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| 1 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 2 | Preparation and magnetic performance of the magnetic fluid stabilized by bi-surfactant显示文摘 | Buhe Bateer Yang Qu Xiangying Meng Chungui Tian Shichao Du Ruihong Wang Kai Pan Honggang Fu | 2012 | Journal of Magnetism and Magnetic Materials2012，，： | 1 |
| 3 | Genome-edited ATP BINDING CASSETTE B1 transporter SD8 knockouts show optimized rice architecture without yield penalty显示文摘Dear editor,In the 1960s,the use of semi-dwarf rice and wheat varieties ushered in the‘‘Green Revolution,’’leading to reduced lodging and increased harvest index.In rice,essentially all modern semidwarf varieties carry a specific null mutation or weak alleles of Semi-Dwarf1(SD1),which encodes a GA20-2 oxidase in the gibberellin biosynthetic pathway(Monna et al.,2002;Sasaki et al.,2002;Spielmeyer et al.,2002).In addition to gibberellins,other plant hormones such as brassinosteroids,strigolactones,and auxin also function in reducing rice height(Ferrero-Serrano et al.,2019).However,many dwarf or semi-dwarf mutants have not been widely used in rice-breeding programs because they adversely impact grain yield(Ferrero-Serrano et al.,2019). | Ruihong Qu Pingxian Zhang Qing Liu Yifan Wang Weijun Guo Zhuoying Du Xiulan Li Liwen Yang Shuangyong Yan Xiaofeng Gu | 2022 | Plant Communications2022，3，5： | 0 |
| 4 | Mechanistic investigation of zwitterionic MOF-catalyzed enyne annulation using UNLPF-14-Mn^(Ⅲ) as catalyst显示文摘Hybrid quantum mechanics/molecular mechanics calculations were performed to elucidate how[Mn^(Ⅲ)porphyrin]^(+X−)-based metal-organic frameworks(MOFs)catalyze the[2+1]cycloisomerization of enynes and why zwitterionic MOFs exhibit strong activity in Lewis acid catalysis.The calculations showed that zwitterionic MOFs have a“pure cationic active center”leading to a concerted nucleophilic attack pathway with lower barriers.In contrast,metals with coordinating anions have reduced electrophilicity,resulting in a stepwise radical-type pathway with much higher barriers.Further calculations showed the nature of catalysis was strongly depended on the charge on the anion ligand.A good linear relationship between the NPA charge and barrier was found,and verified by 73 anions with small derivations,which presents a universal adaptive character for various coordinated anions. | Taotao Liu Ruihong Duan Yanyan Wang Shijun Li Lingbo Qu Jinshuai Song Qiang Liu Yu Lan | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
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