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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 4 | Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States显示文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD. | Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 5 | Forced convective condensation and boiling of temary non-azeotropic refrigerant mixtures inside water/refrigerant enhanced surface tubing显示文摘 | TULEI P J SONG B | 1994 | Int J Ene Res1994，，： | 1 |
| 6 | Pyramiding Mn-superoxide dismutase transgenes to improve persistence and biornass production in alfalfa显示文摘 | Samis K Bowley S Mekersie B | 2002 | Journal of Experimental Botany2002，53，372： | 1 |
| 7 | Synthesis and rheological properties of an associative star polymer in aqueous solutions显示文摘 | Sami Hietala Pekka Mononen Satu Strandman Paula J?rvi Mika Torkkeli Katja Jankova S?ren Hvilsted Heikki Tenhu | 2007 | Polymer2007，，14： | 1 |
| 8 | Stability of aflatoxins B1 and ochrotoxin A in brewing显示文摘 | CHU F S CHANG C C SAMY H | 1975 | Applied Microbiology1975，19，3： | 1 |
| 9 | Study of flow boiling characteristics of R134a in annulus of enhanced surface tubing显示文摘 | DUONG T N | 1993 | Int J Energy Res1993，，： | 1 |
| 10 | An improved model for predicting the dynamic behavior of adsorption systems显示文摘 | Sami S M Tribes C | 1996 | Applied Thermal Engineering1996，16，2： | 1 |
| 11 | Newer disease - modifying anfirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis 显示文摘 | Samy S Pierre E Marie H | 2004 | The Amercann Journal of Medicine2004，117，： | 1 |
| 12 | Pyramiding Mn-superoxide dismutase transgenes to improve persistence and biomass production in alfalfa 显示文摘 | Samis K Bowley S Mckersie B | 2002 | J Exp Bot2002，53，372： | 1 |
| 13 | Non-Interactive Zero-Knowledge Proof Systems显示文摘 | De Samis A Mieali S Persiano G | 1991 | GSIAM Journal on Computing1991，20，6： | 1 |
| 14 | Anterior deep bite malocclusion treated with connecticut intrusion arch: biomeehanical consideration 显示文摘 | Sana S Bansal A Sami L | 2014 | J Clin Diagn Res2014，8，5： | 1 |
| 15 | Microsporidiosis in South Africa : PCR detection in stool samples of HIV-positive and HIV-negative individuals and school children in Vhembe district, Limpopo Province 显示文摘 | Samie A Obi CL Tzipori S | 2007 | Trans R Soc Trop Med Hyg2007，101，6： | 1 |
| 16 | A new design for an air source heat pump using a ternary mixture for cold climates显示文摘 | Sami S M Tulej P J | 2001 | Heat Recovery Systems & Chp2001，15，6： | 1 |
| 17 | Valproic acid inhibits the growth of cervical cancer both in vitro and in vivo显示文摘 | Sami S Hti N Xu HM | 2008 | J Biochem2008，144，3： | 1 |
| 18 | Heterologous expression of lignin peroxiedase of Phanerochaete chrysosporium in Aspergillus niger显示文摘 | A S Mohamed S Sami G Ali | 1999 | Biotechnology Letters1999，21，： | 1 |
| 19 | Use of cotton gin trash to enhance denitrification in restored forested wetlands 显示文摘 | SAMI ULLAH FAULKNER S P | 2006 | Forest Ecology and Management2006，237，： | 1 |
| 20 | An experimental study of heat transfer characteristics of new alternatives to R22显示文摘 | POIRIER B | 1997 | ASHRAE Trans1997，，： | 1 |
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