPs were only 8% and 10%, respectively and the concentration of di PAPs was two to three times lower compared to PFCAs and PFSAs. | Binghui Zheng Xiaolei Liu Rui Guo Qing Fu Xingru Zhao Shanjun Wang Sheng Chang Xing Wang Mengjiao Geng Guang Yang | 2017 | Journal of Environmental Sciences2017，29，11： | 8 |
| 16 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 17 | Behavioral Abnormality along with NMDAR-related CREB Suppression in Rat Hippocampus after Shortwave Exposure显示文摘Objective To estimate the detrimental effects of shortwave exposure on rat hippocampal structure and function and explore the underlying mechanisms. Methods One hundred Wistar rats were randomly divided into four groups(25 rats per group) and exposed to 27 MHz continuous shortwave at a power density of 5, 10, or 30 m W/cm^2 for 6 min once only or underwent sham exposure for the control. The spatial learning and memory, electroencephalogram(EEG), hippocampal structure and Nissl bodies were analysed. Furthermore, the expressions of N-methyl-D-aspartate receptor(NMDAR) subunits(NR1, NR2 A, and NR2 B), c AMP responsive element-binding protein(CREB) and phosphorylated CREB(p-CREB) in hippocampal tissue were analysed on 1, 7, and 14 days after exposure. Results The rats in the 10 and 30 m W/cm^2 groups had poor learning and memory, disrupted EEG oscillations, and injured hippocampal structures, including hippocampal neurons degeneration, mitochondria cavitation and blood capillaries swelling. The Nissl body content was also reduced in the exposure groups. Moreover, the hippocampal tissue in the 30 m W/cm^2 group had increased expressions of NR2 A and NR2 B and decreased levels of CREB and p-CREB. Conclusion Shortwave exposure(27 MHz, with an average power density of 10 and 30 m W/cm^2) impaired rats' spatial learning and memory and caused a series of dose-dependent pathophysiological changes. Moreover, NMDAR-related CREB pathway suppression might be involved in shortwave-induced structural and functional impairments in the rat hippocampus. | YU Chao BAI Yan Xin XU Xin Ping GAO Ya Bing HAO Yan Hui WANG Hui TAN Sheng Zhi LI Wen Chao ZHANG Jing YAO Bin Wei DONG Ji ZHAO Li PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，3： | 7 |
| 18 | Real-time Microwave Exposure Induces Calcium Efflux in Primary Hippocampal Neurons and Primary Cardiomyocytes显示文摘Objective To detect the effects of microwave on calcium levels in primary hippocampal neurons and primary cardiomyocytes by the real-time microwave exposure combined with laser scanning confocal microscopy. Methods The primary hippocampal neurons and primary cardiomyocytes were cultured and labeled with probes, including Fluo-4 AM, Mag-Fluo-AM, and Rhod-2, to reflect the levels of whole calcium [Ca^(2+)], endoplasmic reticulum calcium [Ca^(2+)]ER, and mitochondrial calcium [Ca^(2+)]MIT, respectively. Then, the cells were exposed to a pulsed microwave of 2.856 GHz with specific absorption rate(SAR) values of 0, 4, and 40 W/kg for 6 min to observe the changes in calcium levels. Results The results showed that the 4 and 40 W/kg microwave radiation caused a significant decrease in the levels of [Ca^(2+)], [Ca^(2+)]ER, and [Ca^(2+)]MIT in primary hippocampal neurons. In the primary cardiomyocytes, only the 40 W/kg microwave radiation caused the decrease in the levels of [Ca^(2+)], [Ca^(2+)]ER, and [Ca^(2+)]MIT. Primary hippocampal neurons were more sensitive to microwave exposure than primary cardiomyocytes. The mitochondria were more sensitive to microwave exposure than the endoplasmic reticulum. Conclusion The calcium efflux was occurred during microwave exposure in primary hippocampal neurons and primary cardiomyocytes. Additionally, neurons and mitochondria were sensitive cells and organelle respectively. | WANG Hui ZHANG Jing HU Shao Hua TAN Sheng Zhi ZHANG Bo ZHOU Hong Mei PENG Rui Yun | 2018 | Biomedical and Environmental Sciences2018，31，8： | 7 |
| 19 | Pore throat characteristics of tight sandstone of Yanchang Formation in eastern Gansu,Ordos Basin显示文摘An important factor to evaluate reservoir quality is the pore-throat size.However,the strong heterogeneity makes it difficult to characterize the pore-throat distribution in tight reservoirs.The field emission scanning electron microscope(FESEM),high pressure mercury injection and rate-controlled mercury injection are used to investigate the pore-throat size distribution in tight sandstone reservoirs of Member 7 of the Yanchang Formation in eastern Gansu,Ordos Basin,and studies of the pore throat size controlling on physical property of the tight sandstone reservoirs are also carried out.The result shows that the pore type is mainly dominated by the residual intergranular pore,dissolution pore,micropore and a few micro-fractures;the high-pressure mercury injection experiment indicates that the pore-throat size ranges from 0.0148 μm to 40mm,the pore throat more than 1 mm is less;the ratecontrolled mercury injection experiment reveals that for samples with different physical properties,the pore radius mainly varies from 80 μm to 350 μm;the throat radius exhibits the strong heterogeneity,and is from 0.12 μm to 30μm;the pore-throat size can be effectively characterized by combination of high-pressure and rate-controlled mercury injections,and it varies from 0.0148 μm to 350 μm.The permeability is mainly controlled by the large pore throat(>R_(50))which accounts for a small proportion;in the tight sandstone with the permeability greater than 0.1 mD,the permeability is mainly controlled by the micropore and mesopore;in the tight sandstone with the permeability smaller than 0.1 mD,the permeability is mainly controlled by the nanopore and micropore;the proportion of small pore throat increases with reduction of permeability,it is important that the small pore throat influences the reservoir storage property though its effect on permeability are small. | Hao Wu Chunlin Zhang Youliang Ji Rui'e Liu Shang Cao Sheng Chen Yunzhao Zhang Ye Wang Wei Du Gang Liu | 2018 | Petroleum Research2018，3，1： | 7 |
| 20 | Fe/MCM-41 as a promising heterogeneous catalyst for ozonation of p-chlorobenzoic acid in aqueous solution显示文摘Mesoporous MCM-41 和 Fe 装载了 MCM-41 (Fe/MCM-41 ) ,它被一个热水的方法和一个蘸的方法成功地分别地准备,在水的答案为 p-chlorobenzoic 酸(p-CBA ) 的 ozonation 作为异构的催化剂被使用。MCM-41 和 Fe/MCM-41 被 XRD,英尺红外和弥漫的反射 UVvis (DR-UVvis ) 技术描绘。MCM-41 或 Fe/MCM-41 的存在改进 p-CBA 和全部的器官的碳(TOC ) 与 ozonation 相比的移动效率独自一个。在试验性的条件下面, Fe/MCM-41/O3 过程的 TOC 移动率在 60 min 氧化时间是超过 63.5% , 44.5% 使用 MCM-41 作为催化剂,仅仅 37.7% 与 ozonation 独自一个。在 Fe/MCM-41/O3 过程的 turt-butanol (TBA ) 的存在显示 p-CBA 的氧化机制发生经由哦在液体体积。并且 Fe/MCM-41 是有希望的催化剂。 | Rui Huan Huang Jie Liu Lai Sheng Li Qiu Yun Zhang Li Xuan Zeng Ping Lu | 2011 | Chinese Chemical Letters2011，22，6： | 6 |
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