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| 1 | The significance of virulence factors in H elicobacter pylori显示文摘 | Seiji Shiota Rumiko Suzuki Yoshio Yamaoka | 2013 | Journal of Digestive Diseases2013，，7： | 3 |
| 2 | Stable carbon, nitrogen, and oxygen isotope analysis as a potential tool for verifying geographical origin of beef显示文摘 | Rumiko Nakashita Yaeko Suzuki Fumikazu Akamatsu Yoshiko Iizumi Takashi Korenaga Yoshito Chikaraishi | 2008 | Analytica Chimica Acta2008，，1： | 2 |
| 3 | Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori显示文摘 | Rumiko Suzuki Seiji Shiota Yoshio Yamaoka | 2011 | Infection Genetics and Evolution2011，，2： | 2 |
| 4 | Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic显示文摘BACKGROUND Helicobacter pylori(H.pylori)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer.However,although the prevalence of H.pylori is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African enigma.The CagA protein produced by H.pylori is the most studied virulence factor.The carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)motifs.AIM To better understand the EPIYA patterns and CM motifs of the cagA gene.METHODS Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 H.pylori strains were cultured.After the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based sequencing.The population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by histopathology.Histological scores of the gastric mucosa were evaluated using the updated Sydney system.RESULTS All CagA-positive strains carried the Western-type CagA according to the identified EPIYA patterns.Twenty-seven kinds of CM motifs were observed.Although the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not observed.However,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 strains.Since this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the'GKDKGPE'motif was observed immediately upstream of the EPIYA motif in the EPIYA-A segment,and there was a significant association between strains with the hpAfrica1 population and those containing the“GKDKGPE”motif(P=0.018).In contrast,there was no significant association between the CM motif patterns and histological scores and clinical outcomes.CONCLUSION We found the unique African CM motif in Western-type CagA and termed it Africa1-CM.The less toxicity of this motif could be one reason to explain the African enigma. | Takaaki Ono Modesto Cruz Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki Celso Hosking Jose A Jimenez Abreu Yoshio Yamaoka | 2020 | World Journal of Gastroenterology2020，26，45： | 1 |
| 5 | Guidance for peptide vaccines for the treatment of cancer显示文摘 | Yoshiyuki Yamaguchi Hiroki Yamaue Takuji Okusaka Kiyotaka Okuno Hiroyuki Suzuki Tomoaki Fujioka Atsushi Otsu Yasuo Ohashi Rumiko Shimazawa Kazuto Nishio Junji Furuse Hironobu Minami Takuya Tsunoda Yuzo Hayashi Yusuke Nakamura | 2014 | Cancer Sci2014，，： | 1 |
| 6 | Association between Helicobacter pylori Virulence Factors and Gastroduodenal Diseases in Okinawa, Japan显示文摘 | Osamu Matsunari Seiji Shiota Rumiko Suzuki Masahide Watada Nagisa Kinjo Kazunari Murakami Toshio Fujioka Fukunori Kinjo Yoshio Yamaoka | 2012 | Journal of Clinical Microbiology2012，，7： | 1 |
| 7 | Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori显示文摘 | Rumiko Suzuki Seiji Shiota Yoshio Yamaoka | 2011 | Infection Genetics and Evolution2011，，2： | 1 |
| 8 | Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori显示文摘 | Rumiko Suzuki Seiji Shiota Yoshio Yamaoka | 2011 | Infection, Genetics and Evolution2011，，2： | 1 |
| 9 | Stable carbon, nitrogen, and oxygen isotope analysis as a potential tool for verifying geographical origin of beef 显示文摘 | Rumiko Nakashitaa Yaeko Suzuki Fumikazu Akamatsu Yoshiko Iizumi Takashi Korenaga Yoshito Chikaraishi | 2008 | Analytica Chimica Acta2008，617，： | 1 |
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