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| 1 | 脑损伤早期神经细胞c-fos基因表达变化与脑水肿显示文摘采用免疫细胞化学方法(ABC)研究大鼠脑损伤早期神经细胞c-fos基因表达变化,探讨脑损伤时神经细胞c-fos基因表达变化与脑水肿的关系。结果发现,脑损伤后仅0.5h,脑损伤区周围神经细胞中c-fos基因表达已明显,伤后3~6h更为显著。同时伴有相应部位脑灰质及脑白质水含量增加。初步研究结果提示,脑损伤早期神经细胞c-fos基因表达变化与脑水肿的发生有密切关系。 | Xu Ruxiang Chen Changcai Yuan Guanqian (Zhujiang Hospital, First Military Medical University ,Guangzhou 510282) | 1995 | 解放军医学杂志1995，20，2： | 11 |
| 2 | Current Status of Neuromodulatory Therapies for Disorders of Consciousness显示文摘Treatment for disorders of consciousness(DOCs) is still a Gordian knot. Evidence-based guidelines on the treatment of DOC patients are not currently available, while neuromodulation techniques are seen as a potential treatment. Multiple neuromodulation therapies have been applied. This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients. Both invasive and noninvasive brain stimulation is discussed. Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare. The efficacy of various such therapies remains a matter of debate. Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed,and new approaches are awaited. | Xiaoyu Xia Yi Yang Yongkun Guo Yang Bai Yuanyuan Dang Ruxiang Xu Jianghong He | 2018 | Neuroscience Bulletin2018，34，4： | 10 |
| 3 | Treatment of epilepsy in China Formal or informal?显示文摘Antiepileptic drugs are the preferred treatment approach for epileptic patients.However,informal treatment is important for intractable epilepsy.In this study,500 epileptic patients were recruited from the General Hospital of Beijing Military Area Command of Chinese PLA during the period of October 2009 to January 2012.These involved patients that had been medically treated for at least1 year.Information on the initial treatment and changes to treatment regimens for each patient was collected through questionnaires.The survey results showed that 52.3%of the epileptic patients searched for treatment after the first seizure,and the mean numbers of seizures was 12.8;59.8%of the epileptic patients were diagnosed at the first visit,and the mean onset time was 17 months after the first seizure.After diagnosis,patients were treated for an average of 20 days,and the median time was 1 day.Formal anti-epileptic drugs were selected as the first treatment regimen by 67.8%of patients,and 77.5%of these drugs were monotherapies.The mean and median numbers of seizure were respectively 36.9 and 3.0 times before the first regimen was changed.The regimen was changed within the first 6 months by 46.6%of patients,and after the first and second years of treatment,the proportions increased to 54.0%and 71.8%,respectively.In total,78.5%of the regimens were changed to informal treatments.The informal treatment of epilepsy in China is common,being initiated by either patients or physicians.Enhancing epileptic treatment services in hospital,improving physicians’professional quality,and strengthening health propaganda may promote the normalization of drug treatment of epilepsy in China. | Jianming Liu Zhiliang Liu Tao Chen Ruxiang Xu | 2013 | Neural Regeneration Research2013，8，35： | 5 |
| 4 | Mechanism of the Rpn13-induced activation of Uch37显示文摘 | Lianying Jiao Songying Ouyang Neil Shaw Gaojie Song Yingang Feng Fengfeng Niu Weicheng Qiu Hongtao Zhu Li-Wei Hung Xiaobing Zuo V. Eleonora Shtykova Ping Zhu Yu-Hui Dong Ruxiang Xu Zhi-Jie Liu | 2014 | Protein & Cell2014，5，8： | 4 |
| 5 | Biochemical properties of norepinephrine as a kind of neurotransmitter secreted by bone marrow-derived neural stem cells induced and differentiated in vitro显示文摘BACKGROUND: It has been proved by many experimental studies from the aspects of morphology and immunocytochemistry in recent years that bone marrow stromal cells (BMSCs) can in vitro induce and differentiate into the cells possessing the properties of nerve cells. But the functions of BMSCs-derived neural stem cells(NSCs) and the differentiated neuron-like cells are still unclear. OBJECTIVE: To observe whether bone marrow-derived NSCs can secrete norepinephrine (NE) under the condition of in vitro culture, induce and differentiation, and analyze the biochemical properties of BMSCs-derived NSCs. DESIGN: A non-randomized and controlled experimental observation. SETTING: Institute of Neuromedicine of Chinese PLA, Zhujiang Hospital, Southern Medical University. MATERIALS: This experiment was carried out in the Institute of Neuromedicine of Chinese PLA, Zhujiang Hospital, Southern Medical University. The bone marrow used in the experiment was collected from 1.5- month-old healthy New Zealand white rabbits. METHODS: This experiment was carried out in the Institute of Neuromedicine of Chinese PLA, Zhujiang Hospital, Southern Medical University. The bone marrow used in the experiment was collected from 1.5 month-old healthy New Zealand white rabbits. BMSCs of rabbits were isolated and performed in vitro culture, induce and differentiation with culture medium of NSCs and differentiation-inducing factor, then identified with immunocytochemical method. Experimental grouping: ①Negative control group: L-02 hepatic cell and RPMI1640 culture medium were used. ② Background culture group: Only culture medium of NSCs as culture solution was added into BMSCs to perform culture, and 0.1 volume fraction of imported fetal bovine serum was supplemented 72 hours later. ③Differentiation inducing factor group: After culture for 72 hours, retinoic acid and glial cell line-derived neurotrophic factors were added in the culture medium of BMSCs and NSCs as corresponding inducing factors. The level of NE in each group was detected on the day of culture and 5, 7, 14 and 20 days after culture with high performance liquid chromatography(HPLC). The procedure was conducted 3 times in each group.Standard working curve was made according to the corresponding relationship of NE concentration and peak area. The concentration of NE every 1×107 cells was calculated according to standard curve and cell counting. MAIN OUTCOME MEASURES: The level of NE of cultured cells was detected with HPLC; immunocytochemistrical identification of Nestin and neuron specific nuclear protein was performed. RESULTS: ① On the 14th day after cell culture, BMSCs turned into magnus and round cells which presented Nestin-positive antigen, then changed into neuron-like cells with long processus and presented neuron specific nuclear protein -positive antigen at the 20th day following culture. ② The ratio of NE concentration and peak area has good linear relationship, and regression equation was Y=1.168 36+0.000 272 8X,r=0.998 4.Coefficient variation (CV) was < 5% and the recovery rate was 92.39%(Y referred to concentration and X was peak area).③NE was well detached within 10 minutes under the condition of this experiment. ④ NE was detected in NSCs and their culture mediums, which were cultured for 7, 14 and 20 days respectively, but no NE in BMSCs, NSCs-free culture medium and L-02 hepatic cell which were as negative control under the HPLC examination. Analysis of variance showed that the level of NE gradually increased following the elongation of culture time (P < 0.01). No significant difference in the level of NE existed at the same time between differentiation inducing factor group and basic culture group(P > 0.05). CONCLUSION: BMSCs of rabbits can proliferate in vitro and express Nestin antigen; They can differentiate into neuron-like cells, express specific neucleoprotein of mature neurons, synthesize and secrete NE as a kind of neurotransmitter. | Jianrong Chen Xiaodan Jiang Ruxiang Xu Peng Jin Yuxi Zou Lianshu Ding | 2006 | Neural Regeneration Research2006，1，2： | 3 |
| 6 | Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury显示文摘Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury. | Mou Gao Qin Dong Zhijun Yang Dan Zou Yajuan Han Zhanfeng Chen Ruxiang Xu | 2024 | Neural Regeneration Research2024，19，4： | 1 |
| 7 | Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients显示文摘 | Yanyang Tu Shiming He Jianfang Fu Gang Li Ruxiang Xu Hongliu Lu Jianping Deng | 2012 | Clinical and Translational Oncology2012，，3： | 1 |
| 8 | Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrow显示文摘 | Jiang Xiaodan Xu Ruxiang Yang Zhijun | 2008 | Cell Mol Neurobiol2008，28，5： | 1 |
| 9 | Absence of Tight Junctions between Microvascular Endothelial Cells in Human Cerebellar Hemangioblastomas显示文摘 | Yizhao Chen Osamu Tachibana Mitsuhiro Hasegawa Ruxiang Xu Jun-ichiro Hamada Junkoh Yamashita Nobuo Hashimoto Jun A. Takahashi | 2006 | Neurosurgery2006，，： | 1 |
| 10 | Effect of anysdamyne or changes of blood- brain barrier permeability following brain in jury rabbits显示文摘 | Ruxiang XU Shengyu Yi Mang Boyuen | 1992 | J Med Col PLA1992，7930，： | 1 |
| 11 | Effct of anisdamine on changes of blood-brain barrier permeability following brain injury in rabbits显示文摘 | Ruxiang Xu Shengyu Yi Wang Boyuen | 1992 | J Med Coll PLA1992，7，3： | 1 |
| 12 | Synaptic plasticity effects on FeCl_2-induced post-traumatic epilepsy onset in the rat显示文摘Studies have confirmed that iron induces epilepsy onset,and iron ion-induced epilepsy in animal models closely resembles the clinical situation.Models of post-traumatic epilepsy (PTE) were established by intracortical injection of FeCl2 using stereotactic techniques.Electron microscopy revealed neuronal degeneration,with shrinkage of the neuronal soma,hyperplasia of rough endoplasmic reticulum,ribosomal detachment from the endoplasmic reticulum,and vacuolar degeneration of glial cells in the right frontal lobe of FeCl2-induced PTE rats.With prolonged time,injuries became more severe and neuronal apoptosis was observed.Synapses in the hippocampal neuropil significantly increased (primarily type I/excitatory synapses) at day 14 following injury.Type II synapses (inhibitory synapse) were observed in the rat hippocampus at day 30.Cortical neuronal degeneration,apoptosis,glial cell proliferation,and ultrastructural hippocampal changes,in particular changes in type of neuronal synapse,play an important role in PTE onset. | Yuanxiang Lin Feng Wang Ruxiang Xu Xiaodan Jiang Dezhi Kang Yiquan Ke Mouxuan Du Lishuang Xu | 2010 | Neural Regeneration Research2010，5，18： | 0 |
| 13 | Why patients with refractory epilepsy reject surgery in China显示文摘Epilepsy is a common neurological disorder among all age groups and socioeconomic classes.Epilepsy surgery has been demonstrated to be a safe and effective treatment for drug-refractory epilepsy. Despite this success,many potential surgical candidates refuse surgery. | Liu Jianming Xu Ruxiang You Yu Man Li Liu Zhiliang | 2014 | Chinese Medical Journal2014，，20： | 0 |
| 14 | Analysis of the personalized treatment and the relevant prognostic factors in children with medulloblastoma显示文摘Purpose:The present study summarized cases of children(n=32)with medulloblastoma(MB)who were treated using stratified therapy based on risk grading and also discussed the factors affecting prognosis.Methods:According to the risk stratification criteria,the cases were divided into the following four risk groups:low,standard,high,and very high.The 5-year overall survival(OS)and progression-free survival(PFS)rates were summarized.Further,the effects on the prognosis of tumor size,tumor stage,degree of resection,treatment mode,metastatic recurrence,molecular typing,and risk stratification were analyzed.Results:In the present study,following surgery,3 cases abandoned radiotherapy(RT)and chemotherapy(CHT),7 cases(<3 years of age)received only CHT,and 22 cases received combined RT and CHT.Total and near-total tumor resections were performed in 29 cases(90.6%).Subtotal resections were performed in 3 cases,and there were no surgery-related deaths.The average follow-up duration was 47 months.The average 5-year PFS and OS rates were 57.3%±7.2%and 68.7%±8.6%,respectively.The OS and PFS rates were significantly correlated with tumor-risk stratification,molecular staging,tumor stage,treatment mode,and recurrence after surgery(p<0.01).The degree of tumor resection,pathological type,and the presence of preoperative implantation were secondary factors affecting the prognosis(p<0.05).Age was correlated with the PFS rate.There was no correlation between age/tumor location/tumor size and prognosis(p>0.05).Favorable prognostic factors in the low-and standard-risk groups were stage M0,wingless-type MB,postoperative RT combined with CHT,no postoperative recurrence,age≥3 years,and total tumor resection.Conclusions:Personalized treatment strategies based on the risk stratification of MB and postoperative stratified comprehensive treatment could help improve the prognosis for MB. | LIHUA CHEN HONGTIAN ZHANG YONG XIA KAI SUN WENJIN CHEN RUXIANG XU | 2023 | BIOCELL2023，47，5： | 0 |
| 15 | Tetrahedral framework nucleic acids promote cognitive impairment recovery post traumatic brain injury显示文摘Cognitive impairment often occurs after post traumatic brain injury. In addition, recovery of cognitive impairment is largely dependent on spontaneous repair and the severity of secondary insult. The tetrahedral framework nucleic acid is a novel nanostructure has been shown to have a positive biological effect in promoting regeneration and anti-inflammation. To explore the treatment effect of tetrahedral framework nucleic acids for cognitive impairment recovery post traumatic brain injury, we established a mouse model of traumatic brain injury and verified the efficacy of tetrahedral framework nucleic acids in promoting cognitive impairment recovery post traumatic brain injury. The results show that the tetrahedral framework nucleic acids promoted the recovery of post-traumatic cognitive function by enhancing the proliferation of endogenous neural stem cells. Besides, tetrahedral framework nucleic acids modulated the neuroinflammatory response in the acute phase by inhibiting excessive astrocyte and microglial activation. Taken together, the results of the study indicate tetrahedral framework nucleic acids for treatment of cognitive impairment post traumatic brain injury. | Yangyang Wang Weiqiang Jia Jianwei Zhu Ruxiang Xu Yunfeng Lin | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 16 | Transient axonal glycoprotein-1 induces apoptosisrelated gene expression without triggering apoptosis in U251 glioma cells显示文摘Previous studies show that transient axonal glycoprotein-1, a ligand of amyloid precursor protein, increases the secretion of amyloid precursor protein intracellular domain and is involved in apoptosis in Alzheimer's disease. In this study, we examined the effects of transient axonal glycoprotein-1 on U251 glioma cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that transient axonal glycoprotein-1 did not inhibit the proliferation of U251 cells, but promoted cell viability. The terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed that transient axonal glycoprotein-1 did not induce U251 cell apoptosis. Real-time PCR revealed that transient axonal glycoprotein-1 substantially upregulated levels of amyloid precursor protein intracellular C-terminal domain, and p53 and epidermal growth factor receptor mRNA expression. Thus, transient axonal glycoprotein-1 increased apoptosis-related gene expression in U251 cells without inducing apoptosis. Instead, transient axonal glycoprotein-1 promoted the proliferation of these glioma cells. | Haigang Chang Shanshan Song Zhongcan Chen Yaxiao Wang Lujun Yang Mouxuan Du Yiquan Ke Ruxiang Xu Baozhe Jin Xiaodan Jiang | 2014 | Neural Regeneration Research2014，9，5： | 0 |
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