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| 1 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | Anti-ulcerogenic effectof methanolic extracts from Enicosanthellum pulchrum (King)Heusden against ethanol-induced acute gastric lesion in animalmodels显示文摘 | Nordin N Salama SM Golbabapour S | 2014 | PLoS One2014，9，11： | 1 |
| 4 | Thermal expansion data of some alkali aluminosilicate glasses and their respective glass-ceramics显示文摘 | SALMAN S M SALAMA S N | 1985 | Thermochim Acta1985，90，： | 1 |
| 5 | Validation of the Spectrophotometric Determination of Omeprazole and Pantoprazole Sodium via Their Metal Chelates显示文摘 | SALAMA F EL-ABASAWY N ABDEL RAZEQ S A | 2003 | Journal of Pharmaceutical and Biomedical Analysis(S0371-7085)2003，33，3： | 1 |
| 6 | An RNA gene expressed during cortical development evolved rapidly in humans显示文摘 | POLLARD K S SALAMA S R LAMBERT N | 2006 | Nature2006，443，： | 1 |
| 7 | Ultra - stuctural changes in collagen of pe- nile tunica albuginea in aged and diabetic rats 显示文摘 | Salama N Kagawa S | 1999 | Int J Impot Res1999，11，2： | 1 |
| 8 | An RNA gene expressed during cortical development evolved rapidly in humans显示文摘 | Pollard K S Salama S R Lambert N Lambot M A Coppens S Ped ersen J S | 2006 | Nature2006，443，： | 1 |
| 9 | Utilization of plant proteins in the manufacture of cheese analogs显示文摘 | Ahmed N S Hassan F A M Salama F M M | 1995 | Egyptian Journal of Food Science1995，23，： | 1 |
| 10 | Validation of HPLC method for determination of tetracyclineresidues in chickenmeat and liver 显示文摘 | SHALABY A R SALAMA N A ABOU-RAYA S H | 2011 | Food Chemistry2011，124，4： | 1 |
| 11 | Antiulcerogenic effect of methanolic extracts from Enieosanthellum pul- chrum (King) Heusden against ethanol-induced acute gastric lesion in animal models 显示文摘 | Nordin N Salama SM Golbabapour S | 2014 | PLoS One2014，9，11： | 1 |
| 12 | Helicobacter pylori's un-conventional role in health and disease显示文摘 | DORER M S TALARICO S SALAMA N R | 2009 | PLoS Pathog2009，5，10： | 1 |
| 13 | Ultra-stuctural changes in collagen of penile tunica albuginea in aged and diabetic rats显示文摘 | Salama N Kagawa S | 1999 | Int J Impot Res1999，11，2： | 1 |
| 14 | Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination显示文摘 | HUMBERT O DORER M S SALAMA N R | | 0，，02： | 1 |
| 15 | Components, therapeutic value and uses of myrrh显示文摘 | El Ashry E S Rashed N Salama O M | 2003 | Pharmazie2003，58，3： | 1 |
| 16 | Ultra-stuctural changes in collagen of penile tuuica albuginea in aged and diabetic rats显示文摘 | Salama N Kagawa S | 1999 | Int J Impot Res1999，11，2： | 1 |
| 17 | Crystallization Characteristics of Some Lithia Calcia Magnesia Borosilicate Glasses显示文摘 | Salama S N Salama S M Darwish H | 1995 | Ceram lnt1995，，21： | 1 |
| 18 | Ultra-stuctural changes in collagen of penile tunica albuginea in aged and diabetic rats显示文摘 | SALAMA N KAGAWA S | 1999 | Int J Impot Res1999，11，2： | 1 |
| 19 | Ultra-stuctural changes in collagen of penile tunica albuginea in aged and diabetic rats显示文摘 | Salama N Kagawa S | 1999 | Int J Impot Res1999，11，2： | 1 |
| 20 | Ultra-structural changes in collagen of penil tunica allbuginea in aged and diabetes rats显示文摘 | Kagawa S | 1999 | Int J Impot Res1999，11，2： | 1 |
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