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| 1 | Fuzzy Comprehensive Evaluation Model for Water Resources Carrying Capacity in Tarim River Basin,Xinjiang,China显示文摘This paper explores the method of comprehensive evaluation of water resources carrying capacity and sets up an evaluation model applying the fuzzy comprehensive evaluation method. Based on the data of nature,society,economics and water resources of the Tarim River Basin in 2002,we evaluated the water resources carrying capacity of the basin by means of the model. The results show that the comprehensive grades are 0.438 and 0.454 for Aksu and Kashi prefectures respectively,where the current water resources exploitation and utilization has reached a relative high degree and there is only a very limited water carrying capacity,0.620 for Kizilsu Kirgiz Autonomous Prefecture,where water resources carrying capacity is much higher,and in between for Hotan Prefecture and Bayingolin Mongo-lian Autonomous Prefecture. As a whole,the comprehensive grade of the Tarim River Basin is 0.508 and the current water resources exploitation and utilization has reached a relative high degree. Thus,we suggest that the integrated management of the water resources in the basin should be strengthened in order to utilize water resources scientifically and sustainably. | MENG Lihong CHEN Yaning LI Weihong ZHAO Ruifeng | 2009 | Chinese Geographical Science2009，19，1： | 55 |
| 2 | Spatial patterns of ephemeral plants in Gurbantünggüt Desert显示文摘In the present research,the authors measured parameters of richness,cover and importance value of ephemeral and ephemeroid plants on south-north and east-west transects in the Gurbantünggüt Desert in early spring,and investigated and analyzed the microhabitats,such as terrain,geomorphology,soil physical-chemical properties and crusts. By comparison,the regional differences in the ephemeral distribution in the desert were revealed. The species of ephemeral plants in the south and center are the richest and those in the west are the poorest in the desert. The cover of ephemeral plants in the mid-south is higher than that in the north,and that in the mid-east is higher than that in the west. The response of ephemeral plants to the spatial variation of the desert habitat forms the population-habitat gradient of ephemeral plants. The characteristics are:(1) In the habitat with higher terrain,coarser textured soil with poorer sorting and correspondingly higher organic matter and lower alkali-saline contents,Carex physoides and Eremopyrum orientale are the dominant ephemeral plants;(2) In the dry habitat with lower terrain,looser textured soil,some organic matter,alkali-saline soil,and developed crust,the ephemeral plants Alyssum linifolium and Erodium oxyrrhynchum are of characteristic of drought and alkali-saline tolerance;(3) In the habitat with lower terrain,some water and more alkali-saline soil,the ephemeral plants Neotorularia torulosa and Hypecoum parviflorum being of alkali-saline tolerance are mainly developed. However,most ephemerals are distributed in a habitat order of higher terrain,some organic,and less alkali-saline soil on the above-mentioned ephemeral population-habitat gradient. The spatial gradient of variation in desert microhabitats is small,and as a whole,the physio-logical character of mesophytism is represented by the desert ephemerals. | QIAN YiBing WU ZhaoNing ZHANG LiYun ZHAO RuiFeng WANG XiaoYan LI YouMin | 2007 | Chinese Science Bulletin2007，52，22： | 16 |
| 3 | Effects of soil water and nitrogen availability on photosynthesis and water use efficiency of Robinia pseudoacacia seedlings显示文摘The efficient use of water and nitrogen (N) to promote growth and increase yield of fruit trees and crops is well studied.However,little is known about their effects on woody plants growing in arid and semiarid areas with limited water and N availability.To examine the effects of water and N supply on early growth and water use efficiency (WUE) of trees on dry soils,one-year-old seedlings of Robinia pseudoacacia were exposed to three soil water contents (non-limiting,medium drought,and severe drought) as well as to low and high N levels,for four months.Photosynthetic parameters,leaf instantaneous WUE (WUEi) and whole tree WUE (WUEb) were determined.Results showed that,independent of N levels,increasing soil water content enhanced the tree transpiration rate (Tr),stomatal conductance (Gs),intercellular CO2 concentration (Ci),maximum net assimilation rate (Amax),apparent quantum yield (AQY),the range of photosynthetically active radiation (PAR) due to both reduced light compensation point and enhanced light saturation point,and dark respiration rate (Rd),resulting in a higher net photosynthetic rate (Pn) and a significantly increased whole tree biomass.Consequently,WUEi and WUEb were reduced at low N,whereas WUE i was enhanced at high N levels.Irrespective of soil water availability,N supply enhanced Pn in association with an increase of Gs and Ci and a decrease of the stomatal limitation value (Ls),while Tr remained unchanged.Biomass and WUEi increased under non-limiting water conditions and medium drought,as well as WUEb under all water conditions;but under severe drought,WUEi and biomass were not affected by N application.In conclusion,increasing soil water availability improves photosynthetic capacity and biomass accumulation under low and high N levels,but its effects on WUE vary with soil N levels.N supply increased Pn and WUE,but under severe drought,N supply did not enhance WUEi and biomass. | Xiping Liu Yangyang Fan Junxia Long Ruifeng Wei Roger Kjelgren Chunmei Gong Jun Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 15 |
| 4 | The impact of land use change on soil organic carbon and labile organic carbon stocks in the Longzhong region of Loess Plateau显示文摘Land use change (LUC) is widely recognized as one of the most important driving forces of global carbon cycles. The soil organic carbon (SOC) and labile organic carbon (LOC) stores were investigated at arable land (AL), artificial grassland (AG), artificial woodland (AW), abandoned arable land (AAL) and desert steppe (DS) in the Longzhong region of the Loess Plateau in Northwest China. The results showed that conversions from DS to AL, AL to AG and AL to AAL led to an increase in SOC content, while the conversion from DS to AW led to a decline. The differences in SOC content were significant between DS and AW at the 20-40 cm depth and between AL and AG at the 0-10 cm depth. The SOC stock in DS at the 0-100 cm depth was 39.4 t/hm 2 , increased by 28.48% after cultivation and decreased by 19.12% after conversion to AW. The SOC stocks increased by 2.11% from AL to AG and 5.10% from AL to AAL. The LOC stocks changed by a larger magnitude than the SOC stocks, which suggests that it is a more sensitive index of carbon dynamics under a short-term LUC. The LOC stocks increased at 0-20 cm and 0-100 cm depths from DS to AW, which is opposite to that observed for SOC. The proportion of LOC to SOC ranged from 0.14 to 0.20 at the 0-20 cm depth for all the five land use types, indicating low SOC dynamics. The allocation proportion of LOC increased for four types of LUC conversion, and the change in magnitude was largest for DS to AW (40.91%). The afforestation, abandonment and forage planting on arable land led to sequestration of SOC; the carbon was lost initially after afforestation. However, the carbon sink effect after abandonment may not be sustainable in the study area. | LiHua ZHANG ZhongKui XIE RuiFeng ZHAO YaJun WANG | 2012 | Journal of Arid Land2012，4，3： | 13 |
| 5 | P wave velocity structure of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions显示文摘The three-dimensional P wave velocity structures of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions were reconstructed by means of the seismic tomography, using the absolute P-arrivals from the events observed by the Three Gorges seismic network. Our preliminary study of the deep structure shows: (1) the lithology of the Huangling anticline, integral and highly so-lidified, exhibits a uniformity. Down to a depth of 20 km, the Huangling anticline still shows high- velocity anomalies. Note that the characteristics of the velocity images with the different depths are not the same; (2) the depth of the sedimentary rocks beneath the entire Zigui basin is not constant, which is less than 6 km; (3) the top boundary of the crystalline basement varies from 0 to 7 km, whereas the bottom one between 14 and 16 km; (4) the partially molten substances of the upper mantle are located in the Badong-Zigui and its adjacent regions as well as nearby Peishi area. The development and evo-lution of the current tectonics are associated with the cooling and solidifying process of the molten substances within the upper mantle; (5) the different velocity structures of the deep crust in both east and west side of the Jiuwanxi fault are to be investigated in order to understand the origin of gravita-tional gradient zone in the Three Gorge areas; and (6) the velocities within the upper crust would be affected by reservoir water permeability. | LI Qiang ZHAO Xu CAI JinAn LIU RuiFeng LONG GuiHua AN YanRu | 2009 | Science China Earth Sciences2009，52，4： | 11 |
| 6 | Vegetation patterns and species-environment relationships in the Gurbantunggut Desert of China显示文摘Gurbantunggut 沙漠在中国是最大的马厩和半马厩沙沙漠,还很少数据为这些多样的荒芜的风景在植被模式和种类环境关系上存在。调查区域的沙沙丘主要具有 | QIAN Yibing WU Zhaoning ZHAO Ruifeng ZHANG Liyun | 2008 | Journal of Geographical Sciences2008，18，4： | 10 |
| 7 | Effects of deficit irrigation on daily and seasonal variations of trunk sap flow and its growth in Calligonum arborescens显示文摘Water deficit in arid and semiarid regions affects whole-plant sap flow and leaf-level water relations. The objectives of this study were to clarify how sap flow of Calligonum arborescens responds to different drought stress conditions and to understand its acclimation mechanism to drought environments. A field experiment was conducted for C. arborescens during the growing season to evaluate the effects of deficit irrigation on the daily and seasonal variations of trunk sap flow in the shelterbelt along the Tarim Desert Highway, Xinjiang, China. Three different water regimes (2,380, 1,960 and 1,225 m3 /hm2 ) were applied at different stages of plant growth. From 1 May to 30 October 2007, a heat-balance stem flow gauge was used to monitor the sap flow dynamics of C. arborescens under different water regimes. Atmospheric evaporation demand and soil moisture conditions for differentially irrigated C. arborescens were also monitored. The result showed that sap flow exhibited a clear diurnal pattern regardless of treatments; the diurnal patterns of sap flow and vapour pressure deficit were very similar under different water regimes and growing seasons, while the slope of the linear regression of this correlation confirmed an increasing water regime. The sap flow decreased under reduced water regimes and there was nocturnal sap flow regardless of water regimes, which was mainly contributed to nocturnal transpiration and water recharge. The sap flow peaked before midnight and dropped afterwards with obviously higher values in summer than in other seasons. It is speculated that the water consumption of C. arborescens during the day can be supplemented through the sap flow at night, which increased with increasing irrigation amount. Net radiation was the most significant correlated factor that influenced sap flow velocity and transpiration under different water regimes (R2 >0.719). Compared with the commonly practiced water regime, the growth of C. arborescens was significantly slower in the stress deficit irrigation, but not significantly different from that in the moderate deficit irrigation. The moderate deficit irrigation would not affect the stability of the shelterbelt and was a more efficient use of water resources compared with the current watering amount. | LiShan SHAN Yi LI RuiFeng ZHAO XiMing ZHANG | 2013 | Journal of Arid Land2013，5，2： | 6 |
| 8 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 9 | Assessment of wetland fragmentation in the middle reaches of the Heihe River by the type change tracker model显示文摘The quantitative research of wetland landscape fragmentation in the middle reaches of the Heihe River is important for the wetland and oasis sustainable development in the Hexi Corridor. Based on the data of remote sensing and GIS, we constructed the type change tracker model with sliding window technique and spatially morphological rule. The suitable scale and optimum scale of the fragmentation model of wetland landscape in the middle reaches of the Heihe River were determined by the area frequency statistics method, Chi-square distribution normalized scale variance, fractal dimension and diversity index. By integrating type change tracker model and the optimum scale with GIS spatial analysis, the spatial distribution characteristics of wetland landscape fragmentation in different periods and the related spatial-temporal change process were clarified. The results showed that(1) the type change tracker model, which analyzes the spatial pattern of wetland fragmentation on the pixel level, is better than the traditional wetland fragmentation analysis on the landscape and patch levels;(2) The suitable scale for the wetland fragmentation ranged from 150 m×150 m to 450 m×450 m and the optimum scale was 250 m×250 m in the middle reaches of the Heihe River; and(3) In the past 35 years, the total wetland area decreased by 23.2% and the fragmentation of wetland markedly increased in the middle reaches of the Heihe River. The areas of core wetlands reduced by 12.8% and the areas of perforated, edge and patch wetlands increased by 0.8%, 3.1% and 8.9%, respectively. The process of wetland fragmentation in the research region showed the order of core wetland, perforated or edge wetland, patch wetland or non-wetland. The results of this study would provide a reference for the protection, utilization and restoration of limited wetland resources and for the sustainable development of the regional eco-environment in the Heihe River Basin. | RuiFeng ZHAO ZuoLun XIE LiHua ZHANG Wen ZHU Jie LI Dan LIANG | 2015 | Journal of Arid Land2015，7，2： | 6 |
| 10 | Activation of STAT3 stimulates AHSP expression in K562 cells显示文摘Studies on the chaperone proteinα-hemoglobin stabilizing protein(AHSP)reveal that abundant AHSP in erythroid cells enhance the cells’tolerance to oxidative stress imposed by excessα-hemoglobin in pathological conditions.However,the potential intracellular modulation of AHSP expression itself in response to oxidative stress is still unknown.The present study examined the effect and molecular mechanism of STAT3,an oxidative regulator,on the expression of AHSP.AHSP expression increased in K562 cells upon cytokine IL-6-induced STAT3 activation and decreased in STAT3 knock-down K562 cells.Regulation of AHSP in oxidative circumstance was then examined inα-globin-overloaded K562 cells,and real-time PCR showed strengthened expression of both AHSP and STAT3.ChIP analysis showed binding of STAT3 to AHSP promoter and binding was significantly augmented with IL6 stimulation and uponα-globin overexpression.Dual luciferase reporter assays of the wildtype and mutated SB3 element,an IL-6RE site,in the AHSP promoter in K562 cells highlighted the direct regulatory effect of STAT3 on AHSP gene.Finally,direct binding of STAT3 to SB3 site of AHSP promoter was confirmed with EMSA assays.Our work reveals an adaptive AHSP regulation mediated by the redox-sensitive STAT3 signaling pathway,and provides clues to the therapeutic strategy for AHSP enhancement. | CAO Cong ZHAO GuoWei YU Wei XIE XueMin WANG WenTian YANG RuiFeng LV Xiang LIU DePei | 2014 | Science China(Life Sciences)2014，57，5： | 5 |
| 11 | ω-Assisted refinement of α phase and its effect on the tensile properties of a near β titanium alloy显示文摘In this work, the phase transformation sequence during the continuous heating process(3℃/min) was investigated in a near β titanium alloy. The results show that the staring formation of ω phase is about267℃, and the ending precipitation temperature about 386℃ during the heating process. When the heating temperature is greater than 485℃, there are no ω phase detected within the β matrix. Combined with the microstructural characterization, it is found that ω phase facilitates the nucleation of αphase nearby the ω/β interface and has a great effect on the refinement for α phase. As compared with the specimens directly aged, the specimens with ω-assisted refinement of α phase possess high tensile strength, but there is no yield stage detected on their stress-strain curve. Combined with the analyses of the fracture morphology, the specimens with ω-assisted refinement of α phase present a brittle fracture.This is mainly ascribed to its relatively lager width of grain boundaries and the absence of widmanst?ttenα precipitates. | Ruifeng Dong Jinshan Li Hongchao Kou Jiangkun Fan Yuhong Zhao Hua Hou Li Wu | 2020 | Journal of Materials Science & Technology2020，44，9： | 5 |
| 12 | A viral protein orchestrates rice ethylene signaling to coordinate viral infection and insect vector-mediated transmission显示文摘Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus that is frequently transmitted by planthoppers. However, the molecular mechanisms underlying its propagation in the host plants and epidemics in the field are largely unknown. Here, we showed that the SRBSDV-encoded P6 protein is a key effector that regulates rice ethylene signaling to coordinate viral infection and transmission. In early SRBSDV infection, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation;this also repels the insect vector to reduce infestation. In late infection, P6 enters the nucleus, where it interacts with OsEIL2, a key transcription factor of ethylene signaling. The P6-OsEIL2 interaction suppresses ethylene signaling by preventing the dimerization of OsEIL2, thereby facilitating viral transmission by attracting the insect vector. Collectively, these findings reveal a novel molecular mechanism by which an arbovirus modulates the host defense system to promote viral infection and transmission. | Yaling Zhao Xue Cao Weihua Zhong Shunkang Zhou Zhanbiao Li Hong An Xiahua Liu Ruifeng Wu Surakshya Bohora Yan Wu Zhenyi Liang Jiahao Chen Xin Yang Guohui Zhou Tong Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 13 | Correlation between the mechanical properties and the<110>texture in a hot-rolled nearβtitanium alloy显示文摘1.Introduction Nearβtitanium alloys have been considered as a potential material to fabricate high-strength fasteners in aerospace field owing to their high specific strength,good crack and fatigue resistance[1,2].It is well known that the processing technology determines the microstructure,and the microstructure eventually correlates with the performance of alloys. | Ruifeng Dong Xiaoyang Zhang Chenhui Li Yuhong Zhao Jinzhong Tian Li Wu Hua Hou | 2022 | Journal of Materials Science & Technology2022，，2： | 4 |
| 14 | Inferring user profiles in social media by joint modeling of text and networks显示文摘Dear editor,With the rapid growth of social media platforms such as Twit ter and Chinese Weibo,personalized services,such as recommendation and personalized advertising,provide more engaging experiences for the users.A prerequisite to personalized services is effective user profiling.However,many users do not want to share their profiles online due to the privacy concerns.To address this problem,automatic user profiling based on users5 posted contents and their social activities online has attracted many attentions in recent years[1-3]. | Ruifeng XU Jiachen DU Zhishan ZHAO Yulan HE Qinghong GAO Lin GUI | 2019 | Science China(Information Sciences)2019，62，11： | 3 |
| 15 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 16 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 17 | Cloning and Expression Analysis of p26 Gene in Artemia sinica显示文摘蛋白质 p26 是作为分子的女伴工作由在胚胎的 development.A 期间阻止不可逆的蛋白质损坏保护胚胎的小热吃惊蛋白质 p26 基因的 542 bp 碎片被克隆并且定序。碎片编码了 174 氨基酸残余,氨基酸顺序包含了 alpha-crystallin 领域。种系发生的分析证明八张 Artemia 人口被划分成四个主要的组。Artemia 中国一(YC ) 属于东亚两性的组。在 A 的不同发展阶段的 p26 基因的表示。中国一用克隆并且定序跟随的即时量的聚合酶链反应被确定。在 p26 基因表达和胚胎的开发的数量之间的关系被分析。结果显示 p26 的巨大的数量在 A 的发展期间被表示。中国一。在 0 h 的发展阶段,一。中国一表示了 p26 的高水平。当开发继续了, p26 基因的表达式层次显著地减少了。有在 16 手的发展阶段的 p26 基因表达的小数量 24 h。我们断定 p26 可能涉及在胚胎的开发期间保护胚胎免受生理的应力的伤害。 | Lijuan JIANG Lin HOU Xiangyang ZOU Ruifeng ZHANG Jiaqing WANG Wenjing SUN Xintao ZHAO Jialu AN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 1 |
| 18 | Soil conversion effectiveness and energy efficiency of alternative rotations and continuous wheat cropping in the Loess Plateau of northwest China 显示文摘 | Li Ruifeng Gao Yuechong Zhao Linha Li Yanxiao | 2002 | Agriculture Ecosystems and Environment2002，91，13： | 1 |
| 19 | Learning to recognize misaligned hyperfine orbital angular momentum modes显示文摘Orbital angular momentum(OAM)-carrying beams have received extensive attention due to their high-dimensional characteristics in the context of free-space optical communication.However,accurate OAM mode recognition still suffers from reference misalignment of lateral displacement,beam waist size,and initial phase.Here we propose a deep-learning method to exquisitely recognize OAM modes under misalignment by using an alignment-free fractal multipoint interferometer.Our experiments achieve 98.35% recognizing accuracy when strong misalignment is added to hyperfine OAM modes whose Bures distance is 0.01.The maximum lateral displacement we added with respect to the perfectly on-axis beam is about±0.5 beam waist size.This work offers a superstable proposal for OAM mode recognition in the application of free-space optical communication and allows an increase of the communication capacity. | Xiao Wang Yufeng Qian JingJing Zhang Guangdong Ma Shupeng Zhao RuiFeng Liu Hongrong Li Pei Zhang Hong Gao Feng Huang Fuli Li | 2021 | Photonics Research2021，9，4： | 1 |
| 20 | Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual显示文摘Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology,it is still largely unclear whether virus-specific T cells are sufficient for host protection.Here,we found that in a previously characterized cohort of convalescent subjects,one individual,though lacking detectable anti-viral neutralizing IgG antibodies,showed virus-specific T cell responses,both in CD4^(+)and CD8^(+)T cells.SARS-CoV-2-specific T cells in this and other individuals are maintained for up to 10 months.This study thus further supports a critical role of T cells in host defense against SARS-CoV-2,offering new insights into the design and evaluation of COVID-19 vaccines. | Ling Ni Fang Ye Qin Qiao Yu Feng Yazheng Yang Hui Zhao Li-Nan Zhang Meng-Li Cheng Gengzhen Zhu Xiaoli Li Xuan Zhong Ruifeng Li Cheng-Feng Qin Fang Chen Chen Dong | 2022 | National Science Open2022，1，1： | 1 |
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