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| 1 | Signaling pathways in vascular function and hypertension:molecular mechanisms and therapeutic interventions显示文摘Hypertension is a global public health issue and the leading cause of premature death in humans.Despite more than a century of research,hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it.Hypertension is a condition that is named after its clinical features.Vascular function is a factor that affects blood pressure directly,and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels.Vascular elasticity,caliber,and reactivity are all characteristic indicators reflecting vascular function.Blood vessels are composed of three distinct layers,out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function.The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development.In this manuscript,we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression,including calcium pathway,NO-NOsGC-cGMP pathway,various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system,oxidative stress-related signaling pathway,immunity/inflammation pathway,etc.Meanwhile,we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work. | Jun Ma Yanan Li Xiangyu Yang Kai Liu Xin Zhang Xianghao Zuo Runyu Ye Ziqiong Wang Rufeng Shi Qingtao Meng Xiaoping Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 2 | The oxygen isotopic composition of phosphate as an effective tracer for phosphate sources in Hongfeng Lake显示文摘In order to characterize the oxygen isotopic composition of internal phosphate and explore the possibility of using these data to identify phosphate sources, we measured oxygen isotopic compositions of phosphate(δ^(18)O_p) in sediment pore water in Hongfeng Lake, a typical deep-water lake in a mountainous area. These data, in combination with δ^(18)O_p in surface water samples and water column samples, were successfully used to identify phosphate sources. The δ^(18)O_p value of sediment pore water ranged from 15.2% to 15.8%, with an average value of 15.5%—the δ^(18)O_p value of internal phosphate. The δ^(18)O_p values decreased gradually through the water column from 19.4% in surface water to 16.4% in deeper water, implying that internal phosphate had more negative δ^(18)O_p values than external phosphate. This finding was substantiated by horizontal variations in δ^(18)O_p values, which decreased with increasing distance from inflowing rivers. All collected evidence suggests that external and internal phosphate have distinctly different isotopic signatures and that these signatures have not been considerably altered by biological mediation in Hongfeng Lake. Therefore, δ^(18)O_p can be used to distinguish phosphate sources. A two-endmember mixing model showed that internal phosphate had an average contribution of 40%, highlighting the influence of internal phosphorus loading on aqueous phosphate and eutrophication. This study illustrates the need to reduce the internal phosphorus load from sediment and provides guidance for nutrient management and in-lake restoration treatment in Hongfeng Lake. The data presented here are limited, but serve to highlight the great potential of δ^(18)O_p as an effective tracer for identifying phosphate sources. Systematic investigations of the oxygen isotopic compositions of external phosphate, internal phosphate, and phosphate through the water column, in combination with in-lake P biogeochemical cycle study, would be desirable in further research. | Yongxue Ji Jingan Chen Runyu Zhang Yong Liu Jingfu Wang | 2017 | Acta Geochimica2017，36，4： | 1 |
| 3 | Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision显示文摘High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases.Current non-invasive neuromodulation methods offer limited precision at the milimeter level.Here,we report opticallygenerated focused ultrasound(OFUS)for non-invasive brain stimulation with ultrahigh precision.OFUS is generated by a soft optoacoustic pad(SOAP)fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film.SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83μm,which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound(tFUS).Here,we show effective OFUS neurostimulation in vitro with a single ultrasound cycle.We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo.An acoustic energy of 0.6 mJ/cm?,four orders of magnitude less than that of tFUS,is suffcient for successful OFUS neurostimulation.OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision noninvasively. | Yueming Li Ying Jiang Lu Lan Xiaowei Ge Ran Cheng Yuewei Zhan Guo Chen Linli Shi Runyu Wang Nan Zheng Chen Yang Ji-Xin Cheng | 2022 | Light(Science & Applications)2022，11，11： | 1 |
| 4 | Engineering upconverting core–shell nano-probe for spectral responsive fluid velocimetry显示文摘Particle velocimetry based on the temporal feature of upconversion luminescent nanocrystals is a newly-raising fluid velocimetry.Exploiting the availability to low flow rate fluid and exempting redundance external calibration(achieving once calibration for all)are highly expected and challenging.Herein,an engineered core–shell nano-probe,NaYF4:Yb/Ho/Ce@NaGdF4,was proposed,in which the Ce3+ions were utilized to manipulate the upconversion dynamic of Ho3+.Through optimization,a superior sensitive against low-speed flow is achieved,and the external calibrations before each operation can be avoided.Application demonstrations were conducted on a fluid circulation system with controllable flow rate.The fluid velocity was monitored successfully,no matter it is permanent,or cyclically variating(imitating the in vivo arterial blood).Moreover,this velocimetric route is competent in spatial scanning for handling the spatially inhomogeneous velocity field.Such sensing nanomaterial and fluid velocimetric method exhibit promising application potential in human blood velocimetry,industrial control,or environmental monitoring. | Hai Huang Shaoxiong Wang Runyu Chen Nianfeng Zhang Hu-Rong Yao Yuanhui Zheng Feng Huang Daqin Chen | 2023 | Nano Research2023，16，1： | 0 |
| 5 | Study on enzymatic hydrolysis of steam exploded straw by using shaking ball显示文摘A novel method of enzymatic hydrolysis was developed in this paper to produce a high conversion yield and hydrolysis rate.A comparison was described by using three methods of enzymatic hydrolysis and adsorption of steam exploded straw(SEWS):shaking ball in the regime,shaking with stirrer bed,and static state.The most adequate filter-paper activity,speed and reaction time were 3.6×10^(-7) mol/(s·mL),150 r/min and 24 h,respectively,with the reducing sugar yield of 0.43.The results showed that the method of shaking ball produced the highest adsorption,conversion yields and hydrolysis rate of the enzyme.This might be due to the continuous frequency increase of enzyme adsorption and desorption on the substrate surface as well as the relieved end-product inhibition.The morphological variation of SEWS was characterized by environmental scanning electron microscopy(ESEM). | Zhanwei SUN Xiaoguo FU Hongzhang CHEN Yanhui WANG Runyu MA | 2008 | Frontiers of Chemical Science and Engineering2008，2，1： | 0 |
| 6 | Late onsets of tropical cyclones in the decaying years of super El Niño events显示文摘The 2015/2016 El Nino event reached the threshold of super El Nino event,and was comparable to the super events in 1982/1983 and 1997/1998.Interestingly,the tropical cyclones(TCs)were found to have very late onsets in the decaying years of the super El Nino events.This study discusses the causes of late TC onsets related with atmospheric circulation,disturbance sources and trigger mechanisms.The analysis shows that the western North Pacific subtropical high(WNPSH)from January–June during the decaying years of the super El Nino events were stronger than the climatic mean,which resulted in a relatively stable atmospheric state by inhibiting deep convection.As a disturbance source,the April–June intertropical convergence zone(ITCZ)during the decaying years of the super El Nino events were significantly weaker than its climatic mean.The cross-equatorial flow and monsoon trough,as important TC generation triggers,were weaker from April–June during the decaying years of the super El Nino events,which further reduced the probability of TC generation.As for the late TC onsets,the role of atmospheric circulation anomalies(i.e.,subtropical-high,the ITCZ,cross-equatorial flow,and monsoon trough)were more important.The cross-equatorial flow may take as predictor of TC onsets in the decaying years of the super El Nino events. | Zhiqiang Li Runyu Zhang Kai Liu Changling Zheng Zhikun Chen | 2019 | Acta Oceanologica Sinica2019，38，7： | 0 |
| 7 | Exploring formation mechanism and source attribution of ozone during the 2019 Wuhan Military World Games:Implications for ozone control strategies显示文摘A series of emission reduction measures were conducted in Wuhan,Central China,to ensure good air quality during the 7th Military World Games(MWG)in October 2019.To better understand the implications for ozone(O_(3))pollution control strategies,we applied integrated analysis approaches based on the de-weathered statistical model,parameterization methods,chemical box model,and positive matrix factorization model.During the MWG,concentrations of O_(3),NO_x,and volatile organic compound(VOCs),OFP(O_(3)formation potential),L_(OH)(OH radical loss rate)were 83μg/m^(3),43μg/m^(3),26 ppbv,188μg/m^(3),and 3.9 s^(-1),respectively,which were 26%,18%,3%,15%,and 13%lower than pre-MWG values and 6%,39%,30%,33%,and 50%lower than post-MWG values,respectively.After removing meteorological influence,O_(3)and its precursors during the MWG decreased largely compared with post-MWG values,and only O_(3),NO_(2),and oxygenated VOCs(OVOCs)declined compared with pre-MWG values,which revealed the emission reduction measures during the MWG played an important role for O_(3)decline.For six VOCs sources,the mass contributions of biomass burning and solvents usage during the MWG decreased largely compared with pre-MWG values.O_(3)production was sensitive to VOCs and the key species were aromatics,OVOCs,and alkenes,which originated mainly from solvents usage,biomass burning,industrial-related combustion,and vehicle exhaust.Decreasing O_(3)concentration during the strict control was mainly caused by OVOCs reduction due to biomass burning control.Generally,the O_(3)abatement strategies of Wuhan should be focused on the mitigation of high-reactivity VOCs. | Lei Zhang Lili Wang Runyu Wang Nan Chen Yuan Yang Ke Li Jie Sun Dan Yao Yuesi Wang Minghui Tao Yang Sun | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 8 | May Traditional Chinese Medicine Reduce the Risk of Developing Rheumatoid Arthritis?An One-armed Prospective Study显示文摘Background:Rheumatoid arthritis(RA)is a worldwide public health problem.Intervention and prevention before the onset of rheumatic diseases is a new direction in current research.Objective:The aim of this study was to evaluate the potential and feasibility of traditional Chinese medicine(TCM)in the prevention of RA.Methods:This was a single-armed prospective clinical trial.All participants were recruited from a single center in Guangdong,China.Adults who were tested positive for anti-cyclic citrullinated peptide antibody(anti-CCP)and/or rheumatoid factor(RF),had no synovitis and never been treated with disease-modifying anti-rheumatic drugs(DMARDs),were enrolled to take the Huayu-Qiangshen-Tongbi(HQT)decoction orally twice daily,200 mL each time for 24 weeks.Primary outcome was the proportion of patients who met 2010 ACR(American College of Rheumatology)/EULAR(European League Against Rheumatism)classification criteria of RA during observation.Secondary outcomes included levels of anti-CCP,RF,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),assessment of signs and symptoms,and radiographic progression by magnetic resonance imaging(MRI).Results:19 individuals were enrolled in the study,4 of which withdrew because of the epidemic of COVID-19.During the observation period,3 individuals(20%)developed RA and they had longer morning stiffness(P=0.009)and more obvious synovial enhancement in MRI(P=0.041)at baseline when compared with those who did not develop RA.After 24 weeks of intervention,there were improvements in 28-swollen joint count(SJC28)(P=0.046),Visual Analog Scale(VAS)(P=0.019),Patient’s Global Assessment(PtGA)(P=0.019)and Physician’s Global Assessment(PGA)(P=0.031),but no statistical significance was observed in the levels of anti-CCP,RF,ESR,CRP,morning stiffness,28-tender joint count(TJC28),Health Assessment Questionnaire(HAQ)and magnetic resonance imaging(MRI)analysis(P>0.05).Conclusion:The HQT formula is safe and could improve joint symptoms and signs in these at-risk individuals,but it remains to be investigated in futher study to see if it might potentially reduce the risk of developing RA.Besides,for individuals at high risk to develop RA,morning stiffness and synovial enhancement in MRI might be predictive factors and warning signs. | Kaixin Gao Qi Liang Dongyun Li Chuanning Li Maojie Wang Xiumin Chen Qingchun Huang Zehuai Wen Per-Johan Jakobsson Runyue Huang | 2024 | Clinical Complementary Medicine and Pharmacology2024，4，1： | 0 |
| 9 | Study on microbial protein and the mechanism of solid-state fermentation with periodical dynamic changes of air显示文摘The effect of different extraction and purification conditions on the microbial protein obtained from solid-state fermentation(SSF)and the effect of periodical dynamic changes of air on protein have been studied.The mechanism of solid-state fermentation with periodical dynamic changes of air is also discussed.Compared with static solid-state fermentation,periodical dynamic changes of air afford a higher protein mass;from 1 g of the fermentation microbe,5.3 mg of the intracellular protein(an increase of 34.63%)and 9.09 mg of the extracellular protein(an increase of 17.8%)were obtained on the sixth day of fermentation.The filter paper activity and carboxymethyl cellulose activity(FPA and CMCase)of the extracellular protein are 1.739μmol/s and 109.592μmol/s,respectively,which represent increases of 60.1%and 21.2%over the corresponding values for static solid-state fermentation.The FPA and CMCase of the intra-cellular protein are 0.245μmol/s and 6.392μmol/s,respec-tively,which represent decreases of 22.2%and 38.7%over the corresponding values for static solid-state fermentation.The enzyme activity of the microbial extracellular protein in solid-state fermentation with periodical dynamic changes of air on the fifth day is nearly equal to that on the sixth day without periodical dynamic changes of air,so the period of fermentation can be shortened.The sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE)experiments suggest that pulsating air pressure stimulation leads to a decrease in the amount of protein component with molecule mass of about 80400Da,and an increase in the amount of protein component with molecule mass of about 28520Da. | FU Xiaoguo CHEN Hongzhang LI Hongqiang MA Runyu | 2007 | Frontiers of Chemical Science and Engineering2007，1，2： | 0 |
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