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| 1 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 2 | Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China:a decision analysis and implications for practice显示文摘Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.Methods: A decision tree model with three scenarios(low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort(100,000 smokers aged45-80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality(primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables.Results: Among the 100,000 subjects, there were 448,541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively(17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, lowdose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths(relative numbers) with low-dose CT screening in the worst and optimal cases were16(5.4%) and 288(40.2%) over no screening, respectively.Conclusions: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China.However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed. | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2017 | Chinese Journal of Cancer2017，36，8： | 9 |
| 3 | 中国城市人群低剂量计算机断层扫描筛查肺癌的死亡率结果:决策分析和实践意义显示文摘背景与目的不同低剂量计算机断层扫描(computed tomography,CT)筛查肺癌试验得出的死亡率结果不一致。本研究旨在评价中国城市CT筛查是否能够降低肺癌死亡率,并探讨影响筛查效果的因素。方法建立了3种场景(低剂量CT筛查、胸部X线筛查和无筛查)的决策树模型来比较模拟的中国城市人群(100,000例年龄45–80岁的吸烟者)的筛查结果。从国家登记和流行病学调查中获得了参与者特征数据并估算了肺癌患病比例。根据文献调研选择了低剂量CT和胸部X线筛查的灵敏度和特异度等其他树变量。计算了3种筛查方法间肺癌死亡率(主要结局)、误诊和误诊导致死亡的差异。通过敏感性分析找出了与筛查结果相关的因素,并确定了在变量可能范围内的最差和最优筛查效果。结果 100,000例研究对象中,低剂量CT、胸部X线和无筛查场景分别有448例、541例和591例肺癌死亡(低剂量CT筛查比胸部X线筛查死亡人数减少17.2%,比无筛查减少24.2%)。100,000例研究对象中,2种筛查场景的代价分别为9387例和2497例误诊及7例和2例误诊导致的死亡。低剂量CT筛查比无筛查的死亡数降低,影响最大的因素是筛查人群的肺癌患病比例、低剂量CT的灵敏度和低剂量CT检出肺癌中早期癌的比例。综合了所有可能性,低剂量CT筛查肺癌的死亡人数(相对数)在最坏和最好情况下分别比无筛查降低了16例(5.4%)和288例(40.2%)。结论就死亡率结局而言,我们的研究结果支持在中国城市人群中进行低剂量CT筛查。然而,急需策略来减少误诊和优化纳入标准等重要筛查条件。 | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2018 | 癌症2018，37，8： | 3 |
| 4 | Involvement of mitogen-activated protein kinase pathways in N-methyl-D-aspartate-induced excitotoxicity显示文摘Previous studies have shown that mitogen-activated protein kinase(MAPK) signaling pathways are involved in N-methyl-D-aspartate(NMDA)-mediated excitotoxicity.However,a systematic observation or analysis of the role of these various MAPK pathways in excitotoxicity processes does not exist.The present study further evaluated the role and contribution of three MAPK pathways extracellular signal-regulated kinase,c-Jun N-terminal kinase,and p38 MAPK in an NMDA-mediated excitotoxicity model using MAPK-specific inhibitor.Results demonstrated that c-Jun N-terminal kinase inhibitor SP600125 and/or p38 MAPK inhibitor SB203580 inhibited NMDA-induced reduction in cell viability,as well as reduced NMDA-induced lactate dehydrogenase leakage and reactive oxygen species production.However,PD98059,an inhibitor of extracellular signal-regulated kinase,did not influence this model.Results demonstrated an involvement of c-Jun N-terminal kinase and p38 MAPK,but not extracellular signal-regulated kinase,in NMDA-mediated excitotoxicity in cortical neurons. | Xiaorong Yang Ping Sun Huaping Qin Rui Wang Ye Wang Ruihong Shi Xin Zhao Ce Zhang | 2011 | Neural Regeneration Research2011，6，4： | 1 |
| 5 | Interobserver Agreement for Classifying Infections in Patients with Decompensated Cirrhosis Based on Centers for Disease Control and Prevention Criteria显示文摘Background:Bacterial infections are common in patients with decompensated cirrhosis,largely owing to bacterial translocation and cirrhosis-associated immune dysfunction.This study aims to determine the reliability for classifying infections in patients with decompensated cirrhosis based on the Centers for Disease Control and Prevention(CDC)criteria.Methods:The patients with decompensated cirrhosis with suspicious infection in a registered prospective cohort of cirrhosis from May 1,2014 to February 25,2015 in the ward of First Affiliated Hospital of Zhejiang University were retrospectively identified.Agreement assessment was conducted focusing on site of infection,the possibility of infection,and pathogens of infection on both system level and specific diagnosis level.A subgroup analysis was performed based on with/without acute-on-chronic liver failure(ACLF).Results:A total of 402 infectious episodes among 351 patients were enrolled for consistency analysis.The overall agreement for site of infection was 94%(378/402)(k=0.90,95%CI 0.86–0.94)on system level and 86%(346/402)(k=0.84,95%CI 0.80–0.88)on specific diagnosis level.On possibility of infection,the overall agreement was 81%(306/378)(weighted k=0.71,95%CI 0.65–0.77),with 84%(224/267)(weighted k=0.75,95%CI 0.63–0.87)in patients with ACLF and 80%(70/88)(weighted k=0.68,95%CI 0.60–0.76)in patients without ACLF,respectively.On pathogens of infection,the overall agreement was 72%(60/83)(k=0.70,95%CI 0.60–0.80)among most frequent infections.Conclusion:The agreement for classifying infections in patients with decompensated cirrhosis based on CDC criteria is acceptable overall,suggesting that it can be a useful tool for clinical management in patients with decompensated cirrhosis with suspicious infections. | Haotang Ren Junjie Yao Ruihong Zhao Kai Gong Shanshan Sun Xia Yu Wei Shen Jinnan Duan Jifang Sheng Yu Shi | 2022 | Infectious Diseases & Immunity2022，2，1： | 0 |
| 6 | Early Permian A-type Granites in the Zhangdaqi Area, Inner Mongolia, China and Their Tectonic Implications显示文摘There is a controversy regarding the amalgamation of Xing’an and Songnen Blocks along the Hegenshan-Heihe Suture(HHS)in the eastern Central Asian Orogenic Belt(CAOB).To solve this problem,we performed detailed study on the granites from the Zhangdaqi area,adjacent to the north of the HHS in the northern part of the Great Xing’an Range,NE China.Geochemically,the granites in the study area are metaluminous-weak peraluminous and high-K calc-alkaline series.Trace elements of the granites show that LREEs are relatively enriched,while HREEs are relatively deficient and obvious REE fractionation.The granites are characterized by obvious negative Eu anomalies,meanwhile,they are relatively enriched in Rb,K,Th and depleted in Ba,Nb,Sr,P,Ti.All the geochemical features suggest that the granites in the Zhangdaqi area are aluminum A-type granites.The zircon LA-ICP-MS U-Pb ages of these granites are 294-298 Ma,indicating that they formed in the Early Permian.These granites also have positiveεHf(t)values(8.4-14.2)and a relatively young two-stage model age between 449 Ma and 977 Ma,implying that the magma was derived from the re-melting of the Early Paleozoic-Neoproterozoic juvenile crust.Combined with geochemical characteristics(Nb/Ta ratios of 9.0-22.2,and Zr/Hf ratios of 52.3-152.0),we believe that the magmatic source area is a mixture of partial melting of the lower crust and depleted mantle.A-type granites and bimodal volcanic rocks along the Hegenshan-Heihe Suture formed during the Late Carboniferous-Early Permian,indicating that the HHS between Xing’an and Songnen Blocks closed in the late EarlyCarboniferous.Subsequently,the Zhangdaqi area was in a post-orogenic extensional environment from Late Carboniferous to Early Permian and resulted in the formation of the A-type granites. | ZHANG Li LIU Yongjiang SHAO Jun LI Weimin LIANG Chenyue CHANG Ruihong YANG Hongzhi FENG Zhiqiang ZHANG Chao XU Jia SHI Yi YANG Fan HE Pengfei | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 0 |
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